{"id":"https://openalex.org/W2017111116","doi":"https://doi.org/10.1016/j.ijpharm.2011.07.013","title":"Design of multifunctional non-viral gene vectors to overcome physiological barriers: Dilemmas and strategies","display_name":"Design of multifunctional non-viral gene vectors to overcome physiological barriers: Dilemmas and strategies","publication_year":2011,"publication_date":"2011-07-25","ids":{"openalex":"https://openalex.org/W2017111116","doi":"https://doi.org/10.1016/j.ijpharm.2011.07.013","mag":"2017111116","pmid":"https://pubmed.ncbi.nlm.nih.gov/21798324"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijpharm.2011.07.013","doi":"https://doi.org/10.1016/j.ijpharm.2011.07.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijpharm.2011.07.013","pdf_url":null,"source":{"id":"https://openalex.org/S131016564","display_name":"International Journal of Pharmaceutics","issn_l":"0378-5173","issn":["0378-5173","1873-3476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2017111116"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100453627","display_name":"Tao Wang","orcid":"https://orcid.org/0000-0002-9623-8800","observed_orcids":["https://orcid.org/0000-0002-9623-8800","https://orcid.org/0000-0001-7483-5850"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tao Wang","raw_affiliation_strings":["Center for Pharmaceutical Biotechnology and Nanomedicine, 312 Mugar Life Sciences Building, 360 Huntington Avenue, Northeastern University, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Pharmaceutical Biotechnology and Nanomedicine, 312 Mugar Life Sciences Building, 360 Huntington Avenue, Northeastern University, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084335738","display_name":"Jaydev R. Upponi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaydev R. Upponi","raw_affiliation_strings":["Center for Pharmaceutical Biotechnology and Nanomedicine, 312 Mugar Life Sciences Building, 360 Huntington Avenue, Northeastern University, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Pharmaceutical Biotechnology and Nanomedicine, 312 Mugar Life Sciences Building, 360 Huntington Avenue, Northeastern University, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103237936","display_name":"Vladimir P. Torchilin","orcid":"https://orcid.org/0000-0003-4245-5196","observed_orcids":["https://orcid.org/0000-0003-4245-5196"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vladimir P. Torchilin","raw_affiliation_strings":["Center for Pharmaceutical Biotechnology and Nanomedicine, 312 Mugar Life Sciences Building, 360 Huntington Avenue, Northeastern University, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Pharmaceutical Biotechnology and Nanomedicine, 312 Mugar Life Sciences Building, 360 Huntington Avenue, Northeastern University, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I12912129"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103237936"],"corresponding_institution_ids":["https://openalex.org/I12912129"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":2.2283,"has_fulltext":false,"cited_by_count":272,"citation_normalized_percentile":{"value":0.90975969,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"427","issue":"1","first_page":"3","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-viral-vectors","display_name":"non-viral vectors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lipoplexes","display_name":"lipoplexes","score":0.9520000219345093},{"id":"https://openalex.org/keywords/polyplexes","display_name":"polyplexes","score":1.0},{"id":"https://openalex.org/keywords/systemic-gene-delivery","display_name":"systemic gene delivery","score":0.753000020980835},{"id":"https://openalex.org/keywords/intracellular-delivery","display_name":"intracellular delivery","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.6747465133666992},{"id":"https://openalex.org/C2778496695","wikidata":"https://www.wikidata.org/wiki/Q254128","display_name":"Dilemma","level":2,"score":0.6543002128601074},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.5655761957168579},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.47212323546409607},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.4625927805900574},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.3770851492881775},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37111127376556396},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3479846715927124},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28094667196273804},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2517783045768738},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21427080035209656},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10883641242980957},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.07092663645744324},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000071228","descriptor_name":"Polyelectrolytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001776","descriptor_name":"Blood Circulation Time","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008252","descriptor_name":"Macaca fascicularis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D011073","descriptor_name":"Polyamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018390","descriptor_name":"Gene Targeting","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ijpharm.2011.07.013","doi":"https://doi.org/10.1016/j.ijpharm.2011.07.