{"id":"https://openalex.org/W2017058877","doi":"https://doi.org/10.1093/infdis/124.4.415","title":"Deactivation of Cholera Toxin by Ganglioside","display_name":"Deactivation of Cholera Toxin by Ganglioside","publication_year":1971,"publication_date":"1971-10-01","ids":{"openalex":"https://openalex.org/W2017058877","doi":"https://doi.org/10.1093/infdis/124.4.415","mag":"2017058877","pmid":"https://pubmed.ncbi.nlm.nih.gov/5143846"},"language":"en","primary_location":{"id":"doi:10.1093/infdis/124.4.415","doi":"https://doi.org/10.1093/infdis/124.4.415","is_oa":false,"landing_page_url":"https://doi.org/10.1093/infdis/124.4.415","pdf_url":null,"source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089810912","display_name":"William Edward Van Heyningen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"W. E. van Heyningen","raw_affiliation_strings":["University of Oxford"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oxford","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071465373","display_name":"Charles C. J. Carpenter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. C. J. Carpenter","raw_affiliation_strings":["University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University School of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108572142","display_name":"Nathaniel F. Pierce","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. F. Pierce","raw_affiliation_strings":["Baltimore Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baltimore Hospital","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111579367","display_name":"W. B. Greenough","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. B. Greenough","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4763,"currency":"USD","value_usd":4763},"apc_paid":null,"fwci":17.0713,"has_fulltext":false,"cited_by_count":280,"citation_normalized_percentile":{"value":0.99412341,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"124","issue":"4","first_page":"415","last_page":"418"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11684","display_name":"Vibrio bacteria research studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11684","display_name":"Vibrio bacteria research studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholera-toxin","display_name":"cholera toxin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/vibrio-cholerae","display_name":"Vibrio cholerae","score":0.890999972820282},{"id":"https://openalex.org/keywords/gangliosides","display_name":"gangliosides","score":0.9850000143051147},{"id":"https://openalex.org/keywords/adenylyl-cyclase-activation","display_name":"adenylate cyclase activation","score":0.9039999842643738},{"id":"https://openalex.org/keywords/lipid-extracts","display_name":"lipid extracts","score":0.5440000295639038},{"id":"https://openalex.org/keywords/epididymal-fat-cells","display_name":"epididymal fat cells","score":0.8379999995231628}],"concepts":[{"id":"https://openalex.org/C2780722889","wikidata":"https://www.wikidata.org/wiki/Q12090","display_name":"Cholera","level":2,"score":0.5524008274078369},{"id":"https://openalex.org/C74916050","wikidata":"https://www.wikidata.org/wiki/Q841090","display_name":"Classics","level":1,"score":0.5110727548599243},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.4460401237010956},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33295485377311707},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.33007293939590454},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.20090791583061218},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.11318209767341614}],"mesh":[{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002771","descriptor_name":"Cholera","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005732","descriptor_name":"Gangliosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007419","descriptor_name":"Intestinal Secretions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014118","descriptor_name":"Toxins, Biological","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014733","descriptor_name":"Vibrio","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/infdis/124.4.415","doi":"https://doi.org/10.1093/infdis/124.4.415","is_oa":false,"landing_page_url":"https://doi.org/10.1093/infdis/124.4.415","pdf_url":null,"source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:5143846","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5143846","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of infectious diseases","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W2014482345","https://openalex.org/W2023601764","https://openalex.org/W2029001394","https://openalex.org/W2067109129","https://openalex.org/W2077993622","https://openalex.org/W2125615605","https://openalex.org/W2138243399","https://openalex.org/W2143822991","https://openalex.org/W2322371911","https://openalex.org/W2328287470","https://openalex.org/W2397038074"],"related_works":["https://openalex.org/W7100909362","https://openalex.org/W999203595","https://openalex.org/W2061878359","https://openalex.org/W2012713559","https://openalex.org/W1996497544","https://openalex.org/W2030961350","https://openalex.org/W86835850","https://openalex.org/W4210997355","https://openalex.org/W2035358096","https://openalex.org/W2331177078"],"abstract_inverted_index":{"The":[0,60,69,90],"toxin":[1,21,73,106],"of":[2,8,22,37,46,52,67,71,77,83,104],"Vibrio":[3],"cholerae":[4,24],"increases":[5],"the":[6,20,27,44,49,53,102],"activity":[7,30,45],"adenyl":[9],"cyclase":[10],"in":[11,32,58,101],"cell":[12,17,108],"membranes.":[13,109],"Interaction":[14],"between":[15],"intestinal":[16,75],"membranes":[18],"and":[19,79],"V.":[23],"leads":[25],"to":[26,42,65,95,107],"profuse":[28],"secretory":[29],"seen":[31],"choleraic":[33],"diarrhea.":[34],"Lipid-containing":[35],"extracts":[36],"various":[38],"tissues":[39],"were":[40,56],"found":[41,57],"inhibit":[43],"cholera":[47,72,105],"toxin;":[48],"highest":[50],"amounts":[51],"inhibitory":[54],"factor":[55],"brain.":[59],"inhibitor":[61],"has":[62],"properties":[63],"similar":[64],"those":[66],"gangliosides.":[68],"effect":[70],"on":[74],"loops":[76],"rabbits":[78],"epididymal":[80],"fat":[81],"cells":[82],"rats":[84],"was":[85],"neutralized":[86],"by":[87],"purified":[88],"ganglioside.":[89],"results":[91],"suggested":[92],"that":[93],"fixation":[94],"gangliosides":[96],"may":[97],"play":[98],"a":[99],"role":[100],"binding":[103]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
