{"id":"https://openalex.org/W2016940905","doi":"https://doi.org/10.1016/j.crvi.2007.03.001","title":"Toxicit\u00e9 de l'hexachlorobenz\u00e8ne chez Meriones unguiculatus : effets sur la thyro\u00efde et le foie","display_name":"Toxicit\u00e9 de l'hexachlorobenz\u00e8ne chez Meriones unguiculatus : effets sur la thyro\u00efde et le foie","publication_year":2007,"publication_date":"2007-04-09","ids":{"openalex":"https://openalex.org/W2016940905","doi":"https://doi.org/10.1016/j.crvi.2007.03.001","mag":"2016940905","pmid":"https://pubmed.ncbi.nlm.nih.gov/17531791"},"language":"fr","primary_location":{"id":"doi:10.1016/j.crvi.2007.03.001","doi":"https://doi.org/10.1016/j.crvi.2007.03.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.crvi.2007.03.001","pdf_url":null,"source":{"id":"https://openalex.org/S119003425","display_name":"Comptes Rendus Biologies","issn_l":"1631-0691","issn":["1631-0691","1768-3238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ddh","doaj","dongbi-d","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4404678052","host_organization_name":"Acad\u00e9mie des sciences","host_organization_lineage":["https://openalex.org/P4404678052"],"host_organization_lineage_names":["Acad\u00e9mie des sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comptes Rendus. Biologies","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008544644","display_name":"Lotfi Bitri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108714496","display_name":"Tunis University","ror":"https://ror.org/02q1spa57","country_code":"TN","type":"education","lineage":["https://openalex.org/I108714496"]},{"id":"https://openalex.org/I63596082","display_name":"Tunis El Manar University","ror":"https://ror.org/029cgt552","country_code":"TN","type":"education","lineage":["https://openalex.org/I63596082"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Lotfi Bitri","raw_affiliation_strings":["Laboratoire de physiologie animale, d\u00e9partement des sciences biologiques, UR Physiologie environnementale et biorythmes, facult\u00e9 des sciences de Tunis, Tunisie. bitrilotfi@yahoo.fr","Laboratoire de physiologie animale, d\u00e9partement des sciences biologiques, UR \u00ab Physiologie environnementale et biorythmes \u00bb, facult\u00e9 des sciences de Tunis, Tunisie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de physiologie animale, d\u00e9partement des sciences biologiques, UR Physiologie environnementale et biorythmes, facult\u00e9 des sciences de Tunis, Tunisie. bitrilotfi@yahoo.fr","institution_ids":["https://openalex.org/I108714496"]},{"raw_affiliation_string":"Laboratoire de physiologie animale, d\u00e9partement des sciences biologiques, UR \u00ab Physiologie environnementale et biorythmes \u00bb, facult\u00e9 des sciences de Tunis, Tunisie","institution_ids":["https://openalex.org/I108714496","https://openalex.org/I63596082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060945539","display_name":"Nedra Dhaouadi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108714496","display_name":"Tunis University","ror":"https://ror.org/02q1spa57","country_code":"TN","type":"education","lineage":["https://openalex.org/I108714496"]},{"id":"https://openalex.org/I63596082","display_name":"Tunis El Manar University","ror":"https://ror.org/029cgt552","country_code":"TN","type":"education","lineage":["https://openalex.org/I63596082"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Nedra Dhaouadi","raw_affiliation_strings":["Laboratoire de physiologie animale, d\u00e9partement des sciences biologiques, UR \u00ab Physiologie environnementale et biorythmes \u00bb, facult\u00e9 des sciences de Tunis, Tunisie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de physiologie animale, d\u00e9partement des sciences biologiques, UR \u00ab Physiologie environnementale et biorythmes \u00bb, facult\u00e9 des sciences de Tunis, Tunisie","institution_ids":["https://openalex.org/I108714496","https://openalex.org/I63596082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025125617","display_name":"L Ouertani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Latifa Ouertani","raw_affiliation_strings":["Service d'anatomo-pathologie, h\u00f4pital Menzel-Bourguiba, Tunisie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'anatomo-pathologie, h\u00f4pital Menzel-Bourguiba, Tunisie","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111892703","display_name":"Daniel Maurel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Daniel Maurel","raw_affiliation_strings":["Physiopathologie et action th\u00e9rapeutique des gaz sous pression, EA 3280, facult\u00e9 de m\u00e9decine secteur