{"id":"https://openalex.org/W2017139263","doi":"https://doi.org/10.1164/rccm.200702-254oc","title":"Early Interstitial Lung Disease in Familial Pulmonary Fibrosis","display_name":"Early Interstitial Lung Disease in Familial Pulmonary Fibrosis","publication_year":2007,"publication_date":"2007-07-19","ids":{"openalex":"https://openalex.org/W2017139263","doi":"https://doi.org/10.1164/rccm.200702-254oc","mag":"2017139263","pmid":"https://pubmed.ncbi.nlm.nih.gov/17641157","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1994234"},"language":"en","primary_location":{"id":"doi:10.1164/rccm.200702-254oc","doi":"https://doi.org/10.1164/rccm.200702-254oc","is_oa":false,"landing_page_url":"https://doi.org/10.1164/rccm.200702-254oc","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1994234","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034439885","display_name":"Iv\u00e1n O. Rosas","orcid":"https://orcid.org/0000-0003-4622-618X","observed_orcids":["https://orcid.org/0000-0003-4622-618X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivan O. Rosas","raw_affiliation_strings":["Pulmonary\u2013Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland","Pulmonary-Critical Care Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1590, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary\u2013Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"Pulmonary-Critical Care Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1590, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ping Ren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ping Ren","raw_affiliation_strings":["Pulmonary\u2013Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary\u2013Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112263701","display_name":"Nilo A. Avila","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nilo A. Avila","raw_affiliation_strings":["Diagnostic Radiology Department, Clinical Center, National Institutes of Health, Bethesda, Maryland","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diagnostic Radiology Department, Clinical Center, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113535085","display_name":"Catherine K. Chow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine K. Chow","raw_affiliation_strings":["Diagnostic Radiology Department, Clinical Center, National Institutes of Health, Bethesda, Maryland","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diagnostic Radiology Department, Clinical Center, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079639853","display_name":"Teri J. Franks","orcid":"https://orcid.org/0000-0003-2407-8593","observed_orcids":["https://orcid.org/0000-0003-2407-8593"]},"institutions":[{"id":"https://openalex.org/I4210151970","display_name":"Armed Forces Institute of Pathology","ror":"https://ror.org/04se3fj97","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210151970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teri J. Franks","raw_affiliation_strings":["Department of Pulmonary and Mediastinal Pathology, Armed Forces Institute of Pathology, Washington, DC","Armed Forces Institute of Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Mediastinal Pathology, Armed Forces Institute of Pathology, Washington, DC","institution_ids":["https://openalex.org/I4210151970"]},{"raw_affiliation_string":"Armed Forces Institute of Pathology","institution_ids":["https://openalex.org/I4210151970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044483075","display_name":"William David Travis","orcid":"https://orcid.org/0000-0003-3160-6729","observed_orcids":["https://orcid.org/0000-0003-3160-6729"]},"institutions":[{"id":"https://openalex.org/I4210151970","display_name":"Armed Forces Institute of Pathology","ror":"https://ror.org/04se3fj97","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210151970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William D. Travis","raw_affiliation_strings":["Department of Pulmonary and Mediastinal Pathology, Armed Forces Institute of Pathology, Washington, DC","Armed Forces Institute of Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Mediastinal Pathology, Armed Forces Institute of Pathology, Washington, DC","institution_ids":["https://openalex.org/I4210151970"]},{"raw_affiliation_string":"Armed Forces Institute of Pathology","institution_ids":["https://openalex.org/I4210151970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102771781","display_name":"John Philip McCoy","orcid":"https://orcid.org/0000-0002-8118-5275","observed_orcids":["https://orcid.org/0000-0002-8118-5275"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Philip McCoy","raw_affiliation_strings":["Flow Cytometry Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Flow Cytometry Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074853375","display_name":"Rose M. May","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rose