{"id":"https://openalex.org/W2016991456","doi":"https://doi.org/10.1242/jcs.00866","title":"Runx2deficiency in chondrocytes causes adipogenic changes in vitro","display_name":"Runx2deficiency in chondrocytes causes adipogenic changes in vitro","publication_year":2003,"publication_date":"2003-12-31","ids":{"openalex":"https://openalex.org/W2016991456","doi":"https://doi.org/10.1242/jcs.00866","mag":"2016991456","pmid":"https://pubmed.ncbi.nlm.nih.gov/14702386"},"language":"en","primary_location":{"id":"doi:10.1242/jcs.00866","doi":"https://doi.org/10.1242/jcs.00866","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.00866","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027049654","display_name":"Hirayuki Enomoto","orcid":"https://orcid.org/0000-0003-1334-1149","observed_orcids":["https://orcid.org/0000-0003-1334-1149"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirayuki Enomoto","raw_affiliation_strings":["Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048288270","display_name":"Tatsuya Furuichi","orcid":"https://orcid.org/0000-0001-5656-1235","observed_orcids":["https://orcid.org/0000-0001-5656-1235"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuya Furuichi","raw_affiliation_strings":["Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063139100","display_name":"Akira Zanma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90469020","display_name":"Teijin (Japan)","ror":"https://ror.org/038kxkq33","country_code":"JP","type":"company","lineage":["https://openalex.org/I90469020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Zanma","raw_affiliation_strings":["Teijin Institute for Biomedical Research, Teijin Ltd., Hino, Tokyo 191-8512, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Teijin Institute for Biomedical Research, Teijin Ltd., Hino, Tokyo 191-8512, Japan","institution_ids":["https://openalex.org/I90469020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001613323","display_name":"Kei Yamana","orcid":"https://orcid.org/0009-0009-5242-4300","observed_orcids":["https://orcid.org/0009-0009-5242-4300"]},"institutions":[{"id":"https://openalex.org/I90469020","display_name":"Teijin (Japan)","ror":"https://ror.org/038kxkq33","country_code":"JP","type":"company","lineage":["https://openalex.org/I90469020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kei Yamana","raw_affiliation_strings":["Teijin Institute for Biomedical Research, Teijin Ltd., Hino, Tokyo 191-8512, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Teijin Institute for Biomedical Research, Teijin Ltd., Hino, Tokyo 191-8512, Japan","institution_ids":["https://openalex.org/I90469020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111698509","display_name":"Carolina Andrea Yoshida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Carolina Yoshida","raw_affiliation_strings":["Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan","Department of Orthodontics and Dentofacial Orthopedics, Osaka University Faculty of Dentistry, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Orthodontics and Dentofacial Orthopedics, Osaka University Faculty of Dentistry, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023497800","display_name":"Satoru Sumitani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoru Sumitani","raw_affiliation_strings":["Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011984129","display_name":"Hiroyasu Yamamoto","orcid":"https://orcid.org/0000-0003-0666-6172","observed_orcids":["https://orcid.org/0000-0003-0666-6172"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyasu Yamamoto","raw_affiliation_strings":["Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101831836","display_name":"Motomi Enomoto\u2010Iwamoto","orcid":"https://orcid.org/0000-0002-9589-9607","observed_orcids":["https://orcid.org/0000-0002-9589-9607","https://orcid.org/0000-0002-1898-5974"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I2799360765","display_name":"Thomas Jefferson University Hospital","ror":"https://ror.org/04zhhva53","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799360765","https://openalex.org/I4210114575"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Motomi Enomoto-Iwamoto","raw_affiliation_strings":["Department of Orthopaedic Surgery, Thomas Jefferson Medical College, Philadelphia PA 19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Thomas Jefferson Medical College, Philadelphia PA 19107, USA","institution_ids":["https://openalex.org/I149251103","https://openalex.org/I2799360765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101831835","display_name":"Masahiro Iwamoto","orcid":"https://orcid.org/0000-0001-5045-9352","observed_orcids":["https://orcid.org/0000-0001-5045-9352"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I2799360765","display_name":"Thomas Jefferson University