{"id":"https://openalex.org/W2017043004","doi":"https://doi.org/10.1207/s15327914nc5202_10","title":"Zyflamend\u00ae, a Unique Herbal Preparation With Nonselective OX Inhibitory Activity, Induces Apoptosis of Prostate Cancer Cells That Lack COX-2 Expression","display_name":"Zyflamend\u00ae, a Unique Herbal Preparation With Nonselective OX Inhibitory Activity, Induces Apoptosis of Prostate Cancer Cells That Lack COX-2 Expression","publication_year":2005,"publication_date":"2005-07-01","ids":{"openalex":"https://openalex.org/W2017043004","doi":"https://doi.org/10.1207/s15327914nc5202_10","mag":"2017043004","pmid":"https://pubmed.ncbi.nlm.nih.gov/16201851"},"language":"en","primary_location":{"id":"doi:10.1207/s15327914nc5202_10","doi":"https://doi.org/10.1207/s15327914nc5202_10","is_oa":false,"landing_page_url":"https://doi.org/10.1207/s15327914nc5202_10","pdf_url":null,"source":{"id":"https://openalex.org/S105083709","display_name":"Nutrition and Cancer","issn_l":"0163-5581","issn":["0163-5581","1532-7914"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319847","host_organization_name":"Routledge","host_organization_lineage":["https://openalex.org/P4310319847","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Routledge","Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition and Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011181008","display_name":"Debra L. Bemis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debra L. Bemis","raw_affiliation_strings":["Department of Urology, Columbia University Medical Center, New York, NY 10032, USA. dlb2004@columbia.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Columbia University Medical Center, New York, NY 10032, USA. dlb2004@columbia.edu","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085548354","display_name":"Jillian L. Capodice","orcid":"https://orcid.org/0000-0002-1953-1771","observed_orcids":["https://orcid.org/0000-0002-1953-1771"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jillian L. Capodice","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106183593","display_name":"Aristotelis G. Anastasiadis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aristotelis G. Anastasiadis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103352989","display_name":"Aaron E. Katz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aaron E. Katz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088350338","display_name":"Ralph Buttyan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ralph Buttyan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.122,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.8601162,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"52","issue":"2","first_page":"202","last_page":"212"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.6510000228881836},{"id":"https://openalex.org/keywords/cyclooxygenase-inhibition","display_name":"cyclooxygenase inhibition","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cox-1","display_name":"cyclooxygenase-1","score":0.890999972820282},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":1.0},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9660000205039978},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.9359999895095825},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.8989999890327454},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.7160000205039978},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cell-growth-inhibition","display_name":"cell growth inhibition","score":0.5619999766349792},{"id":"https://openalex.org/keywords/parp-cleavage","display_name":"PARP cleavage","score":0.7929999828338623},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9449999928474426},{"id":"https://openalex.org/keywords/cox-independent-mechanism","display_name":"COX-independent mechanism","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.9196696281433105},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.6092960238456726},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6015638113021851},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5426339507102966},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.44963547587394714},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.4334985017776489},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.4211442172527313},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.42093777656555176},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4209291934967041},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4116598069667816},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4114791750907898},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3813338577747345},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3780863583087921},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.23587706685066223},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23338592052459717},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2329304814338684},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.22989633679389954},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20208096504211426},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.065818190574646},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051545","descriptor_name":"Cyclooxygenase 1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051545","descriptor_name":"Cyclooxygenase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052246","descriptor_name":"Cyclooxygenase 2 Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1207/s15327914nc5202_10","doi":"https://doi.org/10.1207/s15327914nc5202_10","is_oa":false,"landing_page_url":"https://doi.org/10.1207/s15327914nc5202_10","pdf_url":null,"source":{"id":"https://openalex.org/S105083709","display_name":"Nutrition and Cancer","issn_l":"0163-5581","issn":["0163-5581","1532-7914"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319847","host_organization_name":"Routledge","host_organization_lineage":["https://openalex.org/P4310319847","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Routledge","Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition and Cancer","raw_type":"journal-article"},{"id":"pmid:16201851","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16201851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition and cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W53508600","https://openalex.org/W78238624","https://openalex.org/W80953942","https://openalex.org/W641279851","https://openalex.org/W1487226962","https://openalex.org/W1498692154","https://openalex.org/W1521613365","https://openalex.org/W1541326155","https://openalex.org/W1584314654","https://openalex.org/W1648593433","https://openalex.org/W1829896161","https://openalex.org/W1877627579","https://openalex.org/W1973303608","https://openalex.org/W1975065102","https://openalex.org/W1978265027","https://openalex.org/W1980235624","https://openalex.org/W1984632430","https://openalex.org/W1989969820","https://openalex.org/W1993377197","https://openalex.org/W1995997868","https://openalex.org/W1996174176","https://openalex.org/W1998232267","https://openalex.org/W1998394615","https://openalex.org/W1998402110","https://openalex.org/W1999679464","https://openalex.org/W2002570890","https://openalex.org/W2007454357","https://openalex.org/W2008658340","https://openalex.org/W2011608085","https://openalex.org/W2015636384","https://openalex.org/W2016483890","https://openalex.org/W2019243373","https://openalex.org/W2024087814","https://openalex.org/W2026891551","https://openalex.org/W2034081607","https://openalex.org/W2035768602","https://openalex.org/W2041241505","https://openalex.org/W2042710356","https://openalex.org/W2043707891","https://openalex.org/W2050888137","https://openalex.org/W2052964069","https://openalex.org/W2055759795","https://openalex.org/W2062813587","https://openalex.org/W2068776651","https://openalex.org/W2070851174","https://openalex.org/W2074022118","https://openalex.org/W2074356752","https://openalex.org/W2077991158","https://openalex.org/W2088147285","https://openalex.org/W2089923844","https://openalex.org/W2097997344","https://openalex.org/W2104500186","https://openalex.org/W2105372476","https://openalex.org/W2110430942","https://openalex.org/W2117459641","https://openalex.org/W2124043243","https://openalex.org/W2127449230","https://openalex.org/W2127558096","https://openalex.org/W2129268315","https://openalex.org/W2129497878","https://openalex.org/W2133125477","https://openalex.org/W2135938816","https://openalex.org/W2136555831","https://openalex.org/W2139981029","https://openalex.org/W2141337720","https://openalex.org/W2147114673","https://openalex.org/W2148907720","https://openalex.org/W2149233326","https://openalex.org/W2153154305","https://openalex.org/W2156881931","https://openalex.org/W2159622045","https://openalex.org/W2170271978","https://openalex.org/W2170720478","https://openalex.org/W2185491582","https://openalex.org/W2261807878","https://openalex.org/W2318388129","https://openalex.org/W2330709704","https://openalex.org/W3150740182","https://openalex.org/W4229581080","https://openalex.org/W4242442904"],"related_works":["https://openalex.org/W2023657887","https://openalex.org/W7096215115","https://openalex.org/W111995374","https://openalex.org/W2316227686","https://openalex.org/W2110430942","https://openalex.org/W2900430371","https://openalex.org/W2054094218","https://openalex.org/W101187720","https://openalex.org/W1998394615","https://openalex.org/W6939896609"],"abstract_inverted_index":{"Cyclooxygenase":[0],"(COX)":[1],"inhibitors":[2],"have":[3],"suppressive":[4],"effects":[5,39,110,250],"on":[6,40,69,115],"several":[7,138],"types":[8],"of":[9,24,51,67,85,93,111,118,137,175,196,201,219,261,266],"cancer":[10,44],"cells":[11,152,177],"including":[12],"prostate":[13,43],"cancer.":[14],"In":[15],"this":[16,112],"study,":[17],"we":[18],"considered":[19],"the":[20,41,109,116,119,191,194,216,249],"potential":[21],"COX-inhibitory":[22],"activity":[23,50,95,187],"a":[25,56,145],"unique":[26],"anti-inflammatory":[27],"herbal":[28,113],"preparation":[29,114],"(Zyflamend;":[30],"New":[31],"Chapter,":[32],"Inc.,":[33],"Brattleboro,":[34],"VT)":[35],"and":[36,63,73,91,98,131,153,161,185,211,221,231,238,263,269],"analyzed":[37],"its":[38],"human":[42],"cell":[45,71,80,100,120,171,236],"line":[46],"LNCaP.":[47],"COX":[48],"inhibitory":[49],"Zyflamend":[52,68,157,197,227],"was":[53,142,188],"determined":[54],"by":[55,79,209],"spectrophotometric-based":[57],"assay":[58,149],"using":[59,144],"purified":[60],"ovine":[61],"COX-1":[62,160,230],"COX-2":[64,162,232],"enzymes.":[65],"Effects":[66],"LNCaP":[70,176,225,242],"growth":[72,172],"apoptosis":[74,200,240],"in":[75,96,150,215,223,241],"vitro":[76],"were":[77,105,183,213],"assessed":[78],"counting,":[81],"Western":[82,102],"blot":[83],"detection":[84],"poly":[86],"ADP-ribose":[87],"polymerase":[88],"(PARP)":[89],"cleavage,":[90],"measurement":[92],"caspase-3":[94,186],"treated":[97,151],"control":[99,192],"extracts.":[101],"blotting":[103],"techniques":[104],"conducted":[106],"to":[107,155,198,254],"determine":[108],"expression":[117,167,206,260,265],"signaling":[121],"proteins,":[122],"p21,":[123],"androgen":[124],"receptor":[125,205],"(AR),":[126],"phospho-protein":[127],"kinase":[128],"C":[129],"(pPKC)(alpha/beta),":[130],"phospho":[132],"(p)Stat3.":[133],"The":[134],"phospohorylation":[135],"status":[136],"signal":[139],"transduction":[140],"phosphoproteins":[141],"profiled":[143],"high-throughput":[146],"phosphoprotein":[147],"screening":[148],"compared":[154],"controls.":[156],"dramatically":[158],"decreased":[159],"enzymatic":[163,233],"activity.":[164],"Elevated":[165],"p21":[166,262],"coincided":[168],"with":[169,178],"attenuated":[170],"following":[173],"treatment":[174],"Zyflamend.":[179],"PARP":[180],"cleavage":[181],"fragments":[182],"evident,":[184],"upregulated":[189],"over":[190],"indicating":[193],"ability":[195],"induce":[199],"these":[202],"cells.":[203,226,243],"Androgen":[204],"levels":[207],"declined":[208],"40%,":[210],"decreases":[212],"observed":[214],"active":[217],"forms":[218],"Stat3":[220],"PKC(alpha/beta)":[222],"Zyflamend-treated":[224],"inhibited":[228],"both":[229],"activities,":[234],"suppressed":[235],"growth,":[237],"induced":[239],"However,":[244],"our":[245],"data":[246],"suggests":[247],"that":[248],"are":[251],"likely":[252],"due":[253],"COX-independent":[255],"mechanisms":[256],"potentially":[257],"involving":[258],"enhanced":[259],"reduced":[264],"AR,":[267],"pStat3,":[268],"pPKC(alpha/beta).":[270]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
