{"id":"https://openalex.org/W2016994955","doi":"https://doi.org/10.1074/jbc.272.3.1703","title":"Mutation of an Amino Acid Residue Influencing Potassium Coupling in the Glutamate Transporter GLT-1 Induces Obligate Exchange","display_name":"Mutation of an Amino Acid Residue Influencing Potassium Coupling in the Glutamate Transporter GLT-1 Induces Obligate Exchange","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2016994955","doi":"https://doi.org/10.1074/jbc.272.3.1703","mag":"2016994955","pmid":"https://pubmed.ncbi.nlm.nih.gov/8999849"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.272.3.1703","doi":"https://doi.org/10.1074/jbc.272.3.1703","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.3.1703","pdf_url":"http://www.jbc.org/article/S0021925819674703/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819674703/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112780072","display_name":"Michael P. Kavanaugh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2802707198","display_name":"Vollum Institute","ror":"https://ror.org/054hm6j14","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802707198"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael P. Kavanaugh","raw_affiliation_strings":["Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA","From the \u2021 Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2802707198"]},{"raw_affiliation_string":"From the \u2021 Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201 and","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2802707198"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060349010","display_name":"Annie Bendahan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Annie Bendahan","raw_affiliation_strings":["Department of Biochemistry, Hadassah Medical School, The Hebrew University, Jerusalem 91120, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Hadassah Medical School, The Hebrew University, Jerusalem 91120, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111663051","display_name":"Noa Zerangue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2802707198","display_name":"Vollum Institute","ror":"https://ror.org/054hm6j14","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802707198"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noa Zerangue","raw_affiliation_strings":["From the Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201 and","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2802707198"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100423548","display_name":"Yumin Zhang","orcid":"https://orcid.org/0000-0003-0767-1221","observed_orcids":["https://orcid.org/0000-0003-0767-1221","https://orcid.org/0000-0002-2064-8440"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yumin Zhang","raw_affiliation_strings":["Department of Biochemistry, Hadassah Medical School, The Hebrew University, Jerusalem 91120, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Hadassah Medical School, The Hebrew University, Jerusalem 91120, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112092008","display_name":"Baruch I. Kanner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Baruch I. Kanner","raw_affiliation_strings":["Department of Biochemistry, Hadassah Medical School, The Hebrew University, Jerusalem 91120, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Hadassah Medical School, The Hebrew University, Jerusalem 91120, Israel","institution_ids":["https://openalex.org/I197251160"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5112092008"],"corresponding_institution_ids":["https://openalex.org/I197251160"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":5.9091,"has_fulltext":true,"cited_by_count":165,"citation_normalized_percentile":{"value":0.97942122,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"272","issue":"3","first_page":"1703","last_page":"1708"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.6875,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.6875,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.2964000105857849,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glt-1","display_name":"GLT-1","score":0.8859999775886536},{"id":"https://openalex.org/keywords/glutamate-transporters","display_name":"glutamate transporters","score":0.8930000066757202},{"id":"https://openalex.org/keywords/ion-coupling","display_name":"ion coupling","score":0.6230000257492065},{"id":"https://openalex.org/keywords/chloride-conductance","display_name":"chloride conductance","score":0.8500000238418579},{"id":"https://openalex.org/keywords/ion-permeation-pathway","display_name":"ion permeation pathway","score":0.7639999985694885},{"id":"https://openalex.org/keywords/transporter-kinetics","display_name":"transporter kinetics","score":0.3720000088214874}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6223472356796265},{"id":"https://openalex.org/C2778740566","wikidata":"https://www.wikidata.org/wiki/Q181136","display_name":"Glutamic acid","level":3,"score":0.5473459362983704},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5395350456237793},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.522478461265564},{"id":"https://openalex.org/C16696662","wikidata":"https://www.wikidata.org/wiki/Q17079236","display_name":"Neurotransmitter transporter","level":4,"score":0.5198391079902649},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.5048647522926331},{"id":"https://openalex.org/C189184402","wikidata":"https://www.wikidata.org/wiki/Q3454536","display_name":"Kainate receptor","level":5,"score":0.49297428131103516},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4927249252796173},{"id":"https://openalex.org/C156310829","wikidata":"https://www.wikidata.org/wiki/Q14913170","display_name":"Glutamate