{"id":"https://openalex.org/W2017221150","doi":"https://doi.org/10.1210/en.2009-0664","title":"New Evidence that an Epigenetic Mechanism Mediates Testosterone-Dependent Brain Masculinization","display_name":"New Evidence that an Epigenetic Mechanism Mediates Testosterone-Dependent Brain Masculinization","publication_year":2009,"publication_date":"2009-08-21","ids":{"openalex":"https://openalex.org/W2017221150","doi":"https://doi.org/10.1210/en.2009-0664","mag":"2017221150","pmid":"https://pubmed.ncbi.nlm.nih.gov/19700608","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2736087"},"language":"en","primary_location":{"id":"doi:10.1210/en.2009-0664","doi":"https://doi.org/10.1210/en.2009-0664","is_oa":true,"landing_page_url":"https://doi.org/10.1210/en.2009-0664","pdf_url":"https://academic.oup.com/endo/article-pdf/150/9/3980/9004042/endo3980.pdf","source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/endo/article-pdf/150/9/3980/9004042/endo3980.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017132742","display_name":"Michael J. Baum","orcid":"https://orcid.org/0000-0003-3066-437X","observed_orcids":["https://orcid.org/0000-0003-3066-437X"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael J. Baum","raw_affiliation_strings":["Department of Biology, Boston University, Boston, Massachusetts 02215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Boston University, Boston, Massachusetts 02215","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017132742"],"corresponding_institution_ids":["https://openalex.org/I111088046"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.5363,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.63091576,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"150","issue":"9","first_page":"3980","last_page":"3982"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sexual-differentiation-of-the-brain","display_name":"sexual differentiation of the brain","score":0.7329999804496765},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.5839999914169312},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.7179999947547913},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.8980000019073486},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibition","display_name":"histone deacetylase inhibition","score":0.8870000243186951},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bed-nucleus-of-the-stria-terminalis","display_name":"bed nucleus of the stria terminalis","score":0.972000002861023},{"id":"https://openalex.org/keywords/neonatal-testosterone","display_name":"neonatal testosterone","score":0.5350000262260437},{"id":"https://openalex.org/keywords/sexual-dimorphism","display_name":"sexual dimorphism","score":0.625},{"id":"https://openalex.org/keywords/chromatin-structure","display_name":"chromatin structure","score":0.5249999761581421},{"id":"https://openalex.org/keywords/female-mice","display_name":"female mice","score":0.39500001072883606},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.5839999914169312},{"id":"https://openalex.org/keywords/aromatization","display_name":"aromatization","score":0.5929999947547913},{"id":"https://openalex.org/keywords/dihydrotestosterone","display_name":"dihydrotestosterone","score":0.7310000061988831},{"id":"https://openalex.org/keywords/estradiol-receptor","display_name":"estradiol receptor","score":0.6669999957084656},{"id":"https://openalex.org/keywords/neuron-number","display_name":"neuron number","score":0.3050000071525574}],"concepts":[{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.8019571900367737},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7833690643310547},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7658470869064331},{"id":"https://openalex.org/C63405245","wikidata":"https://www.wikidata.org/wiki/Q9076644","display_name":"Sexual