{"id":"https://openalex.org/W2017129831","doi":"https://doi.org/10.1016/0006-8993(91)91621-7","title":"Chronic desipramine treatment reduces regional neuropeptide Y binding to Y2-type receptors in rat brain","display_name":"Chronic desipramine treatment reduces regional neuropeptide Y binding to Y2-type receptors in rat brain","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W2017129831","doi":"https://doi.org/10.1016/0006-8993(91)91621-7","mag":"2017129831","pmid":"https://pubmed.ncbi.nlm.nih.gov/1647239"},"language":"en","primary_location":{"id":"doi:10.1016/0006-8993(91)91621-7","doi":"https://doi.org/10.1016/0006-8993(91)91621-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-8993(91)91621-7","pdf_url":null,"source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059695945","display_name":"Peter S. Widdowson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299218025","display_name":"MetroHealth","ror":"https://ror.org/0377srw41","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299218025"]},{"id":"https://openalex.org/I4210157264","display_name":"MetroHealth Medical Center","ror":"https://ror.org/05j4p5w63","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299218025","https://openalex.org/I4210157264"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter S. Widdowson","raw_affiliation_strings":["Department of Psychiatry, Case Western Reserve University, Cleveland, OH","Department of Neuroscience, Case Western Reserve University and MetroHealth Medical Center, Cleveland, OH 44109 U.S.A","Department of Psychiatry, Case Western Reserve University and MetroHealth Medical Center, Cleveland, OH 44109 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Case Western Reserve University, Cleveland, OH","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Neuroscience, Case Western Reserve University and MetroHealth Medical Center, Cleveland, OH 44109 U.S.A","institution_ids":["https://openalex.org/I1299218025","https://openalex.org/I4210157264","https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Psychiatry, Case Western Reserve University and MetroHealth Medical Center, Cleveland, OH 44109 U.S.A","institution_ids":["https://openalex.org/I1299218025","https://openalex.org/I4210157264","https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015828524","display_name":"Angelos E Halaris","orcid":"https://orcid.org/0000-0002-6709-3067","observed_orcids":["https://orcid.org/0000-0002-6709-3067"]},"institutions":[{"id":"https://openalex.org/I1299218025","display_name":"MetroHealth","ror":"https://ror.org/0377srw41","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299218025"]},{"id":"https://openalex.org/I4210157264","display_name":"MetroHealth Medical Center","ror":"https://ror.org/05j4p5w63","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299218025","https://openalex.org/I4210157264"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A.E. Halaris","raw_affiliation_strings":["Department of Pharmacology, Case Western Reserve University and MetroHealth Medical Center, Cleveland, OH 44109 U.S.A","Department of Psychiatry, Case Western Reserve University and MetroHealth Medical Center, Cleveland, OH 44109 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Case Western Reserve University and MetroHealth Medical Center, Cleveland, OH 44109 U.S.A","institution_ids":["https://openalex.org/I1299218025","https://openalex.org/I4210157264","https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Psychiatry, Case Western Reserve University and MetroHealth Medical Center, Cleveland, OH 44109 U.S.A","institution_ids":["https://openalex.org/I1299218025","https://openalex.org/I4210157264","https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5059695945"],"corresponding_institution_ids":["https://openalex.org/I1299218025","https://openalex.org/I4210157264","https://openalex.org/I58956616"],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":null,"fwci":0.3794,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.48429855,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"539","issue":"2","first_page":"196","last_page":"202"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/desipramine","display_name":"desipramine","score":0.9229999780654907},{"id":"https://openalex.org/keywords/imipramine","display_name":"imipramine","score":0.9279999732971191},{"id":"https://openalex.org/keywords/tricyclic-antidepressants","display_name":"tricyclic antidepressants","score":0.8949999809265137},{"id":"https://openalex.org/keywords/neuropeptide-y","display_name":"neuropeptide Y","score":0.9739999771118164},{"id":"https://openalex.org/keywords/y2-receptor","display_name":"Y2 receptor","score":0.8519999980926514},{"id":"https://openalex.org/keywords/receptor-binding","display_name":"receptor binding","score":0.5600000023841858},{"id":"https://openalex.org/keywords/chronic-antidepressant-treatment","display_name":"chronic antidepressant treatment","score":0.7699999809265137},{"id":"https://openalex.org/keywords/frontal-cortex","display_name":"frontal