{"id":"https://openalex.org/W2017189702","doi":"https://doi.org/10.1128/jvi.75.16.7494-7505.2001","title":"Prolonged Gray Matter Disease without Demyelination Caused by Theiler's Murine Encephalomyelitis Virus with a Mutation in VP2 Puff B","display_name":"Prolonged Gray Matter Disease without Demyelination Caused by Theiler's Murine Encephalomyelitis Virus with a Mutation in VP2 Puff B","publication_year":2001,"publication_date":"2001-08-15","ids":{"openalex":"https://openalex.org/W2017189702","doi":"https://doi.org/10.1128/jvi.75.16.7494-7505.2001","mag":"2017189702","pmid":"https://pubmed.ncbi.nlm.nih.gov/11462022","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/114985"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.75.16.7494-7505.2001","doi":"https://doi.org/10.1128/jvi.75.16.7494-7505.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.75.16.7494-7505.2001","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/114985","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074673340","display_name":"Ikuo Tsunoda","orcid":"https://orcid.org/0000-0003-1798-714X","observed_orcids":["https://orcid.org/0000-0003-1798-714X"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ikuo Tsunoda","raw_affiliation_strings":["<!--label omitted: 1-->Department of Neurology, University of Utah School of Medicine,1 and","Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, 84132, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Neurology, University of Utah School of Medicine,1 and","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, 84132, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yoshiaki Wada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoshiaki Wada","raw_affiliation_strings":["<!--label omitted: 1-->Department of Neurology, University of Utah School of Medicine,1 and","Department of Neurology, University of Utah School of Medicine,1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Neurology, University of Utah School of Medicine,1 and","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Department of Neurology, University of Utah School of Medicine,1 and","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052902667","display_name":"Jane E. Libbey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane E. Libbey","raw_affiliation_strings":["<!--label omitted: 1-->Department of Neurology, University of Utah School of Medicine,1 and","Department of Neurology, University of Utah School of Medicine,1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Neurology, University of Utah School of Medicine,1 and","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Department of Neurology, University of Utah School of Medicine,1 and","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007868340","display_name":"Thomas S. Cannon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas S. Cannon","raw_affiliation_strings":["<!--label omitted: 1-->Department of Neurology, University of Utah School of Medicine,1 and","Department of Neurology, University of Utah School of Medicine,1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Neurology, University of Utah School of Medicine,1 and","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Department of Neurology, University of Utah School of Medicine,1 and","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029578622","display_name":"Frank G. Whitby","orcid":"https://orcid.org/0000-0003-3511-2216","observed_orcids":["https://orcid.org/0000-0003-3511-2216"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank G. Whitby","raw_affiliation_strings":["<!--label omitted: 2-->Department of Biochemistry, University of Utah,2 Salt Lake City, Utah 84132","Department of Biochemistry, University of Utah,2 Salt Lake City, Utah 84132"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 2-->Department of Biochemistry, University of Utah,2 Salt Lake City, Utah 84132","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Department of Biochemistry, University of Utah,2 Salt Lake City, Utah 84132","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051928962","display_name":"Robert S. Fujinami","orcid":"https://orcid.org/0000-0002-1435-8092","observed_orcids":["https://orcid.org/0000-0002-1435-8092"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert S. Fujinami","raw_affiliation_strings":["<!