{"id":"https://openalex.org/W2017199538","doi":"https://doi.org/10.1021/pr700606w","title":"Application of Proteomics in the Discovery of Candidate Protein Biomarkers in a Diabetes Autoantibody Standardization Program Sample Subset","display_name":"Application of Proteomics in the Discovery of Candidate Protein Biomarkers in a Diabetes Autoantibody Standardization Program Sample Subset","publication_year":2007,"publication_date":"2007-12-20","ids":{"openalex":"https://openalex.org/W2017199538","doi":"https://doi.org/10.1021/pr700606w","mag":"2017199538","pmid":"https://pubmed.ncbi.nlm.nih.gov/18092746","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2672959"},"language":"en","primary_location":{"id":"doi:10.1021/pr700606w","doi":"https://doi.org/10.1021/pr700606w","is_oa":false,"landing_page_url":"https://doi.org/10.1021/pr700606w","pdf_url":null,"source":{"id":"https://openalex.org/S74367812","display_name":"Journal of Proteome Research","issn_l":"1535-3893","issn":["1535-3893","1535-3907"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Proteome Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2672959","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034592694","display_name":"Thomas Metz","orcid":"https://orcid.org/0000-0001-6049-3968","observed_orcids":["https://orcid.org/0000-0001-6049-3968","https://orcid.org/0000-0003-2448-6845"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas O. Metz","raw_affiliation_strings":["Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, and Diabetes and Molecular Risk Assessment Laboratory, United States Centers for Disease Control and Prevention, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, and Diabetes and Molecular Risk Assessment Laboratory, United States Centers for Disease Control and Prevention, Atlanta, Georgia","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075235007","display_name":"Weijun Qian","orcid":"https://orcid.org/0000-0002-5393-2827","observed_orcids":["https://orcid.org/0000-0002-5393-2827"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei-Jun Qian","raw_affiliation_strings":["Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, and Diabetes and Molecular Risk Assessment Laboratory, United States Centers for Disease Control and Prevention, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, and Diabetes and Molecular Risk Assessment Laboratory, United States Centers for Disease Control and Prevention, Atlanta, Georgia","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067276579","display_name":"Jon Jacobs","orcid":"https://orcid.org/0000-0003-0557-7338","observed_orcids":["https://orcid.org/0000-0003-0557-7338"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon M. Jacobs","raw_affiliation_strings":["Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, and Diabetes and Molecular Risk Assessment Laboratory, United States Centers for Disease Control and Prevention, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, and Diabetes and Molecular Risk Assessment Laboratory, United States Centers for Disease Control and Prevention, Atlanta, Georgia","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Marina A. Gritsenko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marina A. Gritsenko","raw_affiliation_strings":["Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, and Diabetes and Molecular Risk Assessment Laboratory, United States Centers for Disease Control and Prevention, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, and Diabetes and Molecular Risk Assessment Laboratory, United States Centers for Disease Control and Prevention, Atlanta, Georgia","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027231249","display_name":"Ronald Moore","orcid":"https://orcid.org/0000-0003-2806-2855","observed_orcids":["https://orcid.org/0000-0003-2806-2855"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald J. Moore","raw_affiliation_strings":["Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, and Diabetes and Molecular Risk Assessment Laboratory, United States Centers for Disease Control and Prevention, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, and Diabetes and Molecular Risk Assessment Laboratory, United States Centers for Disease Control and Prevention, Atlanta, Georgia","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103103454","display_name":"Ashoka D. Polpitiya","orcid":"https://orcid.org/0000-0001-5439-1375","observed_orcids":["https://orcid.org/0000-0001-5439-1375"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashoka D. Polpitiya","raw_affiliation_strings":["Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, and Diabetes and Molecular Risk Assessment Laboratory, United States Centers for Disease Control and Prevention, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, and Diabetes and Molecular Risk Assessment Laboratory, United States Centers for Disease Control and Prevention, Atlanta, Georgia","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005196385","display_name":"Matthew E Monroe","orcid":"https://orcid.org/0000-0002-1210-7169","observed_orcids":["https://orcid.org/0000-0002-1210-7169"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew E. Monroe","raw_affiliation_strings":["Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, and Diabetes and Molecular Risk Assessment Laboratory, United States Centers for Disease Control and Prevention, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, and Diabetes and Molecular Risk Assessment Laboratory, United States Centers for Disease Control and Prevention, Atlanta, Georgia","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111932652","display_name":"David