differentiation","level":3,"score":0.7359664440155029},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.6783183813095093},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6056168079376221},{"id":"https://openalex.org/C2779881493","wikidata":"https://www.wikidata.org/wiki/Q411054","display_name":"Dihydrotestosterone","level":4,"score":0.5800572633743286},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.5697130560874939},{"id":"https://openalex.org/C2778652331","wikidata":"https://www.wikidata.org/wiki/Q3122152","display_name":"Stria terminalis","level":3,"score":0.5335351228713989},{"id":"https://openalex.org/C146819174","wikidata":"https://www.wikidata.org/wiki/Q1703595","display_name":"Hypothalamic\u2013pituitary\u2013gonadal axis","level":4,"score":0.4251835346221924},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.4065101444721222},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.1597205400466919},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15865519642829895},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14605975151062012},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.11975228786468506},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.097116619348526},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012686","descriptor_name":"Septal Nuclei","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012686","descriptor_name":"Septal Nuclei","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012727","descriptor_name":"Sex Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014635","descriptor_name":"Valproic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014770","descriptor_name":"Virilism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1210/en.2009-0664","doi":"https://doi.org/10.1210/en.2009-0664","is_oa":true,"landing_page_url":"https://doi.org/10.1210/en.2009-0664","pdf_url":"https://academic.oup.com/endo/article-pdf/150/9/3980/9004042/endo3980.pdf","source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2736087","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2736087","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Text"},{"id":"pmid:19700608","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19700608","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Comment"}],"best_oa_location":{"id":"doi:10.1210/en.2009-0664","doi":"https://doi.org/10.1210/en.2009-0664","is_oa":true,"landing_page_url":"https://doi.org/10.1210/en.2009-0664","pdf_url":"https://academic.oup.com/endo/article-pdf/150/9/3980/9004042/endo3980.pdf","source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2760503597","display_name":"Contribution of Estradiol to Female Neural Development","funder_award_id":"R01HD044897","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G3821185249","display_name":null,"funder_award_id":"HD44897","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017221150.pdf","grobid_xml":"https://content.openalex.org/works/W2017221150.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1234418111","https://openalex.org/W1980242006","https://openalex.org/W2011700227","https://openalex.org/W2013713678","https://openalex.org/W2039276157","https://openalex.org/W2046818677","https://openalex.org/W2060999889","https://openalex.org/W2062305039","https://openalex.org/W2062631244","https://openalex.org/W2064131017","https://openalex.org/W2070780249","https://openalex.org/W2076173286","https://openalex.org/W2081161251","https://openalex.org/W2108797662","https://openalex.org/W2112203969","https://openalex.org/W2170425512"],"related_works":["https://openalex.org/W2620697552","https://openalex.org/W2108429220","https://openalex.org