{"id":"https://openalex.org/W2017105936","doi":"https://doi.org/10.3390/life5010230","title":"How Amino Acids and Peptides Shaped the RNA World","display_name":"How Amino Acids and Peptides Shaped the RNA World","publication_year":2015,"publication_date":"2015-01-19","ids":{"openalex":"https://openalex.org/W2017105936","doi":"https://doi.org/10.3390/life5010230","mag":"2017105936","pmid":"https://pubmed.ncbi.nlm.nih.gov/25607813","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4390850"},"language":"en","primary_location":{"id":"doi:10.3390/life5010230","doi":"https://doi.org/10.3390/life5010230","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/life5010230","pdf_url":"https://www.mdpi.com/2075-1729/5/1/230/pdf?version=1421672773","source":{"id":"https://openalex.org/S4210200765","display_name":"Life","issn_l":"2075-1729","issn":["2075-1729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2075-1729/5/1/230/pdf?version=1421672773","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059713173","display_name":"Peter T. S. van der Gulik","orcid":"https://orcid.org/0009-0004-6641-6188","observed_orcids":["https://orcid.org/0009-0004-6641-6188"]},"institutions":[{"id":"https://openalex.org/I1341640284","display_name":"Centrum Wiskunde & Informatica","ror":"https://ror.org/00x7ekv49","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1341640284","https://openalex.org/I2800991832","https://openalex.org/I4405262988"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Peter Van der Gulik","raw_affiliation_strings":["Centrum Wiskunde & Informatica, Science Park 123, 1098 SJ Amsterdam, The Netherlands","Centrum Wiskunde & Informatica, Science Park 123, 1098 SJ Amsterdam, The Netherlands. Peter.van.der.Gulik@cwi.nl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centrum Wiskunde & Informatica, Science Park 123, 1098 SJ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I1341640284"]},{"raw_affiliation_string":"Centrum Wiskunde & Informatica, Science Park 123, 1098 SJ Amsterdam, The Netherlands. Peter.van.der.Gulik@cwi.nl","institution_ids":["https://openalex.org/I1341640284"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078480495","display_name":"Dave Speijer","orcid":"https://orcid.org/0000-0002-2340-2753","observed_orcids":["https://orcid.org/0000-0002-2340-2753"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Dave Speijer","raw_affiliation_strings":["Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands","Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands. d.speijer@amc.uva.nl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]},{"raw_affiliation_string":"Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands. d.speijer@amc.uva.nl","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5078480495"],"corresponding_institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":0.4266,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.47887324,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"5","issue":"1","first_page":"230","last_page":"246"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-world-hypothesis","display_name":"RNA world","score":0.9610000252723694},{"id":"https://openalex.org/keywords/origin-of-life","display_name":"origin of life","score":0.9959999918937683},{"id":"https://openalex.org/keywords/amino-acids","display_name":"amino acids","score":0.9800000190734863},{"id":"https://openalex.org/keywords/peptides","display_name":"peptides","score":0.9700000286102295},{"id":"https://openalex.org/keywords/ribosome-evolution","display_name":"ribosome evolution","score":0.7070000171661377},{"id":"https://openalex.org/keywords/ribozymes","display_name":"ribozymes","score":0.8930000066757202},{"id":"https://openalex.org/keywords/aminoacyl-trna","display_name":"aminoacyl-tRNA","score":0.9430000185966492},{"id":"https://openalex.org/keywords/dipeptides","display_name":"dipeptides","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C76346623","wikidata":"https://www.wikidata.org/wiki/Q205858","display_name":"Ribozyme","level":4,"score":0.7821571826934814},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.7577605247497559},{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.7002193927764893},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.6746789216995239},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.667832612991333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5604429244995117},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5388484001159668},{"id":"https://openalex.org/C75442077","wikidata":"https://www.wikidata.org/wiki/Q24726678","display_name":"EF-Tu","level":5,"score":0.507415235042572},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.4856933057308197},{"id":"https://openalex.org/C1342335","wikidata":"https://www.wikidata.org/wiki/Q6545871","display_name":"Ligase ribozyme","level":5,"score":0.44765105843544006},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.4474044144153595},{"id":"https://openalex.org/C2910418148","wikidata":"https://www.wikidata.org/wiki/Q415968","display_name":"Amino Acyl-tRNA