Camp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David G. Camp II","raw_affiliation_strings":["Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, and Diabetes and Molecular Risk Assessment Laboratory, United States Centers for Disease Control and Prevention, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, and Diabetes and Molecular Risk Assessment Laboratory, United States Centers for Disease Control and Prevention, Atlanta, Georgia","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111751939","display_name":"Patricia W. Mueller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia W. Mueller","raw_affiliation_strings":["Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, and Diabetes and Molecular Risk Assessment Laboratory, United States Centers for Disease Control and Prevention, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, and Diabetes and Molecular Risk Assessment Laboratory, United States Centers for Disease Control and Prevention, Atlanta, Georgia","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I142606810"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023982706","display_name":"Richard D. Smith","orcid":"https://orcid.org/0000-0002-2381-2349","observed_orcids":["https://orcid.org/0000-0002-2381-2349"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard D. Smith","raw_affiliation_strings":["Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, and Diabetes and Molecular Risk Assessment Laboratory, United States Centers for Disease Control and Prevention, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, and Diabetes and Molecular Risk Assessment Laboratory, United States Centers for Disease Control and Prevention, Atlanta, Georgia","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I142606810"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034592694"],"corresponding_institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I142606810"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.9323,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.91714798,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"7","issue":"2","first_page":"698","last_page":"707"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.05849999934434891,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/protein-biomarkers","display_name":"protein biomarkers","score":0.9620000123977661},{"id":"https://openalex.org/keywords/plasma-proteomics","display_name":"plasma proteomics","score":0.7799999713897705},{"id":"https://openalex.org/keywords/corticosteroid-binding-globulin","display_name":"corticosteroid-binding globulin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/lumican","display_name":"lumican","score":1.0},{"id":"https://openalex.org/keywords/clusterin","display_name":"clusterin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/serotransferrin","display_name":"serotransferrin","score":0.9599999785423279},{"id":"https://openalex.org/keywords/biomarker-discovery","display_name":"biomarker discovery","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5754799246788025},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.5649715662002563},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5500801205635071},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.49843692779541016},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4808286428451538},{"id":"https://openalex.org/C146543888","wikidata":"https://www.wikidata.org/wiki/Q425056","display_name":"Blood proteins","level":2,"score":0.4103415608406067},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.408527672290802},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3495023846626282},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3121805787086487},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29778575897216797},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.21140903234481812},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1610587239265442},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071234","descriptor_name":"Lumican","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000090203","descriptor_name":"Zn-Alpha-2-Glycoprotein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007632","descriptor_name":"Keratan Sulfate","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007632","descriptor_name":"Keratan Sulfate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011508","descriptor_name":"Chondroitin Sulfate Proteoglycans","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011508","descriptor_name":"Chondroitin Sulfate Proteoglycans","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014156","descriptor_name":"Transcortin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014156","descriptor_name":"Transcortin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D054392","descriptor_name":"Adipokines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/pr700606w","doi":"https://doi.org/10.1021/pr700606w","is_oa":false,"landing_page_url":"https://doi.org/10.1021/pr700606w","pdf_url":null,"source":{"id":"https://openalex.org/S74367812","display_name":"Journal of Proteome Research","issn_l":"1535-3893","issn":["1535-3893","1535-3907"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Proteome Research","raw_type":"journal-article"},{"id":"pmid:18092746","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18092746","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of proteome research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2672959","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2672959","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Proteome Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2672959","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2672959","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Proteome