/W1169090060","https://openalex.org/W1999544044","https://openalex.org/W2070780249","https://openalex.org/W2044100755","https://openalex.org/W2990751675","https://openalex.org/W2002653885","https://openalex.org/W2036933587","https://openalex.org/W7096699973"],"abstract_inverted_index":{"Since":[0],"the":[1,22,30,37,65,84,91,112,129,159,162,180,188,193,196,221,224,228,232,260,279,285,306,318,338,364,382,405,452,473,564,568,585,607,619,622,641,646,661,676,685,695,751,780,796,825,841,844,874,888,892,908,913,921,966,979,985,1003,1006,1046,1054,1111,1121,1143,1156,1179,1221,1226,1257,1281,1284,1288,1301,1313,1339,1345,1349,1381,1385,1404,1413,1418,1426,1433,1460,1476,1484,1500,1511,1520,1570,1574],"seminal":[2],"publication":[3],"of":[4,18,26,33,39,41,62,67,86,94,100,102,114,131,134,147,161,190,195,208,216,223,227,231,255,264,270,281,287,297,305,321,330,340,359,366,384,396,417,430,454,472,488,522,539,548,588,593,603,614,621,648,657,706,724,731,743,774,848,876,916,924,952,968,982,997,1009,1029,1038,1056,1076,1110,1120,1158,1162,1175,1178,1199,1202,1205,1228,1260,1272,1283,1290,1316,1322,1348,1356,1384,1403,1458,1465,1486,1492,1542,1553,1569,1573],"Raisman":[5],"and":[6,44,48,110,139,240,426,468,480,514,767,843,879,890,958,1210,1216,1232,1244,1265,1344,1379,1391,1431],"Field":[7],"(1)":[8],"showing":[9],"that":[10,116,302,361,393,433,447,505,517,524,545,575,584,609,645,816,834,865,965,1041,1137,1255,1332,1397,1469,1503,1527],"neonatal":[11,217,303,324,546,615,679,922,980,995,1010,1027,1074,1160,1317,1505],"exposure":[12],"to":[13,89,136,166,179,211,259,267,275,353,413,428,445,520,697,716,721,779,805,948,992,1024,1045,1059,1086,1116,1170,1208,1220,1263,1327,1376,1445,1488,1562],"testosterone":[14,35,68,88,135,148,184,218,325,332,436,771,983,1011,1487,1506,1586],"organizes":[15],"male-typical":[16,71,92,167,1036,1320,1361],"features":[17,1321],"synaptic":[19],"relationships":[20],"in":[21,36,46,53,70,97,111,158,205,219,236,246,249,278,284,291,326,335,371,404,478,484,562,580,660,675,684,702,736,750,756,759,776,783,794,824,840,887,895,899,907,912,936,940,955,984,1033,1068,1080,1094,1125,1146,1149,1183,1214,1225,1250,1269,1287,1336,1360,1398,1412,1421,1424,1432,1474,1483,1510,1519,1523],"rat":[23],"hypothalamus,":[24],"dozens":[25],"studies":[27,81,126],"have":[28,75,82,127,669,1042,1195],"reaffirmed":[29],"critical":[31,295],"role":[32,130,951],"perinatal":[34,87,132,765,1369,1529],"masculinization":[38,222,592,672,967],"aspects":[40,1037],"brain":[42,72,168,573,662,707,959,1209,1264,1323,1330,1362],"morphology":[43,595,974,1014],"function":[45,735,1040],"rats":[47,853,1070,1127,1215],"mice":[49,251,328,432,633,761,1034],"as":[50,52,442,444,501,503,664,727,911,1063,1065,1239,1241],"well":[51,443,502,963,1064,1240],"several":[54,764],"other":[55,717,1190,1328,1466],"mammalian":[56],"animal":[57],"models":[58],"(2).":[59],"Several":[60],"lines":[61],"investigation":[63],"exploring":[64],"mechanisms":[66,182,1262],"action":[69,215,320,667],"sexual":[73,169,708,1089,1212,1267,1324,1363],"differentiation":[74,1213,1268,1325,1364],"evolved":[76],"since":[77],"1973":[78],"(3).":[79],"Numerous":[80],"explored":[83],"contribution":[85,1201],"specifying":[90],"profile":[93,1174],"neurotransmitter":[95],"phenotypes":[96],"specific":[98,106,1258,1295],"groups":[99,266,429,490],"neurons,":[101],"neuronal":[103,238,1422,1508,1517],"migration":[104],"into":[105,873,1002],"sexually":[107,578,732,1334],"dimorphic":[108,579,733,1335],"nuclei,":[109],"expression":[113,189,280,726,836,1207,1496],"genes":[115,191,283,1358,1468],"control":[117,160,485],"programmed":[118,1471],"cell":[119,466,512,557,1472,1493],"death":[120,1473,1494],"(apoptosis)":[121],"within":[122,374],"these":[123,489,1153,1291],"nuclei.":[124