{"id":"https://openalex.org/W2016971493","doi":"https://doi.org/10.1097/00054725-200502000-00002","title":"Induction of Colonic Transmural Inflammation by Bacteroides Fragilis","display_name":"Induction of Colonic Transmural Inflammation by Bacteroides Fragilis","publication_year":2005,"publication_date":"2005-01-30","ids":{"openalex":"https://openalex.org/W2016971493","doi":"https://doi.org/10.1097/00054725-200502000-00002","mag":"2016971493","pmid":"https://pubmed.ncbi.nlm.nih.gov/15677902"},"language":"en","primary_location":{"id":"doi:10.1097/00054725-200502000-00002","doi":"https://doi.org/10.1097/00054725-200502000-00002","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00054725-200502000-00002","pdf_url":null,"source":{"id":"https://openalex.org/S45123234","display_name":"Inflammatory Bowel Diseases","issn_l":"1078-0998","issn":["1078-0998","1536-4844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammatory Bowel Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Carlos Medina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800401438","display_name":"Hospital Universitario de Canarias","ror":"https://ror.org/05qndj312","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800401438"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carlos Medina","raw_affiliation_strings":["Gastroenterology Department and Research Unit, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain. cmedinammar@hotmail.com","Gastroenterology Department and Research Unit, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology Department and Research Unit, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain. cmedinammar@hotmail.com","institution_ids":["https://openalex.org/I2800401438"]},{"raw_affiliation_string":"Gastroenterology Department and Research Unit, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain","institution_ids":["https://openalex.org/I2800401438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050975185","display_name":"Alfredo Santana","orcid":"https://orcid.org/0000-0002-1075-9948","observed_orcids":["https://orcid.org/0000-0002-1075-9948"]},"institutions":[{"id":"https://openalex.org/I2800401438","display_name":"Hospital Universitario de Canarias","ror":"https://ror.org/05qndj312","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800401438"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alfredo Santana","raw_affiliation_strings":["Gastroenterology Department and Research Unit, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology Department and Research Unit, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain","institution_ids":["https://openalex.org/I2800401438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053186030","display_name":"Marta Llopis","orcid":"https://orcid.org/0000-0002-8877-1031","observed_orcids":["https://orcid.org/0000-0002-8877-1031"]},"institutions":[{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marta Llopis","raw_affiliation_strings":["Digestive System Research Unit, Hospital Vall dHebron, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digestive System Research Unit, Hospital Vall dHebron, Barcelona, Spain","institution_ids":["https://openalex.org/I4210127641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054794696","display_name":"Maria Cristina Paz\u2010Cabrera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800401438","display_name":"Hospital Universitario de Canarias","ror":"https://ror.org/05qndj312","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800401438"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristina M Paz-Cabrera","raw_affiliation_strings":["Gastroenterology Department and Research Unit, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology Department and Research Unit, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain","institution_ids":["https://openalex.org/I2800401438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102891916","display_name":"Maria Antol\u0131\u0301n","orcid":"https://orcid.org/0000-0001-5623-6862","observed_orcids":["https://orcid.org/0000-0001-5623-6862"]},"institutions":[{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Antol\u00edn","raw_affiliation_strings":["Digestive System Research Unit, Hospital Vall dHebron, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digestive System Research Unit, Hospital Vall dHebron, Barcelona, Spain","institution_ids":["https://openalex.org/I4210127641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110094085","display_name":"Marisabel Mourelle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marisabel Mourelle","raw_affiliation_strings":["Digestive System Research Unit, Hospital Vall dHebron, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digestive System Research Unit, Hospital Vall dHebron, Barcelona, Spain","institution_ids":["https://openalex.org/I4210127641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020045811","display_name":"Francisco Guarner","orcid":"https://orcid.org/0000-0002-4051-0836","observed_orcids":["https://orcid.org/0000-0002-4051-0836"]},"institutions":[{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco Guarner","raw_affiliation_strings":["Digestive System Research Unit, Hospital Vall dHebron, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digestive System Research Unit, Hospital Vall dHebron, Barcelona, Spain","institution_ids":["https://openalex.org/I4210127641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110094373","display_name":"J Vilaseca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jaime Vilaseca","raw_affiliation_strings":["Digestive System Research Unit, Hospital Vall dHebron, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digestive System Research Unit, Hospital Vall dHebron, Barcelona, Spain","institution_ids":["https://openalex.org/I4210127641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111151140","display_name":"Clarisa Gonz\u00e1lez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Clarisa Gonzalez","raw_affiliation_strings":["Pathology Department, Hospital Mutua de Tarrassa, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology Department, Hospital Mutua de Tarrassa, Barcelona, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111780102","display_name":"Antonio Salas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antonio Salas","raw_affiliation_strings":["Pathology Department, Hospital Mutua de Tarrassa, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology Department, Hospital Mutua de Tarrassa, Barcelona, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039893343","display_name":"Enrique Quintero","orcid":"https://orcid.org/0000-0002-7244-8125","observed_orcids":["https://orcid.org/0000-0002-7244-8125"]},"institutions":[{"id":"https://openalex.org/I2800401438","display_name":"Hospital Universitario de Canarias","ror":"https://ror.org/05qndj312","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800401438"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Enrique Quintero","raw_affiliation_strings":["Gastroenterology Department and Research Unit, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology Department and Research Unit, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain","institution_ids":["https://openalex.org/I2800401438"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109119636","display_name":"Juan Ramon Malagelada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan Ram\u00f3n. Malagelada","raw_affiliation_strings":["Digestive System Research Unit, Hospital Vall dHebron, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digestive System Research Unit, Hospital Vall dHebron, Barcelona, Spain","institution_ids":["https://openalex.org/I4210127641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3862,"currency":"USD","value_usd":3862},"apc_paid":null,"fwci":2.2279,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.86971311,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"11","issue":"2","first_page":"99","last_page":"105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.14990000426769257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacteroides-fragilis","display_name":"Bacteroides fragilis","score":1.0},{"id":"https://openalex.org/keywords/metalloproteinases","display_name":"metalloproteinases","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C2780246119","wikidata":"https://www.wikidata.org/wiki/Q221817","display_name":"Bacteroides fragilis","level":3,"score":0.9929912686347961},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.738012969493866},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.6394805908203125},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.603268027305603},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.5852993130683899},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5718366503715515},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.5097271800041199},{"id":"https://openalex.org/C2776357993","wikidata":"https://www.wikidata.org/wiki/Q4840030","display_name":"Bacteroidaceae","level":3,"score":0.49545347690582275},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49171262979507446},{"id":"https://openalex.org/C180032290","wikidata":"https://www.wikidata.org/wiki/Q1664296","display_name":"Inoculation","level":2,"score":0.4726772904396057},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.4716493487358093},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2932520806789398},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2163238823413849},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21582037210464478},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.12303000688552856},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0795535147190094},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001441","descriptor_name":"Bacteroides fragilis","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D001441","descriptor_name":"Bacteroides fragilis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001442","descriptor_name":"Bacteroides Infections","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018988","descriptor_name":"Bacterial Translocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020782","descriptor_name":"Matrix