{"id":"https://openalex.org/W2017161750","doi":"https://doi.org/10.1159/000098183","title":"Recruitment of old genes to new functions: evidences obtained by comparing the orthologues of human XLMR genes in mouse and chicken","display_name":"Recruitment of old genes to new functions: evidences obtained by comparing the orthologues of human XLMR genes in mouse and chicken","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2017161750","doi":"https://doi.org/10.1159/000098183","mag":"2017161750","pmid":"https://pubmed.ncbi.nlm.nih.gov/17317956"},"language":"en","primary_location":{"id":"doi:10.1159/000098183","doi":"https://doi.org/10.1159/000098183","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000098183","pdf_url":null,"source":{"id":"https://openalex.org/S4394735535","display_name":"Cytogenetic and Genome Research","issn_l":"1424-859X","issn":["1424-859X","1424-8581"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytogenetic and Genome Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007703668","display_name":"Matthias Kohn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Kohn","raw_affiliation_strings":["Institut fur Humangenetik, Universitat Ulm, Ulm, Germany","Institut f\u00fcr Humangenetik, Universit\u00e4t Ulm, Ulm (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut fur Humangenetik, Universitat Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]},{"raw_affiliation_string":"Institut f\u00fcr Humangenetik, Universit\u00e4t Ulm, Ulm (Germany)","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105779476","display_name":"Hildegard Kehrer-Sawatzki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H. Kehrer-Sawatzki","raw_affiliation_strings":["Institut f\u00fcr Humangenetik, Universit\u00e4t Ulm, Ulm (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Humangenetik, Universit\u00e4t Ulm, Ulm (Germany)","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050655185","display_name":"Peter J. Steinbach","orcid":"https://orcid.org/0000-0002-6710-3472","observed_orcids":["https://orcid.org/0000-0002-6710-3472"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"P. Steinbach","raw_affiliation_strings":["Institut f\u00fcr Humangenetik, Universit\u00e4t Ulm, Ulm (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Humangenetik, Universit\u00e4t Ulm, Ulm (Germany)","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034070636","display_name":"Jennifer A. Marshall Graves","orcid":"https://orcid.org/0000-0001-6480-7856","observed_orcids":["https://orcid.org/0000-0001-6480-7856"]},"institutions":[{"id":"https://openalex.org/I118347636","display_name":"Australian National University","ror":"https://ror.org/019wvm592","country_code":"AU","type":"education","lineage":["https://openalex.org/I118347636"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"J.A. Marshall Graves","raw_affiliation_strings":["Research School of Biological Sciences, Australian National University, Canberra (Australia)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research School of Biological Sciences, Australian National University, Canberra (Australia)","institution_ids":["https://openalex.org/I118347636"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069374987","display_name":"Horst Hameister","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H. Hameister","raw_affiliation_strings":["Institut f\u00fcr Humangenetik, Universit\u00e4t Ulm, Ulm (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Humangenetik, Universit\u00e4t Ulm, Ulm (Germany)","institution_ids":["https://openalex.org/I196349391"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0715,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.77001427,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"116","issue":"3","first_page":"173","last_page":"180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.8715999722480774,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.8715999722480774,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.12189999967813492,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/x-chromosome-evolution","display_name":"X chromosome evolution","score":0.7960000038146973},{"id":"https://openalex.org/keywords/oligophrenin-1","display_name":"OPHN1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pak3","display_name":"PAK3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/orthologs","display_name":"orthologs","score":0.5450000166893005},{"id":"https://openalex.org/keywords/gene-expression-patterns","display_name":"gene expression patterns","score":0.6629999876022339},{"id":"https://openalex.org/keywords/telencephalon","display_name":"telencephalon","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":0.9539999961853027},{"id":"https://openalex.org/keywords/midbrain","display_name":"midbrain","score":0.9800000190734863},{"id":"https://openalex.org/keywords/testis-expression","display_name":"testis expression","score":0.7450000047683716},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.4779999852180481},{"id":"https://openalex.org/keywords/chickens","display_name":"chickens","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9069433212280273},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.8502914905548096},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7109419703483582},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4487546384334564}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038901","descriptor_name":"X-Linked