{"id":"https://openalex.org/W2017201945","doi":"https://doi.org/10.1097/00007890-200109270-00006","title":"PATIENTS AT RISK FOR DEVELOPMENT OF POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDER: PLASMA VERSUS PERIPHERAL BLOOD MONONUCLEAR CELLS AS MATERIAL FOR QUANTIFICATION OF EPSTEIN-BARR VIRAL LOAD BY USING REAL-TIME QUANTITATIVE POLYMERASE CHAIN REACTION1,2","display_name":"PATIENTS AT RISK FOR DEVELOPMENT OF POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDER: PLASMA VERSUS PERIPHERAL BLOOD MONONUCLEAR CELLS AS MATERIAL FOR QUANTIFICATION OF EPSTEIN-BARR VIRAL LOAD BY USING REAL-TIME QUANTITATIVE POLYMERASE CHAIN REACTION1,2","publication_year":2001,"publication_date":"2001-09-01","ids":{"openalex":"https://openalex.org/W2017201945","doi":"https://doi.org/10.1097/00007890-200109270-00006","mag":"2017201945","pmid":"https://pubmed.ncbi.nlm.nih.gov/11579293"},"language":"en","primary_location":{"id":"doi:10.1097/00007890-200109270-00006","doi":"https://doi.org/10.1097/00007890-200109270-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-200109270-00006","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109868023","display_name":"Hans-Joachim Wagner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Hans-Joachim Wagner","raw_affiliation_strings":["Department of Pediatrics, Medical University of L\u00fcbeck, Germany. hjwagner@usa.net","Current affiliation: Center for Gene and Cell Therapy, Baylor College of Medicine, 1102 Bates Street, Houston, TX 77030-3498","Department of Pediatrics, Medical University of L\u00fcbeck","Hans-Joachim Wagner, M.D., Center for Gene and Cell Therapy, Baylor College of Medicine, 1102 Bates Street, Houston, TX 77030-3498. E-mail"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Medical University of L\u00fcbeck, Germany. hjwagner@usa.net","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"Current affiliation: Center for Gene and Cell Therapy, Baylor College of Medicine, 1102 Bates Street, Houston, TX 77030-3498","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Pediatrics, Medical University of L\u00fcbeck","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"Hans-Joachim Wagner, M.D., Center for Gene and Cell Therapy, Baylor College of Medicine, 1102 Bates Street, Houston, TX 77030-3498. E-mail","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077331810","display_name":"Meike Wessel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Meike Wessel","raw_affiliation_strings":["Department of Pediatrics, Medical University of L\u00fcbeck"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Medical University of L\u00fcbeck","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078383982","display_name":"Wolfram Johannes Jabs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfram Jabs","raw_affiliation_strings":["Department of Internal Medicine I, Medical University of L\u00fcbeck"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, Medical University of L\u00fcbeck","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111450087","display_name":"Fran\u00e7oise N. Smets","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Francoise Smets","raw_affiliation_strings":["Cliniques Universitaires St. Luc, Catholic University of Louvain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cliniques Universitaires St. Luc, Catholic University of Louvain","institution_ids":["https://openalex.org/I95674353","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013034674","display_name":"Lars Fischer","orcid":"https://orcid.org/0000-0001-5015-222X","observed_orcids":["https://orcid.org/0000-0001-5015-222X"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lars Fischer","raw_affiliation_strings":["Department of Pediatrics, Medical University of L\u00fcbeck"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Medical University of L\u00fcbeck","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049928162","display_name":"G. Offner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gisela Offner","raw_affiliation_strings":["Department of Pediatrics, Medical School of Hanover"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Medical School of Hanover","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085106672","display_name":"Peter Bucsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter Bucsky","raw_affiliation_strings":["Department of Pediatrics, Medical University of L\u00fcbeck"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Medical