M. May","raw_affiliation_strings":["Pulmonary\u2013Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary\u2013Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100847756","display_name":"Hai-Ping Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hai-Ping Wu","raw_affiliation_strings":["Pulmonary\u2013Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary\u2013Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005067201","display_name":"Dao M. Nguyen","orcid":"https://orcid.org/0000-0003-4012-5441","observed_orcids":["https://orcid.org/0000-0003-4012-5441"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dao M. Nguyen","raw_affiliation_strings":["Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; and","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; and","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015040602","display_name":"Mauricio Arcos\u2010Burgos","orcid":"https://orcid.org/0000-0002-8529-0574","observed_orcids":["https://orcid.org/0000-0002-8529-0574"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mauricio Arcos-Burgos","raw_affiliation_strings":["Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043694392","display_name":"Sandra D. MacDonald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra D. MacDonald","raw_affiliation_strings":["Pulmonary\u2013Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary\u2013Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035323335","display_name":"Bernadette R. Gochuico","orcid":"https://orcid.org/0000-0003-4727-8918","observed_orcids":["https://orcid.org/0000-0003-4727-8918"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bernadette R. Gochuico","raw_affiliation_strings":["Pulmonary\u2013Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary\u2013Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.5087,"has_fulltext":false,"cited_by_count":180,"citation_normalized_percentile":{"value":0.98141599,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"176","issue":"7","first_page":"698","last_page":"705"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interstitial-lung-disease","display_name":"interstitial lung disease","score":0.8790000081062317},{"id":"https://openalex.org/keywords/familial-idiopathic-pulmonary-fibrosis","display_name":"familial idiopathic pulmonary fibrosis","score":0.8970000147819519},{"id":"https://openalex.org/keywords/high-resolution-computed-tomography","display_name":"high-resolution computed tomography","score":0.843999981880188},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.7409999966621399},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage","display_name":"bronchoalveolar lavage","score":0.8539999723434448},{"id":"https://openalex.org/keywords/natural-history-disease","display_name":"natural history (disease)","score":0.6259999871253967},{"id":"https://openalex.org/keywords/family-members","display_name":"family members","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9684154987335205},{"id":"https://openalex.org/C2777543607","wikidata":"https://www.wikidata.org/wiki/Q1153419","display_name":"Interstitial lung disease","level":3,"score":0.703033447265625},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.6876553893089294},{"id":"https://openalex.org/C2778341716","wikidata":"https://www.wikidata.org/wiki/Q2290446","display_name":"Idiopathic pulmonary fibrosis","level":3,"score":0.6005809903144836},{"id":"https://openalex.org/C2983914783","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Lung disease","level":3,"score":0.5827482342720032},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5562336444854736},{"id":"https://openalex.org/C2992779976","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Pulmonary disease","level":2,"score":0.4649710953235626},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.44512295722961426},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.42531687021255493},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3775787949562073},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26459842920303345}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017563","descriptor_name":"Lung Diseases, Interstitial","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D017563","descriptor_name":"Lung Diseases, Interstitial","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D017563","descriptor_name":"Lung Diseases, Interstitial","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017563","descriptor_name":"Lung Diseases, Interstitial","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1164/rccm.200702-254oc","doi":"https://doi.org/10.1164/rccm.200702-254oc","is_oa":false,"landing_page_url":"https://doi.org/10.1164/rccm.200702-254oc","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1171198","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1994234","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1994234","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1994234","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Respir Crit Care Med","raw_type":"Text"},{"id":"pmid:17641157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17641157","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory and critical care medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.667.6402","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.667.6402","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994234/pdf/AJRCCM1767698.