{"id":"https://openalex.org/W2017209031","doi":"https://doi.org/10.1017/s1740925x08000045","title":"Acetylcholine inhibits cell cycle progression in rat Schwann cells by activation of the M2 receptor subtype","display_name":"Acetylcholine inhibits cell cycle progression in rat Schwann cells by activation of the M2 receptor subtype","publication_year":2007,"publication_date":"2007-11-01","ids":{"openalex":"https://openalex.org/W2017209031","doi":"https://doi.org/10.1017/s1740925x08000045","mag":"2017209031","pmid":"https://pubmed.ncbi.nlm.nih.gov/18634559"},"language":"en","primary_location":{"id":"doi:10.1017/s1740925x08000045","doi":"https://doi.org/10.1017/s1740925x08000045","is_oa":false,"landing_page_url":"https://doi.org/10.1017/s1740925x08000045","pdf_url":null,"source":{"id":"https://openalex.org/S194259625","display_name":"Neuron Glia Biology","issn_l":"1740-925X","issn":["1740-925X","1741-0533"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuron Glia Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103876014","display_name":"Simona Loreti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simona Loreti","raw_affiliation_strings":["Department of Cell and Developmental Biology, University of Roma La Sapienza, Research Center of Neuroscience Daniel Bovet, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University of Roma La Sapienza, Research Center of Neuroscience Daniel Bovet, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082675800","display_name":"Ruggero Ricordy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110528","display_name":"Institute of Molecular Biology and Pathology","ror":"https://ror.org/01nyatq71","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210110528","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ruggero Ricordy","raw_affiliation_strings":["Institute of Biology and Molecular Pathology, CNR, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biology and Molecular Pathology, CNR, Roma, Italy","institution_ids":["https://openalex.org/I4210110528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027968514","display_name":"Maria Egle De Stefano","orcid":"https://orcid.org/0000-0002-5730-2996","observed_orcids":["https://orcid.org/0000-0002-5730-2996"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Egle De Stefano","raw_affiliation_strings":["Department of Cell and Developmental Biology, University of Roma \u201cLa Sapienza\u201d, Research Center of Neuroscience Daniel Bovet, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University of Roma \u201cLa Sapienza\u201d, Research Center of Neuroscience Daniel Bovet, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110095225","display_name":"Gabriella Augusti-Tocco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gabriella Augusti-Tocco","raw_affiliation_strings":["Department of Cell and Developmental Biology, University of Roma \u201cLa Sapienza\u201d, Research Center of Neuroscience Daniel Bovet, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University of Roma \u201cLa Sapienza\u201d, Research Center of Neuroscience Daniel Bovet, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007452991","display_name":"Ada Maria Tata","orcid":"https://orcid.org/0000-0003-4868-5435","observed_orcids":["https://orcid.org/0000-0003-4868-5435"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ada Maria Tata","raw_affiliation_strings":["Department of Cell and Developmental Biology, University of Roma \u201cLa Sapienza\u201d, Research Center of Neuroscience Daniel Bovet, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University of Roma \u201cLa Sapienza\u201d, Research Center of Neuroscience Daniel Bovet, Italy","institution_ids":["https://openalex.org/I861853513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2281,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.45113386,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"3","issue":"4","first_page":"269","last_page":"279"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.3813000023365021,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.3813000023365021,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.30399999022483826,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.025100000202655792,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.9950000047683716},{"id":"https://openalex.org/keywords/schwann-cells","display_name":"Schwann cells","score":0.8360000252723694},{"id":"https://openalex.org/keywords/m2-muscarinic-receptor","display_name":"M2 muscarinic receptor","score":0.972000002861023},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.7870000004768372},{"id":"https://openalex.org/keywords/g1-phase","display_name":"G1 phase","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8899999856948853},{"id":"https://openalex.org/keywords/arecaidine","display_name":"arecaidine","score":0.9739999771118164},{"id":"https://openalex.org/keywords/pcna","display_name":"PCNA","score":0.8830000162124634},{"id":"https://openalex.org/keywords/p27","display_name":"p27","score":0.9750000238418579},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":1.0},{"id":"https://openalex.org/keywords/schwann-cell-differentiation","display_name":"Schwann cell differentiation","score":0.718999981880188},{"id":"https://openalex.org/keywords/sciatic-nerve","display_name":"sciatic nerve","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6575796604156494},{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.6149582266807556},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.592574954032898},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.561781644821167},{"id":"https://openalex.org/C80161118","wikidata":"https://www.wikidata.org/wiki/Q408520","display_name":"Acetylcholine