{"id":"https://openalex.org/W2016971744","doi":"https://doi.org/10.1016/s0022-5347(01)66424-3","title":"Urinary Cytokines During Intravesical Bacillus Calmetteguerin Therapy for Superficial Bladder Cancer: Processing, Stability and Prognostic Value","display_name":"Urinary Cytokines During Intravesical Bacillus Calmetteguerin Therapy for Superficial Bladder Cancer: Processing, Stability and Prognostic Value","publication_year":1996,"publication_date":"1996-02-01","ids":{"openalex":"https://openalex.org/W2016971744","doi":"https://doi.org/10.1016/s0022-5347(01)66424-3","mag":"2016971744","pmid":"https://pubmed.ncbi.nlm.nih.gov/8558640"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-5347(01)66424-3","doi":"https://doi.org/10.1016/s0022-5347(01)66424-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(01)66424-3","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005238316","display_name":"Theo M. de Reijke","orcid":"https://orcid.org/0000-0003-0651-7361","observed_orcids":["https://orcid.org/0000-0003-0651-7361"]},"institutions":[{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Theo M. de Reijke","raw_affiliation_strings":["Department of Urology, University of Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111934723","display_name":"Elizabeth C. de Boer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Elizabeth C. de Boer","raw_affiliation_strings":["Department of Urology, University of Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112305237","display_name":"Karl\u2010Heinz Kurth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Karl Heinz Kurth","raw_affiliation_strings":["Department of Urology, University of Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I887064364"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111732807","display_name":"D. H. J. Schamhart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Denis H.J. Schamhart","raw_affiliation_strings":["Department of Urology, University of Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I887064364"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I887064364"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":15.7334,"has_fulltext":false,"cited_by_count":165,"citation_normalized_percentile":{"value":0.99380474,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"155","issue":"2","first_page":"477","last_page":"482"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/superficial-bladder-cancer","display_name":"superficial bladder cancer","score":0.781000018119812},{"id":"https://openalex.org/keywords/urothelial-carcinoma","display_name":"urothelial carcinoma","score":0.8889999985694885},{"id":"https://openalex.org/keywords/bcg-therapy","display_name":"BCG immunotherapy","score":0.9169999957084656},{"id":"https://openalex.org/keywords/urinary-cytokines","display_name":"urinary cytokines","score":0.9760000109672546},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9860000014305115},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.996999979019165},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9440000057220459},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cytokine-stability","display_name":"cytokine stability","score":0.6330000162124634},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7239999771118164},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.8939999938011169},{"id":"https://openalex.org/keywords/immune-response-monitoring","display_name":"immune response monitoring","score":0.7350000143051147}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.944900631904602},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.6970865726470947},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.6542685031890869},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.5628399848937988},{"id":"https://openalex.org/C2908931861","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Urinary Bladder Cancer","level":4,"score":0.5024867057800293},{"id":"https://openalex.org/C2779762690","wikidata":"https://www.wikidata.org/wiki/Q9382","display_name":"Urinary bladder","level":2,"score":0.5022790431976318},{"id":"https://openalex.org/C2779150676","wikidata":"https://www.wikidata.org/wiki/Q2091405","display_name":"Bacillus (shape)","level":2,"score":0.452882319688797},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4376615285873413},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3912801146507263},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32526180148124695},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.09574276208877563},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000283","descriptor_name":"Administration, Intravesical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001500","descriptor_name":"BCG Vaccine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D002295","descriptor_name":"Carcinoma, Transitional Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002295","descriptor_name":"Carcinoma, Transitional Cell","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/s0022-5347(01)66424-3","doi":"https://doi.org/10.1016/s0022-5347(01)66424-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(01)66424-3","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},{"id":"pmid:8558640","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8558640","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of urology","raw_type":"Clinical Trial"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/ffe0c089-4675-42cc-86ea-a08fc8c0f3f0","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/ffe0c089-4675-42cc-86ea-a08fc8c0f3f0","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"de Reijke, T M, de Boer, E C, Kurth, K H & Schamhart, D H 1996, 'Urinary cytokines during intravesical Bacillus Calmette-Guerin therapy for superficial bladder cancer: Processing, stability and prognostic value', Journal of urology, vol. 155, no. 2, pp. 477-482. https://doi.org/10.1016/S0022-5347(01)66424-3","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/5e1c3415-7795-481d-977e-11ad544aba56","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/urinary-cytokines-during-intravesical-bacillus-calmetteguerin-therapy-for-superficial-bladder-cancer-processing-stability-and-prognostic-value(5e1c3415-7795-481d-977e-11ad544aba56).