{"id":"https://openalex.org/W2016993760","doi":"https://doi.org/10.1021/cb300018x","title":"Small-Molecule Inhibitors of Bacterial AddAB and RecBCD Helicase-Nuclease DNA Repair Enzymes","display_name":"Small-Molecule Inhibitors of Bacterial AddAB and RecBCD Helicase-Nuclease DNA Repair Enzymes","publication_year":2012,"publication_date":"2012-03-23","ids":{"openalex":"https://openalex.org/W2016993760","doi":"https://doi.org/10.1021/cb300018x","mag":"2016993760","pmid":"https://pubmed.ncbi.nlm.nih.gov/22443934","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3356449"},"language":"en","primary_location":{"id":"doi:10.1021/cb300018x","doi":"https://doi.org/10.1021/cb300018x","is_oa":false,"landing_page_url":"https://doi.org/10.1021/cb300018x","pdf_url":null,"source":{"id":"https://openalex.org/S118914585","display_name":"ACS Chemical Biology","issn_l":"1554-8929","issn":["1554-8929","1554-8937"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3356449","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051283248","display_name":"Susan K. Amundsen","orcid":"https://orcid.org/0000-0003-2953-7998","observed_orcids":["https://orcid.org/0000-0003-2953-7998"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan K. Amundsen","raw_affiliation_strings":["Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington\r98109, United States","Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington#R#98109, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington\r98109, United States","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington#R#98109, United States","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034348335","display_name":"Timothy Spicer","orcid":"https://orcid.org/0000-0002-9080-4226","observed_orcids":["https://orcid.org/0000-0002-9080-4226"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Spicer","raw_affiliation_strings":["Scripps\rResearch Institute Molecular\rScreening Center, Lead Identification Division, Translational Research Institute, Jupiter, Florida 33458, United States","Scripps#R#Research Institute Molecular#R#Screening Center, Lead Identification Division, Translational Research Institute, Jupiter, Florida 33458, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scripps\rResearch Institute Molecular\rScreening Center, Lead Identification Division, Translational Research Institute, Jupiter, Florida 33458, United States","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Scripps#R#Research Institute Molecular#R#Screening Center, Lead Identification Division, Translational Research Institute, Jupiter, Florida 33458, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020192580","display_name":"Ahmet Karabulut","orcid":"https://orcid.org/0000-0003-2577-841X","observed_orcids":["https://orcid.org/0000-0003-2577-841X"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahmet C. Karabulut","raw_affiliation_strings":["Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington\r98109, United States","Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington#R#98109, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington\r98109, United States","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington#R#98109, United States","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111663046","display_name":"Luz M. Londono","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luz Marina Londo\u00f1o","raw_affiliation_strings":["Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington\r98109, United States","Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington#R#98109, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington\r98109, United States","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington#R#98109, United States","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021420487","display_name":"Christina Eberhart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Eberhart","raw_affiliation_strings":["Scripps\rResearch Institute Molecular\rScreening Center, Lead Identification Division, Translational Research Institute, Jupiter, Florida 33458, United States","Scripps#R#Research Institute Molecular#R#Screening Center, Lead Identification Division, Translational Research Institute, Jupiter, Florida 33458, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scripps\rResearch Institute Molecular\rScreening Center, Lead Identification Division, Translational Research Institute, Jupiter, Florida 33458, United States","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Scripps#R#Research Institute Molecular#R#Screening Center, Lead Identification Division, Translational Research Institute, Jupiter, Florida 33458, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047400165","display_name":"Virneliz Fern\u00e1ndez Vega","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Virneliz Fernandez Vega","raw_affiliation_strings":["Scripps\rResearch Institute Molecular\rScreening Center, Lead Identification Division, Translational Research Institute, Jupiter, Florida 33458, United States","Scripps#R#Research Institute Molecular#R#Screening Center, Lead Identification Division, Translational Research Institute, Jupiter, Florida 33458, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scripps\rResearch Institute Molecular\rScreening Center, Lead Identification Division, Translational Research Institute, Jupiter, Florida 33458, United States","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Scripps#R#Research Institute Molecular#R#Screening Center, Lead Identification Division, Translational Research Institute, Jupiter, Florida 33458, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085206283","display_name":"Thomas D. Bannister","orcid":"https://orcid.org/0000-0003-0683-8886","observed_orcids":["https://orcid.org/0000-0003-0683-8886"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas D. Bannister","raw_affiliation_strings":["Scripps Research Institute Department\rof Chemistry, Translational Research