{"id":"https://openalex.org/W2016983155","doi":"https://doi.org/10.1074/jbc.c110.112573","title":"Deviant Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-mediated Ca2+ Signaling upon Lysosome Proliferation","display_name":"Deviant Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-mediated Ca2+ Signaling upon Lysosome Proliferation","publication_year":2010,"publication_date":"2010-03-16","ids":{"openalex":"https://openalex.org/W2016983155","doi":"https://doi.org/10.1074/jbc.c110.112573","mag":"2016983155","pmid":"https://pubmed.ncbi.nlm.nih.gov/20231291","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2859490"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.c110.112573","doi":"https://doi.org/10.1074/jbc.c110.112573","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.c110.112573","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.c110.112573","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017767446","display_name":"George David Dickinson","orcid":"https://orcid.org/0000-0001-7711-0388","observed_orcids":["https://orcid.org/0000-0001-7711-0388"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"George D. Dickinson","raw_affiliation_strings":["Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013996756","display_name":"Grant C. Churchill","orcid":"https://orcid.org/0000-0001-9591-9391","observed_orcids":["https://orcid.org/0000-0001-9591-9391"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Grant C. Churchill","raw_affiliation_strings":["Department of Pharmacology, University of Oxford, Oxford OX1 3QT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Oxford, Oxford OX1 3QT, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085776987","display_name":"Eugen Brailoiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugen Brailoiu","raw_affiliation_strings":["Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086481218","display_name":"Sandip Patel","orcid":"https://orcid.org/0000-0001-7247-2013","observed_orcids":["https://orcid.org/0000-0001-7247-2013"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Sandip Patel","raw_affiliation_strings":["Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5086481218"],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.8257,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.81541156,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"285","issue":"18","first_page":"13321","last_page":"13325"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/naadp","display_name":"NAADP","score":0.902999997138977},{"id":"https://openalex.org/keywords/intracellular-calcium-homeostasis","display_name":"intracellular calcium homeostasis","score":0.8389999866485596},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.5740000009536743},{"id":"https://openalex.org/keywords/cathepsin-inhibition","display_name":"cathepsin inhibition","score":0.7929999828338623},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.8320000171661377},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.9829999804496765},{"id":"https://openalex.org/keywords/neuronal-dysfunction","display_name":"neuronal dysfunction","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C2780216420","wikidata":"https://www.wikidata.org/wiki/Q83330","display_name":"Lysosome","level":3,"score":0.8167939186096191},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6324300169944763},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5904127955436707},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4915214478969574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46891579031944275},{"id":"https://openalex.org/C173633252","wikidata":"https://www.wikidata.org/wiki/Q3663475","display_name":"Cathepsin D","level":3,"score":0.45337268710136414},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3971426486968994},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2016260027885437}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002403","descriptor_name":"Cathepsins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D002403","descriptor_name":"Cathepsins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1074/jbc.c110.112573","doi":"https://doi.org/10.1074/jbc.c110.112573","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.c110.112573","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2092084","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2859490","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2859490","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2859490","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:20231291","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20231291","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:171711","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/171711/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J BIOL CHEM , 285 (18) 13321 - 13325. (2010)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.c110.112573","doi":"https://doi.org/10.1074/jbc.c110.112573","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.c110.112573","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.428600013256073,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G220313525","display_name":"Rational design and biological evaluation of cell-permeant small molecule agonists and antagonists of the NAADP receptor","funder_award_id":"BB/G008523/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G2741465026","display_name":"The molecular basis for calcium release by NAADP","funder_award_id":"BB/G013721/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G4000932854","display_name":"Synthesis and biological testing of cell-permeant NAADP","funder_award_id":"BB/D012694/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G5310369708","display_name":null,"funder_award_id":"BB/D012694/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W46088057","https://openalex.org/W1599277155","https://openalex.org/W1754345123","https://openalex.org/W1967329828","https://openalex.org/W1968004900","https://openalex.org/W1969211111","https://openalex.org/W1976074221","https://openalex.org/W1976269779","https://openalex.org/W1980828399","https://openalex.org/W1986119684","https://openalex.org/W1990708583","https://openalex.org/W1992199981","https://openalex.org/W1997119596","https://openalex.org/W2000075190","https://openalex.org/W2003787957","https://openalex.org/W2004879508","https://openalex.org/W2006528456","https://openalex.org/W2011432266","https://openalex.org/W2015426350","https://openalex.org/W2019593939","https://openalex.org/W2029072905","https://openalex.org/W2030537610","https://openalex.org/W2031790758","https://openalex.org/W2037388166","https://openalex.org/W2046985049","https://openalex.org/W2053173773","https://openalex.org/W2065368005","https://openalex.org/W2066094716","https://openalex.org/W2068412376","https://openalex.org/W2076497080","https://openalex.org/W2082625926","https://openalex.org/W2088093088","https://openalex.org/W2109234448","https://openalex.org/W2112045725","https://openalex.org/W2119141725","https://openalex.org/W2133772521","https://openalex.org/W2138786573","https://openalex.org/W2145358088","https://openalex.org/W2149062606"],"related_works":["https://openalex.org/W2080308068","https://openalex.org/W3037071034","https://openalex.org/W4221041233","https://openalex.org/W2150832037","https://openalex.org/W39456580","https://openalex.org/W2018745495","https://openalex.org/W179198326","https://openalex.org/W2348040914","https://openalex.org/W2157645762","https://openalex.org/W2007574498"],"abstract_inverted_index":{"Accumulating":[0],"evidence":[1],"suggests":[2],"that":[3,81,113],"the":[4,15,38,47,75,85,88,127],"endolysosomal":[5],"system":[6],"is":[7,44],"a":[8],"novel":[9],"intracellular":[10],"Ca(2+)":[11,53,90,94,116],"pool":[12,91],"mobilized":[13],"by":[14],"second":[16],"messenger,":[17],"nicotinic":[18],"acid":[19],"adenine":[20],"dinucleotide":[21],"phosphate":[22],"(NAADP).":[23],"Although":[24],"lysosomes":[25,60],"in":[26,32,61,96,133],"neurons":[27,67],"are":[28],"known":[29,45],"to":[30,98,122],"proliferate":[31],"numerous":[33],"neurodegenerative":[34],"diseases":[35],"and":[36,68,92,104,125],"during":[37],"normal":[39],"course":[40],"of":[41,49,59,64,87,102,129],"aging,":[42],"little":[43],"concerning":[46],"effect":[48],"lysosomal":[50,89,115,130],"proliferation":[51,58,83],"on":[52],"homeostasis.":[54],"Here,":[55],"we":[56],"induce":[57],"primary":[62],"cultures":[63],"rat":[65],"hippocampal":[66],"PC12":[69],"cells":[70],"through":[71,118],"chronic":[72],"treatment":[73],"with":[74],"cathepsin":[76],"inhibitor,":[77],"Z-Phe-Ala-diazomethylketone.":[78],"We":[79],"demonstrate":[80],"lysosome":[82],"increases":[84],"size":[86],"enhances":[93],"signals":[95],"response":[97],"direct":[99],"cellular":[100],"delivery":[101],"NAADP":[103,119,135],"glutamate,":[105],"an":[106],"identified":[107],"NAADP-producing":[108],"agonist.":[109],"Our":[110],"data":[111],"suggest":[112],"deregulated":[114],"signaling":[117],"may":[120],"contribute":[121],"neuronal":[123],"dysfunction":[124],"highlight":[126],"usefulness":[128],"hydrolase":[131],"inhibition":[132],"probing":[134],"action.":[136]},"counts_by_year":[{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
