{"id":"https://openalex.org/W2017140295","doi":"https://doi.org/10.1038/sj.cdd.4400565","title":"Calcium induced release of mitochondrial cytochrome c by different mechanisms selective for brain versus liver","display_name":"Calcium induced release of mitochondrial cytochrome c by different mechanisms selective for brain versus liver","publication_year":1999,"publication_date":"1999-09-01","ids":{"openalex":"https://openalex.org/W2017140295","doi":"https://doi.org/10.1038/sj.cdd.4400565","mag":"2017140295","pmid":"https://pubmed.ncbi.nlm.nih.gov/10510464"},"language":"en","primary_location":{"id":"doi:10.1038/sj.cdd.4400565","doi":"https://doi.org/10.1038/sj.cdd.4400565","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.cdd.4400565","pdf_url":null,"source":{"id":"https://openalex.org/S152938505","display_name":"Cell Death and Differentiation","issn_l":"1350-9047","issn":["1350-9047","1476-5403"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Differentiation","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2017140295"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033439967","display_name":"Alexander Y. Andreyev","orcid":"https://orcid.org/0000-0002-9246-9943","observed_orcids":["https://orcid.org/0000-0002-9246-9943"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Andreyev","raw_affiliation_strings":["Department of Anesthesiology, University of Maryland, Baltimore School of Medicine, Baltimore, Maryland, 21201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Maryland, Baltimore School of Medicine, Baltimore, Maryland, 21201, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080399968","display_name":"Gary M. Fiskum","orcid":"https://orcid.org/0000-0001-5909-0539","observed_orcids":["https://orcid.org/0000-0001-5909-0539"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gary Fiskum","raw_affiliation_strings":["Department of Anesthesiology, University of Maryland, Baltimore School of Medicine, Baltimore, 21201, Maryland, USA","Department of Anesthesiology, University of Maryland, Baltimore School of Medicine, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Maryland, Baltimore School of Medicine, Baltimore, 21201, Maryland, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Department of Anesthesiology, University of Maryland, Baltimore School of Medicine, Baltimore, USA","institution_ids":["https://openalex.org/I126744593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5080399968"],"corresponding_institution_ids":["https://openalex.org/I126744593"],"apc_list":{"value":5790,"currency":"USD","value_usd":5790},"apc_paid":null,"fwci":4.6926,"has_fulltext":true,"cited_by_count":191,"citation_normalized_percentile":{"value":0.96086769,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"6","issue":"9","first_page":"825","last_page":"832"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.6797000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.6797000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.31520000100135803,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytochrome-c-release","display_name":"cytochrome c release","score":0.9390000104904175},{"id":"https://openalex.org/keywords/mitochondrial-calcium-accumulation","display_name":"mitochondrial calcium accumulation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.972000002861023},{"id":"https://openalex.org/keywords/brain-mitochondria","display_name":"brain mitochondria","score":0.777999997138977},{"id":"https://openalex.org/keywords/liver-mitochondria","display_name":"liver mitochondria","score":1.0},{"id":"https://openalex.org/keywords/tissue-specific-differences","display_name":"tissue-specific differences","score":0.5609999895095825},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.7559999823570251},{"id":"https://openalex.org/keywords/mitochondrial-swelling","display_name":"mitochondrial swelling","score":0.7179999947547913},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7760000228881836},{"id":"https://openalex.org/keywords/caspase-activation","display_name":"caspase activation","score":0.7910000085830688}],"concepts":[{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.8322117924690247},{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.8270273208618164},{"id":"https://openalex.org/C13591479","wikidata":"https://www.wikidata.org/wiki/Q6881880","display_name":"Mitochondrial permeability transition pore","level":4,"score":0.6212508082389832},{"id":"https://openalex.org/C173358068","wikidata":"https://www.wikidata.org/wiki/Q6881847","display_name":"Mitochondrial apoptosis-induced