Institute, Jupiter, Florida 33458, United States","Scripps Research Institute Department#R#of Chemistry, Translational Research Institute, Jupiter, Florida 33458, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scripps Research Institute Department\rof Chemistry, Translational Research Institute, Jupiter, Florida 33458, United States","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Scripps Research Institute Department#R#of Chemistry, Translational Research Institute, Jupiter, Florida 33458, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105562989","display_name":"Peter Hodder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter Hodder","raw_affiliation_strings":["Department of Molecular Therapeutics, Scripps Florida, Jupiter, Florida 33458, United States","Scripps\rResearch Institute Molecular\rScreening Center, Lead Identification Division, Translational Research Institute, Jupiter, Florida 33458, United States","Scripps#R#Research Institute Molecular#R#Screening Center, Lead Identification Division, Translational Research Institute, Jupiter, Florida 33458, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Therapeutics, Scripps Florida, Jupiter, Florida 33458, United States","institution_ids":[]},{"raw_affiliation_string":"Scripps\rResearch Institute Molecular\rScreening Center, Lead Identification Division, Translational Research Institute, Jupiter, Florida 33458, United States","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Scripps#R#Research Institute Molecular#R#Screening Center, Lead Identification Division, Translational Research Institute, Jupiter, Florida 33458, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017146305","display_name":"Gerald R. Smith","orcid":"https://orcid.org/0000-0002-8747-1352","observed_orcids":["https://orcid.org/0000-0002-8747-1352"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gerald R. Smith","raw_affiliation_strings":["Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington\r98109, United States","Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington#R#98109, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington\r98109, United States","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington#R#98109, United States","institution_ids":["https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017146305","https://openalex.org/A5105562989"],"corresponding_institution_ids":["https://openalex.org/I123431417","https://openalex.org/I4210089486"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.6423,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.64921094,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"7","issue":"5","first_page":"879","last_page":"891"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.043299999088048935,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recbcd","display_name":"RecBCD","score":0.9890000224113464},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.8629999756813049},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.9419999718666077},{"id":"https://openalex.org/keywords/genetic-recombination","display_name":"genetic recombination","score":0.8970000147819519},{"id":"https://openalex.org/keywords/helicobacter-pylori","display_name":"Helicobacter pylori","score":0.8539999723434448},{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"high-throughput screening","score":0.906000018119812},{"id":"https://openalex.org/keywords/antibacterial-agents","display_name":"antibacterial agents","score":0.8629999756813049},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8970000147819519}],"concepts":[{"id":"https://openalex.org/C174742784","wikidata":"https://www.wikidata.org/wiki/Q2066326","display_name":"RecBCD","level":4,"score":0.9780325293540955},{"id":"https://openalex.org/C2777271071","wikidata":"https://www.wikidata.org/wiki/Q422529","display_name":"Nuclease","level":3,"score":0.8580241203308105},{"id":"https://openalex.org/C161223559","wikidata":"https://www.wikidata.org/wiki/Q138864","display_name":"Helicase","level":4,"score":0.8149051666259766},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6887113451957703},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6144647002220154},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.593672513961792},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.5912957787513733},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4957664906978607},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.4941401779651642},{"id":"https://openalex.org/C2780852648","wikidata":"https://www.wikidata.org/wiki/Q143584","display_name":"SOS response","level":4,"score":0.4841040372848511},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.4435872435569763},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42764389514923096},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28873419761657715},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.08610349893569946}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D005090","descriptor_name":"Exodeoxyribonucleases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D043211","descriptor_name":"Exodeoxyribonuclease V","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/cb300018x","doi":"https://doi.org/10.1021/cb300018x","is_oa":false,"landing_page_url":"https://doi.org/10.1021/cb300018x","pdf_url":null,"source":{"id":"https://openalex.org/S118914585","display_name":"ACS Chemical Biology","issn_l":"1554-8929","issn":["1554-8929","1554-8937"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Biology","raw_type":"journal-article"},{"id":"pmid:22443934","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22443934","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS chemical biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2653408","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3356449","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3356449","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3356449","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ACS