{"id":"https://openalex.org/W2017148802","doi":"https://doi.org/10.1055/s-2008-1063722","title":"Die prim\u00e4r-sklerosierende Cholangitis","display_name":"Die prim\u00e4r-sklerosierende Cholangitis","publication_year":2008,"publication_date":"2008-03-25","ids":{"openalex":"https://openalex.org/W2017148802","doi":"https://doi.org/10.1055/s-2008-1063722","mag":"2017148802","pmid":"https://pubmed.ncbi.nlm.nih.gov/1648472"},"language":"de","primary_location":{"id":"doi:10.1055/s-2008-1063722","doi":"https://doi.org/10.1055/s-2008-1063722","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2008-1063722","pdf_url":null,"source":{"id":"https://openalex.org/S38943393","display_name":"DMW - Deutsche Medizinische Wochenschrift","issn_l":"0012-0472","issn":["0012-0472","1439-4413"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DMW - Deutsche Medizinische Wochenschrift","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085709526","display_name":"Stefan Grune","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"S. Gr\u00fcne","raw_affiliation_strings":["Departement f\u00fcr Innere Medizin, Universit\u00e4tsspital Z\u00fcrich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departement f\u00fcr Innere Medizin, Universit\u00e4tsspital Z\u00fcrich","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040857444","display_name":"Beat M\u00fcllhaupt","orcid":"https://orcid.org/0000-0002-9020-8192","observed_orcids":["https://orcid.org/0000-0002-9020-8192"]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"B. M\u00fcllhaupt","raw_affiliation_strings":["Medizinische Poliklinik, Departement f\u00fcr Innere Medizin, Universit\u00e4tsspital Z\u00fcrich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Poliklinik, Departement f\u00fcr Innere Medizin, Universit\u00e4tsspital Z\u00fcrich","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067391258","display_name":"Darius Moradpour","orcid":"https://orcid.org/0000-0003-1977-6792","observed_orcids":["https://orcid.org/0000-0003-1977-6792"]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"D. Moradpour","raw_affiliation_strings":["Medizinische Poliklinik, Departement f\u00fcr Innere Medizin, Universit\u00e4tsspital Z\u00fcrich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Poliklinik, Departement f\u00fcr Innere Medizin, Universit\u00e4tsspital Z\u00fcrich","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033185798","display_name":"R M\u00fcnch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"R. M\u00fcnch","raw_affiliation_strings":["Medizinische Poliklinik, Departement f\u00fcr Innere Medizin, Universit\u00e4tsspital Z\u00fcrich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Poliklinik, Departement f\u00fcr Innere Medizin, Universit\u00e4tsspital Z\u00fcrich","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081433556","display_name":"G Siegenthaler-Zuber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"G. Siegenthaler-Zuber","raw_affiliation_strings":["Medizinische Poliklinik, Departement f\u00fcr Innere Medizin, Universit\u00e4tsspital Z\u00fcrich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Poliklinik, Departement f\u00fcr Innere Medizin, Universit\u00e4tsspital Z\u00fcrich","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010875182","display_name":"Walter E. Siegenthaler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"W. Siegenthaler","raw_affiliation_strings":["Medizinische Poliklinik, Departement f\u00fcr Innere Medizin, Universit\u00e4tsspital Z\u00fcrich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Poliklinik, Departement f\u00fcr Innere Medizin, Universit\u00e4tsspital Z\u00fcrich","institution_ids":["https://openalex.org/I4210100468"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210100468"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.1674836,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"116","issue":"28/29","first_page":"1095","last_page":"1100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11576","display_name":"IgG4-Related and Inflammatory Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-sclerosing-cholangitis","display_name":"primary sclerosing cholangitis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cholangiocarcinoma","display_name":"cholangiocarcinoma","score":0.8090000152587891},{"id":"https://openalex.org/keywords/ursodeoxycholic-acid","display_name":"ursodeoxycholic acid","score":0.8349999785423279},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.8939999938011169},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/graft-rejection","display_name":"graft rejection","score":0.7229999899864197},{"id":"https://openalex.org/keywords/endoscopic-retrograde-cholangiopancreatography","display_name":"endoscopic retrograde cholangiopancreatography","score":0.8479999899864197},{"id":"https://openalex.org/keywords/liver-biopsy","display_name":"liver biopsy","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8834189772605896},{"id":"https://openalex.org/C2778444009","wikidata":"https://www.wikidata.org/wiki/Q637883","display_name":"Endoscopic retrograde cholangiopancreatography","level":3,"score":0.6498733758926392},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6162725687026978},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.5904220342636108},{"id":"https://openalex.org/C2777766500","wikidata":"https://www.wikidata.org/wiki/Q360841","display_name":"Liver