{"id":"https://openalex.org/W2017191812","doi":"https://doi.org/10.1097/00006842-200203000-00009","title":"Reduced Primary Antibody Responses in a Genetic Animal Model of Depression","display_name":"Reduced Primary Antibody Responses in a Genetic Animal Model of Depression","publication_year":2002,"publication_date":"2002-03-01","ids":{"openalex":"https://openalex.org/W2017191812","doi":"https://doi.org/10.1097/00006842-200203000-00009","mag":"2017191812","pmid":"https://pubmed.ncbi.nlm.nih.gov/11914442"},"language":"en","primary_location":{"id":"doi:10.1097/00006842-200203000-00009","doi":"https://doi.org/10.1097/00006842-200203000-00009","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00006842-200203000-00009","pdf_url":null,"source":{"id":"https://openalex.org/S78750095","display_name":"Psychosomatic Medicine","issn_l":"0033-3174","issn":["0033-3174","1534-7796","2998-8748","2998-8756"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychosomatic Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073703492","display_name":"Elliot M. Friedman","orcid":"https://orcid.org/0000-0002-3587-2138","observed_orcids":["https://orcid.org/0000-0002-3587-2138"]},"institutions":[{"id":"https://openalex.org/I22675022","display_name":"Williams College","ror":"https://ror.org/04avkmd49","country_code":"US","type":"education","lineage":["https://openalex.org/I22675022"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elliot M. Friedman","raw_affiliation_strings":["Psychology Department, Bronfman Science Center, Williams College, Williamstown, MA 01267, USA. Elliot.M.Friedman@williams.edu","Psychology Department, Bronfman Science Center, Williams College, Williamstown, MA 01267, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychology Department, Bronfman Science Center, Williams College, Williamstown, MA 01267, USA. Elliot.M.Friedman@williams.edu","institution_ids":["https://openalex.org/I22675022"]},{"raw_affiliation_string":"Psychology Department, Bronfman Science Center, Williams College, Williamstown, MA 01267, USA","institution_ids":["https://openalex.org/I22675022"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058217730","display_name":"Kelly A. Becker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]},{"id":"https://openalex.org/I1339417872","display_name":"Wadsworth Center","ror":"https://ror.org/050kf9c55","country_code":"US","type":"facility","lineage":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]},{"id":"https://openalex.org/I22675022","display_name":"Williams College","ror":"https://ror.org/04avkmd49","country_code":"US","type":"education","lineage":["https://openalex.org/I22675022"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly A. Becker","raw_affiliation_strings":["From the Psychology Department (E.M.F., K.A.B.), Williams College, Williamstown, MA","Skipper Bowles Center for Alcohol Studies and Department of Psychiatry (D.H.O.), University of North Carolina at Chapel Hill, Chapel Hill, NC","and Division of Molecular Medicine (D.A.L.), Wadsworth Laboratories, New York State Department of Health, Albany, NY","Division of Molecular Medicine (D.A.L.), Wadsworth Laboratories, New York State Department of Health, Albany, NY","Received for publication January 4, 2000","revision received May 25, 2001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Psychology Department (E.M.F., K.A.B.), Williams College, Williamstown, MA","institution_ids":["https://openalex.org/I22675022"]},{"raw_affiliation_string":"Skipper Bowles Center for Alcohol Studies and Department of Psychiatry (D.H.O.), University of North Carolina at Chapel Hill, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"and Division of Molecular Medicine (D.A.L.), Wadsworth Laboratories, New York State Department of Health, Albany, NY","institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]},{"raw_affiliation_string":"Division of Molecular Medicine (D.A.L.), Wadsworth Laboratories, New York State Department of Health, Albany, NY","institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]},{"raw_affiliation_string":"Received for publication January 4, 2000","institution_ids":[]},{"raw_affiliation_string":"revision received May 25, 2001","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111683164","display_name":"David H. Overstreet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]},{"id":"https://openalex.org/I1339417872","display_name":"Wadsworth Center","ror":"https://ror.org/050kf9c55","country_code":"US","type":"facility","lineage":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]},{"id":"https://openalex.org/I22675022","display_name":"Williams College","ror":"https://ror.org/04avkmd49","country_code":"US","type":"education","lineage":["https://openalex.org/I22675022"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David H. Overstreet","raw_affiliation_strings":["From the Psychology Department (E.M.F., K.A.B.), Williams College, Williamstown, MA","Skipper Bowles Center for Alcohol Studies and Department of Psychiatry (D.H.O.), University of North Carolina at Chapel Hill, Chapel Hill, NC","and Division of Molecular Medicine (D.A.L.), Wadsworth Laboratories, New York State Department of Health, Albany, NY","Division of Molecular Medicine (D.A.L.), Wadsworth Laboratories, New York State Department of Health, Albany, NY","Received for publication January 4, 2000","revision received May 25, 2001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Psychology Department (E.M.F., K.A.B.), Williams