{"id":"https://openalex.org/W2017093764","doi":"https://doi.org/10.1007/s00402-010-1192-2","title":"Systemic exposure to tobramycin after local antibiotic treatment with calcium sulphate as carrier material","display_name":"Systemic exposure to tobramycin after local antibiotic treatment with calcium sulphate as carrier material","publication_year":2010,"publication_date":"2010-10-12","ids":{"openalex":"https://openalex.org/W2017093764","doi":"https://doi.org/10.1007/s00402-010-1192-2","mag":"2017093764","pmid":"https://pubmed.ncbi.nlm.nih.gov/20938669"},"language":"en","primary_location":{"id":"doi:10.1007/s00402-010-1192-2","doi":"https://doi.org/10.1007/s00402-010-1192-2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00402-010-1192-2","pdf_url":null,"source":{"id":"https://openalex.org/S118785805","display_name":"Archives of Orthopaedic and Trauma Surgery","issn_l":"0936-8051","issn":["0936-8051","1434-3916"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Orthopaedic and Trauma Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061460945","display_name":"Peter M. Wahl","orcid":"https://orcid.org/0000-0002-8895-8621","observed_orcids":["https://orcid.org/0000-0002-8895-8621"]},"institutions":[{"id":"https://openalex.org/I4210093738","display_name":"HFR Freiburg Kantonsspital","ror":"https://ror.org/00fz8k419","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210093738"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Peter Wahl","raw_affiliation_strings":["Department for Orthopaedic Surgery, Cantonal Hospital, 1708 Fribourg, Switzerland. wahlp@h-fr.ch","Department for Orthopaedic Surgery, Cantonal Hospital, Fribourg, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Orthopaedic Surgery, Cantonal Hospital, 1708 Fribourg, Switzerland. wahlp@h-fr.ch","institution_ids":["https://openalex.org/I4210093738"]},{"raw_affiliation_string":"Department for Orthopaedic Surgery, Cantonal Hospital, Fribourg, Switzerland","institution_ids":["https://openalex.org/I4210093738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042362264","display_name":"Fran\u00e7oise Livio","orcid":"https://orcid.org/0000-0001-7427-5953","observed_orcids":["https://orcid.org/0000-0001-7427-5953"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I4210115126","display_name":"H\u00f4pital Orthop\u00e9dique de la Suisse Romande","ror":"https://ror.org/022vd9g66","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882","https://openalex.org/I4210115126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Fran\u00e7oise Livio","raw_affiliation_strings":["Department for Clinical Pharmacology, CHUV, 1011, Lausanne, Switzerland","Department for Clinical Pharmacology, CHUV, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Clinical Pharmacology, CHUV, 1011, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I4210115126"]},{"raw_affiliation_string":"Department for Clinical Pharmacology, CHUV, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I4210115126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048390279","display_name":"Matthias Jacobi","orcid":"https://orcid.org/0000-0003-2103-8721","observed_orcids":["https://orcid.org/0000-0003-2103-8721"]},"institutions":[{"id":"https://openalex.org/I4210093738","display_name":"HFR Freiburg Kantonsspital","ror":"https://ror.org/00fz8k419","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210093738"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Matthias Jacobi","raw_affiliation_strings":["Department for Orthopaedic Surgery, Cantonal Hospital, 1708, Fribourg, Switzerland","Department for Orthopaedic Surgery, Cantonal Hospital, Fribourg, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Orthopaedic Surgery, Cantonal Hospital, 1708, Fribourg, Switzerland","institution_ids":["https://openalex.org/I4210093738"]},{"raw_affiliation_string":"Department for Orthopaedic Surgery, Cantonal Hospital, Fribourg, Switzerland","institution_ids":["https://openalex.org/I4210093738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013222181","display_name":"Emanuel Gautier","orcid":"https://orcid.org/0000-0003-2876-7986","observed_orcids":["https://orcid.org/0000-0003-2876-7986"]},"institutions":[{"id":"https://openalex.org/I4210093738","display_name":"HFR Freiburg Kantonsspital","ror":"https://ror.org/00fz8k419","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210093738"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Emanuel Gautier","raw_affiliation_strings":["Department for Orthopaedic Surgery, Cantonal Hospital, 1708, Fribourg, Switzerland","Department for Orthopaedic Surgery, Cantonal Hospital, Fribourg, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Orthopaedic Surgery, Cantonal Hospital, 1708, Fribourg, Switzerland","institution_ids":["https://openalex.org/I4210093738"]},{"raw_affiliation_string":"Department for Orthopaedic Surgery, Cantonal Hospital, Fribourg, Switzerland","institution_ids":["https://openalex.org/I4210093738"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091531260","display_name":"Thierry Buclin","orcid":"https://orcid.org/0000-0003-0639-5536","observed_orcids":["https://orcid.org/0000-0003-0639-5536"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I4210115126","display_name":"H\u00f4pital Orthop\u00e9dique de la Suisse Romande","ror":"https://ror.org/022vd9g66","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882","https://openalex.org/I4210115126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Thierry Buclin","raw_affiliation_strings":["Department for Clinical Pharmacology, CHUV, 1011, Lausanne, Switzerland","Department for Clinical Pharmacology, CHUV, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Clinical Pharmacology, CHUV, 1011, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I4210115126"]},{"raw_affiliation_string":"Department for Clinical