aspartate transporter","level":5,"score":0.43214157223701477},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.4267587661743164},{"id":"https://openalex.org/C188053792","wikidata":"https://www.wikidata.org/wiki/Q3640664","display_name":"Cotransporter","level":3,"score":0.4258365333080292},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.4116694927215576},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.3981216847896576},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2569168210029602},{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.15646326541900635},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C49051014","wikidata":"https://www.wikidata.org/wiki/Q2033959","display_name":"Metabotropic glutamate receptor","level":4,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D027322","descriptor_name":"Amino Acid Transport System X-AG","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.272.3.1703","doi":"https://doi.org/10.1074/jbc.272.3.1703","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.3.1703","pdf_url":"http://www.jbc.org/article/S0021925819674703/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:8999849","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8999849","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:scholarworks.umt.edu:biopharm_pubs-1055","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.umt.edu/biopharm_pubs/55","pdf_url":null,"source":{"id":"https://openalex.org/S190740074","display_name":"The Mathematics Enthusiast","issn_l":"1551-3440","issn":["1551-3440"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedical and Pharmaceutical Sciences Faculty Publications","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1074/jbc.272.3.1703","doi":"https://doi.org/10.1074/jbc.272.3.1703","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.3.1703","pdf_url":"http://www.jbc.org/article/S0021925819674703/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5447155094","display_name":"BASIC AMINO ACID TRANSPORTERS","funder_award_id":"R01GM048709","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306489","display_name":"Charles H. Revson Foundation","ror":"https://ror.org/02c9tf451"},{"id":"https://openalex.org/F4320322248","display_name":"Israel Academy of Sciences and Humanities","ror":"https://ror.org/03c6c9520"},{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016994955.pdf","grobid_xml":"https://content.openalex.org/works/W2016994955.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1486976896","https://openalex.org/W1491108164","https://openalex.org/W1512720139","https://openalex.org/W1582586031","https://openalex.org/W1604834760","https://openalex.org/W1615205471","https://openalex.org/W1969400861","https://openalex.org/W1972161610","https://openalex.org/W1975715220","https://openalex.org/W1976754780","https://openalex.org/W1977634657","https://openalex.org/W1981837661","https://openalex.org/W1983197885","https://openalex.org/W1991701465","https://openalex.org/W1995122601","https://openalex.org/W1997213144","https://openalex.org/W1998478437","https://openalex.org/W1998527909","https://openalex.org/W1999613366","https://openalex.org/W2005242158","https://openalex.org/W2009812273","https://openalex.org/W2017519243","https://openalex.org/W2027905503","https://openalex.org/W2028002685","https://openalex.org/W2038189991","https://openalex.org/W2040091117","https://openalex.org/W2074792377","https://openalex.org/W2075625699","https://openalex.org/W2078310394","https://openalex.org/W2086529934","https://openalex.org/W2090796300","https://openalex.org/W2094533832","https://openalex.org/W2094673798","https://openalex.org/W2094843626","https://openalex.org/W2157853053","https://openalex.org/W2168614027"],"related_works":["https://openalex.org/W2106227890","https://openalex.org/W2168614027","https://openalex.org/W2068961732","https://openalex.org/W2026338972","https://openalex.org/W2046055422","https://openalex.org/W2080963138","https://openalex.org/W2972348590","https://openalex.org/W1994260444","https://openalex.org/W2000577135","https://openalex.org/W2075185645"],"abstract_inverted_index":{"Glutamate":[0],"transporters":[1],"maintain":[2],"low":[3],"synaptic":[4],"concentrations":[5],"of":[6,13,18,29,46,55,115],"neurotransmitter":[7],"by":[8,27,68,80],"coupling":[9,42],"uptake":[10],"to":[11,58],"flux":[12,90],"other":[14],"ions.":[15],"After":[16],"cotransport":[17],"glutamic":[19],"acid":[20,36],"with":[21,121],"Na+,":[22],"the":[23,47,81,116,122],"cycle":[24],"is":[25,118],"completed":[26],"countertransport":[28],"K+.":[30,69],"We":[31],"have":[32],"identified":[33],"an":[34],"amino":[35],"residue":[37,57,86],"(glutamate":[38],"404)":[39],"influencing":[40],"ion":[41,123],"in":[43,51,98,105],"a":[44,74,95],"domain":[45],"transporter":[48,117],"implicated":[49],"previously":[50],"kainate":[52],"binding.":[53],"Mutation":[54],"this":[56,85,111],"aspartate":[59],"(E404D)":[60],"prevents":[61],"both":[62],"forward":[63],"and":[64,73,101,108],"reverse":[65],"transport":[66],"induced":[67],"Sodium-dependent":[70],"transmitter":[71],"exchange":[72],"transporter-mediated":[75],"chloride":[76],"conductance":[77],"are":[78,103],"unaffected":[79],"mutation,":[82],"indicating":[83],"that":[84,110],"selectively":[87],"influences":[88],"potassium":[89,102],"coupling.":[91],"The":[92],"results":[93],"support":[94],"kinetic":[96],"model":[97],"which":[99],"sodium":[100],"translocated":[104],"distinct":[106],"steps":[107],"suggest":[109],"highly":[112],"conserved":[113],"region":[114],"intimately":[119],"associated":[120],"permeation":[124],"pathway.":[125]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
