{"id":"https://openalex.org/W2017188367","doi":"https://doi.org/10.1002/bies.950141004","title":"On the nature of origins of DNA replication in eukaryotes","display_name":"On the nature of origins of DNA replication in eukaryotes","publication_year":1992,"publication_date":"1992-10-01","ids":{"openalex":"https://openalex.org/W2017188367","doi":"https://doi.org/10.1002/bies.950141004","mag":"2017188367","pmid":"https://pubmed.ncbi.nlm.nih.gov/1365878"},"language":"en","primary_location":{"id":"doi:10.1002/bies.950141004","doi":"https://doi.org/10.1002/bies.950141004","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bies.950141004","pdf_url":null,"source":{"id":"https://openalex.org/S27819959","display_name":"BioEssays","issn_l":"0265-9247","issn":["0265-9247","1521-1878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioEssays","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050955279","display_name":"Robert Michael Benbow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Benbow","raw_affiliation_strings":["Nucleic Acid Research Facility, Iowa State University, Ames 50011","The Nucleic Acid Research Facility and Department of Zoology and Department of Zoology and Genetics, Iowa State University, Ames, Iowa 50011, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nucleic Acid Research Facility, Iowa State University, Ames 50011","institution_ids":["https://openalex.org/I173911158"]},{"raw_affiliation_string":"The Nucleic Acid Research Facility and Department of Zoology and Department of Zoology and Genetics, Iowa State University, Ames, Iowa 50011, USA","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110013495","display_name":"Jiyong Zhao","orcid":"https://orcid.org/0000-0001-5677-5508","observed_orcids":["https://orcid.org/0000-0001-5677-5508"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiyong Zhao","raw_affiliation_strings":["The Nucleic Acid Research Facility and Department of Zoology and Department of Zoology and Genetics, Iowa State University, Ames, Iowa 50011, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Nucleic Acid Research Facility and Department of Zoology and Department of Zoology and Genetics, Iowa State University, Ames, Iowa 50011, USA","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074103258","display_name":"Drena L Dobbs","orcid":"https://orcid.org/0000-0003-4404-9554","observed_orcids":["https://orcid.org/0000-0003-4404-9554"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Drena D. Larson","raw_affiliation_strings":["The Department of Zoology and Genetics, Iowa State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Zoology and Genetics, Iowa State University","institution_ids":["https://openalex.org/I173911158"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I173911158"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":1.0862,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.77826087,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"14","issue":"10","first_page":"661","last_page":"670"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.8618000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.8618000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.09849999845027924,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-replication-initiation","display_name":"DNA replication initiation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/origin-of-eukaryotes","display_name":"eukaryotic origin","score":0.7390000224113464},{"id":"https://openalex.org/keywords/dna-unwinding","display_name":"DNA unwinding","score":0.8090000152587891},{"id":"https://openalex.org/keywords/pyrimidine-tracts","display_name":"pyrimidine tracts","score":0.9240000247955322},{"id":"https://openalex.org/keywords/transcriptional-regulatory-sequences","display_name":"transcriptional regulatory sequences","score":0.8550000190734863},{"id":"https://openalex.org/keywords/replication-fork","display_name":"replication fork","score":0.5770000219345093},{"id":"https://openalex.org/keywords/higher-eukaryotes","display_name":"higher eukaryotes","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7185258865356445},{"id":"https://openalex.org/C194830204","wikidata":"https://www.wikidata.org/wiki/Q106940703","display_name":"Primase","level":5,"score":0.695371150970459},{"id":"https://openalex.org/C151158763","wikidata":"https://www.wikidata.org/wiki/Q1626856","display_name":"Origin recognition complex","level":5,"score":0.645427942276001},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.6271683573722839},{"id":"https://openalex.org/C41141232","wikidata":"https://www.wikidata.org/wiki/Q3685229","display_name":"Pre-replication complex","level":5,"score":0.5888976454734802},{"id":"https://openalex.org/C98086919","wikidata":"https://www.wikidata.org/wiki/Q118019","display_name":"Eukaryotic DNA replication","level":4,"score":0.5882896184921265},{"id":"https://openalex.org/C104690221","wikidata":"https://www.wikidata.org/wiki/Q5165872","display_name":"Control of chromosome duplication","level":4,"score":0.5504740476608276},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5271500945091248},{"id":"https://openalex.org/C58337764","wikidata":"https://www.wikidata.org/wiki/Q976651","display_name":"Origin of