{"id":"https://openalex.org/W2017014342","doi":"https://doi.org/10.1371/journal.pone.0043250","title":"Exercise Does Not Protect against MPTP-Induced Neurotoxicity in BDNF Happloinsufficent Mice","display_name":"Exercise Does Not Protect against MPTP-Induced Neurotoxicity in BDNF Happloinsufficent Mice","publication_year":2012,"publication_date":"2012-08-17","ids":{"openalex":"https://openalex.org/W2017014342","doi":"https://doi.org/10.1371/journal.pone.0043250","mag":"2017014342","pmid":"https://pubmed.ncbi.nlm.nih.gov/22912838","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3422268"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0043250","doi":"https://doi.org/10.1371/journal.pone.0043250","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0043250","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0043250&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0043250&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090470499","display_name":"Kim M. Gerecke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117979880","display_name":"Rhodes College","ror":"https://ror.org/049xfwy04","country_code":"US","type":"education","lineage":["https://openalex.org/I117979880"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kim M. Gerecke","raw_affiliation_strings":["Department of Psychology and Neuroscience Program, Rhodes College, Memphis, Tennessee, United States of America. gereckek@rhodes.edu","Department of Psychology and Neuroscience Program, Rhodes College, Memphis, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology and Neuroscience Program, Rhodes College, Memphis, Tennessee, United States of America. gereckek@rhodes.edu","institution_ids":["https://openalex.org/I117979880"]},{"raw_affiliation_string":"Department of Psychology and Neuroscience Program, Rhodes College, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I117979880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031290818","display_name":"Yun Jiao","orcid":"https://orcid.org/0000-0002-9579-8398","observed_orcids":["https://orcid.org/0000-0002-9579-8398"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yun Jiao","raw_affiliation_strings":["Department of Developmental Neurobiology, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee, United States of America","Department of Developmental Neurobiology, St. Jude Children's#N#                    Research Hospital, Memphis, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Neurobiology, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Developmental Neurobiology, St. Jude Children's#N#                    Research Hospital, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016515026","display_name":"Viswajeeth Pagala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Viswajeeth Pagala","raw_affiliation_strings":["Hartwell Center for Bioinformatics, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hartwell Center for Bioinformatics, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058143660","display_name":"Richard Jay Smeyne","orcid":"https://orcid.org/0000-0002-8459-5472","observed_orcids":["https://orcid.org/0000-0002-8459-5472"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard J. Smeyne","raw_affiliation_strings":["Department of Developmental Neurobiology, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee, United States of America","Department of Developmental Neurobiology, St. Jude Children's#N#                    Research Hospital, Memphis, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Neurobiology, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Developmental Neurobiology, St. Jude Children's#N#                    Research Hospital, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I1313298211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5090470499"],"corresponding_institution_ids":["https://openalex.org/I117979880"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.5407,"has_fulltext":true,"cited_by_count":53,"citation_normalized_percentile":{"value":0.92149458,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"7","issue":"8","first_page":"e43250","last_page":"e43250"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.02280000038444996,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.5889999866485596},{"id":"https://openalex.org/keywords/mptp-neurotoxicity","display_name":"MPTP-induced neurotoxicity","score":0.9020000100135803},{"id":"https://openalex.org/keywords/substantia-nigra-pars-compacta","display_name":"substantia nigra pars compacta","score":0.9290000200271606},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.9229999780654907},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9929999709129333},{"id":"https://openalex.org/keywords/neurotrophic-factors","display_name":"neurotrophic factors","score":0.8550000190734863},{"id":"https://openalex.org/keywords/voluntary-running","display_name":"voluntary running","score":0.6570000052452087},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.5379999876022339},{"id":"https://openalex.org/keywords/protein-expression","display_name":"protein expression","score":0.42100000381469727},{"id":"https://openalex.org/keywords/parkinson-s-disease-model","display_name":"Parkinson's disease model","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C2778674702","wikidata":"https://www.wikidata.org/wiki/Q239816","display_name":"MPTP","level":4,"score":0.9119850397109985},{"id":"https://openalex.org/C2776773494","wikidata":"https://www.wikidata.org/wiki/Q3366041","display_name":"Pars