{"id":"https://openalex.org/W2017120814","doi":"https://doi.org/10.1126/science.155.3762.570","title":"Urea and Its Formation in Coelacanth Liver","display_name":"Urea and Its Formation in Coelacanth Liver","publication_year":1967,"publication_date":"1967-02-03","ids":{"openalex":"https://openalex.org/W2017120814","doi":"https://doi.org/10.1126/science.155.3762.570","mag":"2017120814","pmid":"https://pubmed.ncbi.nlm.nih.gov/6015872"},"language":"en","primary_location":{"id":"doi:10.1126/science.155.3762.570","doi":"https://doi.org/10.1126/science.155.3762.570","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.155.3762.570","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103477634","display_name":"George William Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. W. Brown","raw_affiliation_strings":["Department of Biochemistry, University of Texas Medical Branch, and Tiburon Company, Biomarine Preparations, Galveston, Texas 77550"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Texas Medical Branch, and Tiburon Company, Biomarine Preparations, Galveston, Texas 77550","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110257571","display_name":"Susan G. Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan G. Brown","raw_affiliation_strings":["Department of Biochemistry, University of Texas Medical Branch, and Tiburon Company, Biomarine Preparations, Galveston, Texas 77550"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Texas Medical Branch, and Tiburon Company, Biomarine Preparations, Galveston, Texas 77550","institution_ids":["https://openalex.org/I55302922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I55302922"],"apc_list":null,"apc_paid":null,"fwci":13.8878,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.99169099,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"155","issue":"3762","first_page":"570","last_page":"573"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11056","display_name":"Physiological and biochemical adaptations","score":0.24449999630451202,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11056","display_name":"Physiological and biochemical adaptations","score":0.24449999630451202,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.15889999270439148,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12319","display_name":"Fish Biology and Ecology Studies","score":0.15809999406337738,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urea","display_name":"urea","score":0.9449999928474426},{"id":"https://openalex.org/keywords/coelacanth","display_name":"coelacanth","score":0.953000009059906},{"id":"https://openalex.org/keywords/latimeria-chalumnae","display_name":"Latimeria chalumnae","score":0.9980000257492065},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.9120000004768372},{"id":"https://openalex.org/keywords/urea-formation","display_name":"urea formation","score":0.7070000171661377},{"id":"https://openalex.org/keywords/urea-cycle","display_name":"urea cycle","score":0.8939999938011169},{"id":"https://openalex.org/keywords/arginase","display_name":"arginase","score":0.9760000109672546},{"id":"https://openalex.org/keywords/ornithine-carbamoyltransferase","display_name":"ornithine carbamoyltransferase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/urea-cycle-enzymes","display_name":"urea cycle enzymes","score":0.5830000042915344},{"id":"https://openalex.org/keywords/osmoregulation","display_name":"osmoregulation","score":0.949999988079071},{"id":"https://openalex.org/keywords/ammonia","display_name":"ammonia","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.8062613010406494},{"id":"https://openalex.org/C164007495","wikidata":"https://www.wikidata.org/wiki/Q24721374","display_name":"Arginase","level":4,"score":0.8030160665512085},{"id":"https://openalex.org/C2779521917","wikidata":"https://www.wikidata.org/wiki/Q22327086","display_name":"Urease","level":3,"score":0.7062612771987915},{"id":"https://openalex.org/C77061444","wikidata":"https://www.wikidata.org/wiki/Q595994","display_name":"Urea cycle","level":4,"score":0.6791539788246155},{"id":"https://openalex.org/C2776382133","wikidata":"https://www.wikidata.org/wiki/Q4087","display_name":"Ammonia","level":2,"score":0.5483100414276123},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4758298695087433},{"id":"https://openalex.org/C2776796294","wikidata":"https://www.wikidata.org/wiki/Q410198","display_name":"Ornithine","level":4,"score":0.4629529118537903},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4542056918144226},{"id":"https://openalex.org/C2909874926","wikidata":"https://www.wikidata.org/wiki/Q420678","display_name":"Ornithine Carbamoyltransferase","level":5,"score":0.4277772009372711},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4046843647956848},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.3697076737880707},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.2721058130264282},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0653347373008728}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001119","descriptor_name":"Arginase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005399","descriptor_name":"Fishes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009954","descriptor_name":"Ornithine Carbamoyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.155.3762.570","doi":"https://doi.org/10.1126/science.155.3762.570","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.155.3762.570","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:6015872","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6015872","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W83100947","https://openalex.org/W563680134","https://openalex.org/W1535175535","https://openalex.org/W1543266659","https://openalex.org/W1553165412","https://openalex.org/W1631176743","https://openalex.org/W1775749144","https://openalex.org/W1902464762","https://openalex.org/W1906482008","https://openalex.org/W1964653036","https://openalex.org/W1987216175","https://openalex.org/W1998284179","https://openalex.org/W2002918551","https://openalex.org/W2007870738","https://openalex.org/W2009471122","https://openalex.org/W2013452154","https://openalex.org/W2016854753","https://openalex.org/W2025781114","https://openalex.org/W2042591953","https://openalex.org/W2053957600","https://openalex.org/W2070396971","https://openalex.org/W2078935880","https://openalex.org/W2084286228","https://openalex.org/W2086068164","https://openalex.org/W2099962365","https://openalex.org/W2194582951","https://openalex.org/W2295085981","https://openalex.org/W2320984744","https://openalex.org/W2335150801","https://openalex.org/W2346639688","https://openalex.org/W2432195370","https://openalex.org/W2565814766","https://openalex.org/W2618726426","https://openalex.org/W4210996654","https://openalex.org/W4233073285","https://openalex.org/W4233924556"],"related_works":["https://openalex.org/W2331200761","https://openalex.org/W2161737112","https://openalex.org/W1759562007","https://openalex.org/W2018536726","https://openalex.org/W2314628659","https://openalex.org/W2068505838","https://openalex.org/W4317679760","https://openalex.org/W2059296775","https://openalex.org/W2618726426","https://openalex.org/W4230933234"],"abstract_inverted_index":{"Urea":[0],"occurs":[1],"in":[2,44,49,54,60,72,78],"liver":[3],"of":[4,12,31,47,56],"the":[5,10,45,63,73],"coelacanth":[6,57,74],"Latimeria":[7],"chalumnae":[8],"to":[9],"extent":[11],"about":[13],"1.7":[14],"percent":[15],"by":[16,22,29,62],"weight.":[17],"It":[18],"was":[19],"determined":[20],"quantitatively":[21],"reaction":[23],"with":[24,36],"1-phenyl-1,2-propanedione-2-oxime":[25],"(Archibald":[26],"reagent)":[27],"and":[28,39],"measurement":[30],"ammonia":[32],"released":[33],"upon":[34],"treatment":[35],"urease.":[37],"Arginase":[38],"ornithine":[40],"carbamoyltransferase,":[41],"enzymes":[42],"instrumental":[43],"formation":[46],"urea":[48,66],"typical":[50],"ureotelic":[51],"vertebrates,":[52],"occur":[53],"homogenates":[55],"liver.":[58],"Formed":[59],"part":[61],"ornithine-urea":[64],"cycle,":[65],"may":[67],"have":[68],"an":[69],"osmoregulatory":[70],"function":[71],"as":[75],"it":[76],"has":[77],"elasmobranchs.":[79]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