Pharmacology, CHUV, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I4210115126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5061460945"],"corresponding_institution_ids":["https://openalex.org/I4210093738"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":1.0939,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.75745399,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"131","issue":"5","first_page":"657","last_page":"662"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.8784000277519226,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.8784000277519226,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.11429999768733978,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11080","display_name":"Surgical site infection prevention","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tobramycin","display_name":"tobramycin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/local-antibiotic-therapy","display_name":"local antibiotic therapy","score":0.6819999814033508},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8450000286102295},{"id":"https://openalex.org/keywords/aminoglycosides","display_name":"aminoglycosides","score":0.8809999823570251},{"id":"https://openalex.org/keywords/bone-and-soft-tissue-infections","display_name":"bone and soft tissue infections","score":0.8790000081062317},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.6919999718666077},{"id":"https://openalex.org/keywords/creatinine-clearance","display_name":"creatinine clearance","score":0.9369999766349792},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C2778974779","wikidata":"https://www.wikidata.org/wiki/Q1758380","display_name":"Tobramycin","level":4,"score":0.9543467164039612},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.787011981010437},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7772752642631531},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5666907429695129},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.5392462611198425},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4898390471935272},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.4596192240715027},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4590841829776764},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.4563671946525574},{"id":"https://openalex.org/C2777787772","wikidata":"https://www.wikidata.org/wiki/Q45355603","display_name":"Aminoglycoside","level":3,"score":0.4429522752761841},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36076855659484863},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.33479392528533936},{"id":"https://openalex.org/C2775832221","wikidata":"https://www.wikidata.org/wiki/Q422482","display_name":"Gentamicin","level":3,"score":0.1485331952571869},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.12871208786964417},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06847679615020752}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D001850","descriptor_name":"Bone Diseases, Infectious","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002133","descriptor_name":"Calcium Sulfate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007592","descriptor_name":"Joint Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014031","descriptor_name":"Tobramycin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014031","descriptor_name":"Tobramycin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014031","descriptor_name":"Tobramycin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D018461","descriptor_name":"Soft Tissue Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/s00402-010-1192-2","doi":"https://doi.org/10.1007/s00402-010-1192-2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00402-010-1192-2","pdf_url":null,"source":{"id":"https://openalex.org/S118785805","display_name":"Archives of Orthopaedic and Trauma Surgery","issn_l":"0936-8051","issn":["0936-8051","1434-3916"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Orthopaedic and Trauma Surgery","raw_type":"journal-article"},{"id":"pmid:20938669","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20938669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of orthopaedic and trauma surgery","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unil.ch:iris/243659","doi":null,"is_oa":false,"landing_page_url":"https://iris.unil.ch/handle/iris/243659","pdf_url":null,"source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:serval.unil.ch:BIB_DCE890EC0F53","doi":null,"is_oa":false,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_DCE890EC0F53","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Archives of Orthopaedic and Trauma Surgery, vol. 131, no. 5, pp. 657-662","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W225304015","https://openalex.org/W1502205002","https://openalex.org/W1522404613","https://openalex.org/W1550111394","https://openalex.org/W1845690157","https://openalex.org/W1968516060","https://openalex.org/W1970421004","https://openalex.org/W1983589078","https://openalex.org/W1988308062","https://openalex.org/W1990076650","https://openalex.org/W1999869481","https://openalex.org/W2006333306","https://openalex.org/W2008722836","https://openalex.org/W2018835416","https://openalex.org/W2020865983","https://openalex.org/W2027538446","https://openalex.org/W2039934578","https://openalex.org/W2049393551","https://openalex.org/W2055119128","https://openalex.org/W2055864845","https://openalex.org/W2062862329","https://openalex.org/W2063227476","https://openalex.org/W2064409905","https://openalex.org/W2072661347","https://openalex.org/W2077518515","https://openalex.org/W2090750145","https://openalex.org/W2093923848","https://openalex.org/W2101379393","https://openalex.org/W2130132841","https://openalex.org/W2142472196","https://openalex.org/W2154358116","https://openalex.org/W2167768564","https://openalex.org/W2409386927","https://openalex.org/W2413451270","https://openalex.org/W4294253811"],"related_works":["https://openalex.org/W2070872589","https://openalex.org/W4315436543","https://openalex.org/W4221057708","https://openalex.org/W2008722836","https://openalex.org/W2389750941","https://openalex.org/W4390570990","https://openalex.org/W2010053298","https://openalex.org/W2982229984","https://openalex.org/W2130132841","https://openalex.org/W4193569"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}