{"id":"https://openalex.org/W2017014359","doi":"https://doi.org/10.1111/j.1440-1843.2008.01259.x","title":"Association of \u03b22\u2010adrenoreceptor genotypes with bronchodilatory effect of tiotropium in COPD","display_name":"Association of \u03b22\u2010adrenoreceptor genotypes with bronchodilatory effect of tiotropium in COPD","publication_year":2008,"publication_date":"2008-03-12","ids":{"openalex":"https://openalex.org/W2017014359","doi":"https://doi.org/10.1111/j.1440-1843.2008.01259.x","mag":"2017014359","pmid":"https://pubmed.ncbi.nlm.nih.gov/18399855"},"language":"en","primary_location":{"id":"doi:10.1111/j.1440-1843.2008.01259.x","doi":"https://doi.org/10.1111/j.1440-1843.2008.01259.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1440-1843.2008.01259.x","pdf_url":null,"source":{"id":"https://openalex.org/S125119059","display_name":"Respirology","issn_l":"1323-7799","issn":["1323-7799","1440-1843"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respirology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018219885","display_name":"Nobuaki Umeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuaki UMEDA","raw_affiliation_strings":["Department of Sports Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan","Departments of Sports Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Sports Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan","institution_ids":["https://openalex.org/I317356780"]},{"raw_affiliation_string":"Departments of Sports Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101636615","display_name":"Takahiro Yoshikawa","orcid":"https://orcid.org/0000-0002-8175-5880","observed_orcids":["https://orcid.org/0000-0002-8175-5880"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Takahiro YOSHIKAWA","raw_affiliation_strings":["Departments of Sports Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Sports Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111883822","display_name":"Hiroshi Kanazawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi KANAZAWA","raw_affiliation_strings":["Respiratory Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112307973","display_name":"Kazuto Hirata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuto HIRATA","raw_affiliation_strings":["Respiratory Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110751504","display_name":"Shigeo Fujimoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shigeo FUJIMOTO","raw_affiliation_strings":["Departments of Sports Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Sports Medicine and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101636615"],"corresponding_institution_ids":[],"apc_list":{"value":4330,"currency":"USD","value_usd":4330},"apc_paid":null,"fwci":3.7305,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.92500972,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"13","issue":"3","first_page":"346","last_page":"352"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta2-adrenergic-receptor","display_name":"beta2-adrenergic receptor","score":0.8740000128746033},{"id":"https://openalex.org/keywords/tiotropium","display_name":"tiotropium","score":0.8840000033378601},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.8320000171661377},{"id":"https://openalex.org/keywords/bronchodilator-response","display_name":"bronchodilator response","score":0.8769999742507935},{"id":"https://openalex.org/keywords/muscarinic-receptors","display_name":"muscarinic receptors","score":0.8349999785423279},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":0.8849999904632568},{"id":"https://openalex.org/keywords/fev1","display_name":"FEV1","score":0.8059999942779541},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.37700000405311584}],"concepts":[{"id":"https://openalex.org/C2776968687","wikidata":"https://www.wikidata.org/wiki/Q424316","display_name":"Tiotropium bromide","level":4,"score":0.9085284471511841},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8830530643463135},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.815416693687439},{"id":"https://openalex.org/C2781018748","wikidata":"https://www.wikidata.org/wiki/Q927234","display_name":"Bronchodilator","level":3,"score":0.6817033886909485},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.600532054901123},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5822869539260864},{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.4959927499294281},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.4391769468784332},{"id":"https://openalex.org/C2909548125","wikidata":"https://www.wikidata.org/wiki/Q927234","display_name":"Bronchodilator Agents","level":4,"score":0.41838476061820984},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.41699904203414917},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3874184787273407},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3579729199409485},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34386032819747925},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.32093602418899536},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.20597869157791138},{"id":"https://openalex.org/C3018587741","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung function","level":3,"score":0.11402633786201477},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07992056012153625},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069447","descriptor_name":"Tiotropium Bromide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000420","descriptor_name":"Albuterol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000420","descriptor_name":"Albuterol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005541","descriptor_name":"Forced Expiratory Volume","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012602","descriptor_name":"Scopolamine Derivatives","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012602","descriptor_name":"Scopolamine Derivatives","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1440-1843.2008.01259.x","doi":"https://doi.org/10.1111/j.1440-1843.2008.01259.