Hospital","ror":"https://ror.org/04zhhva53","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799360765","https://openalex.org/I4210114575"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masahiro Iwamoto","raw_affiliation_strings":["Department of Orthopaedic Surgery, Thomas Jefferson Medical College, Philadelphia PA 19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Thomas Jefferson Medical College, Philadelphia PA 19107, USA","institution_ids":["https://openalex.org/I149251103","https://openalex.org/I2799360765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010742020","display_name":"Toshihisa Komori","orcid":"https://orcid.org/0000-0002-0284-5723","observed_orcids":["https://orcid.org/0000-0002-0284-5723"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihisa Komori","raw_affiliation_strings":["Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4422,"has_fulltext":false,"cited_by_count":146,"citation_normalized_percentile":{"value":0.87898979,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"117","issue":"3","first_page":"417","last_page":"425"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.01940000057220459,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/runx2","display_name":"Runx2","score":1.0},{"id":"https://openalex.org/keywords/chondrocytes","display_name":"chondrocytes","score":0.9629999995231628},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.8299999833106995},{"id":"https://openalex.org/keywords/interleukin-11","display_name":"interleukin-11","score":0.9139999747276306},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.8679999709129333},{"id":"https://openalex.org/keywords/type-ii-collagen","display_name":"type II collagen","score":0.7260000109672546},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.7839999794960022},{"id":"https://openalex.org/keywords/pref-1","display_name":"Pref-1","score":0.8790000081062317},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.5389999747276306},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C2776363554","wikidata":"https://www.wikidata.org/wiki/Q14907085","display_name":"RUNX2","level":4,"score":0.9257142543792725},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.8261085748672485},{"id":"https://openalex.org/C122927707","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Adipogenesis","level":3,"score":0.7790581583976746},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6440891027450562},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.5217902660369873},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46879205107688904},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45490607619285583},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43260055780410767},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.3817744851112366},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.17326760292053223},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.13427937030792236},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11177206039428711},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.08173289895057678},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07893580198287964}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017370","descriptor_name":"Interleukin-11","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024043","descriptor_name":"Collagen Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D033962","descriptor_name":"Adaptor Protein Complex 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048429","descriptor_name":"Cell Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050659","descriptor_name":"Core Binding Factor Alpha 1 Subunit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1242/jcs.00866","doi":"https://doi.org/10.1242/jcs.00866","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.00866","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},{"id":"pmid:14702386","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14702386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cell science","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:joces:117/3/417","doi":null,"is_oa":false,"landing_page_url":"http://jcs.biologists.org/cgi/content/short/117/3/417","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W292140028","https://openalex.org/W1487122735","https://openalex.org/W1488147817","https://openalex.org/W1516514843","https://openalex.org/W1524146716","https://openalex.org/W1529922177","https://openalex.org/W1623983039","https://openalex.org/W1861117943","https://openalex.org/W1865658459","https://openalex.org/W1965574057","https://openalex.org/W1965698106","https://openalex.org/W1965962129","https://openalex.org/W1966032459","https://openalex.org/W1967357201","https://openalex.org/W1973546377","https://openalex.org/W1979287051","https://openalex.org/W1983911826","https://openalex.org/W1992570938","https://openalex.org/W1995995225","https://openalex.org/W1997812904","https://openalex.org/W2002468800","https://openalex.org/W2002519246