{"id":"https://openalex.org/W2017106430","doi":"https://doi.org/10.1128/aac.00032-15","title":"Achieving Target Voriconazole Concentrations More Accurately in Children and Adolescents","display_name":"Achieving Target Voriconazole Concentrations More Accurately in Children and Adolescents","publication_year":2015,"publication_date":"2015-03-17","ids":{"openalex":"https://openalex.org/W2017106430","doi":"https://doi.org/10.1128/aac.00032-15","mag":"2017106430","pmid":"https://pubmed.ncbi.nlm.nih.gov/25779580","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4432122"},"language":"en","primary_location":{"id":"doi:10.1128/aac.00032-15","doi":"https://doi.org/10.1128/aac.00032-15","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.00032-15","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4432122","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026635936","display_name":"Michael Noel Neely","orcid":"https://orcid.org/0000-0002-1675-8276","observed_orcids":["https://orcid.org/0000-0002-1675-8276"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I4405270452","display_name":"Saban Research Institute","ror":"https://ror.org/00qe7sv26","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405270452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Neely","raw_affiliation_strings":["Laboratory of Applied Pharmacokinetics and Bioinformatics, The Saban Research Institute and the Division of Pediatric Infectious Diseases, University of Southern California Children's Hospital Los Angeles, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Applied Pharmacokinetics and Bioinformatics, The Saban Research Institute and the Division of Pediatric Infectious Diseases, University of Southern California Children's Hospital Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626","https://openalex.org/I4405270452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000737281","display_name":"Ashley Margol","orcid":"https://orcid.org/0000-0002-3038-8005","observed_orcids":["https://orcid.org/0000-0002-3038-8005"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley Margol","raw_affiliation_strings":["Division of Pediatric Hematology/Oncology, University of Southern California Children's Hospital Los Angeles, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Hematology/Oncology, University of Southern California Children's Hospital Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039039915","display_name":"Xiaowei Fu","orcid":"https://orcid.org/0000-0002-8613-9171","observed_orcids":["https://orcid.org/0000-0002-8613-9171"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaowei Fu","raw_affiliation_strings":["Pathology and Laboratory Medicine, University of Southern California Children's Hospital Los Angeles, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology and Laboratory Medicine, University of Southern California Children's Hospital Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110748314","display_name":"Michael Van Guilder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I4405270452","display_name":"Saban Research Institute","ror":"https://ror.org/00qe7sv26","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405270452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael van Guilder","raw_affiliation_strings":["Laboratory of Applied Pharmacokinetics and Bioinformatics, The Saban Research Institute and the Division of Pediatric Infectious Diseases, University of Southern California Children's Hospital Los Angeles, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Applied Pharmacokinetics and Bioinformatics, The Saban Research Institute and the Division of Pediatric Infectious Diseases, University of Southern California Children's Hospital Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626","https://openalex.org/I4405270452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059430209","display_name":"David S. Bayard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I4405270452","display_name":"Saban Research Institute","ror":"https://ror.org/00qe7sv26","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405270452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Bayard","raw_affiliation_strings":["Laboratory of Applied Pharmacokinetics and Bioinformatics, The Saban Research Institute and the Division of Pediatric Infectious Diseases, University of Southern California Children's Hospital Los Angeles, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Applied Pharmacokinetics and Bioinformatics, The Saban Research Institute and the Division of Pediatric Infectious Diseases, University of Southern California Children's Hospital Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626","https://openalex.org/I4405270452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054296777","display_name":"Alan Schumitzky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I4405270452","display_name":"Saban Research Institute","ror":"https://ror.org/00qe7sv26","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405270452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Schumitzky","raw_affiliation_strings":["Laboratory of Applied Pharmacokinetics and Bioinformatics, The Saban Research