{"id":"https://openalex.org/W2017052005","doi":"https://doi.org/10.1371/journal.pone.0005233","title":"Targeting Angiogenesis-Dependent Calcified Neoplasms Using Combined Polymer Therapeutics","display_name":"Targeting Angiogenesis-Dependent Calcified Neoplasms Using Combined Polymer Therapeutics","publication_year":2009,"publication_date":"2009-04-20","ids":{"openalex":"https://openalex.org/W2017052005","doi":"https://doi.org/10.1371/journal.pone.0005233","mag":"2017052005","pmid":"https://pubmed.ncbi.nlm.nih.gov/19381291","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2667669"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0005233","doi":"https://doi.org/10.1371/journal.pone.0005233","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0005233","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005233&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005233&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112147267","display_name":"Ehud Segal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ehud Segal","raw_affiliation_strings":["Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel","Department of Physiology and Pharmacology Sackler School of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Department of Physiology and Pharmacology Sackler School of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102253549","display_name":"Huaizhong Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huaizhong Pan","raw_affiliation_strings":["Department of Pharmaceutics and Pharmaceutical Chemistry, Center for Controlled Chemical Delivery, University of Utah, Salt Lake City, Utah, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Pharmaceutical Chemistry, Center for Controlled Chemical Delivery, University of Utah, Salt Lake City, Utah, United States of America","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049307370","display_name":"Paula Ofek","orcid":"https://orcid.org/0000-0002-8516-1107","observed_orcids":["https://orcid.org/0000-0002-8516-1107"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Paula Ofek","raw_affiliation_strings":["Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel","Department of Physiology and Pharmacology Sackler School of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Department of Physiology and Pharmacology Sackler School of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088545148","display_name":"Taturo Udagawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taturo Udagawa","raw_affiliation_strings":["Vascular Biology Program and Department of Surgery, Karp Family Research Laboratories, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Biology Program and Department of Surgery, Karp Family Research Laboratories, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070242893","display_name":"Pavla Kope\u010dkov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pavla Kope\u010dkov\u00e1","raw_affiliation_strings":["Department of Pharmaceutics and Pharmaceutical Chemistry, Center for Controlled Chemical Delivery, University of Utah, Salt Lake City, Utah, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Pharmaceutical Chemistry, Center for Controlled Chemical Delivery, University of Utah, Salt Lake City, Utah, United States of America","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007440695","display_name":"Jind\u0155ich Kopec\u0306ek","orcid":"https://orcid.org/0000-0002-4451-6944","observed_orcids":["https://orcid.org/0000-0002-4451-6944"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jind\u0159ich Kope\u010dek","raw_affiliation_strings":["Department of Pharmaceutics and Pharmaceutical Chemistry, Center for Controlled Chemical Delivery, University of Utah, Salt Lake City, Utah, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Pharmaceutical Chemistry, Center for Controlled Chemical Delivery, University of Utah, Salt Lake City, Utah, United States of America","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061202040","display_name":"Ronit Satchi\u2010Fainaro","orcid":"https://orcid.org/0000-0002-7360-7837","observed_orcids":["https://orcid.org/0000-0002-7360-7837"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Ronit Satchi-Fainaro","raw_affiliation_strings":["Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel","Department of Physiology and Pharmacology Sackler School of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Department of Physiology and Pharmacology Sackler School of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel","institution_ids":["https://openalex.org/I16391192"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5061202040"],"corresponding_institution_ids":["https://openalex.org/I16391192"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":5.9941,"has_fulltext":true,"cited_by_count":116,"citation_normalized_percentile":{"value":0.96949231,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"4","issue":"4","first_page":"e5233","last_page":"e5233"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.5717999935150146,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.5717999935150146,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.12890000641345978,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.04859999939799309,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.8790000081062317},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.984000027179718},{"id":"https://openalex.org/keywords/raft-polymerization","display_name":"RAFT