{"id":"https://openalex.org/W2017133886","doi":"https://doi.org/10.1210/en.2008-0949","title":"Metal Transcription Factor-1 Is Involved in Hypoxia-Dependent Regulation of Placenta Growth Factor in Trophoblast-Derived Cells","display_name":"Metal Transcription Factor-1 Is Involved in Hypoxia-Dependent Regulation of Placenta Growth Factor in Trophoblast-Derived Cells","publication_year":2008,"publication_date":"2008-11-20","ids":{"openalex":"https://openalex.org/W2017133886","doi":"https://doi.org/10.1210/en.2008-0949","mag":"2017133886","pmid":"https://pubmed.ncbi.nlm.nih.gov/19022893"},"language":"en","primary_location":{"id":"doi:10.1210/en.2008-0949","doi":"https://doi.org/10.1210/en.2008-0949","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.2008-0949","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048289688","display_name":"Fumihito Nishimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumihito Nishimoto","raw_affiliation_strings":["Department of Obstetrics and Gynecology (F.N., M.S., R.M., A.M., A.I., T.T., E.I., K.S., K.M., T.K.), Osaka University Faculty of Medicine, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology (F.N., M.S., R.M., A.M., A.I., T.T., E.I., K.S., K.M., T.K.), Osaka University Faculty of Medicine, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019463160","display_name":"Masahiro Sakata","orcid":"https://orcid.org/0000-0001-7406-3117","observed_orcids":["https://orcid.org/0000-0001-7406-3117"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masahiro Sakata","raw_affiliation_strings":["Department of Obstetrics and Gynecology (F.N., M.S., R.M., A.M., A.I., T.T., E.I., K.S., K.M., T.K.), Osaka University Faculty of Medicine, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology (F.N., M.S., R.M., A.M., A.I., T.T., E.I., K.S., K.M., T.K.), Osaka University Faculty of Medicine, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080253062","display_name":"Ryoko Minekawa","orcid":"https://orcid.org/0000-0001-7429-3203","observed_orcids":["https://orcid.org/0000-0001-7429-3203"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryoko Minekawa","raw_affiliation_strings":["Department of Obstetrics and Gynecology (F.N., M.S., R.M., A.M., A.I., T.T., E.I., K.S., K.M., T.K.), Osaka University Faculty of Medicine, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology (F.N., M.S., R.M., A.M., A.I., T.T., E.I., K.S., K.M., T.K.), Osaka University Faculty of Medicine, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101828479","display_name":"Yoko Okamoto","orcid":"https://orcid.org/0000-0002-9222-0662","observed_orcids":["https://orcid.org/0000-0002-9222-0662"]},"institutions":[{"id":"https://openalex.org/I4210095711","display_name":"Osaka Women's and Children's Hospital","ror":"https://ror.org/00nx7n658","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210095711","https://openalex.org/I4405282797"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoko Okamoto","raw_affiliation_strings":["Osaka Medical Center and Research Institute for Maternal and Child Health (Y.O.), Osaka 594-1101, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osaka Medical Center and Research Institute for Maternal and Child Health (Y.O.), Osaka 594-1101, Japan","institution_ids":["https://openalex.org/I4210095711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113575879","display_name":"Asako Miyake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Asako Miyake","raw_affiliation_strings":["Department of Obstetrics and Gynecology (F.N., M.S., R.M., A.M., A.I., T.T., E.I., K.S., K.M., T.K.), Osaka University Faculty of Medicine, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology (F.N., M.S., R.M., A.M., A.I., T.T., E.I., K.S., K.M., T.K.), Osaka University Faculty of Medicine, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110199877","display_name":"Aki Isobe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Aki Isobe","raw_affiliation_strings":["Department of Obstetrics and Gynecology (F.N., M.S., R.M., A.M., A.I., T.T., E.I., K.S., K.M., T.K.), Osaka University Faculty of Medicine, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology (F.N., M.S., R.M., A.M., A.I., T.T., E.I., K.S., K.M., T.K.), Osaka University Faculty of Medicine, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101888571","display_name":"Toshiya Yamamoto","orcid":"https://orcid.org/0000-0002-2106-8421","observed_orcids":["https://orcid.org/0000-0002-2106-8421"]},"institutions":[{"id":"https://openalex.org/I4210104391","display_name":"Sakai City Medical Center","ror":"https://ror.org/014nm9q97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104391","https://openalex.org/I4405286217"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiya Yamamoto","raw_affiliation_strings":["Sakai Municipal Hospital (T.Y.), Osaka 591-0064, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sakai Municipal Hospital (T.Y.), Osaka 591-0064, Japan","institution_ids":["https://openalex.org/I4210104391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009399227","display_name":"Takashi Takeda","orcid":"https://orcid.org/0000-0003-2428-1946","observed_orcids":["https://orcid.org/0000-0003-2428-1946"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Takeda","raw_affiliation_strings":["Department of Obstetrics and Gynecology (F.N., M.S., R.M., A.M., A.I., T.T., E.I., K.S., K.M., T.K.), Osaka University Faculty of Medicine, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology (F.N., M.S., R.M., A.M., A.I., T.T., E.I., K.S., K.M., T.K.), Osaka University Faculty of Medicine, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Emi