biopsy","level":3,"score":0.5472419857978821},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5461670756340027},{"id":"https://openalex.org/C2776884468","wikidata":"https://www.wikidata.org/wiki/Q1263617","display_name":"Common bile duct","level":2,"score":0.5115388631820679},{"id":"https://openalex.org/C2778593092","wikidata":"https://www.wikidata.org/wiki/Q1075923","display_name":"Cholestasis","level":2,"score":0.5062312483787537},{"id":"https://openalex.org/C2777969384","wikidata":"https://www.wikidata.org/wiki/Q17011974","display_name":"Elevated alkaline phosphatase","level":4,"score":0.4979248046875},{"id":"https://openalex.org/C2780965833","wikidata":"https://www.wikidata.org/wiki/Q241374","display_name":"Ursodeoxycholic acid","level":2,"score":0.4837946593761444},{"id":"https://openalex.org/C2780615123","wikidata":"https://www.wikidata.org/wiki/Q1058608","display_name":"Primary sclerosing cholangitis","level":3,"score":0.44555899500846863},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.4178262948989868},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32120606303215027},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.2967386543750763},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.2678431272506714},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.08244174718856812},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002759","descriptor_name":"Adenoma, Bile Duct","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002760","descriptor_name":"Cholangiopancreatography, Endoscopic Retrograde","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006500","descriptor_name":"Hepatic Duct, Common","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014580","descriptor_name":"Ursodeoxycholic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015209","descriptor_name":"Cholangitis, Sclerosing","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015209","descriptor_name":"Cholangitis, Sclerosing","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D016031","descriptor_name":"Liver Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-2008-1063722","doi":"https://doi.org/10.1055/s-2008-1063722","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2008-1063722","pdf_url":null,"source":{"id":"https://openalex.org/S38943393","display_name":"DMW - Deutsche Medizinische Wochenschrift","issn_l":"0012-0472","issn":["0012-0472","1439-4413"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DMW - Deutsche Medizinische Wochenschrift","raw_type":"journal-article"},{"id":"pmid:1648472","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1648472","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Deutsche medizinische Wochenschrift (1946)","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.699999988079071}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7046481882","https://openalex.org/W2979125074","https://openalex.org/W1982853709","https://openalex.org/W2326141190","https://openalex.org/W4388706840","https://openalex.org/W65973610","https://openalex.org/W2321032489","https://openalex.org/W2327797626","https://openalex.org/W1527964952","https://openalex.org/W3200436032"],"abstract_inverted_index":{"In":[0],"a":[1,16,109,158,172],"40-year-old":[2],"patient":[3,21,104,204],"unexplained":[4],"recurrent":[5],"attacks":[6],"of":[7,26,63,71,74,126,168,177,180],"epigastric":[8],"colic":[9],"with":[10,31,115],"transient":[11],"cholestatic":[12],"icterus":[13,29],"occurred":[14,137],"over":[15],"9-year":[17],"period.":[18],"When":[19],"the":[20,69,72,75,103,127,169,175,178,181,187,198,203],"was":[22,96,113,200],"again":[23],"hospitalised":[24],"because":[25],"progressive":[27],"pain-free":[28],"associated":[30],"mild":[32],"pruritus":[33],"(alkaline":[34],"phosphatase":[35],"900":[36],"U/l,":[37,44],"direct":[38],"bilirubin":[39],"305":[40],"mumol/l,":[41],"GOT":[42],"187":[43],"GPT":[45],"103":[46],"U/l)":[47],"sonography":[48],"revealed":[49,171],"liver":[50,99,110,128,159],"enlargement":[51],"to":[52,91,108,162],"17":[53],"cm,":[54],"extended":[55],"intrahepatic":[56],"bile":[57],"ducts":[58],"and":[59,133,145,194,202],"an":[60],"echodense":[61],"area":[62],"about":[64,138],"1":[65],"cm":[66],"size":[67],"in":[68,123,174],"region":[70,176],"bifurcation":[73,179],"common":[76,182],"hepatic":[77,183],"duct.":[78,184],"Fine-needle":[79],"puncture":[80],"did":[81,105],"not":[82,106,149],"yield":[83],"clear":[84],"cytological":[85],"findings.":[86],"Endoscopic":[87],"retrograde":[88],"cholangiopancreatography":[89],"pointed":[90],"sclerosing":[92],"cholangitis.":[93],"This":[94],"diagnosis":[95],"confirmed":[97],"by":[98],"punch":[100],"biopsy.":[101],"Since":[102],"agree":[107],"transplantation,":[111],"he":[112],"treated":[114],"450":[116],"mg":[117],"ursodeoxycholic":[118],"acid":[119],"twice":[120],"daily,":[121],"resulting":[122],"marked":[124],"reduction":[125],"parameters":[129],"until":[130],"severe":[131],"cholangiosepsis":[132],"acute":[134],"renal":[135],"failure":[136],"4":[139],"months":[140,196],"later.":[141],"The":[142],"septic":[143],"condition":[144,189],"its":[146],"complications":[147],"could":[148],"be":[150,163],"managed":[151],"despite":[152],"thorough":[153],"intensive-care":[154],"measures":[155],"so":[156],"that":[157],"transplant":[160,199],"had":[161],"performed":[164],"after":[165],"all.":[166],"Histology":[167],"explantate":[170],"cholangiocarcinoma":[173],"At":[185],"first":[186],"patient's":[188],"improved":[190],"markedly":[191],"but":[192],"one":[193],"half":[195],"later":[197],"rejected":[201],"died.":[205]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