],"Other":[125,1132],"examined":[128],"conversion":[133],"estradiol":[137,142,186],"(aromatization)":[138],"actions":[140,146,981,1008],"via":[141],"receptors":[143,157,659],"vs.":[144],"direct":[145],"or":[149,262,329,419,439,528,559,567,625,789,798,820,930,939,1091,1449,1464,1478],"its":[150,378,1450],"androgenic":[151],"metabolite,":[152],"dihydrotestosterone,":[153],"on":[154,337,381,422,451,556,590,618,626,636,978,1012,1280,1319,1538],"neural":[155,734,931,1030,1077,1163,1451,1467],"androgen":[156],"above-named":[163],"functions":[164],"leading":[165],"differentiation.":[170,709],"Until":[171],"recently,":[172],"however,":[173],"little":[174],"attention":[175,1233],"has":[176,1560],"been":[177,1043],"paid":[178],"molecular":[181],"whereby":[183],"and/or":[185],"modulate":[187],"controlling":[192,220],"development":[194,339,620],"male":[197,247,757,852,878,937,986,1069,1081,1126,1150,1168,1512,1521],"nervous":[198,407,1415],"system.":[199,408],"A":[200,1351],"new":[201,299],"study":[202,300,740,915],"(4)":[203,350,535,691,933],"published":[204],"this":[206,298,415,549,604,682,861,1539,1543],"issue":[207],"Endocrinology":[209],"points":[210],"a":[212,312,344,355,599,949,1017,1172,1200,1270,1400],"possible":[213,950],"epigenetic":[214,700,722,953,1203,1261,1366,1455,1490],"principal":[225,1567],"nucleus":[226,230,470,515,566,571,847,1342,1347,1568,1572],"bed":[229,1571],"stria":[233,1575],"terminalis":[234],"(BNSTp),":[235],"which":[237],"number":[239,467,513,558,1423,1509,1518],"nuclear":[241,560,747,1580],"volume":[242,471,561],"are":[243,576,693,1298,1333,1374],"normally":[244],"greater":[245,477,839],"than":[248,483,758,1148],"female":[250,327,431,623,760,849,880,1057,1147],"(5).":[252],"Epigenetic":[253],"modification":[254,1367],"chromatin":[256],"structure":[257],"due":[258],"addition":[261],"deletion":[263],"acetyl":[265],"lysine":[268],"residues":[269],"histone":[271,313,368,401,550,745,814,1031,1078,1164,1456,1578],"tails":[272],"can":[273,817],"lead":[274],"long-term":[276],"changes":[277],"particular":[282,1357],"absence":[286],"any":[288,703],"underlying":[289],"change":[290],"DNA":[292,807],"sequences.":[293],"The":[294,409,687,1309],"observation":[296,544,608,1502],"was":[301,606,611,837,1548],"administration":[304,547],"anticonvulsant":[307],"drug":[308,605],"valproic":[309,1588],"acid":[310],"(VPA),":[311],"deacetylase":[314,402,551],"inhibitor,":[315],"completely":[316],"blocked":[317,399,681,1053],"masculinizing":[319,1007],"either":[322,435,526,563,795,818,1088,1459,1475],"exogenous,":[323],"testicular":[331],"secreted":[333],"neonatally":[334,508,871],"males":[336,446,479,504],"BNSTp":[341,474,511,594,624,973,1050,1112,1427,1477,1514],"morphology.":[342],"In":[343,738,1016,1438],"preliminary":[345],"experiment,":[346,910],"Murray":[347,532,688,917,1105,1185,1305,1386],"et":[348,533,689,830,918,1106,1186,1306,1387],"al.":[349,534,690,831,919,1107,1187,1307,1388],"took":[351],"pains":[352],"identify":[354],"dose":[356,395,416],"(50":[357],"mg/kg)":[358],"VPA":[360,397,418,507,529,540,589,616,649,680,1318],"reliably":[362],"increased":[363],"levels":[365,742,773,886],"acetylated":[367,744,1577],"H3":[369,746,1579],"protein":[370,748,801,885,1408,1584],"whole-brain":[372],"homogenates":[373],"24":[375],"h":[376],"after":[377,857],"sc":[379],"injection":[380],"day":[383,453,463],"birth,":[385],"without":[386],"causing":[387],"toxic":[388],"effects.":[389],"This":[390],"outcome":[391],"ensured":[392],"their":[394,543,1084,1392],"effectively":[398,882],"endogenous":[400,1504],"activity":[403,1119],"developing":[406,1414],"investigators":[410],"then":[411],"proceeded":[412],"administer":[414],"saline":[420,493,527],"vehicle":[421,441,450,494],"postnatal":[423,462,637,903