--label omitted: 1-->Department of Neurology, University of Utah School of Medicine,1 and","Department of Neurology, University of Utah School of Medicine,1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Neurology, University of Utah School of Medicine,1 and","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Department of Neurology, University of Utah School of Medicine,1 and","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I223532165"],"apc_list":null,"apc_paid":null,"fwci":0.9797,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.78692736,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"75","issue":"16","first_page":"7494","last_page":"7505"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.548799991607666,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.548799991607666,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.2703000009059906,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.05260000005364418,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/theiler-s-murine-encephalomyelitis-virus","display_name":"Theiler's murine encephalomyelitis virus","score":0.996999979019165},{"id":"https://openalex.org/keywords/demyelination","display_name":"demyelination","score":0.8379999995231628},{"id":"https://openalex.org/keywords/neurovirulence","display_name":"neurovirulence","score":0.7630000114440918},{"id":"https://openalex.org/keywords/polioencephalomyelitis","display_name":"polioencephalomyelitis","score":0.8050000071525574},{"id":"https://openalex.org/keywords/viral-mutants","display_name":"viral mutants","score":0.4580000042915344},{"id":"https://openalex.org/keywords/acute-and-chronic-infection","display_name":"acute and chronic infection","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.7930302023887634},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7836445569992065},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7528469562530518},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.6880866289138794},{"id":"https://openalex.org/C2778531937","wikidata":"https://www.wikidata.org/wiki/Q1186703","display_name":"Demyelinating disease","level":3,"score":0.5190006494522095},{"id":"https://openalex.org/C2777899865","wikidata":"https://www.wikidata.org/wiki/Q1634879","display_name":"Encephalomyelitis","level":3,"score":0.5033537745475769},{"id":"https://openalex.org/C148632171","wikidata":"https://www.wikidata.org/wiki/Q7542129","display_name":"Slow virus","level":4,"score":0.47104907035827637},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.41872966289520264},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4178462326526642},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.19008496403694153},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1036834716796875},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09279447793960571},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0889265239238739},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.055666595697402954},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002213","descriptor_name":"Capsid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002213","descriptor_name":"Capsid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002213","descriptor_name":"Capsid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D003711","descriptor_name":"Demyelinating Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003711","descriptor_name":"Demyelinating Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003711","descriptor_name":"Demyelinating Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003711","descriptor_name":"Demyelinating Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003711","descriptor_name":"Demyelinating Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003711","descriptor_name":"Demyelinating Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003711","descriptor_name":"Demyelinating Diseases","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D003711","descriptor_name":"Demyelinating Diseases","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D003711","descriptor_name":"Demyelinating Diseases","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017945","descriptor_name":"Theilovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017945","descriptor_name":"Theilovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017945","descriptor_name":"Theilovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017945","descriptor_name":"Theilovirus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D017945","descriptor_name":"Theilovirus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D017945","descriptor_name":"Theilovirus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/jvi.75.16.7494-7505.2001","doi":"https://doi.org/10.1128/jvi.75.16.7494-7505.