{"id":"https://openalex.org/W2017001010","doi":"https://doi.org/10.1097/01.alc.0000183008.62955.2e","title":"A Microdialysis Profile of Met-Enkephalin Release in the Rat Nucleus Accumbens Following Alcohol Administration","display_name":"A Microdialysis Profile of Met-Enkephalin Release in the Rat Nucleus Accumbens Following Alcohol Administration","publication_year":2005,"publication_date":"2005-10-01","ids":{"openalex":"https://openalex.org/W2017001010","doi":"https://doi.org/10.1097/01.alc.0000183008.62955.2e","mag":"2017001010","pmid":"https://pubmed.ncbi.nlm.nih.gov/16269911"},"language":"en","primary_location":{"id":"doi:10.1097/01.alc.0000183008.62955.2e","doi":"https://doi.org/10.1097/01.alc.0000183008.62955.2e","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.alc.0000183008.62955.2e","pdf_url":null,"source":{"id":"https://openalex.org/S115510430","display_name":"Alcoholism Clinical and Experimental Research","issn_l":"0145-6008","issn":["0145-6008","1530-0277","2993-7175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism: Clinical &amp; Experimental Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084556014","display_name":"Peter W. Marinelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]},{"id":"https://openalex.org/I2799434747","display_name":"Douglas Mental Health University Institute","ror":"https://ror.org/05dk2r620","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2799434747"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Peter W. Marinelli","raw_affiliation_strings":["Biobehavioural Pharmacology Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada","Biobehavioural Pharmacology Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada (PWM)","the Departments of Psychiatry and Physiology, Douglas Hospital Research Centre and McGill University, Montr\u00e9al, Qu\u00e9bec, Canada (CG)","the Departments of Psychiatry, Pharmacology, and Therapeutics and Neurology and Neurosurgery, Douglas Hospital Research Centre and McGill University, Montr\u00e9al, Qu\u00e9bec, Canada (RQ)","the Neuroscience Division, the Douglas Hospital Research Centre, Montr\u00e9al, Qu\u00e9bec, Canada (LB)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biobehavioural Pharmacology Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"Biobehavioural Pharmacology Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada (PWM)","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"the Departments of Psychiatry and Physiology, Douglas Hospital Research Centre and McGill University, Montr\u00e9al, Qu\u00e9bec, Canada (CG)","institution_ids":["https://openalex.org/I2799434747","https://openalex.org/I5023651"]},{"raw_affiliation_string":"the Departments of Psychiatry, Pharmacology, and Therapeutics and Neurology and Neurosurgery, Douglas Hospital Research Centre and McGill University, Montr\u00e9al, Qu\u00e9bec, Canada (RQ)","institution_ids":["https://openalex.org/I2799434747","https://openalex.org/I5023651"]},{"raw_affiliation_string":"the Neuroscience Division, the Douglas Hospital Research Centre, Montr\u00e9al, Qu\u00e9bec, Canada (LB)","institution_ids":["https://openalex.org/I2799434747"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Li Bai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]},{"id":"https://openalex.org/I2799434747","display_name":"Douglas Mental Health University Institute","ror":"https://ror.org/05dk2r620","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2799434747"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Li Bai","raw_affiliation_strings":["Biobehavioural Pharmacology Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada (PWM); the Neuroscience Division, the Douglas Hospital Research Centre, Montre\u0301al, Que\u0301bec, Canada (LB); the Departments of Psychiatry, Pharmacology, and Therapeutics and Neurology and Neurosurgery, Douglas Hospital Research Centre and McGill University, Montre\u0301al, Que\u0301bec, Canada (RQ); and the Departments of Psychiatry and Physiology, Douglas Hospital Research Centre and McGill University, Montre\u0301al, Que\u0301bec, Canada (CG)","Biobehavioural Pharmacology Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada (PWM)","the Departments of Psychiatry and Physiology, Douglas Hospital Research Centre and McGill University, Montr\u00e9al, Qu\u00e9bec, Canada (CG)","the Departments of Psychiatry, Pharmacology, and Therapeutics and Neurology and Neurosurgery, Douglas Hospital Research Centre and McGill University, Montr\u00e9al, Qu\u00e9bec, Canada (RQ)","the Neuroscience Division, the Douglas Hospital Research Centre, Montr\u00e9al, Qu\u00e9bec, Canada (LB)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biobehavioural Pharmacology Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada (PWM); the Neuroscience Division, the Douglas Hospital Research Centre, Montre\u0301al, Que\u0301bec, Canada (LB); the Departments of Psychiatry, Pharmacology, and Therapeutics and Neurology and Neurosurgery, Douglas Hospital Research Centre and McGill University, Montre\u0301al, Que\u0301bec, Canada (RQ); and the Departments of Psychiatry and Physiology, Douglas Hospital Research Centre and McGill University, Montre\u0301al, Que\u0301bec, Canada (CG)","institution_ids":["https://openalex.org/I1338135719","https://openalex.org/I2799434747","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Biobehavioural Pharmacology Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada (PWM)","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"the Departments of Psychiatry and Physiology, Douglas Hospital Research Centre and McGill University, Montr\u00e9al, Qu\u00e9bec, Canada (CG)","institution_ids":["https://openalex.org/I2799434747","https://openalex.org/I5023651"]},{"raw_affiliation_string":"the Departments of Psychiatry, Pharmacology, and Therapeutics and Neurology and Neurosurgery, Douglas Hospital Research Centre and McGill University, Montr\u00e9al, Qu\u00e9bec, Canada (RQ)","institution_ids":["https://openalex.org/I2799434747","https://openalex.org/I5023651"]},{"raw_affiliation_string":"the Neuroscience Division, the Douglas Hospital Research Centre, Montr\u00e9al, Qu\u00e9bec, Canada (LB)","institution_ids":["https://openalex.org/I2799434747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113575096","display_name":"R. Quirion","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]},{"id":"https://openalex.org/I2799434747","display_name":"Douglas Mental Health University Institute","ror":"https://ror.org/05dk2r620","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2799434747"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"R??mi Quirion","raw_affiliation_strings":["Biobehavioural Pharmacology Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada (PWM); the Neuroscience Division, the Douglas Hospital Research Centre, Montre\u0301al, Que\u0301bec, Canada (LB); the Departments of Psychiatry, Pharmacology, and Therapeutics and Neurology and Neurosurgery, Douglas Hospital Research Centre and McGill University, Montre\u0301al, Que\u0301bec, Canada (RQ); and the Departments of Psychiatry and Physiology, Douglas Hospital Research Centre and McGill University, Montre\u0301al, Que\u0301bec, Canada (CG)","Biobehavioural Pharmacology Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada (PWM)","the Departments of Psychiatry and Physiology, Douglas Hospital Research Centre and McGill University, Montr\u00e9al, Qu\u00e9bec, Canada (CG)","the Departments of Psychiatry, Pharmacology, and Therapeutics and Neurology and Neurosurgery, Douglas Hospital Research Centre and McGill University, Montr\u00e9al, Qu\u00e9bec, Canada (RQ)","the Neuroscience Division, the Douglas Hospital Research Centre, Montr\u00e9al, Qu\u00e9bec, Canada (LB)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biobehavioural Pharmacology Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada (PWM); the Neuroscience Division, the Douglas Hospital Research Centre, Montre\u0301al, Que\u0301bec, Canada (LB); the Departments of Psychiatry, Pharmacology, and Therapeutics and Neurology and Neurosurgery, Douglas Hospital Research Centre and McGill University, Montre\u0301al, Que\u0301bec, Canada (RQ); and the Departments of Psychiatry and Physiology, Douglas Hospital Research Centre and McGill University, Montre\u0301al, Que\u0301bec, Canada (CG)","institution_ids":["https://openalex.org/I1338135719","https://openalex.org/I2799434747","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Biobehavioural Pharmacology Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada (PWM)","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"the Departments of Psychiatry and Physiology, Douglas Hospital Research Centre and McGill University, Montr\u00e9al, Qu\u00e9bec, Canada (CG)","institution_ids":["https://openalex.org/I2799434747","https://openalex.org/I5023651"]},{"raw_affiliation_string":"the Departments of Psychiatry, Pharmacology, and Therapeutics and Neurology and Neurosurgery, Douglas Hospital Research Centre and McGill