","https://openalex.org/W2003865274","https://openalex.org/W2005381157","https://openalex.org/W2006537158","https://openalex.org/W2006763543","https://openalex.org/W2010254035","https://openalex.org/W2010576286","https://openalex.org/W2012295730","https://openalex.org/W2020774254","https://openalex.org/W2022640830","https://openalex.org/W2025046506","https://openalex.org/W2025505666","https://openalex.org/W2029584461","https://openalex.org/W2040003495","https://openalex.org/W2041840159","https://openalex.org/W2046080398","https://openalex.org/W2055694376","https://openalex.org/W2056560239","https://openalex.org/W2063141151","https://openalex.org/W2066504997","https://openalex.org/W2066978821","https://openalex.org/W2070591061","https://openalex.org/W2073719628","https://openalex.org/W2079475603","https://openalex.org/W2080988481","https://openalex.org/W2090121982","https://openalex.org/W2091617948","https://openalex.org/W2098326006","https://openalex.org/W2102059629","https://openalex.org/W2103735500","https://openalex.org/W2122367477","https://openalex.org/W2126931608","https://openalex.org/W2128888529","https://openalex.org/W2130671879","https://openalex.org/W2132599643","https://openalex.org/W2136156020","https://openalex.org/W2148965620","https://openalex.org/W2152216439","https://openalex.org/W2166920965","https://openalex.org/W2168880873","https://openalex.org/W2401164797","https://openalex.org/W2413142463","https://openalex.org/W4234875791","https://openalex.org/W4241595918","https://openalex.org/W4320800126","https://openalex.org/W4321428327"],"related_works":["https://openalex.org/W3035826179","https://openalex.org/W3108216847","https://openalex.org/W898760283","https://openalex.org/W1480838859","https://openalex.org/W3209083126","https://openalex.org/W1998538991","https://openalex.org/W2789054899","https://openalex.org/W2901120025","https://openalex.org/W7125790337","https://openalex.org/W2122433264"],"abstract_inverted_index":{"Runx2":[0,24,43,148,176,205,225],"(runt-related":[1],"transcription":[2,8],"factor":[3,9,165],"2)":[4],"is":[5],"an":[6,136],"important":[7,137,227],"for":[10,16,52],"chondrocyte":[11,46,232],"differentiation":[12,106,219],"as":[13,15],"well":[14],"osteoblast":[17],"differentiation.":[18],"To":[19],"investigate":[20],"the":[21,31,40,58,61,102,132,170,186,191,208,211,231],"function":[22,47],"of":[23,34,42,60,80,104,126,134,140,147,188,204,210],"in":[25,50,122,173,196,207,214,220,229,235,249],"chondrocytes,":[26],"we":[27],"isolated":[28],"chondrocytes":[29,64,215],"from":[30],"rib":[32],"cartilage":[33],"Runx2-deficient":[35],"(Runx2-/-)":[36],"mice":[37],"and":[38,48,71,94,117,177,185,216,222,234],"examined":[39],"effect":[41],"deficiency":[44],"on":[45],"behavior":[49],"culture":[51,192],"up":[53],"to":[54,190],"12":[55],"days.":[56],"At":[57],"beginning":[59],"culture,":[62,123],"Runx2-/-":[63,174,197],"actively":[65],"proliferated,":[66],"had":[67],"a":[68],"polygonal":[69],"shape":[70],"expressed":[72],"type":[73,127],"II":[74,128],"collagen;":[75],"these":[76,242],"are":[77,245],"all":[78],"characteristics":[79],"chondrocytes.":[81,175,198],"However,":[82],"they":[83],"gradually":[84],"accumulated":[85],"lipid":[86],"droplets":[87],"that":[88,101,202,224,241],"stained":[89],"with":[90,151],"oil":[91],"red":[92],"O":[93],"resembled":[95],"adipocytes.":[96],"Northern":[97],"blot":[98],"analysis":[99],"revealed":[100],"expression":[103,125,133],"adipocyte-related":[105],"marker":[107],"genes":[108],"including":[109],"PPAR":[110],"gamma":[111],"(peroxisome":[112],"proliferator-activated":[113],"receptor":[114],"gamma),":[115],"aP2":[116],"Glut4":[118],"increased":[119],"over":[120],"time":[121],"whereas":[124],"collagen":[129],"decreased.":[130,144],"Furthermore,":[131],"Pref-1,":[135],"inhibitory":[138],"gene":[139],"adipogenesis,":[141],"was":[142],"remarkably":[143],"Adenoviral":[145],"introduction":[146],"or":[149,166],"treatment":[150],"transforming":[152,178],"growth":[153,161,164,179],"factor-beta,":[154],"retinoic":[155],"acid,":[156],"interleukin-1":[157],"beta,":[158],"basic":[159],"fibroblast":[160],"factor,":[162],"platelet-derived":[163],"parathyroid":[167],"hormone":[168],"inhibited":[169],"adipogenic":[171,218],"changes":[172],"factor-beta":[180],"synergistically":[181],"upregulated":[182],"interleukin-11":[183,189],"expression,":[184],"addition":[187],"medium":[193],"reduced":[194],"adipogenesis":[195],"These":[199],"findings":[200,239],"indicate":[201],"depletion":[203],"resulted":[206],"loss":[209],"differentiated":[212],"phenotype":[213,233],"induced":[217],"vitro,":[221],"show":[223],"plays":[226],"roles":[228],"maintaining":[230],"inhibiting":[236],"adipogenesis.":[237],"Our":[238],"suggest":[240],"Runx2-dependent":[243],"functions":[244],"mediated,":[246],"at":[247],"least":[248],"part,":[250],"by":[251],"interleukin-11.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}