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijpharm.2011.07.013","pdf_url":null,"source":{"id":"https://openalex.org/S131016564","display_name":"International Journal of Pharmaceutics","issn_l":"0378-5173","issn":["0378-5173","1873-3476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:21798324","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21798324","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of pharmaceutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7994999885559082}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":228,"referenced_works":["https://openalex.org/W3628815","https://openalex.org/W79310683","https://openalex.org/W109274713","https://openalex.org/W594780930","https://openalex.org/W1481565655","https://openalex.org/W1516954147","https://openalex.org/W1533570071","https://openalex.org/W1549673200","https://openalex.org/W1577071491","https://openalex.org/W1582443957","https://openalex.org/W1587227490","https://openalex.org/W1602020336","https://openalex.org/W1611419331","https://openalex.org/W1647075334","https://openalex.org/W1904721796","https://openalex.org/W1964146045","https://openalex.org/W1964377917","https://openalex.org/W1966334833","https://openalex.org/W1967464559","https://openalex.org/W1967589967","https://openalex.org/W1968829868","https://openalex.org/W1968949797","https://openalex.org/W1969989481","https://openalex.org/W1970668909","https://openalex.org/W1971290197","https://openalex.org/W1971550264","https://openalex.org/W1972376076","https://openalex.org/W1973773389","https://openalex.org/W1974265689","https://openalex.org/W1974303227","https://openalex.org/W1975581901","https://openalex.org/W1977285033","https://openalex.org/W1982195500","https://openalex.org/W1982210988","https://openalex.org/W1982223458","https://openalex.org/W1982630518","https://openalex.org/W1982814720","https://openalex.org/W1982951756","https://openalex.org/W1984483611","https://openalex.org/W1985222229","https://openalex.org/W1989065176","https://openalex.org/W1990548509","https://openalex.org/W1990622580","https://openalex.org/W1992736089","https://openalex.org/W1995997091","https://openalex.org/W1996617040","https://openalex.org/W1996686306","https://openalex.org/W1997103748","https://openalex.org/W1997181834","https://openalex.org/W1997216252","https://openalex.org/W1997448358","https://openalex.org/W2000462001","https://openalex.org/W2000888033","https://openalex.org/W2001176644","https://openalex.org/W2001723579","https://openalex.org/W2002819354","https://openalex.org/W2003327999","https://openalex.org/W2003414091","https://openalex.org/W2009447610","https://openalex.org/W2010655741","https://openalex.org/W2011284494","https://openalex.org/W2011383034","https://openalex.org/W2011879414","https://openalex.org/W2012694727","https://openalex.org/W2014356856","https://openalex.org/W2014393858","https://openalex.org/W2014509855","https://openalex.org/W2015878656","https://openalex.org/W2015920239","https://openalex.org/W2016232662","https://openalex.org/W2017720816","https://openalex.org/W2018116983","https://openalex.org/W2019631541","https://openalex.org/W2020260050","https://openalex.org/W2020412719","https://openalex.org/W2021043619","https://openalex.org/W2025334824","https://openalex.org/W2027417866","https://openalex.org/W2027840972","https://openalex.org/W2028392530","https://openalex.org/W2028469454","https://openalex.org/W2029346749","https://openalex.org/W2029532796","https://openalex.org/W2030040544","https://openalex.org/W2031247754","https://openalex.org/W2032291478","https://openalex.org/W2032307190","https://openalex.org/W2032576390","https://openalex.org/W2033023421","https://openalex.org/W2034342858","https://openalex.org/W2034413987","https://openalex.org/W2034450106","https://openalex.org/W2034462646","https://openalex.org/W2034486404","https://openalex.org/W2035062073","https://openalex.org/W2035801841","https://openalex.org/W2036118869","https://openalex.org/W2036659469","https://openalex.org/W2037501805","https://openalex.org/W2040693145","https://openalex.org/W2041315407","https://openalex.org/W2042114144","https://openalex.org/W2043656143","https://openalex.org/W2043977277","https://openalex.org/W2044074008","https://openalex.org/W2044194952","https://openalex.org/W2046007755","https