polymerization","score":0.7490000128746033},{"id":"https://openalex.org/keywords/hpma-copolymer","display_name":"HPMA copolymer","score":0.9879999756813049},{"id":"https://openalex.org/keywords/alendronate","display_name":"alendronate","score":0.9549999833106995},{"id":"https://openalex.org/keywords/tnp-470","display_name":"TNP-470","score":0.9879999756813049},{"id":"https://openalex.org/keywords/dual-drug-delivery","display_name":"dual drug delivery","score":0.4300000071525574},{"id":"https://openalex.org/keywords/tumor-vascular-permeability","display_name":"tumor vascular permeability","score":0.47600001096725464},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6249797344207764},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5600693821907043},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5375401973724365},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4882562458515167},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.4252853989601135},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2418821156024933},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pone.0005233","doi":"https://doi.org/10.1371/journal.pone.0005233","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0005233","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005233&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2667669","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2667669","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:19381291","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19381291","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:0e8c16c5ea0a4b2aa00c1d59c15eb56e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0e8c16c5ea0a4b2aa00c1d59c15eb56e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 4, Iss 4, p e5233 (2009)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0005233","doi":"https://doi.org/10.1371/journal.pone.0005233","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0005233","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005233&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2195720128","display_name":"BONE TARGETED DELIVERY OF ANABOLIC AGENTS","funder_award_id":"R01GM069847","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2337630452","display_name":null,"funder_award_id":"1300/06","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"},{"id":"https://openalex.org/G9000335914","display_name":null,"funder_award_id":"GM069847","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320307869","display_name":"European Association for Cancer Research","ror":"https://ror.org/031p7wh32"},{"id":"https://openalex.org/F4320322250","display_name":"Israel Cancer Association","ror":"https://ror.org/03yxd7304"},{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"},{"id":"https://openalex.org/F4320324099","display_name":"Russian Science Foundation","ror":"https://ror.org/03y2gwe85"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017052005.pdf","grobid_xml":"https://content.openalex.org/works/W2017052005.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W43146402","https://openalex.org/W121961865","https://openalex.org/W605885627","https://openalex.org/W1489547988","https://openalex.org/W1535486835","https://openalex.org/W1559714867","https://openalex.org/W1596072784","https://openalex.org/W1871308790","https://openalex.org/W1948868238","https://openalex.org/W1966463670","https://openalex.org/W1971230694","https://openalex.org/W1978139448","https://openalex.org/W1978183755","https://openalex.org/W1992212956","https://openalex.org/W1996177349","https://openalex.org/W2000144084","https://openalex.org/W2006202974","https://openalex.org/W2006878588","https://openalex.org/W2008636068","https://openalex.org/W2010435021","https://openalex.org/W2010486222","https://openalex.org/W2012852444","https://openalex.org/W2017052005","https://openalex.org/W2020558434","https://openalex.org/W2032215744","https://openalex.org/W2034447474","https://openalex.org/W2034965201","https://openalex.org/W2036759587","https://openalex.org/W2040922374","https://openalex.org/W2041402315","https://openalex.org/W2044030495","https://openalex.org/W2044268096","https://openalex.org/W2044332600","https://openalex.org/W2045023599","https://openalex.org/W2048224440","https://openalex.org/W2051499339","https://openalex.org/W2054803078","https://openalex.org/W2055838505","https://openalex.org/W2062012969","https://openalex.org/W2069754084","https://openalex.org/W2076424556","https://openalex.org/W2076765938","https://openalex.org/W2077304538","https://openalex.org/W2079313855","https://openalex.org/W2084071045","https://openalex.org/W2084792872","https://openalex.org/W2088796820