Synthetases","level":5,"score":0.43909990787506104},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.4226333498954773},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3263852894306183},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.1356271207332611},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08648282289505005}],"mesh":[],"locations_count":12,"locations":[{"id":"doi:10.3390/life5010230","doi":"https://doi.org/10.3390/life5010230","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/life5010230","pdf_url":"https://www.mdpi.com/2075-1729/5/1/230/pdf?version=1421672773","source":{"id":"https://openalex.org/S4210200765","display_name":"Life","issn_l":"2075-1729","issn":["2075-1729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3402098","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4390850","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4390850","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4390850","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life (Basel)","raw_type":"Text"},{"id":"pmid:25607813","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25607813","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:dare.uva.nl:openaire/6c6da8d6-2b0a-4bb3-b2f0-482a8270b554","doi":null,"is_oa":true,"landing_page_url":"https://handle.uba.uva.nl/personal/pure/en/publications/how-amino-acids-and-peptides-shaped-the-rna-world(6c6da8d6-2b0a-4bb3-b2f0-482a8270b554).html","pdf_url":"https://pure.uva.nl/ws/files/25581597/life_05_00230.pdf","source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"van der Gulik, P T S & Speijer, D 2015, 'How amino acids and peptides shaped the RNA world', Life, vol. 5, no. 1, pp. 230-246. https://doi.org/10.3390/life5010230","raw_type":"info:eu-repo/semantics/review"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/3c0f52bd-8fd4-4604-84b7-8c1b4d666d48","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/3c0f52bd-8fd4-4604-84b7-8c1b4d666d48","pdf_url":"https://pure.amsterdamumc.nl/ws/files/160897308/How-amino-acids-and-peptides-shaped-the-rna-world.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"van der Gulik, P T S & Speijer, D 2015, 'How amino acids and peptides shaped the RNA world', Life (Basel, Switzerland), vol. 5, no. 1, pp. 230-246. https://doi.org/10.3390/life5010230","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:cwi.nl:23699","doi":null,"is_oa":true,"landing_page_url":"https://ir.cwi.nl/pub/23699","pdf_url":"https://ir.cwi.nl/pub/23699/23699D.pdf","source":{"id":"https://openalex.org/S7407055335","display_name":"Centrum Wiskunde & Informatica (CWI), the national research institute for mathematics and computer science in the Netherlands","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Life vol. 5 no. 1, pp. 230-246","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.697.2487","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.697.2487","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.mdpi.com/2075-1729/5/1/230/pdf/","raw_type":"text"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/321df3e9-d539-45b1-a2ef-c0e0ee25bd81","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/how-amino-acids-and-peptides-shaped-the-rna-world(321df3e9-d539-45b1-a2ef-c0e0ee25bd81).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Life (Basel, Switzerland), 5(1), 230 - 246. Multidisciplinary Digital Publishing Institute (MDPI)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:cwi:oai:cwi.nl:23699","doi":null,"is_oa":true,"landing_page_url":"https://ir.cwi.nl/pub/23699","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Life, 5(1), 230 - 246","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:8f21a35cf05c496587b50e03016181f5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8f21a35cf05c496587b50e03016181f5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Life, Vol 5, Iss 1, Pp 230-246 (2015)","raw_type":"article"},{"id":"pmh:uvapub:oai:dare.uva.nl:publications/6c6da8d6-2b0a-4bb3-b2f0-482a8270b554","doi":null,"is_oa":true,"landing_page_url":"https://dare.uva.nl/personal/pure/en/publications/how-amino-acids-and-peptides-shaped-the-rna-world(6c6da8d6-2b0a-4bb3-b2f0-482a8270b554).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Life, 5(1), 230 - 246. MDPI","raw_type":"info:eu-repo/semantics/other"}],"best_oa_location":{"id":"doi:10.3390/life5010230","doi":"https://doi.org/10.3390/life5010230","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/life5010230","pdf_url":"https://www.mdpi.com/2075-1729/5/1/230/pdf?version=1421672773","source":{"id":"https://openalex.org/S4210200765","display_name":"Life","issn_l":"2075-1729","issn":["2075-1729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017105936.pdf","grobid_xml":"https://content.openalex.org/works/W2017105936.