University of L\u00fcbeck","institution_ids":["https://openalex.org/I9341345"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5109868023"],"corresponding_institution_ids":["https://openalex.org/I181547552","https://openalex.org/I9341345"],"apc_list":null,"apc_paid":null,"fwci":6.4587,"has_fulltext":false,"cited_by_count":217,"citation_normalized_percentile":{"value":0.97116694,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"72","issue":"6","first_page":"1012","last_page":"1019"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epstein-barr-virus","display_name":"Epstein-Barr virus","score":0.8989999890327454},{"id":"https://openalex.org/keywords/post-transplant-lymphoproliferative-disorder","display_name":"post-transplant lymphoproliferative disorder","score":0.9919999837875366},{"id":"https://openalex.org/keywords/ebv-viral-load","display_name":"EBV viral load","score":0.8820000290870667},{"id":"https://openalex.org/keywords/plasma-ebv-dna","display_name":"plasma EBV DNA","score":0.878000020980835},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/real-time-quantitative-pcr","display_name":"real-time quantitative PCR","score":0.765999972820282},{"id":"https://openalex.org/keywords/primary-ebv-infection","display_name":"primary EBV infection","score":0.7870000004768372},{"id":"https://openalex.org/keywords/ebv-reactivation","display_name":"EBV reactivation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8500000238418579},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.7777723073959351},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.7211941480636597},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.658616304397583},{"id":"https://openalex.org/C2781375147","wikidata":"https://www.wikidata.org/wiki/Q6900","display_name":"Epstein\u2013Barr virus","level":3,"score":0.6240939497947693},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5648578405380249},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5566481351852417},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.5412186980247498},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5084961652755737},{"id":"https://openalex.org/C2776995267","wikidata":"https://www.wikidata.org/wiki/Q4165484","display_name":"Lymphoproliferative disorders","level":3,"score":0.5001366138458252},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.4816788136959076},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4070233106613159},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34098178148269653},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2245713472366333},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12877315282821655},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.12242001295089722},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0622347891330719},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.061836063861846924}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001769","descriptor_name":"Blood","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003199","descriptor_name":"Computer Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008232","descriptor_name":"Lymphoproliferative Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008232","descriptor_name":"Lymphoproliferative Disorders","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/00007890-200109270-00006","doi":"https://doi.org/10.1097/00007890-200109270-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-200109270-00006","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},{"id":"pmid:11579293","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11579293","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"Evaluation Study"},{"id":"pmh:oai:dial.uclouvain.be:boreal:164494","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2078.1/164494","pdf_url":null,"source":{"id":"https://openalex.org/S4306400166","display_name":"Digital Access to Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800384882","host_organization_name":"Harris County Public Library","host_organization_lineage":["https://openalex.org/I2800384882"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Transplantation, Vol. 72, no. 6, p. 1012-1019 (2001)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W41015475","https://openalex.org/W53184713","https://openalex.org/W126717145","https://openalex.org/W181804556","https://openalex.org/W1266345587","https://openalex.org/W1493511377","https://openalex.org/W1512604580","https://openalex.org/W1520981706","https://openalex.org/W1737344958","https://openalex.org/W1958495128","https://openalex.org/W1978253803","https://openalex.org/W1981399268","https://openalex.org/W1982103585","https://openalex.org/W1983386156","https://openalex.org/W1991335524","https://openalex.org/W1993741037","https://openalex.org/W2008323503","https://openalex.org/W2009349791","https://openalex.org/W2026795477","https://openalex.org/W2079910001","https://openalex.org/W2080657806","https://openalex.org/W2090280060","https://openalex.org/W2090825699","https://openalex.org/W2091627115","https://openalex.org/W2100079494","https://openalex.org/W2104261439","https://openalex.org/W2108814071","https://openalex.org/W2109582134","https://openalex.org/W2118947572","https://openalex.org/W2119445283","https://openalex.org/W2124203548","https://openalex.org/W2127913738","https://openalex.org/W2129139757","https://openalex.org/W2136080892","https://openalex.org/W2152247674","https://openalex.org/W2154509002","https://openalex.org/W2155881634","https://openalex.org/W2164578725","https://openalex.org/W2168801583","https://openalex.org/W2184460735"],"related_works":["https://openalex.org/W2346503426","https://openalex.org/W2026715665","https://openalex.org/W4239816347","https://openalex.org/W2110149887","https://openalex.org/W1965250059","https://openalex.org/W2138790929","https://openalex.org/W2413395065","https://openalex.org/W2104844692","https://openalex.org/W1996729395","https://openalex.org/W4238203068"],"abstract_inverted_index":{"BACKGROUND:":[0],"Early":[1],"diagnosis":[2,192,228],"of":[3,17,29,37,42,64,72,85,98,132,141,162,174,188,193,197,212,219,229,236,288],"Epstein-Barr":[4,65],"virus":[5],"(EBV)-associated":[6],"posttransplant":[7],"lymphoproliferative":[8],"disorder":[9],"(PTLD)":[10],"is":[11,20],"required":[12],"to":[13,23,25,243,246,291],"detect":[14],"a":[15,94,139,152,158,172,184,216,239],"stage":[16],"disease":[18],"that":[19],"more":[21,202],"likely":[22],"respond":[24],"treatment.":[26],"Elevated":[27],"levels":[28],"EBV":[30,87,100,106,124,134,145,178,231,252,260,263],"DNA":[31,102,148,238],"were":[32,273],"found":[33],"in":[34,205,280],"peripheral":[35,49],"blood":[36,50],"patients":[38,117,128,257,282],"at":[39],"the":[40,78,86,191,227,286],"onset":[41],"PTLD.":[43,194],"METHODS:":[44],"To":[45],"compare":[46],"plasma":[47,109,168,181,206,211,272,295],"and":[48,74,160,186,224,271,283],"mononuclear":[51],"cells":[52],"(PBMCs)":[53],"as":[54,151,275],"material":[55,276],"for":[56,77,155,190,226,234,277,298],"real-time":[57],"quantitative":[58,240],"polymerase":[59],"chain":[60],"reaction":[61],"(RQ-PCR)":[62],"measurement":[63],"viral":[66,96,199],"load,":[67],"we":[68],"used":[69],"two":[70],"sets":[71],"primers":[73],"probes":[75],"specific":[76,225],"BAM":[79,82],"HI-K":[80],"or":[81,104,121,126,164],"HI-W":[83],"region":[84],"genome.":[88],"RESULTS:":[89],"Patients":[90],"with":[91,115,118,157,208,258],"PTLD":[92,156],"had":[93,182,242],"median":[95],"load":[97,200],"19,200":[99],"genomes/microg":[101,146,253,264],"(n=9)":[103,120],"3,225":[105],"genomes/100":[107,179],"microl":[108,180],"(n=5),":[110],"being":[111],"significantly":[112],"higher":[113,293],"compared":[114,207],"immunosuppressed":[116,127,281],"primary":[119,230,259],"reactivated":[122],"(n=20)":[123],"infection":[125,135,261],"without":[129],"serological":[130],"signs":[131],"active":[133],"(n=67)":[136],"(P<0.001).":[137],"Hence,":[138],"value":[140,173],"greater":[142,175],"than":[143,176],"5,000":[144],"PBMC":[147,237,254,265],"was":[149,169,201,222,296],"considered":[150,245],"diagnostic":[153],"parameter":[154,241],"sensitivity":[159,185],"specificity":[161,187,287],"1.00":[163,189],"0.89,":[165],"respectively.":[166],"When":[167],"analyzed,":[170],"however,":[171],"1,000":[177],"both":[183,269],"During":[195],"remission":[196],"PTLD,":[198],"effectively":[203],"cleared":[204],"PBMCs.":[209],"In":[210],"nonimmunosuppressed":[213,284],"individuals,":[214,285],"even":[215],"qualitative":[217],"detection":[218],"EBV-related":[220],"sequences":[221],"sensitive":[223],"infection,":[232],"whereas":[233],"analysis":[235,289],"be":[244,292],"differentiate":[247],"healthy":[248],"individuals":[249],"(<":[250],"100":[251],"DNA)":[255],"from":[256],"(>100":[262],"DNA).":[266],"CONCLUSION:":[267],"Although":[268],"PBMCs":[270],"useful":[274],"EBV-specific":[278],"RQ-PCR":[279],"seemed":[290],"if":[294],"taken":[297],"analysis.":[299]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}