compacta","level":5,"score":0.9096752405166626},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.8776928782463074},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.8604479432106018},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.8030375242233276},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.7634221315383911},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.6371262669563293},{"id":"https://openalex.org/C2780358027","wikidata":"https://www.wikidata.org/wiki/Q407752","display_name":"Neurotoxin","level":2,"score":0.5166869163513184},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.46997135877609253},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.456923246383667},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41389793157577515},{"id":"https://openalex.org/C185856081","wikidata":"https://www.wikidata.org/wiki/Q14916286","display_name":"Glial cell line-derived neurotrophic factor","level":4,"score":0.41350236535072327},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4111083447933197},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3787687420845032},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3648231029510498},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35485130548477173},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33239930868148804},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28990209102630615},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.22390460968017578},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.12701168656349182},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004587","descriptor_name":"Electrophoresis, Agar Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010805","descriptor_name":"Physical Conditioning, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020267","descriptor_name":"MPTP Poisoning","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020267","descriptor_name":"MPTP Poisoning","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057895","descriptor_name":"Haploinsufficiency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0043250","doi":"https://doi.org/10.1371/journal.pone.0043250","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0043250","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0043250&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2425353","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3422268","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3422268","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3422268","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:22912838","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22912838","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.817.4619","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.817.4619","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/d3/02/pone.0043250.PMC3422268.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:0449733c00204627974b8a39b8876ad2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0449733c00204627974b8a39b8876ad2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 8, p e43250 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0043250","doi":"https://doi.org/10.1371/journal.pone.0043250","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0043250","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0043250&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4095277257","display_name":"Mechanisms of Exercise-Induced Protection and Rescue in Models of Dopamine Loss","funder_award_id":"R01NS070825","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6960607984","display_name":"Genetics of MPTP-Induced Parkinsonism","funder_award_id":"R01NS039006","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G943377722","display_name":null,"funder_award_id":"NS039006","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320313598","display_name":"American Lebanese Syrian Associated Charities","ror":"https://ror.org/03rx10x31"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017014342.pdf","grobid_xml":"https://content.openalex.org/works/W2017014342.grobid-xml"},"referenced_works_count":139,"referenced_works":["https://openalex.org/W77937653","https://openalex.org/W194914142","https://openalex.org/W1516912887","https://openalex.org/W1528797989","https://openalex.org/W1530199299","https://openalex.org/W1557435879","https://openalex.org/W1599925064","https://openalex.org/W1800951710","https://openalex.org/W1899025964","https://openalex.org/W1923518481","https://openalex.org/W1966579742","https://openalex.org/W1967074270","https://openalex.org/W1969140956","https://openalex.org/W1969659388","https://openalex.org/W1970095022","https://openalex.org/W1970516662","https://openalex.org/W1970801990","https://openalex.org/W1974190504","https://openalex.org/W1974729135","https://openalex.org/W1974924674","https://openalex.org/W1976999555","https://openalex.org/W1978047491","https://openalex.org/W1978469186","https://openalex.org/W1979739159","https://openalex.org/W1983822376","https://openalex.org/W1984965817","https://openalex.org/W1986148405","https://openalex.org/W1986716278","https://openalex.org/W1987777210","https://openalex.org/W1989875962","https://openalex.org/W1994914264","https://openalex.org/W1995341268","https://openalex.org/W1998583491","https://openalex.org/W2002842000","https://openalex.org/W2003245640","https://openalex.org/W2005170723","https://openalex.org/W2006000330","https://openalex.org/W2007108464","https://openalex.org/W2008719521","https://openalex.org/W2009582310","https://openalex.org/W2009612123","https://openalex.org/W2009742165","https://openalex.org/W2011226249","https://openalex.org/W2012220731","https://openalex.org/W2012907539","https://openalex.org/W2013168439","https://openalex.org/W2014078610","https://openalex.org/W2014725