","https://openalex.org/W2089961321","https://openalex.org/W2092483187","https://openalex.org/W2096659441","https://openalex.org/W2100593186","https://openalex.org/W2101624026","https://openalex.org/W2110920272","https://openalex.org/W2111293594","https://openalex.org/W2112431117","https://openalex.org/W2117791498","https://openalex.org/W2119405093","https://openalex.org/W2120806678","https://openalex.org/W2130392240","https://openalex.org/W2137841367","https://openalex.org/W2139175722","https://openalex.org/W2139780910","https://openalex.org/W2145786098","https://openalex.org/W2147513976","https://openalex.org/W2147640616","https://openalex.org/W2152179330","https://openalex.org/W2154251583","https://openalex.org/W2155393958","https://openalex.org/W2163048481","https://openalex.org/W2164327861","https://openalex.org/W2164363535","https://openalex.org/W2168100008","https://openalex.org/W2242768312","https://openalex.org/W2275795519","https://openalex.org/W2319962899","https://openalex.org/W2384161907","https://openalex.org/W2417764220","https://openalex.org/W2481759204","https://openalex.org/W4254572210"],"related_works":["https://openalex.org/W2086035454","https://openalex.org/W2604087128","https://openalex.org/W2140895387","https://openalex.org/W2076418862","https://openalex.org/W1978482115","https://openalex.org/W2044030495","https://openalex.org/W2133087992","https://openalex.org/W2008000140","https://openalex.org/W2110369939","https://openalex.org/W2004845708"],"abstract_inverted_index":{"BACKGROUND:":[0],"There":[1],"is":[2,92,96,130,241],"an":[3,42],"immense":[4],"clinical":[5,285],"need":[6],"for":[7,10,291],"novel":[8],"therapeutics":[9],"the":[11,47,55,60,100,109,114,127,242],"treatment":[12],"of":[13,108,146,179,188,195,250,264,277,279],"angiogenesis-dependent":[14,292],"calcified":[15,34,128,268],"neoplasms":[16,35,269],"such":[17,294],"as":[18,287,295],"osteosarcomas":[19],"and":[20,33,59,118,143,155,162,168,175,181,192,214,230,261,267,297],"bone":[21,31,85,136,265,298],"metastases.":[22,299],"We":[23,158],"developed":[24],"a":[25,70,77,247,251,271,288],"new":[26,248,275],"therapeutic":[27,255],"strategy":[28],"to":[29,99,126,135,245,257],"target":[30,258],"metastases":[32,266],"using":[36],"combined":[37,203,253],"polymer-bound":[38],"angiogenesis":[39],"inhibitors.":[40],"Using":[41],"advanced":[43],"\"living":[44],"polymerization\"":[45],"technique,":[46],"reversible":[48],"addition-fragmentation":[49],"chain":[50],"transfer":[51],"(RAFT),":[52],"we":[53],"conjugated":[54,163],"aminobisphosphonate":[56],"alendronate":[57],"(ALN),":[58],"potent":[61],"anti-angiogenic":[62,142,167],"agent":[63],"TNP-470":[64],"with":[65,209],"N-(2-hydroxypropyl)methacrylamide":[66],"(HPMA)":[67],"copolymer":[68],"through":[69],"Glycine-Glycine-Proline-Norleucine":[71],"linker,":[72],"cleaved":[73],"by":[74,132,171,215,228,237],"cathepsin":[75],"K,":[76],"cysteine":[78],"protease":[79],"overexpressed":[80],"at":[81,270],"resorption":[82],"sites":[83],"in":[84,102,153,156,185,235],"tissues.":[86],"In":[87],"this":[88],"approach,":[89],"dual":[90],"targeting":[91,125],"achieved.":[93],"Passive":[94],"accumulation":[95],"possible":[97],"due":[98],"increase":[101],"molecular":[103],"weight":[104],"following":[105],"polymer":[106,254],"conjugation":[107],"drugs,":[110],"thus":[111],"extravasating":[112],"from":[113,120],"tumor":[115,260],"leaky":[116],"vessels":[117],"not":[119],"normal":[121],"healthy":[122],"vessels.":[123],"Active":[124],"tissues":[129],"achieved":[131],"ALN's":[133],"affinity":[134],"mineral.":[137],"METHODS":[138],"AND":[139],"FINDING:":[140],"The":[141],"antitumor":[144,169,190],"potency":[145],"HPMA":[147,196],"copolymer-ALN-TNP-470":[148,197],"conjugate":[149,198,223],"was":[150,199],"evaluated":[151],"both":[152,259],"vitro":[154],"vivo.":[157],"show":[159],"that":[160],"free":[161],"ALN-TNP-470":[164],"have":[165,284],"synergistic":[166,281],"activity":[170,191],"inhibiting":[172],"proliferation,":[173],"migration":[174],"capillary-like":[176],"tube":[177],"formation":[178],"endothelial":[180,262],"human":[182,212],"osteosarcoma":[183,213,233,296],"cells":[184],"vitro.":[186],"Evaluation":[187],"anti-angiogenic,":[189],"body":[193],"distribution":[194],"performed":[200],"on":[201],"severe":[202],"immunodeficiency":[204],"(SCID)":[205],"male":[206],"mice":[207,236],"inoculated":[208],"mCherry-labeled":[210],"MG-63-Ras":[211],"modified":[216],"Miles":[217],"permeability":[218],"assay.":[219],"Our":[220],"targeted":[221],"bi-specific":[222],"reduced":[224],"VEGF-induced":[225],"vascular":[226],"hyperpermeability":[227],"92%":[229],"remarkably":[231],"inhibited":[232],"growth":[234],"96%.":[238],"CONCLUSIONS:":[239],"This":[240,274],"first":[243],"report":[244],"describe":[246],"concept":[249],"narrowly-dispersed":[252],"designed":[256],"compartments":[263],"single":[272],"administration.":[273],"approach":[276],"co-delivery":[278],"two":[280],"drugs":[282],"may":[283],"utility":[286],"potential":[289],"therapy":[290],"cancers":[293]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
