{"id":"https://openalex.org/W2017053170","doi":"https://doi.org/10.1038/jcbfm.1991.84","title":"Localization of 70 kDa Stress Protein mRNA Induction in Gerbil Brain after Ischemia","display_name":"Localization of 70 kDa Stress Protein mRNA Induction in Gerbil Brain after Ischemia","publication_year":1991,"publication_date":"1991-05-01","ids":{"openalex":"https://openalex.org/W2017053170","doi":"https://doi.org/10.1038/jcbfm.1991.84","mag":"2017053170","pmid":"https://pubmed.ncbi.nlm.nih.gov/2016350"},"language":"en","primary_location":{"id":"doi:10.1038/jcbfm.1991.84","doi":"https://doi.org/10.1038/jcbfm.1991.84","is_oa":false,"landing_page_url":"https://doi.org/10.1038/jcbfm.1991.84","pdf_url":null,"source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111645665","display_name":"Thaddeus S. Nowak","orcid":"https://orcid.org/0000-0002-8601-773X","observed_orcids":["https://orcid.org/0000-0002-8601-773X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thaddeus S. Nowak","raw_affiliation_strings":["Laboratory of Neuropathology and Neuroanatomical Sciences, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuropathology and Neuroanatomical Sciences, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111645665"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":9.2498,"has_fulltext":false,"cited_by_count":197,"citation_normalized_percentile":{"value":0.98733837,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"11","issue":"3","first_page":"432","last_page":"439"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.9179999828338623},{"id":"https://openalex.org/keywords/mrna-induction","display_name":"mRNA induction","score":0.699999988079071},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.9269999861717224},{"id":"https://openalex.org/keywords/ca1-pyramidal-neurons","display_name":"CA1 pyramidal neurons","score":0.8989999890327454},{"id":"https://openalex.org/keywords/dentate-granule-cells","display_name":"dentate gyrus granule cells","score":0.722000002861023},{"id":"https://openalex.org/keywords/delayed-neuronal-death","display_name":"delayed neuronal death","score":0.718999981880188},{"id":"https://openalex.org/keywords/mk-801","display_name":"MK-801","score":0.9269999861717224},{"id":"https://openalex.org/keywords/hypothermia","display_name":"hypothermia","score":0.8209999799728394},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6520000100135803},{"id":"https://openalex.org/keywords/gerbil-brain","display_name":"gerbil brain","score":0.5529999732971191},{"id":"https://openalex.org/keywords/ischemic-cell-death","display_name":"ischemic cell death","score":0.46700000762939453},{"id":"https://openalex.org/keywords/transcriptional-stress-response","display_name":"transcriptional stress response","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C68991219","wikidata":"https://www.wikidata.org/wiki/Q419102","display_name":"Hsp70","level":4,"score":0.85706627368927},{"id":"https://openalex.org/C2780222073","wikidata":"https://www.wikidata.org/wiki/Q649817","display_name":"Gerbil","level":3,"score":0.8491529226303101},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.7673273682594299},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.6767609119415283},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6112328767776489},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5734204053878784},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5346837043762207},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.4794101417064667},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45978549122810364},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.4462413787841797},{"id":"https://openalex.org/C117838200","wikidata":"https://www.wikidata.org/wiki/Q14592582","display_name":"Stress granule","level":5,"score":0.4436860978603363},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40847814083099365},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3773849308490753},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3419075608253479},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3339945673942566},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.294237345457077},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1934678852558136},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18529629707336426},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16928017139434814}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001831","descriptor_name":"Body Temperature","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005849","descriptor_name":"Gerbillinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D015345","descriptor_name":"Oligonucleotide Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016291","descriptor_name":"Dizocilpine