Res","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2287113261","display_name":null,"funder_award_id":"DK070146","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2711023690","display_name":null,"funder_award_id":"106-554","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G3211406543","display_name":"Proteomics and Metabolomics Studies of Type 1 Diabetes","funder_award_id":"R21DK070146","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3875803176","display_name":"A Proteomics Research Resource for Integrative Biology","funder_award_id":"P41RR018522","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4128915086","display_name":"Proteomics and Metabolomics Studies of Type 1 Diabetes","funder_award_id":"R33DK070146","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6639254393","display_name":null,"funder_award_id":"106-310","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G6800734483","display_name":null,"funder_award_id":"107-360","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G6962983069","display_name":null,"funder_award_id":"PL105-33","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W45534775","https://openalex.org/W1520092900","https://openalex.org/W1597883912","https://openalex.org/W1971280282","https://openalex.org/W1971735540","https://openalex.org/W1979319235","https://openalex.org/W1993751988","https://openalex.org/W1994450827","https://openalex.org/W2015556811","https://openalex.org/W2016646213","https://openalex.org/W2019196704","https://openalex.org/W2021316249","https://openalex.org/W2022370900","https://openalex.org/W2026465178","https://openalex.org/W2027832974","https://openalex.org/W2031999503","https://openalex.org/W2032961810","https://openalex.org/W2036341761","https://openalex.org/W2036348360","https://openalex.org/W2039746184","https://openalex.org/W2045390090","https://openalex.org/W2045754763","https://openalex.org/W2049119567","https://openalex.org/W2049948296","https://openalex.org/W2050783490","https://openalex.org/W2060391087","https://openalex.org/W2065674693","https://openalex.org/W2068565992","https://openalex.org/W2068608108","https://openalex.org/W2072000480","https://openalex.org/W2082656526","https://openalex.org/W2096057003","https://openalex.org/W2101938218","https://openalex.org/W2112143438","https://openalex.org/W2117326627","https://openalex.org/W2119699023","https://openalex.org/W2124114991","https://openalex.org/W2125468516","https://openalex.org/W2128988773","https://openalex.org/W2129551653","https://openalex.org/W2136338814","https://openalex.org/W2143450422","https://openalex.org/W2160344431","https://openalex.org/W2171757797","https://openalex.org/W2331309043","https://openalex.org/W3187594710"],"related_works":["https://openalex.org/W4386933372","https://openalex.org/W2807745221","https://openalex.org/W2622082408","https://openalex.org/W2046425998","https://openalex.org/W2138042818","https://openalex.org/W2151168574","https://openalex.org/W7083107386","https://openalex.org/W4295681382","https://openalex.org/W7096851570","https://openalex.org/W2124400068"],"abstract_inverted_index":{"Novel":[0],"biomarkers":[1,83,124,191],"of":[2,32,40,55,63,80,84,112,116,125,169,187,192,209,214],"type":[3,66,85,126,140,160,181,193],"1":[4,67,86,127,130,141,161,182,194],"diabetes":[5,195],"must":[6],"be":[7,18],"identified":[8,106,120],"and":[9,58,65,134,150,211,217],"validated":[10],"in":[11,20,29,50,71,109,139,155,166,180,205],"initial,":[12],"exploratory":[13],"studies":[14,31,105,200],"before":[15],"they":[16],"can":[17],"assessed":[19],"proficiency":[21],"evaluations.":[22],"Currently,":[23],"untargeted":[24],"\"-omics\"":[25],"approaches":[26],"are":[27,173,201],"underutilized":[28],"profiling":[30],"clinical":[33],"samples.":[34,163,222],"This":[35],"report":[36],"describes":[37],"the":[38,72,78,110,167,176,185],"evaluation":[39],"capillary":[41,90],"liquid":[42],"chromatography":[43],"(LC)":[44],"coupled":[45],"with":[46,77,175],"mass":[47],"spectrometry":[48],"(MS)":[49],"a":[51,61,206],"pilot":[52],"proteomic":[53,118],"analysis":[54],"human":[56],"plasma":[57,99,113],"serum":[59],"from":[60],"subset":[62],"control":[64,146,156],"diabetic":[68,142,162],"individuals":[69,210],"enrolled":[70],"Diabetes":[73],"Autoantibody":[74],"Standardization":[75],"Program,":[76],"goal":[79],"identifying":[81],"candidate":[82,122,189],"diabetes.":[87,128,183],"Initial":[88],"high-resolution":[89],"LC-MS/MS":[91],"experiments":[92],"were":[93,136,152],"performed":[94],"to":[95,145,159],"augment":[96],"an":[97],"existing":[98],"peptide":[100],"database,":[101],"while":[102],"subsequent":[103],"LC-FTICR":[104,117],"quantitative":[107],"differences":[108],"abundance":[111],"proteins.":[114],"Analysis":[115],"data":[119],"five":[121,171],"protein":[123,190],"alpha-2-Glycoprotein":[129],"(zinc),":[131],"corticosteroid-binding":[132],"globulin,":[133],"lumican":[135],"2-fold":[137,153],"up-regulated":[138,154],"samples":[143,157],"relative":[144,158],"samples,":[147],"whereas":[148],"clusterin":[149],"serotransferrin":[151],"Observed":[164],"perturbations":[165],"levels":[168],"all":[170],"proteins":[172],"consistent":[174],"metabolic":[177],"aberrations":[178],"found":[179],"While":[184],"discovery":[186],"these":[188],"is":[196],"encouraging,":[197],"follow":[198],"up":[199],"required":[202],"for":[203,212],"validation":[204],"larger":[207],"population":[208],"determination":[213],"laboratory-defined":[215],"sensitivity":[216],"specificity":[218],"values":[219],"using":[220],"blinded":[221]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}