{"id":"https://openalex.org/W2017032430","doi":"https://doi.org/10.1074/jbc.m112.358721","title":"Arginine in \u03b1-Defensins","display_name":"Arginine in \u03b1-Defensins","publication_year":2012,"publication_date":"2012-05-08","ids":{"openalex":"https://openalex.org/W2017032430","doi":"https://doi.org/10.1074/jbc.m112.358721","mag":"2017032430","pmid":"https://pubmed.ncbi.nlm.nih.gov/22566697","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3381149"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m112.358721","doi":"https://doi.org/10.1074/jbc.m112.358721","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112.358721","pdf_url":"http://www.jbc.org/article/S0021925820497170/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820497170/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Nathan W. Schmidt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan W. Schmidt","raw_affiliation_strings":["Department of Bioengineering, UCLA, Los Angeles, California 90095-1600, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, UCLA, Los Angeles, California 90095-1600, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075629423","display_name":"Kenneth P. Tai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth P. Tai","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, USC Norris Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089-9601"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, USC Norris Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089-9601","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040893451","display_name":"Karishma Kamdar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karishma Kamdar","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, USC Norris Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089-9601"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, USC Norris Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089-9601","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089885266","display_name":"Abhijit Mishra","orcid":"https://orcid.org/0000-0003-1057-3550","observed_orcids":["https://orcid.org/0000-0003-1057-3550"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I27674431","display_name":"Indian Institute of Technology Gandhinagar","ror":"https://ror.org/0036p5w23","country_code":"IN","type":"education","lineage":["https://openalex.org/I27674431"]}],"countries":["IN","US"],"is_corresponding":false,"raw_author_name":"Abhijit Mishra","raw_affiliation_strings":["Department of Bioengineering, UCLA, Los Angeles, California, 90095-1600","Metallurgical Engineering and Materials Science Department, Indian Institute of Technology Gandhinagar, Ahmedabad, 382424 Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, UCLA, Los Angeles, California, 90095-1600","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Metallurgical Engineering and Materials Science Department, Indian Institute of Technology Gandhinagar, Ahmedabad, 382424 Gujarat, India","institution_ids":["https://openalex.org/I27674431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058206431","display_name":"Ghee Hwee Lai","orcid":"https://orcid.org/0000-0002-3310-3992","observed_orcids":["https://orcid.org/0000-0002-3310-3992"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ghee Hwee Lai","raw_affiliation_strings":["Department of Bioengineering, UCLA, Los Angeles, California, 90095-1600"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, UCLA, Los Angeles, California, 90095-1600","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047734667","display_name":"Kun Zhao","orcid":"https://orcid.org/0000-0003-3928-1981","observed_orcids":["https://orcid.org/0000-0003-3928-1981"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kun Zhao","raw_affiliation_strings":["Department of Bioengineering, UCLA, Los Angeles, California, 90095-1600"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, UCLA, Los Angeles, California, 90095-1600","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014273111","display_name":"Andr\u00e9 J. Ouellette","orcid":"https://orcid.org/0000-0002-7987-5779","observed_orcids":["https://orcid.org/0000-0002-7987-5779"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 J. Ouellette","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, USC Norris Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089-9601"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, USC Norris Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089-9601","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078191755","display_name":"Gerard C. L. Wong","orcid":"https://orcid.org/0000-0003-0893-6383","observed_orcids":["https://orcid.org/0000-0003-0893-6383"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gerard C.L. Wong","raw_affiliation_strings":["Department of Bioengineering, UCLA, Los Angeles, California, 90095-1600"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, UCLA, Los Angeles, California, 90095-1600","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5078191755"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":5.812,"has_fulltext":true,"cited_by_count":62,"citation_normalized_percentile":{"value":0.96344309,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"287","issue":"26","first_page":"21866","last_page":"21872"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-defensins","display_name":"alpha-defensins","score":0.8849999904632568},{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.8299999833106995},{"id":"https://openalex.org/keywords/bactericidal-activity","display_name":"bactericidal activity","score":0.8610000014305115},{"id":"https://openalex.org/keywords/membrane-curvature","display_name":"membrane curvature","score":0.9330000281333923},{"id":"https://openalex.org/keywords/membrane-perturbation","display_name":"membrane