University, Montr\u00e9al, Qu\u00e9bec, Canada (RQ)","institution_ids":["https://openalex.org/I2799434747","https://openalex.org/I5023651"]},{"raw_affiliation_string":"the Neuroscience Division, the Douglas Hospital Research Centre, Montr\u00e9al, Qu\u00e9bec, Canada (LB)","institution_ids":["https://openalex.org/I2799434747"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030142121","display_name":"Christina Gianoulakis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]},{"id":"https://openalex.org/I2799434747","display_name":"Douglas Mental Health University Institute","ror":"https://ror.org/05dk2r620","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2799434747"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Christina Gianoulakis","raw_affiliation_strings":["Biobehavioural Pharmacology Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada (PWM); the Neuroscience Division, the Douglas Hospital Research Centre, Montre\u0301al, Que\u0301bec, Canada (LB); the Departments of Psychiatry, Pharmacology, and Therapeutics and Neurology and Neurosurgery, Douglas Hospital Research Centre and McGill University, Montre\u0301al, Que\u0301bec, Canada (RQ); and the Departments of Psychiatry and Physiology, Douglas Hospital Research Centre and McGill University, Montre\u0301al, Que\u0301bec, Canada (CG)","Biobehavioural Pharmacology Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada (PWM)","the Departments of Psychiatry and Physiology, Douglas Hospital Research Centre and McGill University, Montr\u00e9al, Qu\u00e9bec, Canada (CG)","the Departments of Psychiatry, Pharmacology, and Therapeutics and Neurology and Neurosurgery, Douglas Hospital Research Centre and McGill University, Montr\u00e9al, Qu\u00e9bec, Canada (RQ)","the Neuroscience Division, the Douglas Hospital Research Centre, Montr\u00e9al, Qu\u00e9bec, Canada (LB)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biobehavioural Pharmacology Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada (PWM); the Neuroscience Division, the Douglas Hospital Research Centre, Montre\u0301al, Que\u0301bec, Canada (LB); the Departments of Psychiatry, Pharmacology, and Therapeutics and Neurology and Neurosurgery, Douglas Hospital Research Centre and McGill University, Montre\u0301al, Que\u0301bec, Canada (RQ); and the Departments of Psychiatry and Physiology, Douglas Hospital Research Centre and McGill University, Montre\u0301al, Que\u0301bec, Canada (CG)","institution_ids":["https://openalex.org/I1338135719","https://openalex.org/I2799434747","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Biobehavioural Pharmacology Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada (PWM)","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"the Departments of Psychiatry and Physiology, Douglas Hospital Research Centre and McGill University, Montr\u00e9al, Qu\u00e9bec, Canada (CG)","institution_ids":["https://openalex.org/I2799434747","https://openalex.org/I5023651"]},{"raw_affiliation_string":"the Departments of Psychiatry, Pharmacology, and Therapeutics and Neurology and Neurosurgery, Douglas Hospital Research Centre and McGill University, Montr\u00e9al, Qu\u00e9bec, Canada (RQ)","institution_ids":["https://openalex.org/I2799434747","https://openalex.org/I5023651"]},{"raw_affiliation_string":"the Neuroscience Division, the Douglas Hospital Research Centre, Montr\u00e9al, Qu\u00e9bec, Canada (LB)","institution_ids":["https://openalex.org/I2799434747"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5030142121"],"corresponding_institution_ids":["https://openalex.org/I1338135719","https://openalex.org/I2799434747","https://openalex.org/I5023651"],"apc_list":{"value":4110,"currency":"USD","value_usd":4110},"apc_paid":null,"fwci":1.7607,"has_fulltext":false,"cited_by_count":94,"citation_normalized_percentile":{"value":0.82470092,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"29","issue":"10","first_page":"1821","last_page":"1828"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0575999990105629,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/met-enkephalin","display_name":"met-enkephalin","score":0.9380000233650208},{"id":"https://openalex.org/keywords/nucleus-accumbens-shell","display_name":"nucleus accumbens shell","score":0.8740000128746033},{"id":"https://openalex.org/keywords/alcohol-administration","display_name":"alcohol administration","score":0.8399999737739563},{"id":"https://openalex.org/keywords/opioid-system","display_name":"opioid