Maleate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/jcbfm.1991.84","doi":"https://doi.org/10.1038/jcbfm.1991.84","is_oa":false,"landing_page_url":"https://doi.org/10.1038/jcbfm.1991.84","pdf_url":null,"source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:2016350","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2016350","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W6973128","https://openalex.org/W1160856300","https://openalex.org/W1568275541","https://openalex.org/W1756228969","https://openalex.org/W1896045165","https://openalex.org/W1928260425","https://openalex.org/W1968209090","https://openalex.org/W1970523903","https://openalex.org/W1971102302","https://openalex.org/W1971452220","https://openalex.org/W1975288390","https://openalex.org/W1977388184","https://openalex.org/W1980014349","https://openalex.org/W1986643770","https://openalex.org/W1988568219","https://openalex.org/W1988687569","https://openalex.org/W1995056605","https://openalex.org/W1996830959","https://openalex.org/W2001631877","https://openalex.org/W2003013739","https://openalex.org/W2003102216","https://openalex.org/W2005383788","https://openalex.org/W2012762150","https://openalex.org/W2013024855","https://openalex.org/W2013317828","https://openalex.org/W2015469236","https://openalex.org/W2016469055","https://openalex.org/W2016716112","https://openalex.org/W2017803860","https://openalex.org/W2021497992","https://openalex.org/W2025383172","https://openalex.org/W2029112104","https://openalex.org/W2029808323","https://openalex.org/W2035750459","https://openalex.org/W2036735419","https://openalex.org/W2038146209","https://openalex.org/W2042550512","https://openalex.org/W2047154051","https://openalex.org/W2052819504","https://openalex.org/W2053211604","https://openalex.org/W2054492361","https://openalex.org/W2055533988","https://openalex.org/W2058601367","https://openalex.org/W2062430167","https://openalex.org/W2066281989","https://openalex.org/W2067708969","https://openalex.org/W2069737416","https://openalex.org/W2069884149","https://openalex.org/W2070851087","https://openalex.org/W2071306520","https://openalex.org/W2072866840","https://openalex.org/W2072889943","https://openalex.org/W2081304551","https://openalex.org/W2088411685","https://openalex.org/W2092198909","https://openalex.org/W2102654854","https://openalex.org/W2116940117","https://openalex.org/W2125199383","https://openalex.org/W2127090550","https://openalex.org/W2137417707","https://openalex.org/W2146638685","https://openalex.org/W2147236303","https://openalex.org/W2404496781","https://openalex.org/W2408675665","https://openalex.org/W2419402373","https://openalex.org/W2460588152","https://openalex.org/W4206296617"],"related_works":["https://openalex.org/W1965766555","https://openalex.org/W6973128","https://openalex.org/W2348542214","https://openalex.org/W1975221200","https://openalex.org/W2035773751","https://openalex.org/W2057564697","https://openalex.org/W1032278008","https://openalex.org/W2418906301","https://openalex.org/W2045516682","https://openalex.org/W2049661276"],"abstract_inverted_index":{"Induction":[0],"of":[1,29,34,75,97,105,113,126,134,142,161,178],"mRNA":[2,99,136],"encoding":[3],"the":[4,73,92,101,111,132,157,175,190],"70":[5],"kDa":[6],"stress/heat":[7],"shock":[8],"protein,":[9,50],"hsp70,":[10],"was":[11,37],"evaluated":[12],"in":[13,18,40,64,78,117,137,164,193],"post-ischemic":[14],"gerbil":[15],"brain":[16],"by":[17,148],"situ":[19],"hybridization":[20,163],"using":[21],"an":[22,144],"oligonucleotide":[23],"probe":[24],"selective":[25,159],"for":[26,204],"stress-inducible":[27],"members":[28],"this":[30,79],"gene":[31],"family.":[32],"Expression":[33],"hsp70":[35,49,98,115,135,162],"sequences":[36],"most":[38],"pronounced":[39],"hippocampal":[41,195],"CA1":[42,65,165],"neurons":[43,88,166],"that":[44,52,107],"fail":[45],"to":[46,61,90,110],"accumulate":[47],"immunoreactive":[48],"and":[51,86,197],"are":[53],"selectively":[54],"lost":[55],"following":[56],"ischemia.":[57],"Hybridizable":[58],"RNA":[59],"continued":[60],"be":[62],"expressed":[63],"through":[66],"at":[67,139,167,189],"least":[68],"48":[69],"h,":[70,169],"essentially":[71],"until":[72],"onset":[74],"cell":[76,119],"death":[77],"model.":[80],"In":[81],"contrast,":[82],"dentate":[83],"granule":[84],"cells":[85],"CA2":[87],"destined":[89],"survive":[91],"insult":[93],"showed":[94],"transient":[95],"induction":[96,133],"during":[100],"first":[102],"24":[103,168],"h":[104,141],"recirculation":[106],"disappeared":[108],"prior":[109],"detection":[112],"maximal":[114],"immunoreactivity":[116],"these":[118,179],"populations.":[120],"Pretreatment":[121],"with":[122,208],"a":[123,184,202],"single":[124],"injection":[125],"MK-801":[127],"(10":[128],"mg/kg)":[129],"considerably":[130],"attenuated":[131],"hippocampus":[138],"6":[140],"recirculation,":[143],"effect":[145],"apparently":[146],"mediated":[147],"persistent":[149],"drug-induced":[150],"hypothermia.":[151],"The":[152],"drug":[153],"did":[154,171],"not":[155],"prevent":[156],"later,":[158],"appearance":[160],"nor":[170],"it":[172],"protect":[173],"against":[174],"subsequent":[176],"loss":[177],"cells.":[180],"These":[181],"results":[182],"demonstrate":[183],"prolonged":[185],"postischemic":[186],"stress":[187],"response":[188],"transcriptional":[191],"level":[192],"vulnerable":[194],"neurons,":[196],"suggest":[198],"its":[199],"utility":[200],"as":[201],"marker":[203],"neuronal":[205,212],"pathophysiology":[206],"associated":[207],"mechanisms":[209],"mediating":[210],"delayed":[211],"death.":[213]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