perturbation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C2776498113","wikidata":"https://www.wikidata.org/wiki/Q412820","display_name":"Defensin","level":3,"score":0.6859021782875061},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6681634187698364},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.6681126356124878},{"id":"https://openalex.org/C2777278457","wikidata":"https://www.wikidata.org/wiki/Q6815124","display_name":"Membrane curvature","level":4,"score":0.49079498648643494},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48925304412841797},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.47992143034935},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4515612721443176},{"id":"https://openalex.org/C534586","wikidata":"https://www.wikidata.org/wiki/Q6815143","display_name":"Membrane topology","level":4,"score":0.43739423155784607},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4153684377670288},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4124307632446289},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40645331144332886},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32029786705970764},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.2768380641937256},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.26301318407058716},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.255859911441803},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.21698099374771118},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13118290901184082}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012542","descriptor_name":"Scattering, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014965","descriptor_name":"X-Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016011","descriptor_name":"Normal Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023082","descriptor_name":"Defensins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D023084","descriptor_name":"alpha-Defensins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D023084","descriptor_name":"alpha-Defensins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m112.358721","doi":"https://doi.org/10.1074/jbc.m112.358721","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112.358721","pdf_url":"http://www.jbc.org/article/S0021925820497170/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2683042","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3381149","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3381149","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3381149","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:22566697","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22566697","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m112.358721","doi":"https://doi.org/10.1074/jbc.m112.358721","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112.358721","pdf_url":"http://www.jbc.org/article/S0021925820497170/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1199642319","display_name":null,"funder_award_id":"1UO1 AI082192-01","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1286236842","display_name":null,"funder_award_id":"-AC02-05CH11231","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G1286251239","display_name":null,"funder_award_id":"DE-AC02","funder_id":"https://openalex.org/F4320337480","funder_display_name":"Basic Energy Sciences"},{"id":"https://openalex.org/G1451874870","display_name":null,"funder_award_id":"DE-AC02-05-CH11231","funder_id":"https://openalex.org/F4320338381","funder_display_name":"SLAC National Accelerator Laboratory"},{"id":"https://openalex.org/G1863003419","display_name":null,"funder_award_id":"DEAC02-05CH11231","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2575115269","display_name":"Wet Electrostatics and Biomolecular Self-Assembly","funder_award_id":"0409769","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2880384052","display_name":null,"funder_award_id":"Contract DE-AC02-05CH11231","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G3062317534","display_name":null,"funder_award_id":"DMR1106106","funder_id":"https://openalex.org/F4320337367","funder_display_name":"Division of Materials Research"},{"id":"https://openalex.org/G30714459","display_name":null,"funder_award_id":"DE-AC02-05CH11231.","funder_id":"https://openalex.org/F4320337480","funder_display_name":"Basic Energy Sciences"},{"id":"https://openalex.org/G3083819904","display_name":null,"funder_award_id":"05CH11231","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G3687380347","display_name":null,"funder_award_id":"P30CA014089","funder_id":"https://openalex.org/F4320317194","funder_display_name":"USC Norris Comprehensive Cancer Center"},{"id":"https://openalex.org/G419881185","display_name":null,"funder_award_id":"DEAC02\u201305CH11231","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G42916606","display_name":null,"funder_award_id":"DE AC02 05CH11231","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G4501827968","display_name":null,"funder_award_id":"AC02-05CH11231","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G465867758","display_name":null,"funder_award_id":"Contract DE-AC02-05CH11231.","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G498139845","display_name":null,"funder_award_id":"DE-AC02","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G5897016827","display_name":"PEPTIDE EFFECTORS OF ENTERIC HOST DEFENSE","funder_award_id":"R01DK044632","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G650090426","display_name":null,"funder_award_id":"AC02\u201305CH11231","funder_id":"https://openalex.org/F4320337480","funder_display_name":"Basic Energy Sciences"},{"id":"https://openalex.org/G6836730322","display_name":"CAREER: Geometry of Directed Folding and