{"id":"https://openalex.org/W2017024005","doi":"https://doi.org/10.1074/jbc.m111.235473","title":"l-Tryptophan-mediated Enhancement of Susceptibility to Nonalcoholic Fatty Liver Disease Is Dependent on the Mammalian Target of Rapamycin","display_name":"l-Tryptophan-mediated Enhancement of Susceptibility to Nonalcoholic Fatty Liver Disease Is Dependent on the Mammalian Target of Rapamycin","publication_year":2011,"publication_date":"2011-08-13","ids":{"openalex":"https://openalex.org/W2017024005","doi":"https://doi.org/10.1074/jbc.m111.235473","mag":"2017024005","pmid":"https://pubmed.ncbi.nlm.nih.gov/21841000","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3186417"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m111.235473","doi":"https://doi.org/10.1074/jbc.m111.235473","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.235473","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m111.235473","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089562604","display_name":"Yosuke Osawa","orcid":"https://orcid.org/0000-0003-3581-1009","observed_orcids":["https://orcid.org/0000-0003-3581-1009"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yosuke Osawa","raw_affiliation_strings":["Departments of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. osawa-gif@umin.ac.jp","Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan","Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. osawa-gif@umin.ac.jp","institution_ids":["https://openalex.org/I42405503"]},{"raw_affiliation_string":"Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan","institution_ids":["https://openalex.org/I42405503"]},{"raw_affiliation_string":"Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046826386","display_name":"Hiromitsu Kanamori","orcid":"https://orcid.org/0009-0004-7705-715X","observed_orcids":["https://orcid.org/0009-0004-7705-715X"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromitsu Kanamori","raw_affiliation_strings":["Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039550467","display_name":"Ekihiro Seki","orcid":"https://orcid.org/0000-0002-9472-6085","observed_orcids":["https://orcid.org/0000-0002-9472-6085"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ekihiro Seki","raw_affiliation_strings":["Department of Medicine, University of California, San Diego, School of Medicine, La Jolla, California 92093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, San Diego, School of Medicine, La Jolla, California 92093","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103269635","display_name":"Masato Hoshi","orcid":"https://orcid.org/0000-0001-6260-8300","observed_orcids":["https://orcid.org/0000-0001-6260-8300"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masato Hoshi","raw_affiliation_strings":["Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072943072","display_name":"Hirofumi Ohtaki","orcid":"https://orcid.org/0000-0001-7072-5056","observed_orcids":["https://orcid.org/0000-0001-7072-5056"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirofumi Ohtaki","raw_affiliation_strings":["Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109164982","display_name":"Yoichi Yasuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoichi Yasuda","raw_affiliation_strings":["Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015030858","display_name":"Hiroyasu Ito","orcid":"https://orcid.org/0000-0002-4836-4001","observed_orcids":["https://orcid.org/0000-0002-4836-4001"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyasu Ito","raw_affiliation_strings":["Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037875479","display_name":"Atsushi Suetsugu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Suetsugu","raw_affiliation_strings":["Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079953843","display_name":"Masahito Nagaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahito Nagaki","raw_affiliation_strings":["Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041284607","display_name":"Hisataka Moriwaki","orcid":"https://orcid.org/0000-0002-3798-4432","observed_orcids":["https://orcid.org/0000-0002-3798-4432"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisataka Moriwaki","raw_affiliation_strings":["Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101463445","display_name":"Kuniaki Saito","orcid":"https://orcid.org/0000-0001-5800-9305","observed_orcids":["https://orcid.org/0000-0001-5800-9305"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kuniaki Saito","raw_affiliation_strings":["Department of Human Health Science, Graduate School of Medicine and Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Health Science, Graduate School of Medicine and Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109372920","display_name":"Mitsuru Seishima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuru Seishima","raw_affiliation_strings":["Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan","institution_ids":["https://openalex.org/I42405503"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5089562604"],"corresponding_institution_ids":["https://openalex.org/I42405503"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.2332,"has_fulltext":true,"cited_by_count":97,"citation_normalized_percentile":{"value":0.87895381,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"286","issue":"40","first_page":"34800","last_page":"34808"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tryptophan","display_name":"tryptophan","score":0.9869999885559082},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9850000143051147},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.9350000023841858},{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.6610000133514404},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.9120000004768372},{"id":"https://openalex.org/keywords/aromatic-l-amino-acid-decarboxylase","display_name":"aromatic L-amino acid decarboxylase","score":0.9589999914169312},{"id":"https://openalex.org/keywords/high-fat-high-fructose-diet","display_name":"high-fat high-fructose diet","score":0.8849999904632568},{"id":"https://openalex.org/keywords/hepatocyte-lipid-accumulation","display_name":"hepatocyte lipid accumulation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.8021611571311951},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7035046815872192},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6784132719039917},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.6354336738586426},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.6319547891616821},{"id":"https://openalex.org/C2776954865","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic fatty liver