replication","level":4,"score":0.48098814487457275},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.44618457555770874},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.43499118089675903},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32693904638290405},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17225313186645508},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.11089092493057251},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.06328931450843811}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002875","descriptor_name":"Chromosomes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002875","descriptor_name":"Chromosomes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005057","descriptor_name":"Eukaryotic Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011387","descriptor_name":"Prokaryotic Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013539","descriptor_name":"Simian virus 40","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013539","descriptor_name":"Simian virus 40","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018741","descriptor_name":"Replication Origin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/bies.950141004","doi":"https://doi.org/10.1002/bies.950141004","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bies.950141004","pdf_url":null,"source":{"id":"https://openalex.org/S27819959","display_name":"BioEssays","issn_l":"0265-9247","issn":["0265-9247","1521-1878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioEssays","raw_type":"journal-article"},{"id":"pmid:1365878","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1365878","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioEssays : news and reviews in molecular, cellular and developmental biology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W104862819","https://openalex.org/W334843571","https://openalex.org/W1536559874","https://openalex.org/W1558519049","https://openalex.org/W1801459154","https://openalex.org/W1857926442","https://openalex.org/W1879682107","https://openalex.org/W1887868672","https://openalex.org/W1909586281","https://openalex.org/W1964317450","https://openalex.org/W1967726584","https://openalex.org/W1971045116","https://openalex.org/W1974576056","https://openalex.org/W1977393774","https://openalex.org/W1978680674","https://openalex.org/W1990731600","https://openalex.org/W1992798832","https://openalex.org/W1994053857","https://openalex.org/W1999751951","https://openalex.org/W2001165707","https://openalex.org/W2003279154","https://openalex.org/W2007229783","https://openalex.org/W2009230618","https://openalex.org/W2014141253","https://openalex.org/W2015249727","https://openalex.org/W2017144933","https://openalex.org/W2023060727","https://openalex.org/W2024458445","https://openalex.org/W2028870682","https://openalex.org/W2031408368","https://openalex.org/W2034565761","https://openalex.org/W2043592675","https://openalex.org/W2045512028","https://openalex.org/W2049221234","https://openalex.org/W2051651087","https://openalex.org/W2059124413","https://openalex.org/W2060630688","https://openalex.org/W2061449183","https://openalex.org/W2063443838","https://openalex.org/W2076442600","https://openalex.org/W2079078652","https://openalex.org/W2087719967","https://openalex.org/W2091943115","https://openalex.org/W2098654653","https://openalex.org/W2122909165","https://openalex.org/W2125816354","https://openalex.org/W2135754931","https://openalex.org/W2148080727","https://openalex.org/W2152300974","https://openalex.org/W2154662820","https://openalex.org/W2170536497","https://openalex.org/W2178238598","https://openalex.org/W2220955715","https://openalex.org/W2345070682","https://openalex.org/W2415383247","https://openalex.org/W2475457038","https://openalex.org/W2485048451","https://openalex.org/W4240329030"],"related_works":["https://openalex.org/W1967941788","https://openalex.org/W2087909839","https://openalex.org/W2238310462","https://openalex.org/W2122909165","https://openalex.org/W2183116078","https://openalex.org/W2022663087","https://openalex.org/W2086437961","https://openalex.org/W2082992000","https://openalex.org/W1533011189","https://openalex.org/W1982638125"],"abstract_inverted_index":{"Chromosomal":[0],"origins":[1],"of":[2,12,38,88,98,105,129],"DNA":[3,53,63,99,107,118,135,137],"replication":[4,100,131],"in":[5,101,121,127],"higher":[6,102],"eukaryotes":[7],"differ":[8],"significantly":[9],"from":[10,117],"those":[11],"E.":[13],"coli":[14],"(oriC)":[15],"and":[16,79,115],"the":[17,85,145],"tumor":[18],"virus,":[19],"SV40":[20],"(ori":[21],"sequence).":[22],"Initiation":[23],"events":[24],"appear":[25],"to":[26],"occur":[27],"throughout":[28],"broad":[29],"zones":[30],"rather":[31,148],"than":[32,149],"at":[33,141,150],"specific":[34,151],"origin":[35,41,90,152],"sequences.":[36,153],"Analysis":[37],"four":[39],"chromosomal":[40,89,134],"regions":[42,147],"reveals":[43],"that":[44,58,125],"they":[45],"share":[46],"common":[47],"modular":[48],"sequence":[49],"elements.":[50],"These":[51],"include":[52],"unwinding":[54],"elements,":[55],"pyrimidine":[56],"tracts":[57],"may":[59,110],"serve":[60],"as":[61],"strong":[62],"polymerase-primase":[64],"start":[65],"sites,":[66],"scaffold":[67],"associated":[68],"regions,":[69,91],"transcriptional":[70],"regulatory":[71],"sequences,":[72],"and,":[73],"possibly,":[74],"initiator":[75],"protein":[76],"binding":[77],"sites":[78,143],"inherently":[80],"destabilized":[81],"regions.":[82],"Based":[83],"on":[84],"novel":[86],"organization":[87],"we":[92],"propose":[93],"a":[94],"model":[95],"for":[96],"initiation":[97,109],"eukaryotes.":[103],"Unwinding":[104],"duplex":[106],"during":[108,133],"be":[111],"uncoupled,":[112],"both":[113],"temporally":[114],"spatially,":[116],"synthesis,":[119],"resulting":[120],"transient":[122],"single-stranded":[123],"intermediates":[124],"function":[126],"lieu":[128],"conventional":[130],"forks":[132],"replication.":[136],"synthesis":[138],"begins":[139],"subsequently":[140],"multiple":[142],"within":[144],"unwound":[146]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