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1440-1843.2008.01259.x","pdf_url":null,"source":{"id":"https://openalex.org/S125119059","display_name":"Respirology","issn_l":"1323-7799","issn":["1323-7799","1440-1843"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respirology","raw_type":"journal-article"},{"id":"pmid:18399855","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18399855","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respirology (Carlton, Vic.)","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1544705648","https://openalex.org/W1964156424","https://openalex.org/W1969758883","https://openalex.org/W1970459532","https://openalex.org/W1970629614","https://openalex.org/W1978801965","https://openalex.org/W1989649218","https://openalex.org/W2014191280","https://openalex.org/W2015371796","https://openalex.org/W2033113172","https://openalex.org/W2045291272","https://openalex.org/W2051659559","https://openalex.org/W2056259311","https://openalex.org/W2063945782","https://openalex.org/W2083407012","https://openalex.org/W2083436606","https://openalex.org/W2093482010","https://openalex.org/W2101932319","https://openalex.org/W2108361166","https://openalex.org/W2113096218","https://openalex.org/W2127327473","https://openalex.org/W2131988317","https://openalex.org/W2134436842","https://openalex.org/W2147815892","https://openalex.org/W2149242204","https://openalex.org/W2152059578","https://openalex.org/W2155106926","https://openalex.org/W2169527010","https://openalex.org/W4405992955"],"related_works":["https://openalex.org/W2097845477","https://openalex.org/W2257157079","https://openalex.org/W2721971431","https://openalex.org/W6885091418","https://openalex.org/W4286801046","https://openalex.org/W2003709806","https://openalex.org/W2779504675","https://openalex.org/W2141610484","https://openalex.org/W2089611746","https://openalex.org/W2596020814"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"OBJECTIVE:":[2],"Recently,":[3],"there":[4],"has":[5],"been":[6],"interest":[7],"in":[8,45,147,180,185,193,233],"interactions":[9],"of":[10,28,92,121,224,243],"beta(2)":[11],"adrenergic":[12],"receptors":[13,18],"(beta(2)-AR)":[14],"and":[15,80,89,104,114,172,187],"muscarinic":[16],"acetylcholine":[17],"(mAChR),":[19],"which":[20],"share":[21],"intracellular":[22],"signal":[23],"transduction":[24],"systems.":[25],"The":[26],"aim":[27],"the":[29,97,122,132,137,155,176,216,225],"present":[30],"study":[31],"was":[32,94,109],"to":[33,38,53,231],"investigate":[34],"whether":[35],"bronchodilator":[36,229],"response":[37,230],"tiotropium":[39,69,232],"is":[40],"influenced":[41],"by":[42],"beta(2)-AR":[43,85,123,226],"genotype":[44,139,157,219],"patients":[46,62,128,135,194,234],"with":[47,63,67,83,129,136,152,195,198,235,237],"COPD":[48,64,130,134,236],"who":[49],"show":[50],"poor":[51],"responsiveness":[52],"inhaled":[54,68,84],"beta(2)-agonists.":[55],"METHODS:":[56],"After":[57],"a":[58,144],"4-week":[59],"run-in":[60],"period,":[61],"were":[65,87,124,190],"treated":[66],"bromide":[70],"(18":[71],"microg":[72],"once":[73],"daily)":[74],"for":[75],"8":[76],"weeks.":[77],"Spirometric":[78],"measurements":[79],"reversibility":[81],"testing":[82],"agonists":[86],"performed":[88],"health-related":[90,241],"quality":[91,242],"life":[93],"assessed":[95],"using":[96],"St":[98],"George's":[99],"respiratory":[100],"questionnaire":[101],"(SGRQ)":[102],"before":[103],"after":[105],"treatment.":[106],"Genomic":[107],"DNA":[108],"prepared":[110],"from":[111],"peripheral":[112],"blood":[113],"individual":[115],"genotypes":[116],"at":[117,220],"amino":[118,221],"acid":[119,222],"16":[120,223],"examined.":[125],"RESULTS:":[126],"Forty-four":[127],"completed":[131],"study.":[133],"Arg/Arg":[138,156,196,218],"(n":[140,158],"=":[141,159,163,167,204],"22)":[142,160],"had":[143],"significant":[145,238],"increase":[146],"FEV(1)":[148],"during":[149],"treatment":[150],"compared":[151,197],"those":[153,199],"without":[154,200],"(FEV(1),":[161],"P":[162,166,203,208],"0.009;":[164],"FEV(1)%,":[165],"0.006).":[168],"While":[169],"all":[170],"component":[171],"total":[173,188],"scores":[174,189],"on":[175,240],"SGRQ":[177],"improved":[178],"significantly":[179,191],"both":[181],"genetic":[182],"groups,":[183],"changes":[184],"impact":[186,206],"greater":[192],"(total":[201],"scores,":[202,207],"0.005;":[205],"<":[209],"0.001).":[210],"CONCLUSIONS:":[211],"These":[212],"findings":[213],"indicate":[214],"that":[215],"homozygous":[217],"could":[227],"affect":[228],"effects":[239],"life.":[244]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
