{"id":"https://openalex.org/W2017004620","doi":"https://doi.org/10.1046/j.1365-2885.2001.00329.x","title":"Inflammatory mediators induce endothelium\u2010dependent adherence of equine eosinophils to cultured endothelial cells","display_name":"Inflammatory mediators induce endothelium\u2010dependent adherence of equine eosinophils to cultured endothelial cells","publication_year":2001,"publication_date":"2001-06-07","ids":{"openalex":"https://openalex.org/W2017004620","doi":"https://doi.org/10.1046/j.1365-2885.2001.00329.x","mag":"2017004620","pmid":"https://pubmed.ncbi.nlm.nih.gov/11442800"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2885.2001.00329.x","doi":"https://doi.org/10.1046/j.1365-2885.2001.00329.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-2885.2001.00329.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2885.2001.00329.x","source":{"id":"https://openalex.org/S23625584","display_name":"Journal of Veterinary Pharmacology and Therapeutics","issn_l":"0140-7783","issn":["0140-7783","1365-2885"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Pharmacology and Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2885.2001.00329.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"S. R. Bailey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133836048","display_name":"Royal Veterinary College","ror":"https://ror.org/01wka8n18","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I133836048"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. R. Bailey","raw_affiliation_strings":["Department of Veterinary Basic Sciences, The Royal Veterinary College, Hawkshead Campus, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Basic Sciences, The Royal Veterinary College, Hawkshead Campus, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK","institution_ids":["https://openalex.org/I133836048"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007575726","display_name":"Fiona M Cunningham","orcid":"https://orcid.org/0000-0002-7445-2419","observed_orcids":["https://orcid.org/0000-0002-7445-2419"]},"institutions":[{"id":"https://openalex.org/I133836048","display_name":"Royal Veterinary College","ror":"https://ror.org/01wka8n18","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I133836048"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"F. M. Cunningham","raw_affiliation_strings":["Department of Veterinary Basic Sciences, The Royal Veterinary College, Hawkshead Campus, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Basic Sciences, The Royal Veterinary College, Hawkshead Campus, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK","institution_ids":["https://openalex.org/I133836048"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007575726"],"corresponding_institution_ids":["https://openalex.org/I133836048"],"apc_list":{"value":4520,"currency":"USD","value_usd":4520},"apc_paid":{"value":4520,"currency":"USD","value_usd":4520},"fwci":0.5712,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.6747209,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"24","issue":"3","first_page":"209","last_page":"214"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.6772000193595886,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.6772000193595886,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.133200004696846,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.032099999487400055,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9150000214576721},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.6389999985694885},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9449999928474426},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9160000085830688},{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":0.7910000085830688},{"id":"https://openalex.org/keywords/substance-p","display_name":"substance P","score":1.0},{"id":"https://openalex.org/keywords/allergic-inflammation","display_name":"allergic inflammation","score":0.7490000128746033},{"id":"https://openalex.org/keywords/eosinophil-recruitment","display_name":"eosinophil recruitment","score":0.9520000219345093},{"id":"https://openalex.org/keywords/horses","display_name":"horses","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.873774528503418},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.7608970999717712},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5845025777816772},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.5330274105072021},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4891117215156555},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.43816766142845154},{"id":"https://openalex.org/C2779675166","wikidata":"https://www.wikidata.org/wiki/Q4732119","display_name":"Allergic inflammation","level":3,"score":0.4134894013404846},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39906883239746094},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35275399684906006},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3503931760787964},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31989356875419617},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.22450211644172668},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10180041193962097},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006734","descriptor_name":"Horse Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006736","descriptor_name":"Horses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006969","descriptor_name":"Hypersensitivity, Immediate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006969","descriptor_name":"Hypersensitivity, Immediate","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013373","descriptor_name":"Substance P","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1046/j.1365-2885.2001.00329.x","doi":"https://doi.org/10.1046/j.1365-2885.2001.00329.