://openalex.org/W2046404405","https://openalex.org/W2047043718","https://openalex.org/W2048284285","https://openalex.org/W2050932091","https://openalex.org/W2051212988","https://openalex.org/W2052462542","https://openalex.org/W2053513183","https://openalex.org/W2054185238","https://openalex.org/W2054308913","https://openalex.org/W2054757478","https://openalex.org/W2058150445","https://openalex.org/W2060870337","https://openalex.org/W2061136666","https://openalex.org/W2061312545","https://openalex.org/W2061555550","https://openalex.org/W2061724765","https://openalex.org/W2061729355","https://openalex.org/W2061907331","https://openalex.org/W2062302958","https://openalex.org/W2065544364","https://openalex.org/W2065836638","https://openalex.org/W2066215258","https://openalex.org/W2066778206","https://openalex.org/W2067379696","https://openalex.org/W2068668897","https://openalex.org/W2069047046","https://openalex.org/W2069187356","https://openalex.org/W2069382206","https://openalex.org/W2069879613","https://openalex.org/W2069880685","https://openalex.org/W2070805187","https://openalex.org/W2071732315","https://openalex.org/W2071758848","https://openalex.org/W2072139568","https://openalex.org/W2073026167","https://openalex.org/W2073115409","https://openalex.org/W2074087150","https://openalex.org/W2074206014","https://openalex.org/W2074846276","https://openalex.org/W2074870430","https://openalex.org/W2074918424","https://openalex.org/W2075846851","https://openalex.org/W2078775246","https://openalex.org/W2078988079","https://openalex.org/W2083249633","https://openalex.org/W2083609039","https://openalex.org/W2083707689","https://openalex.org/W2085434191","https://openalex.org/W2086274688","https://openalex.org/W2087296092","https://openalex.org/W2087497808","https://openalex.org/W2087916955","https://openalex.org/W2089108851","https://openalex.org/W2090888546","https://openalex.org/W2091936548","https://openalex.org/W2095151181","https://openalex.org/W2095971796","https://openalex.org/W2097777898","https://openalex.org/W2102110918","https://openalex.org/W2102583209","https://openalex.org/W2107161595","https://openalex.org/W2107638822","https://openalex.org/W2108234913","https://openalex.org/W2108882170","https://openalex.org/W2110393059","https://openalex.org/W2111598262","https://openalex.org/W2113972541","https://openalex.org/W2115824449","https://openalex.org/W2116653595","https://openalex.org/W2117991391","https://openalex.org/W2119324304","https://openalex.org/W2120085804","https://openalex.org/W2120862472","https://openalex.org/W2121541586","https://openalex.org/W2125301080","https://openalex.org/W2128061275","https://openalex.org/W2128317669","https://openalex.org/W2128520971","https://openalex.org/W2129825215","https://openalex.org/W2132337295","https://openalex.org/W2133782648","https://openalex.org/W2134444723","https://openalex.org/W2135566609","https://openalex.org/W2136240349","https://openalex.org/W2136274459","https://openalex.org/W2139257010","https://openalex.org/W2139957948","https://openalex.org/W2141729181","https://openalex.org/W2143729842","https://openalex.org/W2144241117","https://openalex.org/W2145920825","https://openalex.org/W2146888510","https://openalex.org/W2147584970","https://openalex.org/W2147859982","https://openalex.org/W2148919642","https://openalex.org/W2151419499","https://openalex.org/W2151488213","https://openalex.org/W2151509589","https://openalex.org/W2153222771","https://openalex.org/W2157406719","https://openalex.org/W2157571916","https://openalex.org/W2162194950","https://openalex.org/W2162355697","https://openalex.org/W2162527922","https://openalex.org/W2166915947","https://openalex.org/W2167551641","https://openalex.org/W2167650832","https://openalex.org/W2169678660","https://openalex.org/W2254699157","https://openalex.org/W2321220965","https://openalex.org/W2322755200","https://openalex.org/W2323505647","https://openalex.org/W2325520886","https://openalex.org/W2326434797","https://openalex.org/W2333539510","https://openalex.org/W2413837777","https://openalex.org/W2418383551","https://openalex.org/W2474479495","https://openalex.org/W3023288964","https://openalex.org/W4252592689","https://openalex.org/W6604453121"],"related_works":["https://openalex.org/W2066407795","https://openalex.org/W2056219450","https://openalex.org/W2884080528","https://openalex.org/W2321877594","https://openalex.org/W2181868342","https://openalex.org/W2047534125","https://openalex.org/W2379648265","https://openalex.org/W2182142806","https://openalex.org/W1587281889","https://openalex.org/W2920171636"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":22},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":30},{"year":2015,"cited_by_count":27},{"year":2014,"cited_by_count":37},{"year":2013,"cited_by_count":25},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}