system","score":0.5809999704360962},{"id":"https://openalex.org/keywords/enkephalin-release","display_name":"enkephalin release","score":0.7620000243186951},{"id":"https://openalex.org/keywords/delta-opioid-receptor","display_name":"delta opioid receptor","score":0.8379999995231628},{"id":"https://openalex.org/keywords/mu-opioid-receptor","display_name":"mu-opioid receptor","score":0.9179999828338623},{"id":"https://openalex.org/keywords/alcohol-drinking-behavior","display_name":"alcohol drinking behavior","score":0.6909999847412109},{"id":"https://openalex.org/keywords/ethanol-dose-response","display_name":"ethanol dose-response","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C50156730","wikidata":"https://www.wikidata.org/wiki/Q3856966","display_name":"Microdialysis","level":3,"score":0.9549292922019958},{"id":"https://openalex.org/C2776552330","wikidata":"https://www.wikidata.org/wiki/Q1476178","display_name":"Nucleus accumbens","level":3,"score":0.9123979806900024},{"id":"https://openalex.org/C2777803847","wikidata":"https://www.wikidata.org/wiki/Q325101","display_name":"Enkephalin","level":4,"score":0.6430776119232178},{"id":"https://openalex.org/C3017995582","wikidata":"https://www.wikidata.org/wiki/Q417189","display_name":"Endogenous opioid","level":4,"score":0.6263645887374878},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.6200157999992371},{"id":"https://openalex.org/C88016717","wikidata":"https://www.wikidata.org/wiki/Q417189","display_name":"Opioid peptide","level":4,"score":0.5848124027252197},{"id":"https://openalex.org/C2776007765","wikidata":"https://www.wikidata.org/wiki/Q1960495","display_name":"Met-enkephalin","level":5,"score":0.5195967555046082},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.4910552501678467},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.48935598134994507},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.482995867729187},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4628870189189911},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.46258899569511414},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45883578062057495},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.4214562475681305},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41011613607406616},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37199175357818604},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.34483158588409424},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3269686698913574},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1167183518409729},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10331737995147705}],"mesh":[{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002492","descriptor_name":"Central Nervous System Depressants","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002492","descriptor_name":"Central Nervous System Depressants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004744","descriptor_name":"Enkephalin, Methionine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009714","descriptor_name":"Nucleus Accumbens","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009714","descriptor_name":"Nucleus Accumbens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017551","descriptor_name":"Microdialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/01.alc.0000183008.62955.2e","doi":"https://doi.org/10.1097/01.alc.0000183008.62955.2e","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.alc.0000183008.62955.2e","pdf_url":null,"source":{"id":"https://openalex.org/S115510430","display_name":"Alcoholism Clinical and Experimental Research","issn_l":"0145-6008","issn":["0145-6008","1530-0277","2993-7175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism: Clinical &amp; Experimental Research","raw_type":"journal-article"},{"id":"pmid:16269911","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16269911","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism, clinical and experimental