{"id":"https://openalex.org/W2016938202","doi":"https://doi.org/10.1371/journal.pone.0018088","title":"Identification of a Gene Regulatory Network Necessary for the Initiation of Oligodendrocyte Differentiation","display_name":"Identification of a Gene Regulatory Network Necessary for the Initiation of Oligodendrocyte Differentiation","publication_year":2011,"publication_date":"2011-04-07","ids":{"openalex":"https://openalex.org/W2016938202","doi":"https://doi.org/10.1371/journal.pone.0018088","mag":"2016938202","pmid":"https://pubmed.ncbi.nlm.nih.gov/21490970","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3072388"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0018088","doi":"https://doi.org/10.1371/journal.pone.0018088","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0018088","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0018088&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0018088&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074295324","display_name":"Victoria A. Swiss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria A. Swiss","raw_affiliation_strings":["Department of Neuroscience and Genetics and Genomic, Mount Sinai School of Medicine, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Genetics and Genomic, Mount Sinai School of Medicine, New York, New York, United States of America","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100642009","display_name":"Tung Thanh Nguyen","orcid":"https://orcid.org/0000-0003-4232-0566","observed_orcids":["https://orcid.org/0000-0003-4232-0566"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tung Nguyen","raw_affiliation_strings":["BioMAPS Institute for Quantitative Biology, Rutgers University, Piscataway, New Jersey, United States of America","Departments of Biomedical Engineering and Chemical Biochemical Engineering, Rutgers University, Piscataway, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMAPS Institute for Quantitative Biology, Rutgers University, Piscataway, New Jersey, United States of America","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Departments of Biomedical Engineering and Chemical Biochemical Engineering, Rutgers University, Piscataway, New Jersey, United States of America","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035524962","display_name":"Jason C. Dugas","orcid":"https://orcid.org/0000-0003-0849-9830","observed_orcids":["https://orcid.org/0000-0003-0849-9830"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Dugas","raw_affiliation_strings":["Department of Neuroscience, Stanford University School of Medicine, Stanford, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Stanford University School of Medicine, Stanford, California, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049186116","display_name":"Adiljan Ibrahim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adiljan Ibrahim","raw_affiliation_strings":["Department of Neuroscience, Stanford University School of Medicine, Stanford, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Stanford University School of Medicine, Stanford, California, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027970945","display_name":"Ben A. Barres","orcid":"https://orcid.org/0000-0003-2905-4136","observed_orcids":["https://orcid.org/0000-0003-2905-4136"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ben Barres","raw_affiliation_strings":["Department of Neuroscience, Stanford University School of Medicine, Stanford, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Stanford University School of Medicine, Stanford, California, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049184270","display_name":"Ioannis P. Androulakis","orcid":"https://orcid.org/0000-0002-3795-3628","observed_orcids":["https://orcid.org/0000-0002-3795-3628"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ioannis P. Androulakis","raw_affiliation_strings":["Departments of Biomedical Engineering and Chemical Biochemical Engineering, Rutgers University, Piscataway, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biomedical Engineering and Chemical Biochemical Engineering, Rutgers University, Piscataway, New Jersey, United States of America","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071596838","display_name":"Patrizia Casaccia","orcid":"https://orcid.org/0000-0002-4785-9264","observed_orcids":["https://orcid.org/0000-0002-4785-9264"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Patrizia Casaccia","raw_affiliation_strings":["Department of Neuroscience and Genetics and Genomic, Mount Sinai School of Medicine, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Genetics and Genomic, Mount Sinai School of Medicine, New York, New York, United States of America","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5071596838"],"corresponding_institution_ids":["https://openalex.org/I98704320"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.3211,"has_fulltext":true,"cited_by_count":116,"citation_normalized_percentile":{"value":0.88514308,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"6","issue":"4","first_page":"e18088","last_page":"e18088"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oligodendrocyte-differentiation","display_name":"oligodendrocyte differentiation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/oligodendrocyte-precursor-cells","display_name":"oligodendrocyte precursor cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/histone-deacetylase","display_name":"histone