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W195524405","https://openalex.org/W1514080071","https://openalex.org/W1516549123","https://openalex.org/W1542426682","https://openalex.org/W1797223236","https://openalex.org/W1947447592","https://openalex.org/W1964291083","https://openalex.org/W1964696746","https://openalex.org/W1965528417","https://openalex.org/W1965897796","https://openalex.org/W1968532770","https://openalex.org/W1989029725","https://openalex.org/W1991352235","https://openalex.org/W1991942854","https://openalex.org/W2002193643","https://openalex.org/W2005339189","https://openalex.org/W2006525704","https://openalex.org/W2007410732","https://openalex.org/W2013061560","https://openalex.org/W2016198366","https://openalex.org/W2017119083","https://openalex.org/W2018865499","https://openalex.org/W2019713686","https://openalex.org/W2019978827","https://openalex.org/W2023236299","https://openalex.org/W2028528516","https://openalex.org/W2033843196","https://openalex.org/W2035118220","https://openalex.org/W2040450453","https://openalex.org/W2040581144","https://openalex.org/W2047041795","https://openalex.org/W2048822729","https://openalex.org/W2051439786","https://openalex.org/W2052196208","https://openalex.org/W2053688173","https://openalex.org/W2053910321","https://openalex.org/W2055410661","https://openalex.org/W2057781025","https://openalex.org/W2058415281","https://openalex.org/W2062758560","https://openalex.org/W2065548742","https://openalex.org/W2067086438","https://openalex.org/W2068603584","https://openalex.org/W2079800805","https://openalex.org/W2080601739","https://openalex.org/W2083627310","https://openalex.org/W2087705045","https://openalex.org/W2089524040","https://openalex.org/W2089644153","https://openalex.org/W2093113961","https://openalex.org/W2093663214","https://openalex.org/W2097459096","https://openalex.org/W2097775710","https://openalex.org/W2100049196","https://openalex.org/W2116100216","https://openalex.org/W2123541473","https://openalex.org/W2123720645","https://openalex.org/W2126644712","https://openalex.org/W2134145945","https://openalex.org/W2137913279","https://openalex.org/W2138220095","https://openalex.org/W2140139413","https://openalex.org/W2142681587","https://openalex.org/W2147455604","https://openalex.org/W2152139273","https://openalex.org/W2154027599","https://openalex.org/W2155775086","https://openalex.org/W2155862593","https://openalex.org/W2164123092","https://openalex.org/W2164222049","https://openalex.org/W2167482153","https://openalex.org/W2171874733","https://openalex.org/W2172293327","https://openalex.org/W2320231456","https://openalex.org/W2333229651","https://openalex.org/W2334169772","https://openalex.org/W4240695170"],"related_works":["https://openalex.org/W2736217492","https://openalex.org/W4390006932","https://openalex.org/W4319812194","https://openalex.org/W2759861875","https://openalex.org/W6950290198","https://openalex.org/W4323347704","https://openalex.org/W2100776285","https://openalex.org/W7100156748","https://openalex.org/W2340535548","https://openalex.org/W3036219924"],"abstract_inverted_index":{"The":[0,57,183],"\"RNA":[1,85,162],"world\"":[2,163],"hypothesis":[3],"is":[4,28,35,53,63,123,193],"seen":[5,36],"as":[6,37,116,118],"one":[7],"of":[8,19,68,81,127,142,147,152,160,165,180,188,196,207,211,225],"the":[9,17,33,78,82,124,134,143,150,158,161,168,177,205,208],"main":[10],"contenders":[11],"for":[12,46],"a":[13,38,65,69],"viable":[14],"theory":[15],"on":[16],"origin":[18],"life.":[20,156],"Relatively":[21],"small":[22,105],"RNAs":[23,106],"have":[24,172],"catalytic":[25],"power,":[26],"RNA":[27,71,221],"everywhere":[29],"in":[30,96,155,194],"present-day":[31],"life,":[32,167],"ribosome":[34,60,83],"ribozyme,":[39],"and":[40,42,108,113,138,186,191],"rRNA":[41],"tRNA":[43,129],"are":[44],"crucial":[45],"modern":[47,58],"protein":[48],"synthesis.":[49],"However,":[50],"this":[51,91,199],"view":[52,164],"incomplete":[54],"at":[55],"best.":[56],"protein-RNA":[59],"most":[61],"probably":[62],"not":[64],"distorted":[66],"form":[67],"\"pure":[70],"ribosome\"":[72],"evolution":[73],"started":[74],"out":[75],"with.":[76],"Though":[77],"oldest":[79],"center":[80],"seems":[84,170],"only\",":[86],"we":[87,201],"cannot":[88],"conclude":[89],"from":[90],"that":[92,130,219],"it":[93,122],"ever":[94],"functioned":[95],"an":[97,220],"environment":[98],"without":[99],"amino":[100,114,125,144,153,189,226],"acids":[101,154,190,227],"and/or":[102],"peptides.":[103],"Very":[104],"(versatile":[107],"stable":[109],"due":[110],"to":[111,171,203],"basepairing)":[112],"acids,":[115],"well":[117],"dipeptides,":[119],"coevolved.":[120],"Remember,":[121],"group":[126],"aminoacylated":[128],"attacks":[131],"peptidyl-tRNA,":[132],"destroying":[133],"bond":[135],"between":[136],"peptide":[137,209],"tRNA.":[139],"This":[140],"activity":[141,187],"acid":[145],"part":[146,179],"aminoacyl-tRNA":[148],"illustrates":[149],"centrality":[151],"With":[157],"rise":[159],"early":[166,181,212],"pendulum":[169],"swung":[173],"too":[174],"much":[175],"towards":[176],"ribozymatic":[178],"biochemistry.":[182],"necessary":[184],"presence":[185],"peptides":[192],"need":[195],"highlighting.":[197],"In":[198],"article,":[200],"try":[202],"bring":[204],"role":[206],"component":[210],"life":[213],"back":[214],"into":[215],"focus.":[216],"We":[217],"argue":[218],"world":[222],"completely":[223],"independent":[224],"never":[228],"existed.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}