research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1006799540","https://openalex.org/W1965472158","https://openalex.org/W1968338376","https://openalex.org/W1974215157","https://openalex.org/W1975711542","https://openalex.org/W1978251406","https://openalex.org/W1983446192","https://openalex.org/W1983676227","https://openalex.org/W1992677947","https://openalex.org/W1993631201","https://openalex.org/W1994689111","https://openalex.org/W1995865564","https://openalex.org/W1999193429","https://openalex.org/W2000885259","https://openalex.org/W2001345670","https://openalex.org/W2002947893","https://openalex.org/W2021349110","https://openalex.org/W2025506805","https://openalex.org/W2026659085","https://openalex.org/W2030713688","https://openalex.org/W2030913487","https://openalex.org/W2031376506","https://openalex.org/W2034228917","https://openalex.org/W2035911300","https://openalex.org/W2038492374","https://openalex.org/W2043681784","https://openalex.org/W2047213946","https://openalex.org/W2050983933","https://openalex.org/W2053051844","https://openalex.org/W2059665812","https://openalex.org/W2063696773","https://openalex.org/W2072165879","https://openalex.org/W2080126622","https://openalex.org/W2081910239","https://openalex.org/W2124237113","https://openalex.org/W2166104912","https://openalex.org/W2172323892","https://openalex.org/W2395479098","https://openalex.org/W2443163703","https://openalex.org/W4301271664"],"related_works":["https://openalex.org/W1996859371","https://openalex.org/W7010663876","https://openalex.org/W2061500344","https://openalex.org/W1974215157","https://openalex.org/W2031376506","https://openalex.org/W2081748369","https://openalex.org/W1997197859","https://openalex.org/W7038631795","https://openalex.org/W2974415342","https://openalex.org/W2050983933"],"abstract_inverted_index":{"BACKGROUND:":[0],"Pharmacological":[1],"studies":[2,30],"have":[3,31,40,216],"implicated":[4,56],"the":[5,27,48,69,75,86,98,116,120,180,189,208,221,246],"endogenous":[6],"opioid":[7,22,38],"system":[8],"in":[9,62,85,97,134,179,207,245],"mediating":[10,63],"alcohol":[11,18,64,78,196,238],"intake.":[12],"Other":[13],"evidence":[14,53],"has":[15,55],"shown":[16],"that":[17,54,92,283],"administration":[19,79],"can":[20],"influence":[21],"activity.":[23],"In":[24,230],"this":[25,231],"regard,":[26],"majority":[28],"of":[29,68,77,83,119,131,161,164,177,193,198,211,223,237,241,279],"concentrated":[32],"on":[33,80,220],"endorphinergic":[34],"systems,":[35,59],"whereas":[36],"other":[37,227],"systems":[39],"been":[41],"granted":[42],"comparably":[43],"less":[44],"attention.":[45],"This":[46,275],"is":[47],"case":[49],"despite":[50],"some":[51],"compelling":[52],"enkephalinergic":[57],"peptide":[58],"particularly":[60],"Met-enkephalin,":[61],"preference.":[65],"The":[66,175],"aim":[67],"present":[70],"study":[71],"was":[72,126,239],"to":[73,257,269],"investigate":[74],"effect":[76,219],"extracellular":[81,209],"levels":[82,176,210],"Met-enkephalin":[84,178,224,243],"rat":[87],"nucleus":[88,121,247],"accumbens--a":[89],"brain":[90],"region":[91,118],"plays":[93],"a":[94,111,129,202,217,234],"significant":[95,203],"role":[96],"processes":[99],"underlying":[100],"reinforcement":[101],"and":[102,136,140,204],"stress.":[103],"METHODS:":[104],"Male":[105],"Sprague-Dawley":[106],"rats":[107,139,151],"were":[108,142,152,182],"implanted":[109],"with":[110,155,184],"microdialysis":[112],"probe":[113],"aimed":[114],"at":[115,128,144,225],"shell":[117],"accumbens.":[122,248],"Artificial":[123],"cerebrospinal":[124],"fluid":[125],"pumped":[127],"rate":[130],"1.75":[132],"mul/min":[133],"awake":[135],"freely":[137],"moving":[138],"dialysates":[141,181],"collected":[143],"30-minute":[145],"intervals.":[146],"After":[147],"several":[148],"baseline":[149],"collections,":[150],"injected":[153],"intraperitoneally":[154],"either":[156],"physiological":[157],"saline":[158],"or":[159,169,272],"one":[160,278],"four":[162],"doses":[163],"alcohol:":[165],"0.8,":[166],"1.6,":[167],"2.4,":[168],"3.2":[170],"g/kg":[171,200],"ethanol":[172],"body":[173],"weight.":[174],"analyzed":[183],"solid-phase":[185],"radioimmunoassay.":[186],"RESULTS:":[187],"Within":[188],"first":[190],"30":[191],"minutes":[192],"administration,":[194],"an":[195],"dose":[197,236],"1.6":[199],"caused":[201],"prolonged":[205],"elevation":[206],"Met-enkephalin.":[212],"Alcohol":[213],"did":[214],"not":[215],"major":[218],"release":[222,244,254],"any":[226],"dose.":[228],"CONCLUSIONS:":[229],"experiment,":[232],"only":[233],"moderate":[235],"capable":[240],"stimulating":[242],"Enkephalins":[249],"may":[250,263,276],"modulate":[251,284],"local":[252],"neurotransmitter":[253],"by":[255,267],"binding":[256,268],"presynaptic":[258],"Delta-opioid":[259],"receptors,":[260],"or,":[261],"they":[262],"inhibit":[264],"effector":[265],"cells":[266],"postsynaptic":[270],"Delta-":[271],"mu-opioid":[273],"receptors.":[274],"be":[277],"multiple":[280],"neurological":[281],"mechanisms":[282],"alcohol-drinking":[285],"behavior.":[286]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