deacetylase","score":0.9860000014305115},{"id":"https://openalex.org/keywords/gene-regulatory-networks","display_name":"gene regulatory networks","score":0.7350000143051147},{"id":"https://openalex.org/keywords/trichostatin-a","display_name":"trichostatin A","score":0.824999988079071},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.8659999966621399},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.4449999928474426},{"id":"https://openalex.org/keywords/id2","display_name":"Id2","score":0.9700000286102295},{"id":"https://openalex.org/keywords/egr1","display_name":"EGR1","score":1.0},{"id":"https://openalex.org/keywords/sox11","display_name":"SOX11","score":1.0},{"id":"https://openalex.org/keywords/myelination","display_name":"myelination","score":0.7440000176429749},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.7799999713897705},{"id":"https://openalex.org/keywords/gene-expression-kinetics","display_name":"gene expression kinetics","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6370490789413452},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5659540891647339},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5579864382743835},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5433609485626221},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5360555648803711},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5037438273429871},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.48080554604530334},{"id":"https://openalex.org/C2776985911","wikidata":"https://www.wikidata.org/wiki/Q916698","display_name":"Oligodendrocyte","level":4,"score":0.44464296102523804},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2773863971233368},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.17256951332092285},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.06525790691375732},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pone.0018088","doi":"https://doi.org/10.1371/journal.pone.0018088","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0018088","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0018088&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2085932","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3072388","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3072388","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3072388","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:21490970","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21490970","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.779.9928","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.779.9928","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/45/7e/pone.0018088.PMC3072388.pdf","raw_type":"text"},{"id":"pmh:oai:alma.01RUT_INST:11663371840004646","doi":null,"is_oa":false,"landing_page_url":"https://scholarship.libraries.rutgers.edu/esploro/outputs/journalArticle/Identification-of-a-gene-regulatory-network/991031653869104646","pdf_url":null,"source":{"id":"https://openalex.org/S4306401388","display_name":"Rutgers University Community Repository (Rutgers University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102322142","host_organization_name":"Rutgers, The State University of New Jersey","host_organization_lineage":["https://openalex.org/I102322142"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:doaj.org/article:e078d7860f9349b180a68cf673c94498","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e078d7860f9349b180a68cf673c94498","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 6, Iss 4, p e18088 (2011)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/137667","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Identification_of_a_Gene_Regulatory_Network_Necessary_for_the_Initiation_of_Oligodendrocyte_Differentiation/137667","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0018088","doi":"https://doi.org/10.1371/journal.pone.0018088","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0018088","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0018088&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2260030106","display_name":"Histone Deacetylation in Oligodendrocyte Differentiation","funder_award_id":"R37NS042925","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G229475037","display_name":"Histone deacetylation in oligodendrocyte differentiation","funder_award_id":"R01NS042925","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4182385434","display_name":null,"funder_award_id":"NS42925-S1","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5520316217","display_name":null,"funder_award_id":"NIH-R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6840403735","display_name":null,"funder_award_id":"R01-NS42925-8","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306161","display_name":"National Multiple Sclerosis Society","ror":"https://ror.org/03019wv17"},{"id":"https://openalex.org/F4320313330","display_name":"Myelin Repair Foundation","ror":"https://ror.org/05yb6xa82"},{"id":"https://openalex.org/F4320320084","display_name":"Multiple Sclerosis Society","ror":"https://ror.org/043fwdk81"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016938202.pdf","grobid_xml":"https://content.openalex.org/works/W2016938202.