{"id":"https://openalex.org/W2017158086","doi":"https://doi.org/10.1093/jb/mvi106","title":"Characteristics of Apoptosis in HCT116 Colon Cancer Cells Induced by Deoxycholic Acid","display_name":"Characteristics of Apoptosis in HCT116 Colon Cancer Cells Induced by Deoxycholic Acid","publication_year":2005,"publication_date":"2005-08-01","ids":{"openalex":"https://openalex.org/W2017158086","doi":"https://doi.org/10.1093/jb/mvi106","mag":"2017158086","pmid":"https://pubmed.ncbi.nlm.nih.gov/16091589"},"language":"en","primary_location":{"id":"doi:10.1093/jb/mvi106","doi":"https://doi.org/10.1093/jb/mvi106","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jb/mvi106","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007730401","display_name":"Satoko Yui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169719367","display_name":"Kyoto Prefectural University","ror":"https://ror.org/00ktqrd38","country_code":"JP","type":"education","lineage":["https://openalex.org/I169719367","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Satoko Yui","raw_affiliation_strings":["Laboratory of Molecular Nutrition, Department of Biological Function, Kyoto Prefectural University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Nutrition, Department of Biological Function, Kyoto Prefectural University","institution_ids":["https://openalex.org/I169719367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111645067","display_name":"Tohru SAEKI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169719367","display_name":"Kyoto Prefectural University","ror":"https://ror.org/00ktqrd38","country_code":"JP","type":"education","lineage":["https://openalex.org/I169719367","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tohru Saeki","raw_affiliation_strings":["Laboratory of Molecular Nutrition, Department of Biological Function, Kyoto Prefectural University, Kyoto 606-8522"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Nutrition, Department of Biological Function, Kyoto Prefectural University, Kyoto 606-8522","institution_ids":["https://openalex.org/I169719367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071718557","display_name":"Ryuhei Kanamoto","orcid":"https://orcid.org/0000-0001-8789-8957","observed_orcids":["https://orcid.org/0000-0001-8789-8957"]},"institutions":[{"id":"https://openalex.org/I169719367","display_name":"Kyoto Prefectural University","ror":"https://ror.org/00ktqrd38","country_code":"JP","type":"education","lineage":["https://openalex.org/I169719367","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryuhei Kanamoto","raw_affiliation_strings":["Laboratory of Molecular Nutrition, Department of Biological Function, Kyoto Prefectural University, Kyoto 606-8522"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Nutrition, Department of Biological Function, Kyoto Prefectural University, Kyoto 606-8522","institution_ids":["https://openalex.org/I169719367"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110142428","display_name":"Kimikazu Iwami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169719367","display_name":"Kyoto Prefectural University","ror":"https://ror.org/00ktqrd38","country_code":"JP","type":"education","lineage":["https://openalex.org/I169719367","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kimikazu Iwami","raw_affiliation_strings":["Laboratory of Molecular Nutrition, Department of Biological Function, Kyoto Prefectural University, Kyoto 606-8522"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Nutrition, Department of Biological Function, Kyoto Prefectural University, Kyoto 606-8522","institution_ids":["https://openalex.org/I169719367"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007730401"],"corresponding_institution_ids":["https://openalex.org/I169719367"],"apc_list":{"value":3276,"currency":"USD","value_usd":3276},"apc_paid":null,"fwci":1.7568,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.82597666,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"138","issue":"2","first_page":"151","last_page":"157"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9490000009536743},{"id":"https://openalex.org/keywords/deoxycholic-acid","display_name":"deoxycholic acid","score":0.9679999947547913},{"id":"https://openalex.org/keywords/hydrophobic-bile-acids","display_name":"hydrophobic bile acids","score":0.8730000257492065},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.7429999709129333},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chenodeoxycholic-acid","display_name":"chenodeoxycholic acid","score":0.968999981880188},{"id":"https://openalex.org/keywords/cholic-acid","display_name":"cholic acid","score":0.9369999766349792},{"id":"https://openalex.org/keywords/ursodeoxycholic-acid","display_name":"ursodeoxycholic acid","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cytochrome-c-release","display_name":"cytochrome c release","score":0.9869999885559082},{"id":"https://openalex.org/keywords/mitochondria","display_name":"mitochondria","score":0.7979999780654907},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.9850000143051147},{"id":"https://openalex.org/keywords/bid","display_name":"Bid","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cycloheximide","display_name":"cycloheximide","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C2780749602","wikidata":"https://www.wikidata.org/wiki/Q425680","display_name":"Deoxycholic acid","level":3,"score":0.9010162949562073},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8441061973571777},{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.7975265979766846},{"id":"https://openalex.org/C2779399885","wikidata":"https://www.wikidata.org/wiki/Q413288","display_name":"Bile