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.75.16.7494-7505.2001","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:114985","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/114985","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:11462022","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11462022","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:114985","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/114985","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6000000238418579,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1308342623","display_name":"Viral and Cellular Deteminants Involved in CNS Disease","funder_award_id":"R01NS034497","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3411657126","display_name":null,"funder_award_id":"NS 34497","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320309626","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W166574254","https://openalex.org/W1544228326","https://openalex.org/W1546055799","https://openalex.org/W1549701973","https://openalex.org/W1554180636","https://openalex.org/W1565559999","https://openalex.org/W1567814559","https://openalex.org/W1576969062","https://openalex.org/W1592302229","https://openalex.org/W1781471553","https://openalex.org/W1819413857","https://openalex.org/W1837179553","https://openalex.org/W1847699713","https://openalex.org/W1949321438","https://openalex.org/W1964712337","https://openalex.org/W1965254770","https://openalex.org/W1979108635","https://openalex.org/W1980891271","https://openalex.org/W1983954314","https://openalex.org/W1988140844","https://openalex.org/W1988256009","https://openalex.org/W1995548818","https://openalex.org/W2001129679","https://openalex.org/W2007534543","https://openalex.org/W2007930642","https://openalex.org/W2008647349","https://openalex.org/W2015040029","https://openalex.org/W2022350022","https://openalex.org/W2035544070","https://openalex.org/W2040632916","https://openalex.org/W2050882633","https://openalex.org/W2054927766","https://openalex.org/W2057625692","https://openalex.org/W2063325766","https://openalex.org/W2063978201","https://openalex.org/W2064187774","https://openalex.org/W2073163393","https://openalex.org/W2073272497","https://openalex.org/W2076951170","https://openalex.org/W2081680282","https://openalex.org/W2086716451","https://openalex.org/W2097361239","https://openalex.org/W2104797080","https://openalex.org/W2113367694","https://openalex.org/W2121602918","https://openalex.org/W2129687227","https://openalex.org/W2132129162","https://openalex.org/W2140562370","https://openalex.org/W2141713817","https://openalex.org/W2151428565","https://openalex.org/W2152578495","https://openalex.org/W2417265651","https://openalex.org/W2430004575","https://openalex.org/W2539438871","https://openalex.org/W2764883988"],"related_works":["https://openalex.org/W2073272497","https://openalex.org/W1592302229","https://openalex.org/W2151428565","https://openalex.org/W1998387599","https://openalex.org/W1994691522","https://openalex.org/W2020681642","https://openalex.org/W2163733832","https://openalex.org/W2035544070","https://openalex.org/W2127237078","https://openalex.org/W1567814559"],"abstract_inverted_index":{"Theiler's":[0],"murine":[1],"encephalomyelitis":[2],"virus":[3,18,36,49,65,115,126,139,145,159,192],"(TMEV)":[4],"is":[5,66,184,187,196],"divided":[6],"into":[7],"two":[8,86],"subgroups":[9],"based":[10],"on":[11],"neurovirulence.":[12],"During":[13],"the":[14,22,26,32,41,54,69,76,85,106,120,147,163,173,180,197,226,231,235,238],"acute":[15,148,151],"phase,":[16,34,149,165],"DA":[17,35,114,144,158,191,217],"infects":[19,37,51],"cells":[20,39],"in":[21,40,53,68,75,78,90,133,157,172,179,224,234],"gray":[23,55,169,232],"matter":[24,71,170,177,233,242],"of":[25,124,206,228],"central":[27],"nervous":[28],"system":[29],"(CNS).":[30],"Throughout":[31],"chronic":[33,164],"glial":[38],"white":[42,70,176,241],"matter,":[43,56],"causing":[44],"demyelinating":[45],"disease.":[46],"Although":[47],"GDVII":[48,125,215],"also":[50],"neurons":[52],"infected":[57],"mice":[58],"developed":[59],"a":[60,113,128],"severe":[61],"polioencephalomyelitis,":[62],"and":[63,94,127,210,216],"no":[64],"detected":[67],"or":[72],"other":[73],"areas":[74],"CNS":[77],"rare":[79],"survivors.":[80],"Several":[81],"sequence":[82],"differences":[83,203],"between":[84,214],"viruses":[87,218],"are":[88,99],"located":[89,100],"VP2":[91,134,207],"puff":[92,135,208],"B":[93,209],"VP1":[95,121,211],"loop":[96,122,212],"II,":[97],"which":[98,118],"near":[101],"each":[102],"other,":[103],"close":[104],"to":[105,155,199,237],"proposed":[107],"receptor":[108],"binding":[109],"site.":[110],"We":[111],"constructed":[112],"mutant,":[116],"DApBL2M,":[117],"has":[119],"II":[123,213],"mutation":[129],"at":[130],"position":[131],"171":[132],"B.":[136],"While":[137],"DApBL2M":[138,166],"replicated":[140],"less":[141],"efficiently":[142],"than":[143],"during":[146,162,189,243],"DApBL2M-induced":[150],"polioencephalitis":[152],"was":[153],"comparable":[154],"that":[156,201],"infection.":[160,193,245],"Interestingly,":[161],"caused":[167],"prolonged":[168],"disease":[171],"brain":[174,236],"without":[175],"involvement":[178],"spinal":[181,239],"cord.":[182],"This":[183],"opposite":[185],"what":[186],"observed":[188],"wild-type":[190],"Our":[194],"study":[195],"first":[198],"demonstrate":[200],"conformational":[202],"via":[204],"interaction":[205],"can":[219],"play":[220],"an":[221],"important":[222],"role":[223],"making":[225],"transition":[227],"infection":[229],"from":[230],"cord":[240],"TMEV":[244]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}