{"id":"https://openalex.org/W2017019692","doi":"https://doi.org/10.1016/s0016-5085(98)70251-3","title":"Safety of azathioprine and 6-mercaptopurine in pediatric patients with inflammatory bowel disease","display_name":"Safety of azathioprine and 6-mercaptopurine in pediatric patients with inflammatory bowel disease","publication_year":1998,"publication_date":"1998-10-01","ids":{"openalex":"https://openalex.org/W2017019692","doi":"https://doi.org/10.1016/s0016-5085(98)70251-3","mag":"2017019692","pmid":"https://pubmed.ncbi.nlm.nih.gov/9753482"},"language":"en","primary_location":{"id":"doi:10.1016/s0016-5085(98)70251-3","doi":"https://doi.org/10.1016/s0016-5085(98)70251-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0016-5085(98)70251-3","pdf_url":"http://www.gastrojournal.org/article/S0016508598702513/pdf","source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2017019692"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.gastrojournal.org/article/S0016508598702513/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050767508","display_name":"Barbara S. Kirschner","orcid":"https://orcid.org/0000-0003-4640-2438","observed_orcids":["https://orcid.org/0000-0003-4640-2438"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210136340","display_name":"Comer Children's Hospital","ror":"https://ror.org/02y96rp12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210136340"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Barbara S. Kirschner","raw_affiliation_strings":["Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Chicago Children's Hospital, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Chicago Children's Hospital, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210136340"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050767508"],"corresponding_institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210136340"],"apc_list":{"value":4180,"currency":"USD","value_usd":4180},"apc_paid":null,"fwci":10.6933,"has_fulltext":true,"cited_by_count":234,"citation_normalized_percentile":{"value":0.98621651,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"115","issue":"4","first_page":"813","last_page":"821"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11964","display_name":"Pregnancy and Medication Impact","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/azathioprine","display_name":"azathioprine","score":1.0},{"id":"https://openalex.org/keywords/6-mercaptopurine","display_name":"6-mercaptopurine","score":1.0},{"id":"https://openalex.org/keywords/pediatric-inflammatory-bowel-disease","display_name":"pediatric inflammatory bowel disease","score":0.9599999785423279},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":1.0},{"id":"https://openalex.org/keywords/immunomodulatory-therapy","display_name":"immunomodulatory therapy","score":0.777999997138977},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.9359999895095825},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.8190000057220459},{"id":"https://openalex.org/keywords/aminotransferase-elevation","display_name":"aminotransferase elevation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/prednisone-dose-reduction","display_name":"prednisone dose reduction","score":0.8709999918937683},{"id":"https://openalex.org/keywords/steroid-sparing-therapy","display_name":"steroid-sparing therapy","score":0.8610000014305115},{"id":"https://openalex.org/keywords/pancreatitis","display_name":"pancreatitis","score":0.6290000081062317},{"id":"https://openalex.org/keywords/infection","display_name":"infection","score":0.3779999911785126},{"id":"https://openalex.org/keywords/leukopenia","display_name":"leukopenia","score":0.7960000038146973},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9779999852180481}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9266427755355835},{"id":"https://openalex.org/C2776760755","wikidata":"https://www.wikidata.org/wiki/Q18939","display_name":"Azathioprine","level":3,"score":0.7900229692459106},{"id":"https://openalex.org/C2778720950","wikidata":"https://www.wikidata.org/wiki/Q424972","display_name":"Prednisone","level":2,"score":0.7704232931137085},{"id":"https://openalex.org/C2777173762","wikidata":"https://www.wikidata.org/wiki/Q418529","display_name":"Mercaptopurine","level":2,"score":0.7579364776611328},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.7441796660423279},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.7306323051452637},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6860301494598389},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6800001859664917},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6608763337135315},{"id":"https://openalex.org/C2780873365","wikidata":"https://www.wikidata.org/wiki/Q496812","display_name":"Leukopenia","level":3,"score":0.655536949634552},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.5729362964630127},{"id":"https://openalex.org/C2778570526","wikidata":"https://www.wikidata.org/wiki/Q653197","display_name":"Rash","level":2,"score":0.48127955198287964},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.4675995707511902},{"id":"https://openalex.org/C70917649","wikidata":"https://www.wikidata.org/wiki/Q94307","display_name":"Thiopurine methyltransferase","level":4,"score":0.4488796889781952},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.29091066122055054},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.24366512894630432}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001379","descriptor_name":"Azathioprine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001379","descriptor_name":"Azathioprine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004342","descriptor_name":"Drug Hypersensitivity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007239","descriptor_name":"Infections","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008499","descriptor_name":"Medical Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011241","descriptor_name":"Prednisone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011241","descriptor_name":"Prednisone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015122","descriptor_name":"Mercaptopurine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015122","descriptor_name":"Mercaptopurine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019992","descriptor_name":"Databases as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0016-5085(98)70251-3","doi":"https://doi.org/10.1016/s0016-5085(98)70251-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0016-5085(98)70251-3","pdf_url":"http://www.gastrojournal.org/article/S0016508598702513/pdf","source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},{"id":"pmid:9753482","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9753482","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0016-5085(98)70251-3","doi":"https://doi.org/10.1016/s0016-5085(98)70251-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0016-5085(98)70251-3","pdf_url":"http://www.gastrojournal.org/article/S0016508598702513/pdf","source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017019692.pdf","grobid_xml":"https://content.openalex.org/works/W2017019692.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W11883821","https://openalex.org/W18063648","https://openalex.org/W149199239","https://openalex.org/W181134469","https://openalex.org/W1506429815","https://openalex.org/W1517931144","https://openalex.org/W1592250045","https://openalex.org/W1832483744","https://openalex.org/W1948846488","https://openalex.org/W1966245341","https://openalex.org/W1975645772","https://openalex.org/W1978124935","https://openalex.org/W1984148692","https://openalex.org/W1987208841","https://openalex.org/W1988173708","https://openalex.org/W2001718067","https://openalex.org/W2016894207","https://openalex.org/W2024421394","https://openalex.org/W2025343624","https://openalex.org/W2035541493","https://openalex.org/W2039505363","https://openalex.org/W2043258441","https://openalex.org/W2045123507","https://openalex.org/W2047212658","https://openalex.org/W2048391560","https://openalex.org/W2048469010","https://openalex.org/W2051828495","https://openalex.org/W2060242494","https://openalex.org/W2060635852","https://openalex.org/W2077839744","https://openalex.org/W2090549398","https://openalex.org/W2093253461","https://openalex.org/W2113588554","https://openalex.org/W2135958206","https://openalex.org/W2180305266","https://openalex.org/W2314055620","https://openalex.org/W2320641660","https://openalex.org/W2398394964","https://openalex.org/W2416091231","https://openalex.org/W6600475183","https://openalex.org/W6607309244"],"related_works":["https://openalex.org/W1986656813","https://openalex.org/W2121069866","https://openalex.org/W2034422333","https://openalex.org/W1977298342","https://openalex.org/W2587684920","https://openalex.org/W1968836133","https://openalex.org/W2322475115","https://openalex.org/W2999496807","https://openalex.org/W1975645772","https://openalex.org/W2102457440"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}