College, Williamstown, MA","institution_ids":["https://openalex.org/I22675022"]},{"raw_affiliation_string":"Skipper Bowles Center for Alcohol Studies and Department of Psychiatry (D.H.O.), University of North Carolina at Chapel Hill, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"and Division of Molecular Medicine (D.A.L.), Wadsworth Laboratories, New York State Department of Health, Albany, NY","institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]},{"raw_affiliation_string":"Division of Molecular Medicine (D.A.L.), Wadsworth Laboratories, New York State Department of Health, Albany, NY","institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]},{"raw_affiliation_string":"Received for publication January 4, 2000","institution_ids":[]},{"raw_affiliation_string":"revision received May 25, 2001","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053216437","display_name":"David A. Lawrence","orcid":"https://orcid.org/0000-0002-8940-9640","observed_orcids":["https://orcid.org/0000-0002-8940-9640"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]},{"id":"https://openalex.org/I1339417872","display_name":"Wadsworth Center","ror":"https://ror.org/050kf9c55","country_code":"US","type":"facility","lineage":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]},{"id":"https://openalex.org/I22675022","display_name":"Williams College","ror":"https://ror.org/04avkmd49","country_code":"US","type":"education","lineage":["https://openalex.org/I22675022"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Lawrence","raw_affiliation_strings":["From the Psychology Department (E.M.F., K.A.B.), Williams College, Williamstown, MA","Skipper Bowles Center for Alcohol Studies and Department of Psychiatry (D.H.O.), University of North Carolina at Chapel Hill, Chapel Hill, NC","and Division of Molecular Medicine (D.A.L.), Wadsworth Laboratories, New York State Department of Health, Albany, NY","Division of Molecular Medicine (D.A.L.), Wadsworth Laboratories, New York State Department of Health, Albany, NY","Received for publication January 4, 2000","revision received May 25, 2001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Psychology Department (E.M.F., K.A.B.), Williams College, Williamstown, MA","institution_ids":["https://openalex.org/I22675022"]},{"raw_affiliation_string":"Skipper Bowles Center for Alcohol Studies and Department of Psychiatry (D.H.O.), University of North Carolina at Chapel Hill, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"and Division of Molecular Medicine (D.A.L.), Wadsworth Laboratories, New York State Department of Health, Albany, NY","institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]},{"raw_affiliation_string":"Division of Molecular Medicine (D.A.L.), Wadsworth Laboratories, New York State Department of Health, Albany, NY","institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]},{"raw_affiliation_string":"Received for publication January 4, 2000","institution_ids":[]},{"raw_affiliation_string":"revision received May 25, 2001","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4835,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.50900901,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"64","issue":"2","first_page":"267","last_page":"273"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.6137999892234802,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.6137999892234802,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.38260000944137573,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.8809999823570251},{"id":"https://openalex.org/keywords/flinders-sensitive-line-rats","display_name":"Flinders Sensitive Line rats","score":0.8560000061988831},{"id":"https://openalex.org/keywords/primary-antibody-response","display_name":"primary antibody response","score":0.7889999747276306},{"id":"https://openalex.org/keywords/keyhole-limpet-hemocyanin","display_name":"keyhole limpet hemocyanin","score":0.953000009059906},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8849999904632568},{"id":"https://openalex.org/keywords/antibody-isotypes","display_name":"antibody isotypes","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C2776727803","wikidata":"https://www.wikidata.org/wiki/Q1496686","display_name":"Keyhole limpet hemocyanin","level":3,"score":0.7615833282470703},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6855418682098389},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6509428024291992},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6372159719467163},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6202218532562256},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6099432706832886},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.46467286348342896},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.42814818024635315},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.4251776933670044},{"id":"https://openalex.org/C2776548049","wikidata":"https://www.wikidata.org/wiki/Q1142875","display_name":"Humoral immunity","level":3,"score":0.4164007604122162},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.41385790705680847},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006433","descriptor_name":"Hemocyanins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006433","descriptor_name":"Hemocyanins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006433","descriptor_name":"Hemocyanins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/00006842-200203000-00009","doi":"https://doi.org/10.1097/00006842-200203000-00009","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00006842-200203000-00009","pdf_url":null,"source":{"id":"https://openalex.org/S78750095","display_name":"Psychosomatic Medicine","issn_l":"0033-3174","issn":["0033-3174","1534-7796","2998-8748","2998-8756"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychosomatic Medicine","raw_type":"journal-article"},{"id":"pmid:11914442","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11914442","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychosomatic medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.565.5768","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.565.5768","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://intl.psychosomaticmedicine.org/content/64/2/267.