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of urology, 155(2), 477 - 482. Elsevier Inc.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1709508","https://openalex.org/W19688913","https://openalex.org/W26171313","https://openalex.org/W1969800450","https://openalex.org/W1975679320","https://openalex.org/W1987355376","https://openalex.org/W2000708138","https://openalex.org/W2006649696","https://openalex.org/W2058331779","https://openalex.org/W2066361967","https://openalex.org/W2068950858","https://openalex.org/W2076645550","https://openalex.org/W2089600290","https://openalex.org/W2180705936","https://openalex.org/W2226464234","https://openalex.org/W2406405012","https://openalex.org/W2411940019","https://openalex.org/W2412281282","https://openalex.org/W2412549489","https://openalex.org/W2412740509","https://openalex.org/W2416441643","https://openalex.org/W2418118083","https://openalex.org/W2419575866","https://openalex.org/W2429123395","https://openalex.org/W2432623658","https://openalex.org/W2460892140","https://openalex.org/W2463614369","https://openalex.org/W2469002289","https://openalex.org/W2472680636","https://openalex.org/W3132426763","https://openalex.org/W4243650202"],"related_works":["https://openalex.org/W2358128067","https://openalex.org/W2166242144","https://openalex.org/W2005024488","https://openalex.org/W2039612587","https://openalex.org/W2076645550","https://openalex.org/W2019773633","https://openalex.org/W2025415116","https://openalex.org/W1984794796","https://openalex.org/W2061059597","https://openalex.org/W2068950858"],"abstract_inverted_index":{"PURPOSE:":[0],"An":[1],"accurate":[2],"prognostic":[3,326],"indicator":[4],"to":[5,57,263],"identify":[6],"nonresponding":[7],"patients":[8,66,136],"with":[9,67,254],"superficial":[10,68],"transitional":[11,69],"cell":[12,70],"carcinoma":[13,71],"of":[14,21,38,72,81,90,256,259,275,291,319],"the":[15,48,73,84,91,128,161,167,180,208,292,323],"bladder":[16,60,133],"at":[17,230],"an":[18,144],"early":[19,145],"stage":[20],"intravesical":[22,95,314],"bacillus":[23],"Calmette-Guerin":[24],"(BCG)":[25],"therapy":[26],"is":[27],"urgently":[28],"needed.":[29],"MATERIALS":[30],"AND":[31],"METHODS:":[32],"The":[33,175],"processing":[34],"conditions":[35],"and":[36,59,110,132,197,219,232,249,277,284,310,340],"stability":[37],"several":[39],"BCG":[40,96,169,213,293,315],"induced":[41,294],"urinary":[42,195,307],"cytokines":[43,53,210,237],"were":[44,102,137,177,226,238,286],"analyzed,":[45],"as":[46,336],"was":[47,76,172,200,269],"possible":[49],"correlation":[50,129,193,305],"between":[51,130,194,306],"these":[52,281],"(indicating":[54],"immune":[55,295],"responsiveness":[56],"BCG)":[58],"tumor":[61,117,134,198,223],"recurrence.":[62],"We":[63],"studied":[64,209],"23":[65,205],"bladder.":[74],"Monitoring":[75],"performed":[77],"by":[78,122,261],"serial":[79],"collection":[80,268],"urine":[82,183,229,248,260,333],"during":[83,166],"first":[85],"24":[86],"hours":[87],"after":[88,267],"each":[89,159],"6":[92,154,220,285],"consecutive":[93],"weekly":[94],"instillations.":[97],"Baseline":[98],"pre-therapy":[99],"cytokine":[100,163,308],"levels":[101],"3.9":[103],"+/-":[104,112],"4.7":[105],"pg./mumol":[106,114],"creatinine":[107,115],"for":[108,116,272,288,303,325],"interleukin-6":[109],"0.1":[111],"0.2":[113],"necrosis":[118,224],"factor-alpha":[119,225],"(all":[120],"measured":[121,165],"enzyme-linked":[123],"immunosorbent":[124],"assay).":[125],"To":[126],"investigate":[127],"interleukin-2":[131,187,196,320],"recurrence,":[135],"stratified":[138],"into":[139],"2":[140,218],"groups":[141],"based":[142],"on":[143,280],"(6":[146],"months":[147],"or":[148,150],"less)":[149],"late":[151],"(greater":[152],"than":[153],"months)":[155],"recurrent":[156],"tumor.":[157],"For":[158],"patient":[160],"highest":[162],"value":[164,327],"6-week":[168],"treatment":[170],"course":[171],"evaluated.":[173],"RESULTS:":[174],"results":[176,282],"positive":[178],"if":[179],"level":[181],"in":[182,228,245],"exceeded":[184],"0.34":[185],"units":[186],"per":[188],"mumol.":[189],"creatinine.":[190],"A":[191],"significant":[192,301],"recurrence":[199],"found":[201],"(p":[202],"=":[203],"0.003,":[204],"patients).":[206],"Of":[207],"obtained":[211],"from":[212],"treated":[214],"patients,":[215],"interleukin-1":[216],"beta,":[217],"but":[221],"not":[222,270],"stable":[227],"4C":[231],"20C.":[233],"At":[234],"37C":[235],"all":[236],"unstable.":[239],"Interferon-gamma":[240],"could":[241],"only":[242],"be":[243],"detected":[244],"immediately":[246,266],"dialyzed":[247],"its":[250],"occurrence":[251],"correlated":[252],"most":[253],"that":[255,329],"interleukin-2.":[257],"Processing":[258],"centrifugation":[262],"remove":[264],"leukocytes":[265],"required":[271],"reliable":[273],"measurements":[274],"interleukins-2":[276,283],"6.":[278],"Based":[279],"preferred":[287],"extensive":[289],"monitoring":[290,318],"reaction.":[296],"CONCLUSIONS:":[297],"Our":[298],"study":[299],"provides":[300],"evidence":[302],"a":[304],"induction":[309],"clinical":[311],"response":[312],"following":[313],"therapy.":[316],"Particularly,":[317],"may":[321],"have":[322],"potential":[324],"provided":[328],"strict":[330],"precautions":[331],"regarding":[332],"collection,":[334],"such":[335],"maximal":[337],"2-hour":[338],"sampling":[339],"immediate":[341],"cooling,":[342],"are":[343],"taken.":[344]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