Ishida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Emi Ishida","raw_affiliation_strings":["Department of Obstetrics and Gynecology (F.N., M.S., R.M., A.M., A.I., T.T., E.I., K.S., K.M., T.K.), Osaka University Faculty of Medicine, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology (F.N., M.S., R.M., A.M., A.I., T.T., E.I., K.S., K.M., T.K.), Osaka University Faculty of Medicine, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006897018","display_name":"Kenjiro Sawada","orcid":"https://orcid.org/0000-0001-7384-2581","observed_orcids":["https://orcid.org/0000-0001-7384-2581"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenjiro Sawada","raw_affiliation_strings":["Department of Obstetrics and Gynecology (F.N., M.S., R.M., A.M., A.I., T.T., E.I., K.S., K.M., T.K.), Osaka University Faculty of Medicine, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology (F.N., M.S., R.M., A.M., A.I., T.T., E.I., K.S., K.M., T.K.), Osaka University Faculty of Medicine, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001425851","display_name":"Kenichiro Morishige","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken-ichiro Morishige","raw_affiliation_strings":["Department of Obstetrics and Gynecology (F.N., M.S., R.M., A.M., A.I., T.T., E.I., K.S., K.M., T.K.), Osaka University Faculty of Medicine, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology (F.N., M.S., R.M., A.M., A.I., T.T., E.I., K.S., K.M., T.K.), Osaka University Faculty of Medicine, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055405608","display_name":"Tadashi Kimura","orcid":"https://orcid.org/0000-0003-1279-9078","observed_orcids":["https://orcid.org/0000-0003-1279-9078"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadashi Kimura","raw_affiliation_strings":["Department of Obstetrics and Gynecology (F.N., M.S., R.M., A.M., A.I., T.T., E.I., K.S., K.M., T.K.), Osaka University Faculty of Medicine, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology (F.N., M.S., R.M., A.M., A.I., T.T., E.I., K.S., K.M., T.K.), Osaka University Faculty of Medicine, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5019463160"],"corresponding_institution_ids":["https://openalex.org/I98285908"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":3.3041,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.9131017,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"150","issue":"4","first_page":"1801","last_page":"1808"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/placental-growth-factor","display_name":"placental growth factor","score":0.8619999885559082},{"id":"https://openalex.org/keywords/mtf-1","display_name":"MTF-1","score":0.9409999847412109},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9599999785423279},{"id":"https://openalex.org/keywords/trophoblast","display_name":"trophoblast","score":0.8970000147819519},{"id":"https://openalex.org/keywords/placental-hypoxia","display_name":"placental hypoxia","score":0.7540000081062317},{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":0.8629999756813049},{"id":"https://openalex.org/keywords/metal-responsive-elements","display_name":"metal-responsive elements","score":0.8579999804496765},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7749999761581421},{"id":"https://openalex.org/keywords/bewo-cells","display_name":"BeWo cells","score":0.7400000095367432},{"id":"https://openalex.org/keywords/choriocarcinoma","display_name":"choriocarcinoma","score":0.7990000247955322},{"id":"https://openalex.org/keywords/placenta","display_name":"placenta","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C2776871010","wikidata":"https://www.wikidata.org/wiki/Q18030500","display_name":"Placental growth factor","level":4,"score":0.7642406225204468},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.6319248676300049},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6315838098526001},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.5995304584503174},{"id":"https://openalex.org/C2777495146","wikidata":"https://www.wikidata.org/wiki/Q1889778","display_name":"Trophoblast","level":5,"score":0.5977179408073425},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5714207291603088},{"id":"https://openalex.org/C57467964","wikidata":"https://www.wikidata.org/wiki/Q14888082","display_name":"Sp1 transcription factor","level":5,"score":0.5294815301895142},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.526931881904602},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4974975883960724},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.4933532774448395},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.46325406432151794},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4564693868160248},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.40798258781433105},{"id":"https://openalex.org/C2777218350","wikidata":"https://www.wikidata.org/wiki/Q61335","display_name":"Preeclampsia","level":3,"score":0.3987882435321808},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3114074468612671},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.30892521142959595},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.2675735354423523},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2633937895298004},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20608818531036377},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15623939037322998},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.07632270455360413},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06291612982749939},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072483","descriptor_name":"Placenta Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097809","descriptor_name":"Transcription