Nord, universit\u00e9 de la M\u00e9diterran\u00e9e, bd Pierre-Dramard, 13916 Marseille cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiopathologie et action th\u00e9rapeutique des gaz sous pression, EA 3280, facult\u00e9 de m\u00e9decine secteur Nord, universit\u00e9 de la M\u00e9diterran\u00e9e, bd Pierre-Dramard, 13916 Marseille cedex, France","institution_ids":["https://openalex.org/I21491767"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011827761","display_name":"Moncef Ben Saad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108714496","display_name":"Tunis University","ror":"https://ror.org/02q1spa57","country_code":"TN","type":"education","lineage":["https://openalex.org/I108714496"]},{"id":"https://openalex.org/I63596082","display_name":"Tunis El Manar University","ror":"https://ror.org/029cgt552","country_code":"TN","type":"education","lineage":["https://openalex.org/I63596082"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Moncef Ben Saad","raw_affiliation_strings":["Laboratoire de physiologie animale, d\u00e9partement des sciences biologiques, UR \u00ab Physiologie environnementale et biorythmes \u00bb, facult\u00e9 des sciences de Tunis, Tunisie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de physiologie animale, d\u00e9partement des sciences biologiques, UR \u00ab Physiologie environnementale et biorythmes \u00bb, facult\u00e9 des sciences de Tunis, Tunisie","institution_ids":["https://openalex.org/I108714496","https://openalex.org/I63596082"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2267,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.52988398,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"330","issue":"5","first_page":"410","last_page":"418"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.6348000168800354,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.6348000168800354,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.1680999994277954,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.07660000026226044,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hexachlorobenzene","display_name":"hexachlorobenzene","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mongolian-gerbil","display_name":"Mongolian gerbil","score":0.9169999957084656},{"id":"https://openalex.org/keywords/toxicity","display_name":"toxicity","score":0.3970000147819519},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.5400000214576721},{"id":"https://openalex.org/keywords/thyroid","display_name":"thyroid gland","score":0.9769999980926514},{"id":"https://openalex.org/keywords/hepatic-hypertrophy","display_name":"hepatic hypertrophy","score":0.9679999947547913},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.6729999780654907},{"id":"https://openalex.org/keywords/hepatocellular-necrosis","display_name":"liver necrosis","score":0.6759999990463257},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7039999961853027},{"id":"https://openalex.org/keywords/liver-transaminases","display_name":"liver transaminases","score":0.7110000252723694},{"id":"https://openalex.org/keywords/thyroid-hormones","display_name":"thyroid hormones","score":0.8370000123977661},{"id":"https://openalex.org/keywords/triiodothyronine","display_name":"triiodothyronine","score":0.949999988079071},{"id":"https://openalex.org/keywords/thyroxine","display_name":"thyroxine","score":0.8410000205039978},{"id":"https://openalex.org/keywords/organochlorine-pesticides","display_name":"organochlorine pesticides","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3947921097278595},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.36459970474243164},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36124658584594727},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28942447900772095},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2851283550262451}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005849","descriptor_name":"Gerbillinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006503","descriptor_name":"Hepatic Veins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006503","descriptor_name":"Hepatic Veins","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006581","descriptor_name":"Hexachlorobenzene","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D006984","descriptor_name":"Hypertrophy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.crvi.2007.03.001","doi":"https://doi.org/10.1016/j.crvi.2007.03.