],"d":[424,638,856,904],"1":[425,855],"2":[427,802],"received":[434,448,492,506,525],"propionate":[437],"(TP)":[438],"oil":[440,449],"birth.":[455,858],"When":[456],"brains":[457],"were":[458,475,518,634,753,792,1113],"processed":[459],"histologically":[460],"at":[461,763],"21,":[464],"both":[465,498,877,1425],"total":[469],"significantly":[476,754,838,1117],"TP-treated":[481,499],"females":[482,486,500,523,777,941,1526],"(all":[487],"also":[491],"neonatally).":[495],"By":[496],"contrast,":[497],"later":[509,1182],"had":[510,553],"volumes":[516],"equivalent":[519],"those":[521],"neonatally.":[530,944],"Importantly,":[531],"demonstrated":[536],"considerable":[537],"specificity":[538],"treatment":[541,617,769],"with":[542,770,851,1097,1525],"blocker":[552],"no":[554,612],"effects":[555,647,791,934],"suprachiasmatic":[565],"anterodorsal":[569],"thalamic":[570],"(two":[572],"regions":[574,1331],"not":[577,597,651],"mice).":[581],"Additional":[582],"evidence":[583,1198],"disruptive":[586,1314],"effect":[587,602,613,1315],"testosterone-mediated":[591],"did":[596,650],"reflect":[598],"global":[600],"teratogenic":[601],"there":[610],"subjects\u2019":[627],"body":[628],"weights":[629],"measured":[630],"when":[631,1371],"all":[632,1218],"killed":[635,762,854],"21.":[639],"Finally,":[640],"authors":[642,1191,1383],"argued":[643],"persuasively":[644,1254],"result":[652],"from":[653],"an":[654,666,699,713,728,1098],"unwanted":[655],"stimulation":[656],"GABA":[658],"insofar":[663],"such":[665,786],"would":[668,989,1021,1166],"promoted":[670],"hypothalamic":[671,846],"(6),":[673],"whereas":[674],"present":[677],"study,":[678],"process":[683],"BNSTp.":[686,1047],"results":[692,946,1302],"among":[694],"first":[696,1310],"implicate":[698],"mechanism":[701],"morphological":[704,932],"aspect":[705],"These":[710],"data":[711,1154],"provide":[712],"important":[714,1023,1444],"complement":[715],"recent":[718],"reports":[719],"pointing":[720],"modulation":[723,1204],"gene":[725,822,1206,1462,1495],"essential":[729],"determinant":[730],"rodents.":[737],"one":[739],"(7),":[741],"(H3K9/14Ac)":[749],"cortex/hippocampus":[752],"higher":[755],"ages,":[766],"transplacental":[768],"augmented":[772],"H3K9/14Ac":[775],"up":[778],"level":[781],"seen":[782,793],"males.":[784],"No":[785],"sex":[787,893,1223,1285,1372,1419],"differences":[788,1224,1286,1420,1482],"hormone":[790],"hypothalamus":[797],"amygdala.":[799],"Methyl-CpG-binding":[800],"(MeCP2)":[803],"binds":[804],"methylated":[806],"where":[808],"it":[809,1020,1441],"recruits":[810],"chromatin-binding":[811],"factors,":[812],"including":[813,1275,1338],"deacetylases,":[815],"activate":[819],"repress":[821],"transcription":[823],"rodent":[826,1513],"forebrain":[827],"(8).":[828],"Kurian":[829],"(9)":[832],"reported":[833,864],"MeCP2":[835,866,884,998],"amygdala":[842,875,889,1004],"ventromedial":[845],"compared":[850],"Subsequently":[859],"(10),":[860],"same":[862],"group":[863],"small":[867,999],"interfering":[868,1000],"RNA,":[869],"infused":[870],"directly":[872],"rats,":[881],"suppressed":[883],"eliminated":[891],"difference":[894],"prepubertal":[896],"play":[897,969],"behavior":[898,970,1067,1093],"observations":[900],"made":[901],"over":[902],"25\u201329.":[905],"Thus,":[906],"latter":[909],"current":[914],"(4),":[920,1108,1188,1390],"manipulation":[923],"epigenesis":[925],"exerted":[926],"long-lasting":[927],"behavioral":[928,957,1039,1211,1266],"(10)":[929],"only":[935],"subjects":[938],"given":[942,1128],"TP":[943],"Both":[945],"point":[947,1219],"events":[954],"hormone-controlled":[956],"masculinization.":[960],"It":[961,988],"is":[962,1311,1353],"established":[964],"(11),":[971],"like":[972,1189],"(4,":[975],"12),":[976],"depends":[977],"rodent.":[987