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8299999833106995}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2498610761","display_name":null,"funder_award_id":"F32 MH010881","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W132113112","https://openalex.org/W1829148295","https://openalex.org/W1913008003","https://openalex.org/W1970365988","https://openalex.org/W1972709205","https://openalex.org/W1975928460","https://openalex.org/W1978978844","https://openalex.org/W1981724309","https://openalex.org/W1991527095","https://openalex.org/W1993588416","https://openalex.org/W1993622831","https://openalex.org/W1993856151","https://openalex.org/W1998153328","https://openalex.org/W2005145382","https://openalex.org/W2013624621","https://openalex.org/W2013626321","https://openalex.org/W2014347688","https://openalex.org/W2031152235","https://openalex.org/W2035630528","https://openalex.org/W2038473038","https://openalex.org/W2041533847","https://openalex.org/W2048321333","https://openalex.org/W2048431959","https://openalex.org/W2050595314","https://openalex.org/W2071249192","https://openalex.org/W2073813539","https://openalex.org/W2074597778","https://openalex.org/W2082415996","https://openalex.org/W2085352510","https://openalex.org/W2095795974","https://openalex.org/W2118374036","https://openalex.org/W2149933413","https://openalex.org/W2189200879","https://openalex.org/W2267259862","https://openalex.org/W2472219797"],"related_works":["https://openalex.org/W2011842732","https://openalex.org/W1996310422","https://openalex.org/W1932211265","https://openalex.org/W2320535435","https://openalex.org/W2419114054","https://openalex.org/W2406144595","https://openalex.org/W2021786423","https://openalex.org/W2235001436","https://openalex.org/W2060269837","https://openalex.org/W1611543608"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Clinical":[1],"depression":[2],"is":[3],"associated":[4,121],"with":[5,61,122,148,185],"multiple":[6],"abnormalities":[7],"of":[8,32,97,125,132,203,222],"immune":[9,205],"function,":[10],"including":[11],"reduced":[12,142,213],"virus-specific":[13],"responses.":[14,218],"This":[15,198],"study":[16,199],"tested":[17],"the":[18,21,62,144,149,166,208,248],"hypothesis":[19],"that":[20],"Flinders":[22,51],"Sensitive":[23],"Line":[24,53],"(FSL)":[25],"rat,":[26],"a":[27],"promising":[28],"genetic":[29],"animal":[30],"model":[31],"depression,":[33],"would":[34],"exhibit":[35],"reductions":[36],"in":[37,109,116,143,157,171,187,207,214,233,241,247],"antigen-specific":[38,216],"primary":[39],"antibody":[40,117,217,231],"responses":[41,79],"to":[42,111,211,229],"immunization.":[43,92],"METHODS:":[44],"FSL":[45,145,177,209,249],"(N":[46],"=":[47,56],"13)":[48],"and":[49,71,77,83,88,104,136],"control":[50],"Resistant":[52],"(FRL;":[54],"N":[55],"14)":[57],"rats":[58,146,178,210],"were":[59,80,153],"immunized":[60],"protein":[63],"antigen":[64],"keyhole":[65],"limpet":[66],"hemocyanin":[67],"(KLH;":[68],"300":[69],"microg/kg),":[70],"KLH-specific":[72,130],"immunoglobulin":[73],"(Ig)M,":[74],"IgG,":[75],"IgG1,":[76],"IgG2a":[78,137],"measured":[81,108],"before":[82],"3,":[84],"5,":[85],"7,":[86],"11,":[87],"14":[89],"days":[90],"after":[91],"In":[93],"separate":[94],"experiments,":[95],"production":[96,118,124,131,164,221,232],"interferon-gamma":[98],"(IFN-gamma)":[99],"by":[100,224],"cells":[101,174,190],"from":[102,175,191],"naive":[103,172],"KLH-immunized":[105,176,192],"animals":[106],"was":[107,140,169],"vitro":[110,188],"determine":[112],"whether":[113],"strain":[114,155],"differences":[115,156],"might":[119],"be":[120],"differential":[123],"this":[126],"regulatory":[127],"cytokine.":[128],"RESULTS:":[129],"IgM":[133],"(p":[134,138,195],"<.01)":[135],"<.05)":[139],"significantly":[141,180],"compared":[147],"FRL":[150,193],"controls.":[151],"There":[152],"no":[154],"IgG":[158],"or":[159],"IgG1":[160],"production.":[161],"Although":[162],"IFN-gamma":[163,182,223],"between":[165],"two":[167],"strains":[168],"similar":[170],"animals,":[173],"produced":[179],"less":[181],"when":[183],"stimulated":[184],"KLH":[186],"than":[189],"controls":[194],"=.01).":[196],"CONCLUSIONS:":[197],"extends":[200],"previous":[201],"reports":[202],"altered":[204],"function":[206],"include":[212],"vivo":[215],"Moreover,":[219],"diminished":[220],"KLH-primed":[225],"lymphocytes":[226],"may":[227],"contribute":[228],"lower":[230],"these":[234,237],"animals.":[235],"Collectively,":[236],"data":[238],"suggest":[239],"deficiencies":[240],"type":[242],"1":[243],"T-helper":[244],"cell-mediated":[245],"immunity":[246],"rats.":[250]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-09-23T05:00:35.095934","created_date":"2025-10-10T00:00:00"}