Metalloproteinases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/00054725-200502000-00002","doi":"https://doi.org/10.1097/00054725-200502000-00002","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00054725-200502000-00002","pdf_url":null,"source":{"id":"https://openalex.org/S45123234","display_name":"Inflammatory Bowel Diseases","issn_l":"1078-0998","issn":["1078-0998","1536-4844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammatory Bowel Diseases","raw_type":"journal-article"},{"id":"pmid:15677902","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15677902","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammatory bowel diseases","raw_type":"Journal Article"},{"id":"pmh:oai:accedacris.ulpgc.es:10553/46113","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10553/46113","pdf_url":null,"source":{"id":"https://openalex.org/S4306400136","display_name":"Acceda (Universidad de Las Palmas de Gran Canaria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I119635470","host_organization_name":"Universidad de Las Palmas de Gran Canaria","host_organization_lineage":["https://openalex.org/I119635470"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Inflammatory Bowel Diseases [ISSN 1078-0998],v. 11, p. 99-105","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W14784757","https://openalex.org/W1277373232","https://openalex.org/W1576056687","https://openalex.org/W1921554018","https://openalex.org/W1929323727","https://openalex.org/W1937054431","https://openalex.org/W1955526814","https://openalex.org/W1964994147","https://openalex.org/W1972619353","https://openalex.org/W1977363780","https://openalex.org/W2004757024","https://openalex.org/W2026893048","https://openalex.org/W2036159175","https://openalex.org/W2045766284","https://openalex.org/W2057348119","https://openalex.org/W2082813263","https://openalex.org/W2086660045","https://openalex.org/W2095498651","https://openalex.org/W2100276587","https://openalex.org/W2101175877","https://openalex.org/W2108373505","https://openalex.org/W2109658199","https://openalex.org/W2118783077","https://openalex.org/W2120213130","https://openalex.org/W2124347780","https://openalex.org/W2125130883","https://openalex.org/W2144047596","https://openalex.org/W2147421583","https://openalex.org/W2153055943","https://openalex.org/W2161698332","https://openalex.org/W2170113943","https://openalex.org/W2410659310","https://openalex.org/W2411484149"],"related_works":["https://openalex.org/W2086756585","https://openalex.org/W1591482227","https://openalex.org/W2026203167","https://openalex.org/W2135375882","https://openalex.org/W1999015154","https://openalex.org/W2107879555","https://openalex.org/W4386955583","https://openalex.org/W2322468674","https://openalex.org/W2173131839","https://openalex.org/W2317002959"],"abstract_inverted_index":{"BACKGROUND:":[0],"Commensal":[1],"bacteria":[2],"are":[3,16,26],"implicated":[4,190],"in":[5,46,90,112,126,140,148,191,199],"the":[6,12,32,41,54,71,75,78,113,128,192,200],"pathophysiology":[7],"of":[8,43,50,57,61,77,156,169,195,202],"intestinal":[9,33],"inflammation,":[10],"but":[11,146,162],"precise":[13],"pathogenetic":[14],"mechanisms":[15],"not":[17,147],"known.":[18],"We":[19],"hypothesized":[20],"that":[21,108,185],"Bacteroides":[22],"fragilis-produced":[23],"metalloproteinases":[24],"(MMPs)":[25],"responsible":[27],"for":[28],"bacterial":[29,91,186],"migration":[30,194],"through":[31],"wall":[34],"and":[35,74,130,175,198],"transmural":[36,203],"inflammation.":[37,204],"AIM:":[38],"To":[39],"investigate":[40],"role":[42],"bacterial-MMP":[44],"activity":[45,89,174],"an":[47],"experimental":[48],"model":[49],"colitis":[51],"induced":[52,104,120],"by":[53,95],"intramural":[55],"injection":[56],"bacteria.":[58],"METHODS:":[59],"Suspensions":[60],"viable":[62],"B.":[63,102,144,157,170,196],"fragilis":[64,103,158,171,197],"or":[65],"Escherichia":[66],"coli":[67,119,164],"were":[68,109],"injected":[69],"into":[70],"colonic":[72],"wall,":[73],"effect":[76],"MMP":[79,88,160,173],"inhibitor":[80],"(phenantroline)":[81],"on":[82],"histologic":[83],"lesion":[84,138],"scores":[85,139],"was":[86,93],"tested.":[87],"suspensions":[92,155,165],"measured":[94],"azocoll":[96],"assay.":[97],"RESULTS:":[98],"The":[99],"inoculation":[100,116],"with":[101,117,133,143,151],"chronic":[105],"inflammatory":[106,122],"lesions":[107],"preferentially":[110],"located":[111],"subserosa,":[114],"whereas":[115],"E.":[118,152,163],"acute-type":[121],"reactions,":[123],"evenly":[124],"distributed":[125],"both":[127],"submucosa":[129],"subserosa.":[131],"Treatment":[132],"phenantroline":[134],"significantly":[135],"decreased":[136],"subserosal":[137],"rats":[141,149],"inoculated":[142,150],"fragilis,":[145],"coli.":[153],"Bacterial":[154],"showed":[159],"activity,":[161],"did":[166],"not.":[167],"Sonication":[168],"reduced":[172],"virulence":[176],"to":[177],"induce":[178],"serosal":[179,193],"lesions.":[180],"CONCLUSION:":[181],"Our":[182],"data":[183],"suggest":[184],"MMPs":[187],"may":[188],"be":[189],"induction":[201]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