Institute and the Division of Pediatric Infectious Diseases, University of Southern California Children's Hospital Los Angeles, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Applied Pharmacokinetics and Bioinformatics, The Saban Research Institute and the Division of Pediatric Infectious Diseases, University of Southern California Children's Hospital Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626","https://openalex.org/I4405270452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112254520","display_name":"Regina Orbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Regina Orbach","raw_affiliation_strings":["Pharmacy Department, University of Southern California Children's Hospital Los Angeles, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy Department, University of Southern California Children's Hospital Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100326247","display_name":"Siyu Liu","orcid":"https://orcid.org/0000-0003-0959-4071","observed_orcids":["https://orcid.org/0000-0003-0959-4071"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Siyu Liu","raw_affiliation_strings":["Department of Clinical Pharmacy and Pharmaceutical Economics & Policy, University of Southern California School of Pharmacy, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy and Pharmaceutical Economics & Policy, University of Southern California School of Pharmacy, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002462952","display_name":"Stan G. Louie","orcid":"https://orcid.org/0000-0001-5941-6690","observed_orcids":["https://orcid.org/0000-0001-5941-6690"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stan Louie","raw_affiliation_strings":["Department of Clinical Pharmacy and Pharmaceutical Economics & Policy, University of Southern California School of Pharmacy, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy and Pharmaceutical Economics & Policy, University of Southern California School of Pharmacy, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057302419","display_name":"William W. Hope","orcid":"https://orcid.org/0000-0001-6187-878X","observed_orcids":["https://orcid.org/0000-0001-6187-878X"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"William Hope","raw_affiliation_strings":["Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom","institution_ids":["https://openalex.org/I146655781"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":11.268,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.98796304,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"59","issue":"6","first_page":"3090","last_page":"3097"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.014800000004470348,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/voriconazole","display_name":"voriconazole","score":1.0},{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":0.9049999713897705},{"id":"https://openalex.org/keywords/pediatric-pharmacokinetics","display_name":"pediatric pharmacokinetics","score":0.8579999804496765},{"id":"https://openalex.org/keywords/nonlinear-pharmacokinetics","display_name":"nonlinear pharmacokinetics","score":0.8199999928474426},{"id":"https://openalex.org/keywords/trough-concentration","display_name":"trough concentration","score":0.6039999723434448},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.8130000233650208},{"id":"https://openalex.org/keywords/children-and-adolescents","display_name":"children and adolescents","score":0.7070000171661377},{"id":"https://openalex.org/keywords/antifungal-therapy","display_name":"antifungal therapy","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C119060515","wikidata":"https://www.wikidata.org/wiki/Q1916617","display_name":"Interquartile range","level":2,"score":0.9582583904266357},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5102982521057129},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4933694899082184},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.4517490267753601},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4347432255744934},{"id":"https://openalex.org/C102366305","wikidata":"https://www.wikidata.org/wiki/Q1097688","display_name":"Nonparametric statistics","level":2,"score":0.433828741312027},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.39839160442352295},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3543163537979126},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.24730709195137024},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.06000465154647827}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065819","descriptor_name":"Voriconazole","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1128/aac.00032-15","doi":"https://doi.org/10.1128/aac.00032-15","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.00032-15","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4432122","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4432122","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:25779580","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25779580","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4432122","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4432122","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1435053517","display_name":"Goal-oriented