{"id":"https://openalex.org/W2017222857","doi":"https://doi.org/10.1126/science.133.3470.2067","title":"New Class of Antihypertensive Agents","display_name":"New Class of Antihypertensive Agents","publication_year":1961,"publication_date":"1961-06-30","ids":{"openalex":"https://openalex.org/W2017222857","doi":"https://doi.org/10.1126/science.133.3470.2067","mag":"2017222857","pmid":"https://pubmed.ncbi.nlm.nih.gov/13713776"},"language":"en","primary_location":{"id":"doi:10.1126/science.133.3470.2067","doi":"https://doi.org/10.1126/science.133.3470.2067","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.133.3470.2067","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060749779","display_name":"Alan A. Rubin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. A. Rubin","raw_affiliation_strings":["Schering Corporation, Bloomfield, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schering Corporation, Bloomfield, New Jersey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112727929","display_name":"Franklin E. Roth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. E. Roth","raw_affiliation_strings":["Schering Corporation, Bloomfield, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schering Corporation, Bloomfield, New Jersey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022094038","display_name":"Martin M. Winbury","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. M. Winbury","raw_affiliation_strings":["Schering Corporation, Bloomfield, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schering Corporation, Bloomfield, New Jersey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032896348","display_name":"John G. Topliss","orcid":"https://orcid.org/0000-0002-8916-9405","observed_orcids":["https://orcid.org/0000-0002-8916-9405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. G. Topliss","raw_affiliation_strings":["Schering Corporation, Bloomfield, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schering Corporation, Bloomfield, New Jersey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026736939","display_name":"Margaret H. Sherlock","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. H. Sherlock","raw_affiliation_strings":["Schering Corporation, Bloomfield, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schering Corporation, Bloomfield, New Jersey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061545452","display_name":"Nathan Sperber","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. Sperber","raw_affiliation_strings":["Schering Corporation, Bloomfield, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schering Corporation, Bloomfield, New Jersey","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064195935","display_name":"Jack Black","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Black","raw_affiliation_strings":["Schering Corporation, Bloomfield, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schering Corporation, Bloomfield, New Jersey","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.7334,"has_fulltext":false,"cited_by_count":124,"citation_normalized_percentile":{"value":0.98632983,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"133","issue":"3470","first_page":"2067","last_page":"2067"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13454","display_name":"Phenothiazines and Benzothiazines Synthesis and Activities","score":0.6420999765396118,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13454","display_name":"Phenothiazines and Benzothiazines Synthesis and Activities","score":0.6420999765396118,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.3366999924182892,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.014700000174343586,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.972000002861023},{"id":"https://openalex.org/keywords/benzothiadiazines","display_name":"benzothiadiazines","score":0.9279999732971191},{"id":"https://openalex.org/keywords/synthesis","display_name":"synthesis","score":0.5640000104904175},{"id":"https://openalex.org/keywords/pharmacological-activity","display_name":"pharmacological activity","score":0.871999979019165},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C2778465066","wikidata":"https://www.wikidata.org/wiki/Q4890804","display_name":"Benzothiadiazine","level":2,"score":0.927914023399353},{"id":"https://openalex.org/C2779918671","wikidata":"https://www.wikidata.org/wiki/Q200656","display_name":"Diuretic","level":2,"score":0.5021109580993652},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4859217703342438},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47881513833999634},{"id":"https://openalex.org/C2910328414","wikidata":"https://www.wikidata.org/wiki/Q4890804","display_name":"Benzothiadiazines","level":2,"score":0.4333766996860504},{"id":"https://openalex.org/C2777212361","wikidata":"https://www.wikidata.org/wiki/Q5127848","display_name":"Class (philosophy)","level":2,"score":0.43231895565986633},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2441832721233368},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.20022103190422058},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.11223188042640686},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.07892945408821106}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001519","descriptor_name":"Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005502","descriptor_name":"Food","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010856","descriptor_name":"Columbidae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012054","descriptor_name":"Reinforcement, Psychology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013239","descriptor_name":"Stereotyped Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1126/science.133.3470.2067","doi":"https://doi.org/10.1126/science.133.3470.2067","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.133.3470.2067","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"doi:10.1126/science.133.3470.2067-a","doi":"https://doi.org/10.1126/science.133.3470.2067-a","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.133.3470.2067-a","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:13713776","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13713776","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmid:13744346","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13744346","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1975393912","https://openalex.org/W1979417415","https://openalex.org/W1989902559","https://openalex.org/W2089754759","https://openalex.org/W2320727160","https://openalex.org/W2323210806"],"related_works":["https://openalex.org/W2320281991","https://openalex.org/W2439791000","https://openalex.org/W2325627250","https://openalex.org/W2033742616","https://openalex.org/W2415150891","https://openalex.org/W2043169888","https://openalex.org/W1966908429","https://openalex.org/W2461679424","https://openalex.org/W4301523591","https://openalex.org/W2411321454"],"abstract_inverted_index":{"Effective":[0],"antihypertensive":[1],"agents":[2],"of":[3,8,17,22,26,28],"the":[4,23],"benzothiadiazine":[5],"series,":[6],"devoid":[7],"diuretic":[9],"activity,":[10],"are":[11],"described.":[12],"There":[13],"follows":[14],"a":[15,20],"method":[16],"synthesis":[18],"and":[19],"description":[21],"pharmacological":[24],"activity":[25],"one":[27],"these":[29],"substances":[30]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}