acid","level":2,"score":0.6473376750946045},{"id":"https://openalex.org/C2781089062","wikidata":"https://www.wikidata.org/wiki/Q419028","display_name":"Chenodeoxycholic acid","level":3,"score":0.592521071434021},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5884478092193604},{"id":"https://openalex.org/C2778128677","wikidata":"https://www.wikidata.org/wiki/Q412895","display_name":"Cycloheximide","level":3,"score":0.552998960018158},{"id":"https://openalex.org/C2775900799","wikidata":"https://www.wikidata.org/wiki/Q287415","display_name":"Cholic acid","level":3,"score":0.5314475893974304},{"id":"https://openalex.org/C2780965833","wikidata":"https://www.wikidata.org/wiki/Q241374","display_name":"Ursodeoxycholic acid","level":2,"score":0.5294601321220398},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.522717297077179},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4915655553340912},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4109063446521759},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3359909653663635},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.24329358339309692},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.06445720791816711},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003840","descriptor_name":"Deoxycholic Acid","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D003840","descriptor_name":"Deoxycholic Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014580","descriptor_name":"Ursodeoxycholic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045304","descriptor_name":"Cytochromes c","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053453","descriptor_name":"Caspase 9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/jb/mvi106","doi":"https://doi.org/10.1093/jb/mvi106","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jb/mvi106","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:16091589","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16091589","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W340359662","https://openalex.org/W1496932838","https://openalex.org/W1963690195","https://openalex.org/W1964451387","https://openalex.org/W1971895570","https://openalex.org/W1991807136","https://openalex.org/W2002971838","https://openalex.org/W2005154382","https://openalex.org/W2009310895","https://openalex.org/W2014568498","https://openalex.org/W2015362281","https://openalex.org/W2034091811","https://openalex.org/W2036923154","https://openalex.org/W2054438783","https://openalex.org/W2057337807","https://openalex.org/W2061773657","https://openalex.org/W2065929630","https://openalex.org/W2084403843","https://openalex.org/W2091938592","https://openalex.org/W2098535884","https://openalex.org/W2110797810","https://openalex.org/W2132379232","https://openalex.org/W2157977706","https://openalex.org/W2161227789","https://openalex.org/W2161552357","https://openalex.org/W2163382802","https://openalex.org/W2168413006","https://openalex.org/W2187899020"],"related_works":["https://openalex.org/W1989853693","https://openalex.org/W1993444408","https://openalex.org/W2060914872","https://openalex.org/W1966903677","https://openalex.org/W2155333335","https://openalex.org/W1991807136","https://openalex.org/W1496932838","https://openalex.org/W2057760856","https://openalex.org/W2391769495","https://openalex.org/W2161227789"],"abstract_inverted_index":{"Hydrophobic":[0,45],"bile":[1,21,46,83,174],"acids":[2,22,175],"induce":[3,89,176],"apoptosis":[4,38,56,90,147,177],"in":[5,39,57,74,109,178],"both":[6],"colon":[7,16,40],"cancer":[8,17,41],"cells":[9,18,144,180,198],"and":[10,52,70,76,80,119,127,193],"hepatocytes.":[11,31],"The":[12],"mechanism":[13],"by":[14,181,199],"which":[15],"respond":[19],"to":[20,25,99],"is":[23,106],"thought":[24],"be":[26],"different":[27],"from":[28,117,145,167,185],"that":[29,103,172,194],"of":[30,37,114,121,134,152,202],"Therefore,":[32],"we":[33],"investigated":[34],"the":[35,71,110],"characteristics":[36],"cell":[42],"line":[43],"HCT116.":[44],"acids,":[47],"i.e.,":[48],"deoxycholic":[49],"acid":[50,140],"(DCA),":[51],"chenodeoxycholic":[53],"acid,":[54,84,86],"induced":[55],"HCT116":[58,143,179,197],"cells.":[59],"Apoptotic":[60],"indications":[61],"were":[62,123],"detectable":[63,124],"at":[64,92],"as":[65,67],"early":[66],"30":[68],"min":[69],"extent":[72],"increased":[73],"time-":[75],"concentration-dependent":[77],"manners.":[78],"SDS":[79],"a":[81,149],"hydrophilic":[82],"cholic":[85],"did":[87,161],"not":[88,107,137,162],"even":[91],"cytotoxic":[93],"concentrations.":[94],"Pretreatment":[95],"with":[96],"cycloheximide":[97],"failed":[98],"inhibit":[100,163],"apoptosis,":[101],"suggesting":[102],"protein":[104],"synthesis":[105],"involved":[108],"apoptotic":[111],"response.":[112],"Release":[113],"cytochrome":[115,164,183,203],"c":[116,165,184,204],"mitochondria":[118,186],"activation":[120,133],"caspase-9":[122],"after":[125],"5":[126],"10":[128],"min,":[129],"respectively,":[130],"whereas":[131],"remarkable":[132],"Bid":[135],"was":[136,157],"detected.":[138],"Ursodeoxycholic":[139],"(UDCA)":[141],"protected":[142],"DCA-induced":[146],"but":[148,190],"preincubation":[150],"period":[151],">":[153],"or":[154],"=5":[155],"h":[156],"required.":[158],"Nevertheless,":[159],"UDCA":[160,195],"release":[166],"mitochondria.":[168],"Our":[169],"results":[170],"indicate":[171],"hydrophobic":[173],"releasing":[182],"via":[187],"an":[188],"undefined":[189],"specific":[191],"mechanism,":[192],"protects":[196],"acting":[200],"downstream":[201],"release.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