Factor MTF-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011257","descriptor_name":"Pregnancy Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011257","descriptor_name":"Pregnancy Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014327","descriptor_name":"Trophoblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/en.2008-0949","doi":"https://doi.org/10.1210/en.2008-0949","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.2008-0949","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:19022893","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19022893","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W313189764","https://openalex.org/W1485875137","https://openalex.org/W1542897514","https://openalex.org/W1587020653","https://openalex.org/W1592759509","https://openalex.org/W1624769216","https://openalex.org/W1784095256","https://openalex.org/W1869391303","https://openalex.org/W1875554126","https://openalex.org/W1964037605","https://openalex.org/W1966676932","https://openalex.org/W1970282698","https://openalex.org/W1972739162","https://openalex.org/W1974588461","https://openalex.org/W1975198479","https://openalex.org/W1983763042","https://openalex.org/W1985298466","https://openalex.org/W1987259861","https://openalex.org/W1996128263","https://openalex.org/W1996451325","https://openalex.org/W1998186649","https://openalex.org/W2003425522","https://openalex.org/W2011722454","https://openalex.org/W2017771409","https://openalex.org/W2029763523","https://openalex.org/W2043179564","https://openalex.org/W2043863730","https://openalex.org/W2044144820","https://openalex.org/W2046122656","https://openalex.org/W2049320716","https://openalex.org/W2057909602","https://openalex.org/W2075054245","https://openalex.org/W2076186277","https://openalex.org/W2079249388","https://openalex.org/W2091996440","https://openalex.org/W2100527908","https://openalex.org/W2102013368","https://openalex.org/W2102277066","https://openalex.org/W2119281341","https://openalex.org/W2125847914","https://openalex.org/W2128945729","https://openalex.org/W2137433871","https://openalex.org/W2143474398","https://openalex.org/W2143936341","https://openalex.org/W2144050843","https://openalex.org/W2159139124","https://openalex.org/W2163252729","https://openalex.org/W2273992414","https://openalex.org/W2402964295","https://openalex.org/W2416174399","https://openalex.org/W2440269545","https://openalex.org/W2462619969","https://openalex.org/W2582709257","https://openalex.org/W2600875608","https://openalex.org/W6632686639","https://openalex.org/W6636724236","https://openalex.org/W6650127100","https://openalex.org/W6718396981"],"related_works":["https://openalex.org/W1624769216","https://openalex.org/W2074762773","https://openalex.org/W6983714861","https://openalex.org/W7098202250","https://openalex.org/W2088401580","https://openalex.org/W2154269171","https://openalex.org/W2800852900","https://openalex.org/W2018722206","https://openalex.org/W2759044370","https://openalex.org/W134414765"],"abstract_inverted_index":{"Placenta":[0],"growth":[1],"factor":[2,11],"(PlGF)":[3],"is":[4,220],"a":[5,41,186],"placental":[6,175,189],"angiogenic":[7],"factor.":[8],"Metal-responsive":[9],"transcription":[10,97],"(MTF)-1":[12],"was":[13,79,196],"reported":[14],"to":[15,81,163],"take":[16],"part":[17],"in":[18,24,40,61,126,144,150,171,198,222,227],"the":[19,58,70,96,107,127,132,145,157,160,164,193],"hypoxic":[20,133],"induction":[21],"of":[22,57,72,98,106,117,135,159,173,188,192,225],"PlGF":[23,32,59,91,99,151,226],"RAS-transformed":[25],"mouse":[26],"fibroblasts.":[27],"We":[28,68,167],"contrarily":[29],"showed":[30,156],"that":[31,114,218],"mRNA":[33,92],"and":[34,77,123,182],"protein":[35,162,195],"levels":[36],"decreased":[37,90,147,197],"under":[38,100],"hypoxia":[39,73],"choriocarcinoma":[42],"BeWo":[43],"cell":[44],"line":[45],"derived":[46],"from":[47,177,200,209],"trophoblast.":[48],"In":[49],"this":[50],"report,":[51],"we":[52,102],"examined":[53,168],"whether":[54],"hypoxia-dependent":[55,223],"regulation":[56,134,224],"gene":[60],"these":[62,215],"cells":[63],"also":[64],"depends":[65],"on":[66,74],"MTF-1.":[67],"analyzed":[69],"effect":[71],"MTF-1":[75,85,139,161,169,194,219],"expression,":[76],"it":[78],"revealed":[80],"be":[82],"decreased.":[83],"Moreover,":[84],"small":[86,140],"interfering":[87,141],"RNA":[88,142],"treatment":[89],"level.":[93],"To":[94],"investigate":[95],"hypoxia,":[101],"cloned":[103],"promoter":[104,128,165],"region":[105],"human":[108],"PlGF.":[109,136],"Promoter":[110],"deletion":[111],"analysis":[112],"suggested":[113],"triple":[115],"repeats":[116],"metal-responsive":[118],"element":[119],"located":[120],"between":[121],"-511":[122],"-468":[124],"bp":[125],"are":[129],"important":[130],"for":[131],"Treatment":[137],"with":[138,179,203,207],"resulted":[143],"significant":[146],"luciferase":[148],"activity":[149],"reporter":[152],"constructs.":[153],"Chromatin":[154],"immunoprecipitation":[155],"binding":[158],"region.":[166],"immunoreactivity":[170],"trophoblasts":[172],"term":[174],"tissue":[176],"patients":[178],"normal":[180,210],"pregnancies":[181],"preeclampsia,":[183],"which":[184],"represents":[185],"condition":[187],"hypoxia.":[190],"Immunoreactivity":[191],"placentas":[199],"pregnant":[201,211],"women":[202],"preeclampsia":[204],"when":[205],"compared":[206],"those":[208],"women.":[212],"Taken":[213],"together,":[214],"findings":[216],"suggest":[217],"involved":[221],"trophoblast-derived":[228],"cells.":[229]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}