Intellectual Disability","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050172","descriptor_name":"Genes, X-Linked","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1159/000098183","doi":"https://doi.org/10.1159/000098183","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000098183","pdf_url":null,"source":{"id":"https://openalex.org/S4394735535","display_name":"Cytogenetic and Genome Research","issn_l":"1424-859X","issn":["1424-859X","1424-8581"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytogenetic and Genome Research","raw_type":"journal-article"},{"id":"pmid:17317956","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17317956","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytogenetic and genome research","raw_type":"Comparative Study"},{"id":"pmh:oai:openresearch-repository.anu.edu.au:1885/56902","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1885/56902","pdf_url":null,"source":{"id":"https://openalex.org/S4306402539","display_name":"ANU Open Research (Australian National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118347636","host_organization_name":"Australian National University","host_organization_lineage":["https://openalex.org/I118347636"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cytogenetic and Genome Research","raw_type":"Journal article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W176688131","https://openalex.org/W1496017988","https://openalex.org/W1505060514","https://openalex.org/W1522048223","https://openalex.org/W1539002172","https://openalex.org/W1548084460","https://openalex.org/W1567217875","https://openalex.org/W1600524753","https://openalex.org/W1939885667","https://openalex.org/W1969742740","https://openalex.org/W1971977350","https://openalex.org/W1981233593","https://openalex.org/W1987235181","https://openalex.org/W1995418425","https://openalex.org/W1997549021","https://openalex.org/W2006378142","https://openalex.org/W2014024536","https://openalex.org/W2017400341","https://openalex.org/W2020843364","https://openalex.org/W2023948834","https://openalex.org/W2025999504","https://openalex.org/W2030580169","https://openalex.org/W2034726926","https://openalex.org/W2040322208","https://openalex.org/W2042661483","https://openalex.org/W2046275054","https://openalex.org/W2046784118","https://openalex.org/W2051522166","https://openalex.org/W2067662092","https://openalex.org/W2068987412","https://openalex.org/W2070855445","https://openalex.org/W2080064173","https://openalex.org/W2086929273","https://openalex.org/W2091581005","https://openalex.org/W2103320667","https://openalex.org/W2109067831","https://openalex.org/W2109183032","https://openalex.org/W2113289439","https://openalex.org/W2125126554","https://openalex.org/W2128969076","https://openalex.org/W2136892953","https://openalex.org/W2140034535","https://openalex.org/W2147881874","https://openalex.org/W2152413858","https://openalex.org/W2170333515","https://openalex.org/W2245994765","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2006178891","https://openalex.org/W2030740078","https://openalex.org/W1997549021","https://openalex.org/W106678611","https://openalex.org/W2011023971","https://openalex.org/W2043632023","https://openalex.org/W2106746127","https://openalex.org/W2065827444","https://openalex.org/W2169691228","https://openalex.org/W2066420070"],"abstract_inverted_index":{"Gene":[0],"mapping":[1],"data":[2,134],"indicate":[3],"that":[4,13,138],"the":[5,24,82,95,106,117,121,142],"human":[6],"X":[7,143],"chromosome":[8,144],"is":[9],"enriched":[10],"in":[11,52,55,58,60,89,94,102,116,120,128,131],"genes":[12,35,49,63,85,140],"affect":[14],"both,":[15],"higher":[16],"cognitive":[17],"efficiency":[18],"and":[19,57,75,110],"reproductive":[20],"success.":[21],"This":[22],"raises":[23],"question":[25],"whether":[26,32],"these":[27,62,84],"functions":[28,147],"are":[29,64,86,135],"ancient,":[30],"or":[31],"conserved":[33],"X-linked":[34,45],"were":[36,113],"recruited":[37],"to":[38],"new":[39],"functions.":[40],"We":[41],"have":[42],"studied":[43],"three":[44],"mental":[46],"retardation":[47],"(XLMR)":[48],"by":[50],"RNA":[51],"situ":[53],"hybridization":[54],"mouse":[56,83],"chicken,":[59],"which":[61],"autosomal:":[65],"Rho":[66],"guanine":[67],"nucleotide":[68],"exchange":[69],"factor":[70],"6":[71],"(ARHGEF6),":[72],"oligophrenin":[73],"(OPHN1),":[74],"p21":[76],"activated":[77],"kinase":[78],"3":[79],"(PAK3).":[80],"In":[81],"specifically":[87],"expressed":[88,115],"telencephalic":[90],"regions.":[91],"Their":[92],"orthologues":[93],"chicken":[96],"gave":[97],"patterns":[98],"of":[99,105],"similar":[100],"specificity":[101],"ancient":[103],"parts":[104],"brain,":[107],"i.e.":[108],"cerebellum":[109],"mesencephalon,":[111],"but":[112],"not":[114,130],"telencephalon.":[118],"Also":[119],"testes,":[122],"specific":[123],"expression":[124],"was":[125],"only":[126],"found":[127],"mouse,":[129],"chicken.":[132],"These":[133],"interpreted":[136],"such":[137],"certain":[139],"on":[141],"gained":[145],"novel":[146],"during":[148],"evolution.":[149]},"counts_by_year":[{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