619","https://openalex.org/W2014871698","https://openalex.org/W2015450850","https://openalex.org/W2016204955","https://openalex.org/W2018112449","https://openalex.org/W2019962808","https://openalex.org/W2020942562","https://openalex.org/W2021551531","https://openalex.org/W2022387887","https://openalex.org/W2022662082","https://openalex.org/W2023135934","https://openalex.org/W2025075881","https://openalex.org/W2025354749","https://openalex.org/W2027276086","https://openalex.org/W2030536065","https://openalex.org/W2030558096","https://openalex.org/W2031315586","https://openalex.org/W2032285285","https://openalex.org/W2032327611","https://openalex.org/W2032676029","https://openalex.org/W2034758657","https://openalex.org/W2037577786","https://openalex.org/W2038205410","https://openalex.org/W2038389141","https://openalex.org/W2038986435","https://openalex.org/W2042936248","https://openalex.org/W2043899667","https://openalex.org/W2043990301","https://openalex.org/W2045695914","https://openalex.org/W2049710822","https://openalex.org/W2051085843","https://openalex.org/W2052381549","https://openalex.org/W2052737201","https://openalex.org/W2055308573","https://openalex.org/W2055819632","https://openalex.org/W2057598453","https://openalex.org/W2059718548","https://openalex.org/W2060082076","https://openalex.org/W2060631836","https://openalex.org/W2062001650","https://openalex.org/W2062673250","https://openalex.org/W2064574532","https://openalex.org/W2065057380","https://openalex.org/W2066430727","https://openalex.org/W2069642809","https://openalex.org/W2069849992","https://openalex.org/W2070211287","https://openalex.org/W2070811215","https://openalex.org/W2072190564","https://openalex.org/W2072869105","https://openalex.org/W2073688363","https://openalex.org/W2076894554","https://openalex.org/W2077584190","https://openalex.org/W2079959894","https://openalex.org/W2080117791","https://openalex.org/W2080147271","https://openalex.org/W2080636803","https://openalex.org/W2081250650","https://openalex.org/W2082214510","https://openalex.org/W2084445735","https://openalex.org/W2086765278","https://openalex.org/W2091930637","https://openalex.org/W2093660005","https://openalex.org/W2095283131","https://openalex.org/W2100464372","https://openalex.org/W2101090693","https://openalex.org/W2104142184","https://openalex.org/W2108545260","https://openalex.org/W2109158936","https://openalex.org/W2121489597","https://openalex.org/W2122942786","https://openalex.org/W2130210612","https://openalex.org/W2134241742","https://openalex.org/W2134812282","https://openalex.org/W2136959981","https://openalex.org/W2137508090","https://openalex.org/W2149104679","https://openalex.org/W2150241866","https://openalex.org/W2153038533","https://openalex.org/W2153092987","https://openalex.org/W2160147252","https://openalex.org/W2161471210","https://openalex.org/W2164459320","https://openalex.org/W2165731491","https://openalex.org/W2171047055","https://openalex.org/W2233018857","https://openalex.org/W4235923563","https://openalex.org/W4242573891","https://openalex.org/W4247150946","https://openalex.org/W4256578113","https://openalex.org/W4399053592","https://openalex.org/W6631364419"],"related_works":["https://openalex.org/W2014078610","https://openalex.org/W2009486479","https://openalex.org/W3010636057","https://openalex.org/W2164459320","https://openalex.org/W2084445735","https://openalex.org/W1984965817","https://openalex.org/W1964386825","https://openalex.org/W2790334858","https://openalex.org/W3179846496","https://openalex.org/W2765442536"],"abstract_inverted_index":{"Exercise":[0],"has":[1],"been":[2,42],"demonstrated":[3,98],"to":[4,21,44,48,52,143],"potently":[5],"protect":[6],"substantia":[7],"nigra":[8],"pars":[9],"compacta":[10],"(SN)":[11],"dopaminergic":[12],"neurons":[13,87],"from":[14,88,117,129],"1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine":[15],"(MPTP)-induced":[16],"neurotoxicity.":[17,104],"One":[18],"mechanism":[19],"proposed":[20],"account":[22],"for":[23,72,162],"this":[24],"neuroprotection":[25,56,165],"is":[26,57,160],"the":[27,63,73,102,163],"upregulation":[28],"of":[29,66,84,111,140,158,166],"neurotrophic":[30,33],"factors.":[31],"Several":[32],"factors,":[34],"including":[35],"Brain":[36],"Derived":[37],"Neurotrophic":[38],"Factor":[39],"(BDNF),":[40],"have":[41],"shown":[43],"upregulate":[45],"in":[46,69],"response":[47],"exercise.":[49],"In":[50],"order":[51],"determine":[53],"if":[54],"exercise-induced":[55,164],"dependent":[58],"upon":[59],"BDNF,":[60],"we":[61],"compared":[62],"neuroprotective":[64],"effects":[65],"voluntary":[67],"exercise":[68,94,113],"mice":[70,90,107,136],"heterozygous":[71],"BDNF":[74,159],"gene":[75],"(BDNF+/-)":[76],"with":[77],"strain-matched":[78],"wild-type":[79],"(WT)":[80],"mice.":[81],"Stereological":[82],"estimates":[83],"SNpc":[85,119,167],"DA":[86,120,168],"WT":[89,133],"allowed":[91,108],"90":[92,109,130],"days":[93,110],"via":[95],"unrestricted":[96,112],"running":[97],"complete":[99],"protection":[100],"against":[101],"MPTP-induced":[103,118],"However,":[105],"BDNF+/-":[106,135],"were":[114],"not":[115],"protected":[116],"neuron":[121],"loss.":[122],"Proteomic":[123],"analysis":[124],"comparing":[125],"SN":[126],"and":[127,134,148],"striatum":[128],"day":[131],"exercised":[132],"showed":[137],"differential":[138],"expression":[139],"proteins":[141],"related":[142],"energy":[144],"regulation,":[145],"intracellular":[146],"signaling":[147],"trafficking.":[149],"These":[150],"results":[151],"suggest":[152],"that":[153],"a":[154],"full":[155],"genetic":[156],"complement":[157],"critical":[161],"neurons.":[169]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