disease","level":4,"score":0.5266233086585999},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4791947305202484},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42885977029800415},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.4260202944278717},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40047502517700195},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27806147933006287},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22414350509643555},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.16881224513053894},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.10665985941886902},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07352820038795471},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000821","descriptor_name":"Animal Feed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001142","descriptor_name":"Aromatic-L-Amino-Acid Decarboxylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005632","descriptor_name":"Fructose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007737","descriptor_name":"Kynurenine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m111.235473","doi":"https://doi.org/10.1074/jbc.m111.235473","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.235473","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3186417","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3186417/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3186417/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:21841000","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21841000","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m111.235473","doi":"https://doi.org/10.1074/jbc.m111.235473","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.235473","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3601095186","display_name":"Screening and gene analysis for the protection from muscle damage by statin drugs","funder_award_id":"21390179","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3916445017","display_name":"Synergistic Actions By Multiple Toll-Like Receptors in Alcoholic Liver Disease","funder_award_id":"R01AA020172","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G4147906221","display_name":"The pathophysiologic role of indoleamine 2, 3-dioxygenase in viral infectious diseases","funder_award_id":"20390167","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G9000888793","display_name":"Extracellular Matrix Regulates Hepatic Stellate Cell Activation and Fibrosis","funder_award_id":"R01DK085252","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017024005.pdf","grobid_xml":"https://content.openalex.org/works/W2017024005.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1505887853","https://openalex.org/W1573455563","https://openalex.org/W1648872901","https://openalex.org/W1785572671","https://openalex.org/W1967257827","https://openalex.org/W1967267087","https://openalex.org/W1967977853","https://openalex.org/W1975189993","https://openalex.org/W1977516195","https://openalex.org/W1977922773","https://openalex.org/W1978367598","https://openalex.org/W1985481640","https://openalex.org/W2003295985","https://openalex.org/W2007505836","https://openalex.org/W2015376899","https://openalex.org/W2017948134","https://openalex.org/W2029059439","https://openalex.org/W2029174913","https://openalex.org/W2029641949","https://openalex.org/W2030019992","https://openalex.org/W2031774854","https://openalex.org/W2034189822","https://openalex.org/W2040109162","https://openalex.org/W2046306656","https://openalex.org/W2051423453","https://openalex.org/W2056728315","https://openalex.org/W2057341346","https://openalex.org/W2064857927","https://openalex.org/W2073956836","https://openalex.org/W2074196156","https://openalex.org/W2074871877","https://openalex.org/W2080097363","https://openalex.org/W2086519275","https://openalex.org/W2092297684","https://openalex.org/W2096736282","https://openalex.org/W2131468354","https://openalex.org/W2144019683","https://openalex.org/W2144591738","https://openalex.org/W2145355678","https://openalex.org/W2148483218","https://openalex.org/W2159827561","https://openalex.org/W2161727276","https://openalex.org/W2166130296"],"related_works":["https://openalex.org/W4390127933","https://openalex.org/W2064857927","https://openalex.org/W2901753855","https://openalex.org/W2037258088","https://openalex.org/W3035169363","https://openalex.org/W3024794342","https://openalex.org/W2053922544","https://openalex.org/W4411780332","https://openalex.org/W2342695671","https://openalex.org/W1967019524"],"abstract_inverted_index":{"Nonalcoholic":[0],"fatty":[1,122,180],"liver":[2,10],"disease":[3],"is":[4,27],"one":[5],"of":[6,42,70,101,125,161,165,189,195,210],"the":[7,40,109,119,142,162,187,193],"most":[8],"common":[9],"diseases.":[11],"L-tryptophan":[12,30,43,59,81,93,140,151,200],"and":[13,23,53,75,156,168],"its":[14],"metabolite":[15],"serotonin":[16,97,110,131,148,157],"are":[17],"involved":[18],"in":[19,44,61,86,133],"hepatic":[20,32,46,67,115,145,196,202],"lipid":[21,126,176],"metabolism":[22],"inflammation.":[24],"However,":[25],"it":[26],"unclear":[28],"whether":[29],"promotes":[31],"steatosis.":[33,197],"To":[34],"explore":[35],"this":[36],"issue,":[37],"we":[38],"examined":[39],"role":[41],"mouse":[45],"steatosis":[47,116,146,203],"by":[48,118,130,179,205],"using":[49],"a":[50,169],"high":[51,54],"fat":[52],"fructose":[55],"diet":[56],"(HFHFD)":[57],"model.":[58],"treatment":[60,94,132,158],"combination":[62],"with":[63,182],"an":[64],"HFHFD":[65,206],"exacerbated":[66],"steatosis,":[68],"expression":[69],"HNE-modified":[71],"proteins,":[72],"hydroxyproline":[73],"content,":[74],"serum":[76,96],"alanine":[77],"aminotransaminase":[78],"levels,":[79],"whereas":[80],"alone":[82],"did":[83],"not":[84],"result":[85],"these":[87],"effects.":[88],"We":[89],"also":[90],"found":[91],"that":[92,139],"increases":[95,141],"levels.":[98],"The":[99,121],"introduction":[100],"adenoviral":[102,153],"aromatic":[103],"amino":[104],"acid":[105,181],"decarboxylase,":[106],"which":[107],"stimulates":[108],"synthesis":[111],"from":[112],"L-tryptophan,":[113],"aggravated":[114],"induced":[117,159,178,204],"HFHFD.":[120],"acid-induced":[123],"accumulation":[124,177],"was":[127],"further":[128],"increased":[129],"cultured":[134],"hepatocytes.":[135],"These":[136,184],"results":[137,185],"suggest":[138,186],"sensitivity":[143],"to":[144],"through":[147,207],"production.":[149],"Furthermore,":[150],"treatment,":[152],"AADC":[154],"introduction,":[155],"phosphorylation":[160],"mammalian":[163],"target":[164],"rapamycin":[166,173],"(mTOR),":[167],"potent":[170],"mTOR":[171,190],"inhibitor":[172],"attenuated":[174],"hepatocyte":[175],"serotonin.":[183],"importance":[188],"activation":[191,209],"for":[192],"exacerbation":[194],"In":[198],"conclusion,":[199],"exacerbates":[201],"serotonin-mediated":[208],"mTOR.":[211]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}