channel","level":4,"score":0.6192909479141235},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.5827426314353943},{"id":"https://openalex.org/C193349765","wikidata":"https://www.wikidata.org/wiki/Q2061363","display_name":"Apoptosome","level":5,"score":0.5361786484718323},{"id":"https://openalex.org/C186850619","wikidata":"https://www.wikidata.org/wiki/Q1425206","display_name":"Intermembrane space","level":5,"score":0.5295093059539795},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5073391795158386},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.4992101192474365},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.48425814509391785},{"id":"https://openalex.org/C95580263","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrial intermembrane space","level":5,"score":0.45704466104507446},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.43892234563827515},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4359782040119171},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43498650193214417},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.43206363916397095},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42976799607276917},{"id":"https://openalex.org/C75385678","wikidata":"https://www.wikidata.org/wiki/Q4896390","display_name":"Inner mitochondrial membrane","level":3,"score":0.4125077426433563},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.34404969215393066},{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.2900271415710449},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.2579326033592224},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.21710562705993652},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003574","descriptor_name":"Cytochrome c Group","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/sj.cdd.4400565","doi":"https://doi.org/10.1038/sj.cdd.4400565","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.cdd.4400565","pdf_url":null,"source":{"id":"https://openalex.org/S152938505","display_name":"Cell Death and Differentiation","issn_l":"1350-9047","issn":["1350-9047","1476-5403"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Differentiation","raw_type":"journal-article"},{"id":"pmid:10510464","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10510464","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell death and differentiation","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1798805923","display_name":"Molecular Mechanisms of Ischemia Reperfusion Brain Injury","funder_award_id":"R01NS034152","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320309974","display_name":"Bayer Corporation","ror":"https://ror.org/034ffbg36"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1492823505","https://openalex.org/W1507410890","https://openalex.org/W1553877517","https://openalex.org/W1644794975","https://openalex.org/W1876476959","https://openalex.org/W1966448402","https://openalex.org/W1966539065","https://openalex.org/W1976226379","https://openalex.org/W1979995768","https://openalex.org/W1980969730","https://openalex.org/W1985731963","https://openalex.org/W1988355439","https://openalex.org/W1995628673","https://openalex.org/W1996568613","https://openalex.org/W1996907401","https://openalex.org/W2007294454","https://openalex.org/W2017392776","https://openalex.org/W2019403369","https://openalex.org/W2021528199","https://openalex.org/W2021678802","https://openalex.org/W2029431403","https://openalex.org/W2036599441","https://openalex.org/W2050769762","https://openalex.org/W2050994823","https://openalex.org/W2051258629","https://openalex.org/W2052793452","https://openalex.org/W2053534803","https://openalex.org/W2055094310","https://openalex.org/W2063385957","https://openalex.org/W2063772445","https://openalex.org/W2064196264","https://openalex.org/W2072858020","https://openalex.org/W2074330066","https://openalex.org/W2075477970","https://openalex.org/W2075874065","https://openalex.org/W2076610743","https://openalex.org/W2077529180","https://openalex.org/W2092146469","https://openalex.org/W2094247127","https://openalex.org/W2094748455","https://openalex.org/W2108131089","https://openalex.org/W2110029891","https://openalex.org/W2113999599","https://openalex.org/W2125562918","https://openalex.org/W2130866079","https://openalex.org/W2143302994","https://openalex.org/W2146027360","https://openalex.org/W2149687359","https://openalex.org/W2151863888","https://openalex.org/W2155747798","https://openalex.org/W2168496647","https://openalex.org/W2331647907"],"related_works":["https://openalex.org/W2016655414","https://openalex.org/W1995628673","https://openalex.org/W98689888","https://openalex.org/W2114521612","https://openalex.org/W1972353515","https://openalex.org/W130430081","https://openalex.org/W2012406157","https://openalex.org/W2017392776","https://openalex.org/W2763810591","https://openalex.org/W2122575974"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}