Chem Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2653408","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3356449","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2469392734","display_name":"The Comprehensive Center for Chemical Probe Discovery and Optimization at Scripps","funder_award_id":"U54MH084512","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G4958027118","display_name":null,"funder_award_id":"R01 GM031693-S1","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6480139785","display_name":"Molecular Analysis of Hotspots of Genetic Recombination","funder_award_id":"R01GM031693","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7426578198","display_name":"Novel Antibacterial Drugs Targeting DNA Repair Enzymes","funder_award_id":"R03AI083736","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000880613","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA015704","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1533085219","https://openalex.org/W1561913337","https://openalex.org/W1574517022","https://openalex.org/W1576004660","https://openalex.org/W1587897730","https://openalex.org/W1600849029","https://openalex.org/W1600925677","https://openalex.org/W1928656130","https://openalex.org/W1942298984","https://openalex.org/W1969015205","https://openalex.org/W1980357487","https://openalex.org/W1984090080","https://openalex.org/W1989347011","https://openalex.org/W1995823295","https://openalex.org/W1996007131","https://openalex.org/W2005402849","https://openalex.org/W2015409494","https://openalex.org/W2020490067","https://openalex.org/W2023137476","https://openalex.org/W2024327795","https://openalex.org/W2025248053","https://openalex.org/W2025903402","https://openalex.org/W2026297834","https://openalex.org/W2027989895","https://openalex.org/W2034760752","https://openalex.org/W2036031177","https://openalex.org/W2040921700","https://openalex.org/W2043198662","https://openalex.org/W2047915187","https://openalex.org/W2051549128","https://openalex.org/W2064402458","https://openalex.org/W2065688789","https://openalex.org/W2069957134","https://openalex.org/W2073534733","https://openalex.org/W2078898807","https://openalex.org/W2086978674","https://openalex.org/W2107366422","https://openalex.org/W2108845943","https://openalex.org/W2111714931","https://openalex.org/W2125808742","https://openalex.org/W2130487552","https://openalex.org/W2137816917","https://openalex.org/W2145532900","https://openalex.org/W2151144263","https://openalex.org/W2153556669","https://openalex.org/W2154182477","https://openalex.org/W2154629946","https://openalex.org/W2154691494","https://openalex.org/W2160521062","https://openalex.org/W2169480215","https://openalex.org/W2171841656","https://openalex.org/W2260135563","https://openalex.org/W4251445005"],"related_works":["https://openalex.org/W264072638","https://openalex.org/W2766178777","https://openalex.org/W4292877179","https://openalex.org/W2024293010","https://openalex.org/W2114055740","https://openalex.org/W4391744279","https://openalex.org/W2119455357","https://openalex.org/W2015409494","https://openalex.org/W1972480564","https://openalex.org/W2047915187"],"abstract_inverted_index":{"The":[0],"AddAB":[1,112,129,164],"and":[2,14,24,37,94,132,156,165,168,171,200,218,226],"RecBCD":[3,74,131,166],"helicase-nucleases":[4],"are":[5,15],"related":[6,78,192],"enzymes":[7,30,45,241],"prevalent":[8],"among":[9],"bacteria":[10],"but":[11],"not":[12,47],"eukaryotes":[13],"instrumental":[16],"in":[17,25,67,91,99,115,172,180,185,204,214,227],"the":[18,57,72,100,109,138,181,205],"repair":[19],"of":[20,44,59,108,140,162,195,221,240,248],"DNA":[21],"double-strand":[22],"breaks":[23],"genetic":[26],"recombination.":[27],"Although":[28],"these":[29,196,222],"have":[31,46],"been":[32,48],"extensively":[33],"studied":[34],"both":[35,224],"genetically":[36,83],"biochemically,":[38],"inhibitors":[39,107],"specific":[40],"for":[41,89,106,160,175,244],"this":[42,87,149,238],"class":[43,239],"reported.":[49],"We":[50,85],"developed":[51],"a":[52,77,133],"high-throughput":[53],"screen":[54,88],"based":[55],"on":[56,142],"ability":[58],"phage":[60,146],"T4":[61],"gene":[62],"2":[63],"mutants":[64],"to":[65,193,233],"grow":[66],"Escherichia":[68],"coli":[69,118],"only":[70],"if":[71],"host":[73],"enzyme,":[75],"or":[76,82,130,187],"helicase-nuclease,":[79],"is":[80,242],"inhibited":[81],"inactivated.":[84],"optimized":[86],"use":[90],"1536-well":[92],"plates":[93],"screened":[95],"326,100":[96],"small":[97],"molecules":[98],"NIH":[101],"molecular":[102],"libraries":[103],"sample":[104],"collection":[105],"Helicobacter":[110],"pylori":[111],"enzyme":[113],"expressed":[114],"an":[116],"E.":[117],"recBCD":[119],"deletion":[120],"strain.":[121],"Secondary":[122],"screening":[123,150],"used":[124],"assays":[125,174],"with":[126],"cells":[127],"expressing":[128],"viability":[134],"assay":[135],"that":[136],"measured":[137],"effect":[139],"compounds":[141,153,210],"cell":[143],"growth":[144],"without":[145],"infection.":[147],"From":[148],"campaign,":[151],"12":[152],"exhibiting":[154],"efficacy":[155],"selectivity":[157],"were":[158,178,197,202],"tested":[159],"inhibition":[161],"purified":[163,225],"helicase":[167],"nuclease":[169],"activities":[170],"cell-based":[173],"recombination;":[176],"seven":[177],"active":[179,203],"0.1-50":[182,206],"\u03bcM":[183,207],"range":[184],"one":[186],"another":[188],"assay.":[189],"Compounds":[190],"structurally":[191],"two":[194],"similarly":[198],"tested,":[199],"three":[201],"range.":[208],"These":[209],"should":[211],"be":[212],"useful":[213,234],"further":[215],"enzymatic,":[216],"genetic,":[217],"physiological":[219],"studies":[220],"enzymes,":[223],"cells.":[228],"They":[229],"may":[230],"also":[231],"lead":[232],"antibacterial":[235],"agents,":[236],"since":[237],"needed":[243],"successful":[245],"bacterial":[246],"infection":[247],"mammals.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
