{"id":"https://openalex.org/W2016945249","doi":"https://doi.org/10.2174/2210303111202020083","title":"Freeze-Drying of Protein-Loaded Nanoparticles for Vaccine Delivery","display_name":"Freeze-Drying of Protein-Loaded Nanoparticles for Vaccine Delivery","publication_year":2012,"publication_date":"2012-07-01","ids":{"openalex":"https://openalex.org/W2016945249","doi":"https://doi.org/10.2174/2210303111202020083","mag":"2016945249"},"language":"en","primary_location":{"id":"doi:10.2174/2210303111202020083","doi":"https://doi.org/10.2174/2210303111202020083","is_oa":false,"landing_page_url":"https://doi.org/10.2174/2210303111202020083","pdf_url":null,"source":{"id":"https://openalex.org/S4210210790","display_name":"Drug Delivery Letters","issn_l":"2210-3031","issn":["2210-3031","2210-304X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Delivery Letterse","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026039087","display_name":"Karishma T. Mody","orcid":"https://orcid.org/0000-0002-7499-7988","observed_orcids":["https://orcid.org/0000-0002-7499-7988"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Karishma Mody","raw_affiliation_strings":["Queensland Agricultural Biotechnology Facility, Ritchie Building No.64A, Research Road, The University of Queensland, St Lucia, Queensland Australia, 4072.,Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queensland Agricultural Biotechnology Facility, Ritchie Building No.64A, Research Road, The University of Queensland, St Lucia, Queensland Australia, 4072.,Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111410260","display_name":"Donna Mahony","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donna Mahony","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022653243","display_name":"Timothy John Mahony","orcid":"https://orcid.org/0000-0003-4573-7906","observed_orcids":["https://orcid.org/0000-0003-4573-7906"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy J. Mahony","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086257407","display_name":"Neena Mitter","orcid":"https://orcid.org/0000-0001-6146-6179","observed_orcids":["https://orcid.org/0000-0001-6146-6179"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neena Mitter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026039087"],"corresponding_institution_ids":["https://openalex.org/I165143802"],"apc_list":null,"apc_paid":null,"fwci":0.3513,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.50510382,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"2","issue":"2","first_page":"83","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.4860999882221222,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.4860999882221222,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.22390000522136688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0982000008225441,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/freeze-drying","display_name":"freeze-drying","score":0.9879999756813049},{"id":"https://openalex.org/keywords/nanovaccines","display_name":"nanovaccines","score":0.9520000219345093},{"id":"https://openalex.org/keywords/vaccine-delivery","display_name":"vaccine delivery","score":0.9449999928474426},{"id":"https://openalex.org/keywords/nanoparticle-stability","display_name":"nanoparticle stability","score":0.8420000076293945},{"id":"https://openalex.org/keywords/lyoprotectants","display_name":"lyoprotectants","score":0.847000002861023},{"id":"https://openalex.org/keywords/cryoprotectants","display_name":"cryoprotectants","score":0.8700000047683716},{"id":"https://openalex.org/keywords/pharmaceutical-excipients","display_name":"pharmaceutical excipients","score":0.8679999709129333},{"id":"https://openalex.org/keywords/vaccine-formulation","display_name":"vaccine formulation","score":0.6079999804496765},{"id":"https://openalex.org/keywords/cold-chain-elimination","display_name":"cold chain elimination","score":0.8159999847412109},{"id":"https://openalex.org/keywords/controlled-protein-release","display_name":"controlled protein release","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C84199377","wikidata":"https://www.wikidata.org/wiki/Q723912","display_name":"Freeze-drying","level":2,"score":0.6203867197036743},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.602443516254425},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5827846527099609},{"id":"https://openalex.org/C2988375501","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein stability","level":2,"score":0.5342724919319153},{"id":"https://openalex.org/C2780114722","wikidata":"https://www.wikidata.org/wiki/Q592197","display_name":"Cold chain","level":2,"score":0.47898054122924805},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4133904278278351},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40926507115364075},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.30653050541877747},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.13207760453224182},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11048358678817749},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.10083740949630737}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.2174/2210303111202020083","doi":"https://doi.org/10.2174/2210303111202020083","is_oa":false,"landing_page_url":"https://doi.org/10.2174/2210303111202020083","pdf_url":null,"source":{"id":"https://openalex.org/S4210210790","display_name":"Drug Delivery Letters","issn_l":"2210-3031","issn":["2210-3031","2210-304X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Delivery Letterse","raw_type":"journal-article"},{"id":"doi:10.2174/2210304x11202020083","doi":"https://doi.org/10.2174/2210304x11202020083","is_oa":false,"landing_page_url":"https://doi.org/10.2174/2210304x11202020083","pdf_url":null,"source":{"id":"https://openalex.org/S4210210790","display_name":"Drug Delivery Letters","issn_l":"2210-3031","issn":["2210-3031","2210-304X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Delivery Letters","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4297989476","https://openalex.org/W4413475060","https://openalex.org/W4283155211","https://openalex.org/W2120826143","https://openalex.org/W2509943947","https://openalex.org/W2085026728","https://openalex.org/W7056375640","https://openalex.org/W2055942288","https://openalex.org/W3124936907","https://openalex.org/W7136061597"],"abstract_inverted_index":{"Conventional":[0],"vaccines":[1,12],"either":[2],"use":[3],"attenuated":[4],"pathogens":[5],"(live":[6],"vaccines)":[7],"or":[8],"inactivated":[9],"pathogens,":[10],"such":[11],"can":[13,99,138],"be":[14,100],"expensive,":[15],"difficult":[16],"to":[17,41,102,119,184],"deploy,":[18],"require":[19,28],"a":[20,65,69],"\u2018cold":[21],"chain\u2019,":[22],"may":[23],"have":[24,48],"side":[25],"effects":[26],"and":[27,61,82,107,135,147,158],"multiple":[29],"doses":[30],"for":[31,51,73],"effective":[32],"immunisation.":[33],"Recent":[34],"advances":[35],"in":[36,46,53],"the":[37,52,84,88,105,124,129,140,143,153,159,164,173,179,187],"development":[38,180],"of":[39,56,80,90,96,110,115,123,131,142,161,176,181,189],"technology":[40,72,193],"delivery":[42,55],"biologically":[43],"active":[44],"molecules":[45],"vivo":[47,54],"utilised":[49],"nanoparticles":[50,98,145],"drugs,":[57],"nucleic":[58],"acids,":[59],"proteins":[60,81],"peptides;":[62],"nanotechnology":[63],"has":[64],"promising":[66],"potential":[67],"as":[68],"new":[70],"platform":[71],"vaccine":[74,85,111,192,201],"delivery.":[75,202],"Nanoparticles":[76],"allow":[77],"controlled":[78],"release":[79],"increase":[83],"stability":[86,109,141,157],"with":[87,128],"possibility":[89],"eliminating":[91],"cold":[92],"chain":[93],"storage.":[94],"Freeze-drying":[95],"protein-loaded":[97,144],"used":[101],"improve":[103],"both":[104],"short":[106],"long-term":[108],"components.":[112],"The":[113],"purpose":[114],"this":[116,190],"review":[117,168],"is":[118],"provide":[120,170],"an":[121],"overview":[122],"freeze-drying":[125,165,177],"process":[126],"itself":[127],"aim":[130],"identifying":[132],"current":[133],"procedures":[134],"parameters":[136],"that":[137],"impact":[139],"during":[146,163],"after":[148],"freeze-drying.":[149],"It":[150],"also":[151],"discusses":[152],"formulation":[154],"strategies,":[155],"nanoparticle":[156],"importance":[160],"excipients":[162],"process.":[166],"This":[167],"will":[169],"direction":[171],"towards":[172],"successful":[174],"integration":[175],"into":[178],"protein-based":[182],"nanovaccines":[183],"further":[185],"enhance":[186],"application":[188],"emerging":[191],"platform.":[194],"Keywords:":[195],"Protein,":[196],"antigen,":[197],"nanoparticles,":[198],"freeze-drying/lyophilisation,":[199],"cryo/lyoprotectant,":[200]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}