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1171198","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1994234","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337376","display_name":"NIH Clinical Center","ror":"https://ror.org/04vfsmv21"},{"id":"https://openalex.org/F4320338421","display_name":"NHLBI Division of Intramural Research","ror":"https://ror.org/023ny1p48"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1860863518","https://openalex.org/W1958163310","https://openalex.org/W1965635977","https://openalex.org/W1970876784","https://openalex.org/W1976749251","https://openalex.org/W1977933077","https://openalex.org/W1982865427","https://openalex.org/W1998071926","https://openalex.org/W2011151655","https://openalex.org/W2030108219","https://openalex.org/W2043068531","https://openalex.org/W2046501504","https://openalex.org/W2052397837","https://openalex.org/W2061574596","https://openalex.org/W2072063652","https://openalex.org/W2076579116","https://openalex.org/W2089777640","https://openalex.org/W2097419822","https://openalex.org/W2100059970","https://openalex.org/W2104558481","https://openalex.org/W2108226118","https://openalex.org/W2108683967","https://openalex.org/W2133552593","https://openalex.org/W2144017344","https://openalex.org/W2148042225","https://openalex.org/W2165871186","https://openalex.org/W2167616166","https://openalex.org/W2317782431","https://openalex.org/W2338532680","https://openalex.org/W2411130954","https://openalex.org/W2416914730","https://openalex.org/W2465717902","https://openalex.org/W4210975502","https://openalex.org/W4249200669"],"related_works":["https://openalex.org/W4316127164","https://openalex.org/W3004594729","https://openalex.org/W2959405039","https://openalex.org/W4410272184","https://openalex.org/W4401534569","https://openalex.org/W2145751646","https://openalex.org/W4283712504","https://openalex.org/W2017164741","https://openalex.org/W2914499165","https://openalex.org/W4416636135"],"abstract_inverted_index":{"RATIONALE:":[0],"Identification":[1],"of":[2,13,23,27,38,44,99,133,139,147,159,175,221,233,242,260],"early,":[3],"asymptomatic":[4,39,82,101,105,142,190,208,253],"interstitial":[5],"lung":[6,126,163,197,254],"disease":[7,127,164,198,255],"(ILD)":[8],"in":[9,41,78,96,137,145,182,205,217,237,248],"populations":[10],"at":[11,219],"risk":[12,220],"developing":[14,222],"idiopathic":[15],"pulmonary":[16],"fibrosis":[17],"(IPF)":[18],"may":[19],"improve":[20],"the":[21,24,234],"understanding":[22],"natural":[25],"history":[26,132,241],"IPF.":[28,48],"OBJECTIVES:":[29],"To":[30],"determine":[31],"clinical,":[32],"radiographic,":[33],"physiologic,":[34],"and":[35,119,144,169],"pathologic":[36],"features":[37],"ILD":[40,93,106,143,191,209,216],"family":[42],"members":[43],"patients":[45],"with":[46,58,81,104,112,141,149,189,193,207,239,251],"familial":[47,59,114,150,223],"METHODS:":[49],"One":[50],"hundred":[51],"sixty-four":[52],"subjects":[53,80,111,124,140,148,161,188,195,206],"from":[54,187,246],"18":[55],"kindreds":[56],"affected":[57],"IPF":[60,115,224],"were":[61,69,76,94,107,154,179],"evaluated":[62],"for":[63],"ILD.":[64,83,261],"Bronchoalveolar":[65],"lavage":[66,184],"fluid":[67,185],"cells":[68,186],"analyzed":[70],"using":[71,228],"flow":[72],"cytometry.":[73],"Lung":[74,202,244],"biopsies":[75,203,245],"performed":[77,204],"six":[79],"MEASUREMENTS":[84],"AND":[85],"MAIN":[86],"RESULTS:":[87],"High-resolution":[88],"computed":[89,230],"tomography":[90,231],"abnormalities":[91],"suggesting":[92],"identified":[95,136,227],"31":[97],"(22%)":[98],"143":[100],"subjects.":[102],"Subjects":[103],"significantly":[108,120,155,180],"younger":[109],"than":[110,122,157],"known":[113],"(P":[116,128,166,199],"<":[117,129,171,200],"0.001)":[118],"older":[121],"related":[123,160,194],"without":[125,162,196],"0.001).":[130,201],"A":[131],"smoking":[134],"was":[135],"45%":[138],"67%":[146],"IPF;":[151],"these":[152],"percentages":[153],"higher":[156,181],"that":[158],"(23%)":[165],"=":[167],"0.02":[168],"P":[170],"0.001,":[172],"respectively).":[173],"Percentages":[174],"activated":[176],"CD4(+)":[177],"lymphocytes":[178],"bronchoalveolar":[183],"compared":[192],"revealed":[210],"diverse":[211],"histologic":[212,258],"subtypes.":[213],"CONCLUSIONS:":[214],"Asymptomatic":[215],"individuals":[218,247],"can":[225],"be":[226],"high-resolution":[229],"scan":[232],"chest,":[235],"especially":[236],"those":[238],"a":[240],"smoking.":[243],"this":[249],"cohort":[250],"early":[252],"demonstrate":[256],"various":[257],"subtypes":[259]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":14}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}