cortex","score":0.7680000066757202},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.8399999737739563},{"id":"https://openalex.org/keywords/inositol-phosphates","display_name":"inositol phosphates","score":0.7149999737739563},{"id":"https://openalex.org/keywords/forskolin","display_name":"forskolin","score":0.6499999761581421},{"id":"https://openalex.org/keywords/receptor-downregulation","display_name":"receptor down-regulation","score":0.4860000014305115}],"concepts":[{"id":"https://openalex.org/C2780250439","wikidata":"https://www.wikidata.org/wiki/Q423288","display_name":"Desipramine","level":4,"score":0.872248649597168},{"id":"https://openalex.org/C93984277","wikidata":"https://www.wikidata.org/wiki/Q24782073","display_name":"Neuropeptide Y receptor","level":4,"score":0.8086444139480591},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7623998522758484},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.741746723651886},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5930091142654419},{"id":"https://openalex.org/C2776552330","wikidata":"https://www.wikidata.org/wiki/Q1476178","display_name":"Nucleus accumbens","level":3,"score":0.5746698379516602},{"id":"https://openalex.org/C2779145073","wikidata":"https://www.wikidata.org/wiki/Q58396","display_name":"Imipramine","level":3,"score":0.517140805721283},{"id":"https://openalex.org/C2778618036","wikidata":"https://www.wikidata.org/wiki/Q2878809","display_name":"Inositol phosphate","level":4,"score":0.50932776927948},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4391191899776459},{"id":"https://openalex.org/C8330315","wikidata":"https://www.wikidata.org/wiki/Q414964","display_name":"Vasoactive intestinal peptide","level":4,"score":0.42255303263664246},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.41697561740875244},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.3729730248451233},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.3699241578578949},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2713697552680969},{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.25195959210395813},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.21513324975967407},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.14621198177337646},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14298179745674133},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003891","descriptor_name":"Desipramine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005576","descriptor_name":"Colforsin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007295","descriptor_name":"Inositol Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009478","descriptor_name":"Neuropeptide Y","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017476","descriptor_name":"Receptors, Neuropeptide Y","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017981","descriptor_name":"Receptors, Neurotransmitter","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017981","descriptor_name":"Receptors, Neurotransmitter","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0006-8993(91)91621-7","doi":"https://doi.org/10.1016/0006-8993(91)91621-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-8993(91)91621-7","pdf_url":null,"source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},{"id":"pmid:1647239","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1647239","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W249845531","https://openalex.org/W1775749144","https://openalex.org/W1889236699","https://openalex.org/W1965174921","https://openalex.org/W1966683250","https://openalex.org/W1970644784","https://openalex.org/W1988628530","https://openalex.org/W1991123973","https://openalex.org/W2007903907","https://openalex.org/W2017294014","https://openalex.org/W2026136209","https://openalex.org/W2029180342","https://openalex.org/W2043813981","https://openalex.org/W2055848892","https://openalex.org/W2055953516","https://openalex.org/W2057358608","https://openalex.org/W2060152059","https://openalex.org/W2060422151","https://openalex.org/W2061156895","https://openalex.org/W2062804799","https://openalex.org/W2064110992","https://openalex.org/W2076655132","https://openalex.org/W2080741152","https://openalex.org/W2082394010","https://openalex.org/W2086619790","https://openalex.org/W2090455987","https://openalex.org/W2093108953","https://openalex.org/W2112258927","https://openalex.org/W2113177105","https://openalex.org/W2132194608","https://openalex.org/W2143416713","https://openalex.org/W2154475093","https://openalex.org/W2163815564","https://openalex.org/W2342331067","https://openalex.org/W2738292845","https://openalex.org/W6704820012","https://openalex.org/W6741714596"],"related_works":["https://openalex.org/W2069655522","https://openalex.org/W2012838392","https://openalex.org/W2018072261","https://openalex.org/W2051352892","https://openalex.org/W1988010405","https://openalex.org/W2069777341","https://openalex.org/W1968753009","https://openalex.org/W2064721516","https://openalex.org/W2469676404","https://openalex.org/W2060658993"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