and model-based pharmokinetic dosing of voriconazole in immunocompromised patients","funder_award_id":"CS/08/08/10","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G3154992929","display_name":"Southern California Clinical and Translational Science Institute","funder_award_id":"UL1TR000130","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8309072076","display_name":"Ontogeny of Voriconazole Pharmaockinetics and Metabolism","funder_award_id":"R01HD070886","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320308668","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60"},{"id":"https://openalex.org/F4320311240","display_name":"Southern California Clinical and Translational Science Institute","ror":"https://ror.org/01ncqna34"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1751616979","https://openalex.org/W1900202826","https://openalex.org/W1987684861","https://openalex.org/W1992995027","https://openalex.org/W1999521622","https://openalex.org/W2021298363","https://openalex.org/W2036323185","https://openalex.org/W2065282529","https://openalex.org/W2074793551","https://openalex.org/W2076710786","https://openalex.org/W2081308723","https://openalex.org/W2087509275","https://openalex.org/W2088294854","https://openalex.org/W2093162201","https://openalex.org/W2099303567","https://openalex.org/W2106962923","https://openalex.org/W2116878059","https://openalex.org/W2117255772","https://openalex.org/W2131117794","https://openalex.org/W2137432209","https://openalex.org/W2148605276","https://openalex.org/W2149613723","https://openalex.org/W2152510894","https://openalex.org/W2154146728","https://openalex.org/W2155882139","https://openalex.org/W2161744315","https://openalex.org/W2162210327","https://openalex.org/W2162857158","https://openalex.org/W2165405846","https://openalex.org/W2171105924","https://openalex.org/W2317464648"],"related_works":["https://openalex.org/W7131268411","https://openalex.org/W2093162201","https://openalex.org/W4402859061","https://openalex.org/W7122390172","https://openalex.org/W2508306485","https://openalex.org/W2690523939","https://openalex.org/W7222952853","https://openalex.org/W2766823603","https://openalex.org/W4390901472","https://openalex.org/W2584818869"],"abstract_inverted_index":{"Despite":[0],"the":[1,12,89,95,108,119,125,128,132,148,153,167,173,204,239],"documented":[2],"benefit":[3],"of":[4,14,63,131,187,195,214,228,257],"voriconazole":[5,76,252],"therapeutic":[6],"drug":[7,266],"monitoring,":[8],"nonlinear":[9],"pharmacokinetics":[10],"make":[11],"timing":[13],"steady-state":[15,258],"trough":[16,105,144,205,244],"sampling":[17],"and":[18,40,57,77,172,224,243,260],"appropriate":[19],"dose":[20,121,134,174,226],"adjustments":[21],"unpredictable":[22],"by":[23],"conventional":[24],"methods.":[25],"We":[26,42],"developed":[27],"a":[28,60,80,102,188,199,209,225,268],"nonparametric":[29,240,269],"population":[30,241],"model":[31,242],"with":[32,267],"data":[33],"from":[34],"141":[35],"previously":[36],"richly":[37],"sampled":[38],"children":[39,255],"adults.":[41],"then":[43],"used":[44],"it":[45,261],"in":[46,59,79,107,124,201,208,254],"our":[47,246],"multiple-model":[48],"Bayesian":[49,91,149],"adaptive":[50],"control":[51,247],"algorithm":[52,248],"to":[53,70,87,101,115,118,140,146,161,181,203,219,233,264],"predict":[54],"measured":[55,103],"concentrations":[56,145],"doses":[58],"separate":[61],"cohort":[62],"33":[64],"pediatric":[65],"patients":[66,109],"aged":[67],"8":[68],"months":[69],"17":[71],"years":[72],"who":[73],"were":[74],"receiving":[75],"enrolled":[78],"pharmacokinetic":[81,270],"study.":[82],"Using":[83,142],"all":[84],"available":[85],"samples":[86],"estimate":[88],"individual":[90],"posterior":[92,150,169],"parameter":[93,151,170],"values,":[94,152],"median":[96],"percent":[97,129],"prediction":[98],"bias":[99,130,155,175,213,227],"relative":[100],"target":[104,126,154,212],"concentration":[106],"was":[110,135,156,176],"1.1%":[111],"(interquartile":[112,137,158,178,216,230],"range,":[113,138,159,179,217,231],"-17.1":[114],"10%).":[116],"Compared":[117],"actual":[120],"that":[122],"resulted":[123,207],"concentration,":[127,206],"predicted":[133],"-0.7%":[136],"-7":[139],"20%).":[141],"only":[143],"generate":[147],"6.4%":[157],"-1.4":[160],"14.7%;":[162],"P":[163,183,221,235],"=":[164,184,222,236],"0.16":[165],"versus":[166],"full":[168],"value)":[171],"-6.7%":[177],"-18.7":[180],"2.4%;":[182],"0.15).":[185],"Use":[186],"sample":[189],"collected":[190],"at":[191,277],"an":[192],"optimal":[193],"time":[194],"4":[196],"h":[197],"after":[198],"dose,":[200],"addition":[202],"nonsignificantly":[210],"improved":[211],"3.8%":[215],"-13.1":[218],"18%;":[220],"0.32)":[223],"-3.5%":[229],"-18":[232],"14%;":[234],"0.33).":[237],"With":[238],"concentrations,":[245],"can":[249],"accurately":[250],"manage":[251],"therapy":[253],"independently":[256],"conditions,":[259],"is":[262],"generalizable":[263],"any":[265],"model.":[271],"(This":[272],"study":[273],"has":[274],"been":[275],"registered":[276],"ClinicalTrials.gov":[278],"under":[279],"registration":[280],"no.":[281],"NCT01976078.).":[282]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}