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1527835237","https://openalex.org/W1598255185","https://openalex.org/W1608737740","https://openalex.org/W1937179228","https://openalex.org/W1969339103","https://openalex.org/W1969761972","https://openalex.org/W1979511601","https://openalex.org/W1991294840","https://openalex.org/W2001810970","https://openalex.org/W2007952700","https://openalex.org/W2009364430","https://openalex.org/W2009808755","https://openalex.org/W2014519160","https://openalex.org/W2016928754","https://openalex.org/W2018558728","https://openalex.org/W2022458369","https://openalex.org/W2030349992","https://openalex.org/W2032313226","https://openalex.org/W2035037267","https://openalex.org/W2036518710","https://openalex.org/W2038964409","https://openalex.org/W2039383073","https://openalex.org/W2047606645","https://openalex.org/W2059359814","https://openalex.org/W2059994807","https://openalex.org/W2060525739","https://openalex.org/W2061556393","https://openalex.org/W2062403533","https://openalex.org/W2063653640","https://openalex.org/W2065677411","https://openalex.org/W2088913222","https://openalex.org/W2094971696","https://openalex.org/W2099324344","https://openalex.org/W2100119722","https://openalex.org/W2103650093","https://openalex.org/W2104432245","https://openalex.org/W2106859863","https://openalex.org/W2107295524","https://openalex.org/W2108244474","https://openalex.org/W2110938577","https://openalex.org/W2113672425","https://openalex.org/W2121987758","https://openalex.org/W2122683221","https://openalex.org/W2123453097","https://openalex.org/W2123577119","https://openalex.org/W2123661628","https://openalex.org/W2124940469","https://openalex.org/W2125650861","https://openalex.org/W2128738365","https://openalex.org/W2134290914","https://openalex.org/W2134337471","https://openalex.org/W2142665520","https://openalex.org/W2145544638","https://openalex.org/W2151166716","https://openalex.org/W2154100816","https://openalex.org/W2158217645","https://openalex.org/W2160655220","https://openalex.org/W2160697532","https://openalex.org/W2162163463","https://openalex.org/W2166216415","https://openalex.org/W2166504702","https://openalex.org/W2170040895","https://openalex.org/W2170804629","https://openalex.org/W2297276306"],"related_works":["https://openalex.org/W7099590735","https://openalex.org/W2069081521","https://openalex.org/W2110938577","https://openalex.org/W2042586741","https://openalex.org/W7027034485","https://openalex.org/W4231930172","https://openalex.org/W2902528335","https://openalex.org/W2112170893","https://openalex.org/W3092310680","https://openalex.org/W2145544638"],"abstract_inverted_index":{"Differentiation":[0],"of":[1,22,34,50,78,92,107,117,141,151,173,183,189,193,201,210,219,254,267,277,280],"oligodendrocyte":[2,29,69,162,168,194,268],"progenitor":[3],"cells":[4],"(OPCs)":[5],"into":[6],"mature":[7],"oligodendrocytes":[8],"requires":[9],"extensive":[10],"changes":[11],"in":[12,63,99,110,125,148,258],"gene":[13,79,100,120],"expression,":[14],"which":[15,40],"are":[16,187],"partly":[17],"mediated":[18],"by":[19,43,66,104],"post-translational":[20],"modifications":[21],"nucleosomal":[23],"histones.":[24],"An":[25],"essential":[26],"modification":[27],"for":[28,245],"differentiation":[30],"is":[31,41,243],"the":[32,68,105,118,139,149,166,171,199,217,226,274],"removal":[33],"acetyl":[35],"groups":[36],"from":[37],"lysine":[38],"residues":[39],"catalyzed":[42],"histone":[44],"deacetylases":[45],"(HDACs).":[46],"The":[47,95],"transcriptional":[48,259],"targets":[49,140],"HDAC":[51,142,156,249],"activity":[52],"within":[53],"OPCs":[54,147],"however,":[55],"have":[56,60],"remained":[57],"elusive":[58],"and":[59,85,113,130,239],"been":[61],"identified":[62,122],"this":[64],"study":[65],"interrogating":[67],"transcriptome.":[70],"Using":[71],"a":[72,180,190,222,264],"novel":[73],"algorithm":[74],"that":[75,179,271],"allows":[76],"clustering":[77],"transcripts":[80,123],"according":[81],"to":[82,160],"expression":[83,86,101,200,218],"kinetics":[84],"levels,":[87],"we":[88,144,177,231],"defined":[89,167],"major":[90],"waves":[91],"co-regulated":[93,255],"genes.":[94],"initial":[96],"overall":[97],"decrease":[98],"was":[102],"followed":[103],"up-regulation":[106],"genes":[108,137,186,202,220,230,251,256],"involved":[109,124,257],"lipid":[111],"metabolism":[112],"myelination.":[114],"Functional":[115],"annotation":[116],"down-regulated":[119],"clusters":[121,253],"cell":[126],"cycle":[127],"regulation,":[128],"transcription,":[129],"RNA":[131],"processing.":[132],"To":[133],"define":[134],"whether":[135],"these":[136],"were":[138],"activity,":[143],"cultured":[145],"rat":[146],"presence":[150],"trichostatin":[152],"A":[153],"(TSA),":[154],"an":[155],"inhibitor":[157],"previously":[158],"shown":[159],"inhibit":[161],"differentiation.":[163,195,247,281],"By":[164],"overlaying":[165],"transcriptome":[169],"with":[170,221],"list":[172],"'TSA":[174,184,228],"sensitive'":[175,185,229],"genes,":[176],"determined":[178],"high":[181],"percentage":[182],"part":[188],"normal":[191],"program":[192],"TSA":[196],"treatment":[197],"increased":[198,227],"whose":[203,241],"down-regulation":[204,242,276],"occurs":[205],"very":[206],"early":[207],"after":[208],"induction":[209],"OPC":[211,246],"differentiation,":[212],"but":[213],"did":[214],"not":[215],"affect":[216],"slower":[223],"kinetic.":[224],"Among":[225],"detected":[232],"several":[233,278],"transcription":[234],"factors":[235],"including":[236],"Id2,":[237],"Egr1,":[238],"Sox11,":[240],"critical":[244],"Thus,":[248],"target":[250],"include":[252],"repression.":[260],"These":[261],"results":[262],"support":[263],"de-repression":[265],"model":[266],"lineage":[269],"progression":[270],"relies":[272],"on":[273],"concurrent":[275],"inhibitors":[279]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}