Soft Packing","funder_award_id":"0846582","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7769250255","display_name":"Antimicrobial Oligomers for BioDefense and Emerging Food Borne Infectious Disease","funder_award_id":"U01AI082192","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8414788116","display_name":"STUDIES OF ALPHA-DEFENSINS IN PRIMATE INNATE IMMUNITY","funder_award_id":"R01AI059346","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000910363","display_name":"University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)","funder_award_id":"P30CA014089","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G969749505","display_name":null,"funder_award_id":"Contract DE-AC02-05CH11231","funder_id":"https://openalex.org/F4320337480","funder_display_name":"Basic Energy Sciences"},{"id":"https://openalex.org/G969889393","display_name":null,"funder_award_id":"DE-AC02-","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320310042","display_name":"Aspen Center for Physics","ror":"https://ror.org/05gqcbq50"},{"id":"https://openalex.org/F4320317194","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337367","display_name":"Division of Materials Research","ror":"https://ror.org/01pc7k308"},{"id":"https://openalex.org/F4320337480","display_name":"Basic Energy Sciences","ror":"https://ror.org/05mg91w61"},{"id":"https://openalex.org/F4320337965","display_name":"California NanoSystems Institute","ror":"https://ror.org/00q7fqf35"},{"id":"https://openalex.org/F4320338381","display_name":"SLAC National Accelerator Laboratory","ror":"https://ror.org/05gzmn429"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017032430.pdf","grobid_xml":"https://content.openalex.org/works/W2017032430.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1847489898","https://openalex.org/W1932041686","https://openalex.org/W1967462130","https://openalex.org/W1967544898","https://openalex.org/W1970916267","https://openalex.org/W1977160855","https://openalex.org/W1979502581","https://openalex.org/W1987678987","https://openalex.org/W1997683664","https://openalex.org/W2003589493","https://openalex.org/W2009762504","https://openalex.org/W2011347701","https://openalex.org/W2020015356","https://openalex.org/W2028138612","https://openalex.org/W2034479484","https://openalex.org/W2038766313","https://openalex.org/W2042746016","https://openalex.org/W2043842304","https://openalex.org/W2043936787","https://openalex.org/W2048389635","https://openalex.org/W2049725266","https://openalex.org/W2050871371","https://openalex.org/W2054602599","https://openalex.org/W2055856930","https://openalex.org/W2057198053","https://openalex.org/W2058613673","https://openalex.org/W2064065739","https://openalex.org/W2070512060","https://openalex.org/W2077555091","https://openalex.org/W2080017805","https://openalex.org/W2083443165","https://openalex.org/W2087406439","https://openalex.org/W2089799214","https://openalex.org/W2091106400","https://openalex.org/W2092770422","https://openalex.org/W2118200955","https://openalex.org/W2125449455","https://openalex.org/W2131958110","https://openalex.org/W2132134286","https://openalex.org/W2136842509","https://openalex.org/W2150515351","https://openalex.org/W2152301430","https://openalex.org/W2544311709","https://openalex.org/W4211087238","https://openalex.org/W4211175230"],"related_works":["https://openalex.org/W2189168990","https://openalex.org/W2290079860","https://openalex.org/W1967544898","https://openalex.org/W2034479484","https://openalex.org/W3174391255","https://openalex.org/W2136569949","https://openalex.org/W2009762504","https://openalex.org/W2154638132","https://openalex.org/W2003361945","https://openalex.org/W3173726820"],"abstract_inverted_index":{"The":[0,133],"conserved":[1],"tridisulfide":[2],"array":[3],"of":[4,41,69,80,104,117,148],"the":[5,65,76,81,96,109,115],"\u03b1-defensin":[6],"family":[7],"imposes":[8],"a":[9,101],"common":[10],"triple-stranded":[11],"\u03b2-sheet":[12],"topology":[13],"on":[14],"peptides":[15],"that":[16,64,92,145],"may":[17],"have":[18],"highly":[19],"diverse":[20],"primary":[21],"structures,":[22],"resulting":[23],"in":[24],"differential":[25,66],"outcomes":[26],"after":[27],"targeted":[28],"mutagenesis.":[29],"In":[30,85,123],"mouse":[31],"cryptdin-4":[32],"(Crp4)":[33],"and":[34,140],"rhesus":[35],"myeloid":[36],"\u03b1-defensin-4":[37],"(RMAD4),":[38],"complete":[39],"substitutions":[40],"Arg":[42],"with":[43,108,114],"Lys":[44],"affect":[45],"bactericidal":[46,118,156],"peptide":[47],"activity":[48,57,119,142,157],"very":[49],"differently.":[50],"Lys-for-Arg":[51,70,121],"mutagenesis":[52],"attenuates":[53],"Crp4,":[54,86],"but":[55],"RMAD4":[56,129],"remains":[58],"mostly":[59],"unchanged.":[60,132],"Here,":[61],"we":[62],"show":[63],"biological":[67,141],"effect":[68],"replacements":[71,94],"can":[72],"be":[73],"understood":[74],"by":[75,120,128],"distinct":[77],"phase":[78],"behavior":[79],"experimental":[82],"peptide-lipid":[83],"system.":[84],"small-angle":[87,136],"x-ray":[88,137],"scattering":[89,138],"analyses":[90],"showed":[91],"Arg-to-Lys":[93],"shifted":[95],"induced":[97],"nanoporous":[98],"phases":[99,126],"to":[100,155],"different":[102],"range":[103],"lipid":[105],"compositions":[106],"compared":[107],"Arg-rich":[110],"native":[111],"peptide,":[112],"consistent":[113],"attenuation":[116],"mutations.":[122],"contrast,":[124],"such":[125],"generated":[127],"were":[130],"largely":[131],"concordance":[134],"between":[135],"measurements":[139],"provides":[143],"evidence":[144],"specific":[146],"types":[147],"\u03b1-defensin-induced":[149],"membrane":[150,159],"curvature-generating":[151],"tendencies":[152],"correspond":[153],"directly":[154],"via":[158],"destabilization.":[160]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}