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-2885.2001.00329.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2885.2001.00329.x","source":{"id":"https://openalex.org/S23625584","display_name":"Journal of Veterinary Pharmacology and Therapeutics","issn_l":"0140-7783","issn":["0140-7783","1365-2885"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Pharmacology and Therapeutics","raw_type":"journal-article"},{"id":"pmid:11442800","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11442800","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of veterinary pharmacology and therapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:researchonline.rvc.ac.uk:651","doi":null,"is_oa":true,"landing_page_url":"http://researchonline.rvc.ac.uk/id/eprint/651/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402069","display_name":"RVC Research Online (Royal Veterinary College)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I133836048","host_organization_name":"Royal Veterinary College","host_organization_lineage":["https://openalex.org/I133836048"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1046/j.1365-2885.2001.00329.x","doi":"https://doi.org/10.1046/j.1365-2885.2001.00329.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-2885.2001.00329.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2885.2001.00329.x","source":{"id":"https://openalex.org/S23625584","display_name":"Journal of Veterinary Pharmacology and Therapeutics","issn_l":"0140-7783","issn":["0140-7783","1365-2885"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Pharmacology and Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319993","display_name":"Leverhulme Trust","ror":"https://ror.org/012mzw131"},{"id":"https://openalex.org/F4320329182","display_name":"Consortium of International Agricultural Research Centers","ror":"https://ror.org/04c4bm785"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017004620.pdf","grobid_xml":"https://content.openalex.org/works/W2017004620.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W211452860","https://openalex.org/W1532408892","https://openalex.org/W1732449795","https://openalex.org/W1811625932","https://openalex.org/W1973485202","https://openalex.org/W1991925265","https://openalex.org/W1992267510","https://openalex.org/W2000270243","https://openalex.org/W2031706219","https://openalex.org/W2041747892","https://openalex.org/W2062640133","https://openalex.org/W2074011532","https://openalex.org/W2085313845","https://openalex.org/W2091486123","https://openalex.org/W2093149527","https://openalex.org/W2127961356","https://openalex.org/W2139621906","https://openalex.org/W2300656065","https://openalex.org/W4391201110"],"related_works":["https://openalex.org/W2043476331","https://openalex.org/W1979265199","https://openalex.org/W1532408892","https://openalex.org/W4391201110","https://openalex.org/W1984625946","https://openalex.org/W2085313845","https://openalex.org/W2415185096","https://openalex.org/W3008890771","https://openalex.org/W1811625932","https://openalex.org/W2321189813"],"abstract_inverted_index":{"Accumulation":[0],"of":[1,6,52,95,97,102,152,171],"equine":[2,53,60,65],"eosinophils":[3,54,104],"at":[4,133],"sites":[5],"parasite":[7],"infestation":[8],"or":[9,86],"allergic":[10,195],"inflammation":[11,196],"depends":[12],"upon":[13],"their":[14],"adherence":[15,40,51,62,101,151,190],"to":[16,55,63,123,128],"vascular":[17],"endothelial":[18,37,68,187],"cells":[19,148,173],"and":[20,26,44,46,91,99,114,143,156,164,191],"subsequent":[21],"migration":[22],"through":[23],"the":[24,100,121,134],"endothelium":[25],"extracellular":[27],"matrix.":[28],"This":[29],"study":[30],"has":[31],"examined":[32],"whether":[33],"cytokines,":[34],"which":[35,49],"cause":[36],"cell-dependent":[38,188],"eosinophil":[39,61,189,202],"in":[41,117,182,201],"other":[42,183],"species,":[43,184],"histamine":[45,87],"substance":[47,84,124,162],"P,":[48,125],"increase":[50],"protein":[56],"coated":[57],"plastic,":[58],"induce":[59,186],"cultured":[64],"digital":[66],"vein":[67],"cell":[69],"(EDVEC)":[70],"monolayers.":[71],"The":[72],"EDVEC":[73],"monolayers":[74],"were":[75],"stimulated":[76],"with":[77,92],"recombinant":[78],"human":[79],"(rh)":[80],"interleukin":[81],"(IL)-1beta,":[82],"rhTNFalpha,":[83],"P":[85,163],"for":[88,161],"different":[89],"times":[90],"a":[93,131,169,199],"range":[94],"concentrations":[96],"mediators":[98,111,192],"blood":[103],"from":[105],"normal":[106],"horses":[107],"examined.":[108],"All":[109],"four":[110],"caused":[112],"time-":[113],"concentration-dependent":[115],"increases":[116],"adherence.":[118],"However,":[119],"neither":[120],"response":[122],"nor":[126],"that":[127],"histamine,":[129,165],"reached":[130],"maximum":[132],"highest":[135],"concentration":[136],"tested":[137],"(10-3":[138],"M:":[139],"10.6":[140],"+/-":[141,145,154,158],"2.6%":[142],"4.5":[144],"0.6%":[146],"adherent":[147],"vs.":[149],"background":[150],"1.9":[153],"0.4%":[155],"1.1":[157],"0.2%;":[159],"values":[160],"respectively,":[166],"expressed":[167],"as":[168,181],"percentage":[170],"total":[172],"added":[174],"initially;":[175],"n=4).":[176],"These":[177],"data":[178],"suggest":[179],"that,":[180],"cytokines":[185],"released":[193],"during":[194],"may":[197],"play":[198],"role":[200],"recruitment":[203],"by":[204],"this":[205],"mechanism.":[206]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