],"be":[990,1022,1443],"interesting":[991],"know":[993,1025],"whether":[994,1026,1159,1312,1354,1447],"infusions":[996],"RNA":[1001],"block":[1005],"amygdaloid":[1013],"(13).":[1015],"similar":[1018],"vein,":[1019],"blockade":[1028],"deacetylation":[1032,1079,1165],"disrupts":[1035],"linked":[1044],"For":[1048],"example,":[1049],"lesions":[1051,1109],"selectively":[1052],"ability":[1055,1085,1485],"pheromones":[1058],"elicit":[1060],"penile":[1061],"erections":[1062],"mating":[1066,1092],"(14).":[1071],"Does":[1072],"selective":[1073],"inhibition":[1075,1161],"rodents":[1082,1169],"disrupt":[1083],"show":[1087,1171],"arousal":[1090],"adult":[1095],"tests":[1096],"estrous":[1099],"female?":[1100],"As":[1101],"pointed":[1102],"out":[1103],"by":[1104,1300,1304,1550],"previously":[1114,1395],"found":[1115],"augment":[1118],"hypothalamic-pituitary-adrenal":[1122],"(HPA)":[1123],"axis":[1124,1145,1181],"restraint":[1129,1138],"stress":[1130,1139],"(15).":[1131],"previous":[1133],"research":[1134],"(16)":[1135],"showed":[1136,1396],"more":[1140],"strongly":[1141],"activates":[1142],"HPA":[1144,1180],"rats.":[1151],"Again,":[1152],"raise":[1155],"question":[1157],"cause":[1167],"female-typical":[1173],"stress-induced":[1176],"activation":[1177],"life.":[1184],"(7,":[1192],"9)":[1193],"who":[1194],"recently":[1196],"provided":[1197],"mice,":[1217,1337,1399],"well-known":[1222],"incidence":[1227],"autism":[1229],"spectrum":[1230],"disorder":[1231,1235,1243],"deficit":[1234],"(male":[1236,1428],">":[1237,1248,1429,1436],"female)":[1238,1430],"bipolar":[1242],"Rhett\u2019s":[1245],"syndrome":[1246],"(female":[1247,1435],"male)":[1249],"humans.":[1251],"They":[1252],"argue":[1253],"understanding":[1256],"contributions":[1259],"variety":[1271],"species,":[1273],"eventually":[1274],"humans,":[1276],"may":[1277],"shed":[1278],"light":[1279],"etiology":[1282],"occurrence":[1289],"mental":[1292],"disorders.":[1293],"Two":[1294],"experimental":[1296],"questions":[1297],"raised":[1299],"obtained":[1303],"(4).":[1308],"extends":[1326],"well-studied":[1329],"anteroventral":[1340],"periventricular":[1341,1565],"(AVPV)":[1343],"spinal":[1346],"bulbocavernosus.":[1350],"second":[1352],"promoters":[1355],"implicated":[1359],"undergo":[1365],"during":[1368],"periods":[1370],"hormones":[1373],"known":[1375],"act.":[1377],"Forger":[1378],"DeVries,":[1380],"senior":[1382],"article":[1389],"co-workers":[1393],"(5)":[1394],"null":[1401],"mutation":[1402],"Bax":[1405,1461],"gene,":[1406],"whose":[1407],"product":[1409],"promotes":[1410],"apoptosis":[1411],"system,":[1416],"abolished":[1417],"AVPV":[1434,1522],"male).":[1437],"future":[1439],"studies,":[1440],"will":[1442],"determine":[1446],"testosterone,":[1448],"metabolite":[1452],"estradiol,":[1453],"exerts":[1454],"modifications":[1457,1491],"promoter":[1463],"regulate":[1470],"AVPV.":[1479],"Indeed,":[1480],"region-specific":[1481],"stimulate":[1489],"could":[1497],"help":[1498],"explain":[1499],"paradoxical":[1501],"augments":[1507],"while":[1515],"reducing":[1516],"comparison":[1524],"lack":[1528],"testosterone.":[1530],"I":[1531],"thank":[1532],"Dr.":[1533],"Stuart":[1534],"Tobet":[1535],"for":[1536],"commenting":[1537],"manuscript.":[1540],"Preparation":[1541],"News":[1544],"&":[1545],"Views":[1546],"editorial":[1547],"supported":[1549],"National":[1551],"Institutes":[1552],"Health":[1554],"Grant":[1555],"HD44897.":[1556],"Disclosure":[1557],"Summary:":[1558],"M.J.B.":[1559],"nothing":[1561],"disclose.":[1563],"Anteroventral":[1564],"nucleus;":[1566],"terminalis;":[1576],"protein;":[1581],"hypothalamic-pituitary-adrenal;":[1582],"methyl-CpG-binding":[1583],"2;":[1585],"propionate;":[1587],"acid.":[1589]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