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.crvi.2007.03.001","pdf_url":null,"source":{"id":"https://openalex.org/S119003425","display_name":"Comptes Rendus Biologies","issn_l":"1631-0691","issn":["1631-0691","1768-3238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ddh","doaj","dongbi-d","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4404678052","host_organization_name":"Acad\u00e9mie des sciences","host_organization_lineage":["https://openalex.org/P4404678052"],"host_organization_lineage_names":["Acad\u00e9mie des sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comptes Rendus. Biologies","raw_type":"journal-article"},{"id":"pmid:17531791","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17531791","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comptes rendus biologies","raw_type":"English Abstract"},{"id":"pmh:oai:centre-mersenne.org:CRBIOL_2007__330_5_410_0","doi":null,"is_oa":false,"landing_page_url":"https://comptes-rendus.academie-sciences.fr/biologies/articles/10.1016/j.crvi.2007.03.001/","pdf_url":null,"source":{"id":"https://openalex.org/S4377196241","display_name":"Biology Reports","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1488268062","https://openalex.org/W1969509017","https://openalex.org/W1972698954","https://openalex.org/W1974826990","https://openalex.org/W1998246284","https://openalex.org/W1998758583","https://openalex.org/W1999884366","https://openalex.org/W2010349211","https://openalex.org/W2015926433","https://openalex.org/W2020707280","https://openalex.org/W2021494550","https://openalex.org/W2036976420","https://openalex.org/W2042176916","https://openalex.org/W2046214481","https://openalex.org/W2052658152","https://openalex.org/W2055535412","https://openalex.org/W2057016950","https://openalex.org/W2061367997","https://openalex.org/W2062474103","https://openalex.org/W2066908548","https://openalex.org/W2068550448","https://openalex.org/W2078516084","https://openalex.org/W2080887173","https://openalex.org/W2082793056","https://openalex.org/W2097548418","https://openalex.org/W2143272567","https://openalex.org/W2144528537","https://openalex.org/W2211617398","https://openalex.org/W2332489276","https://openalex.org/W2414998623","https://openalex.org/W2471083496","https://openalex.org/W2472413549"],"related_works":["https://openalex.org/W2025051933","https://openalex.org/W2046214481","https://openalex.org/W2023022614","https://openalex.org/W2037947163","https://openalex.org/W2144896292","https://openalex.org/W2330373629","https://openalex.org/W1550992097","https://openalex.org/W2008335852","https://openalex.org/W2031080885","https://openalex.org/W2082793056"],"abstract_inverted_index":{"The":[0,94],"effect":[1],"of":[2,23,38,44,56,92,97,104],"in":[3,101,118,125,128,135,143,150,165,172,179,183,190],"vivo":[4],"administered":[5,28,90],"hexachlorobenzene":[6],"(HCB)":[7],"on":[8,14,108],"liver":[9],"and":[10,20,77,81,86,107,156,181],"thyroid":[11,109],"was":[12,115],"studied":[13],"Meriones":[15],"unguiculatus.":[16],"HCB":[17,57,98],"(1.6,":[18],"4,":[19],"16":[21],"mg/kg":[22],"body":[24,42],"weight)":[25],"has":[26],"been":[27],"orally":[29],"to":[30,60,66,162],"meriones":[31],"for":[32],"30":[33],"days.":[34],"At":[35],"the":[36,39,41,45,53,89,102],"end":[37],"experiment,":[40],"weight":[43],"animals":[46],"did":[47],"not":[48],"show":[49],"significant":[50],"change.":[51],"However,":[52,137],"higher":[54,95],"dose":[55,96],"treatment":[58],"led":[59],"a":[61],"pronounced":[62,117],"hepatic":[63,105],"hypertrophy":[64],"comparatively":[65],"controls.":[67],"Histological":[68],"observations":[69],"revealed":[70],"many":[71],"cytomorphological":[72],"alterations.":[73],"Cellular":[74],"necrosis,":[75],"periportal,":[76],"centrolobular":[78],"vein":[79],"congestion":[80],"cytoplasmic":[82],"vacuolisation":[83],"were":[84],"noted":[85],"correlated":[87],"with":[88],"doses":[91],"HCB.":[93],"induced":[99],"modifications":[100],"activities":[103],"transaminases":[106],"hormones":[110],"levels:":[111],"ALAT":[112],"activity":[113,139],"level":[114],"more":[116],"males":[119,173],"(170+/-24.7":[120],"U/l":[121,124,131,134,146,149],"vs.":[122,132,147,176,187],"52.66+/-8.29":[123],"controls)":[126,180],"than":[127],"females":[129,144,184],"(120+/-12.47":[130],"56+/-5":[133],"controls).":[136,151,191],"ASAT":[138],"increased":[140],"significantly":[141,171],"only":[142],"(259+/-29":[145],"244.66+/-18":[148],"Plasma":[152],"total":[153,157],"triiodothyronine":[154],"(TT3)":[155],"thyroxine":[158],"(TT4)":[159],"levels":[160],"seemed":[161],"be":[163],"sex-dependent":[164],"intoxicated":[166],"animals,":[167],"since":[168],"TT4":[169],"decreased":[170],"(21.95+/-7.46":[174],"nmol/l":[175,178,186,189],"40.59+/-1.08":[177],"TT3":[182],"(1.42+/-0.11":[185],"3.96+/-0.48":[188]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}