receptor","level":3,"score":0.5443971753120422},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5317306518554688},{"id":"https://openalex.org/C47488739","wikidata":"https://www.wikidata.org/wiki/Q17861931","display_name":"Muscarinic acetylcholine receptor M2","level":4,"score":0.5237522125244141},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5066366791725159},{"id":"https://openalex.org/C64615621","wikidata":"https://www.wikidata.org/wiki/Q15333405","display_name":"Muscarinic acetylcholine receptor M5","level":5,"score":0.4975569546222687},{"id":"https://openalex.org/C116289061","wikidata":"https://www.wikidata.org/wiki/Q17861955","display_name":"Muscarinic acetylcholine receptor M3","level":4,"score":0.4897013008594513},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4790397882461548},{"id":"https://openalex.org/C2777004073","wikidata":"https://www.wikidata.org/wiki/Q465621","display_name":"Schwann cell","level":2,"score":0.44522637128829956},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.42587941884994507},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.38640296459198},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.30258646607398987},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16728425025939941}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1017/s1740925x08000045","doi":"https://doi.org/10.1017/s1740925x08000045","is_oa":false,"landing_page_url":"https://doi.org/10.1017/s1740925x08000045","pdf_url":null,"source":{"id":"https://openalex.org/S194259625","display_name":"Neuron Glia Biology","issn_l":"1740-925X","issn":["1740-925X","1741-0533"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuron Glia Biology","raw_type":"journal-article"},{"id":"pmid:18634559","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18634559","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuron glia biology","raw_type":"Journal Article"},{"id":"pmh:oai:iris.uniroma1.it:11573/365888","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/365888","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322750","display_name":"Istituto Pasteur-Fondazione Cenci Bolognetti","ror":"https://ror.org/051v7w268"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1512655005","https://openalex.org/W1558960310","https://openalex.org/W1921859167","https://openalex.org/W1928529605","https://openalex.org/W1966385755","https://openalex.org/W1970965220","https://openalex.org/W1976138487","https://openalex.org/W1984447821","https://openalex.org/W1985089306","https://openalex.org/W1991074641","https://openalex.org/W1996569896","https://openalex.org/W2001352121","https://openalex.org/W2002494433","https://openalex.org/W2005697934","https://openalex.org/W2023455262","https://openalex.org/W2026079063","https://openalex.org/W2027310689","https://openalex.org/W2051373450","https://openalex.org/W2063063986","https://openalex.org/W2067829451","https://openalex.org/W2071855260","https://openalex.org/W2072706393","https://openalex.org/W2074377398","https://openalex.org/W2078184897","https://openalex.org/W2090621408","https://openalex.org/W2100093054","https://openalex.org/W2101557613","https://openalex.org/W2103575282","https://openalex.org/W2128628045","https://openalex.org/W2128635872","https://openalex.org/W2141426770","https://openalex.org/W2158103455","https://openalex.org/W2340686607","https://openalex.org/W2414366015"],"related_works":["https://openalex.org/W1509458017","https://openalex.org/W4210617531","https://openalex.org/W4313246865","https://openalex.org/W3085809359","https://openalex.org/W2041559782","https://openalex.org/W2128628045","https://openalex.org/W2113665623","https://openalex.org/W1948736584","https://openalex.org/W1508623490","https://openalex.org/W2473225638"],"abstract_inverted_index":{"Cultures":[0],"of":[1,40,48,53,76,90,99,102],"Schwann":[2,122,143,154],"cells":[3,41,144],"from":[4,78],"neonatal":[5],"rat":[6],"sciatic":[7],"nerves":[8],"were":[9],"treated":[10],"with":[11,108],"acetylcholine":[12,25],"agonists":[13,28],"and":[14,32,38,125,130],"the":[15,43,79,85,91,100,117],"effects":[16],"on":[17,63],"cell":[18,30,123,155],"proliferation":[19,156],"evaluated.":[20],"(3)[H]-thymidine":[21],"incorporation":[22],"shows":[23],"that":[24,58,137,150],"(ACh)":[26],"receptor":[27,65,110,159],"inhibit":[29],"proliferation,":[31],"FACS":[33],"analysis":[34],"demonstrates":[35,136],"cell-cycle":[36,104],"arrest":[37],"accumulation":[39],"in":[42,70,116,121,128,145],"G1":[44,71],"phase.":[45,87],"The":[46,67,88],"use":[47],"arecaidine,":[49],"a":[50,114,167],"selective":[51],"agonist":[52,111],"muscarinic":[54],"M2":[55,64,138,158],"receptors":[56,139],"reveals":[57],"this":[59],"effect":[60],"depends":[61],"mainly":[62],"activation.":[66],"arecaidine":[68,77],"dependent-block":[69],"is":[72,94],"reversible":[73],"because":[74],"removal":[75],"culture":[80],"medium":[81],"induces":[82],"progression":[83,165],"to":[84,163,166],"S":[86],"block":[89],"G1-S":[92],"transition":[93],"also":[95],"characterized":[96],"by":[97,142,152],"modulation":[98],"expression":[101],"several":[103],"markers.":[105],"Moreover,":[106],"treatment":[107],"ACh":[109],"causes":[112],"both":[113],"decrease":[115],"PCNA":[118],"protein":[119],"levels":[120],"nuclei":[124],"an":[126],"increase":[127],"p27":[129],"p53":[131],"proteins.":[132],"Finally,":[133],"immuno-electron":[134],"microscopy":[135],"are":[140],"expressed":[141],"vivo.":[146],"These":[147],"results":[148],"indicate":[149],"ACh,":[151],"modulating":[153],"through":[157],"activation,":[160],"might":[161],"contribute":[162],"their":[164],"more":[168],"differentiated":[169],"phenotype.":[170]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}