{"id":"https://openalex.org/W2016927230","doi":"https://doi.org/10.1073/pnas.0712390105","title":"Protection from fatal viral encephalomyelitis: AMPA receptor antagonists have a direct effect on the inflammatory response to infection","display_name":"Protection from fatal viral encephalomyelitis: AMPA receptor antagonists have a direct effect on the inflammatory response to infection","publication_year":2008,"publication_date":"2008-02-22","ids":{"openalex":"https://openalex.org/W2016927230","doi":"https://doi.org/10.1073/pnas.0712390105","mag":"2016927230","pmid":"https://pubmed.ncbi.nlm.nih.gov/18296635","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2265123"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0712390105","doi":"https://doi.org/10.1073/pnas.0712390105","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0712390105","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2265123","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021992185","display_name":"Ivorlyne P. Greene","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivorlyne P. Greene","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205","Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Eun-Young Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Eun-Young Lee","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205","Chungbuk National University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Chungbuk National University","institution_ids":["https://openalex.org/I163753206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034545228","display_name":"Natalie A. Prow","orcid":"https://orcid.org/0000-0001-7312-8767","observed_orcids":["https://orcid.org/0000-0001-7312-8767"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"Natalie Prow","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205","University of Queensland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"University of Queensland","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038763400","display_name":"Brownhilda Ngwang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brownhilda Ngwang","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040754947","display_name":"Diane E. Griffin","orcid":"https://orcid.org/0000-0001-6643-2429","observed_orcids":["https://orcid.org/0000-0001-6643-2429"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane E. Griffin","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5209,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.87044534,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"105","issue":"9","first_page":"3575","last_page":"3580"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.5493000149726868,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.5493000149726868,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.10050000250339508,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.09640000015497208,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/viral-encephalomyelitis","display_name":"viral encephalomyelitis","score":0.9020000100135803},{"id":"https://openalex.org/keywords/sindbis-virus","display_name":"Sindbis virus","score":0.9070000052452087},{"id":"https://openalex.org/keywords/ampa-receptor-antagonists","display_name":"AMPA receptor antagonists","score":0.8939999938011169},{"id":"https://openalex.org/keywords/gyki-52466","display_name":"GYKI 52466","score":0.8889999985694885},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7649999856948853},{"id":"https://openalex.org/keywords/motor-neuron-degeneration","display_name":"motor neuron degeneration","score":0.7070000171661377},{"id":"https://openalex.org/keywords/glutamate-excitotoxicity","display_name":"glutamate excitotoxicity","score":0.8149999976158142},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.6610000133514404},{"id":"https://openalex.org/keywords/mononuclear-cell-infiltration","display_name":"mononuclear cell infiltration","score":0.8379999995231628},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.8429999947547913},{"id":"https://openalex.org/keywords/lymphocyte-activation","display_name":"lymphocyte activation","score":0.7200000286102295},{"id":"https://openalex.org/keywords/secondary-lymphoid-organs","display_name":"secondary lymphoid organs","score":0.8059999942779541},{"id":"https://openalex.org/keywords/antibody-response","display_name":"antibody response","score":0.8309999704360962},{"id":"https://openalex.org/keywords/viral-clearance","display_name":"viral clearance","score":0.7900000214576721},{"id":"https://openalex.org/keywords/alphavirus","display_name":"alphavirus","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.7229965329170227},{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.679937481880188},{"id":"https://openalex.org/C2781313946","wikidata":"https://www.wikidata.org/wiki/Q4735280","display_name":"Alphavirus infection","level":4,"score":0.5827347636222839},{"id":"https://openalex.org/C2777899865","wikidata":"https://www.wikidata.org/wiki/Q1634879","display_name":"Encephalomyelitis","level":3,"score":0.5403675436973572},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.49872255325317383},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4687493145465851},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.4669647514820099},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.43239784240722656},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42373722791671753},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41634491086006165},{"id":"https://openalex.org/C2778486448","wikidata":"https://www.wikidata.org/wiki/Q494066","display_name":"Experimental autoimmune encephalomyelitis","level":3,"score":0.41285422444343567},{"id":"https://openalex.org/C2777474056","wikidata":"https://www.wikidata.org/wiki/Q1111605","display_name":"Alphavirus","level":3,"score":0.39814454317092896},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3468324840068817},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.33819645643234253},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3351113498210907},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06950205564498901},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001569","descriptor_name":"Benzodiazepines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001569","descriptor_name":"Benzodiazepines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D004679","descriptor_name":"Encephalomyelitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004679","descriptor_name":"Encephalomyelitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004679","descriptor_name":"Encephalomyelitis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D004679","descriptor_name":"Encephalomyelitis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012845","descriptor_name":"Sindbis Virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018091","descriptor_name":"Receptors, AMPA","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D018354","descriptor_name":"Alphavirus Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018354","descriptor_name":"Alphavirus Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.0712390105","doi":"https://doi.org/10.1073/pnas.0712390105","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0712390105","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2265123","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2265123","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:18296635","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18296635","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2265123","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2265123","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7980193082","display_name":"Control of alphavirous replacation in the nervous system","funder_award_id":"R01NS038932","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000869215","display_name":"Cellular and Molecular Mechanisms of Immune Inflammatory Reactions","funder_award_id":"T32AI007247","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W9980252","https://openalex.org/W204348490","https://openalex.org/W1500225421","https://openalex.org/W1517159675","https://openalex.org/W1554736362","https://openalex.org/W1558647135","https://openalex.org/W1565999785","https://openalex.org/W1596817582","https://openalex.org/W1835937600","https://openalex.org/W1904248154","https://openalex.org/W1974809331","https://openalex.org/W1982963480","https://openalex.org/W1985693146","https://openalex.org/W1986003731","https://openalex.org/W1988256009","https://openalex.org/W1989839710","https://openalex.org/W1995032030","https://openalex.org/W1995643379","https://openalex.org/W1996975123","https://openalex.org/W1998430487","https://openalex.org/W2000452226","https://openalex.org/W2007633164","https://openalex.org/W2010417355","https://openalex.org/W2011654786","https://openalex.org/W2015237292","https://openalex.org/W2025182790","https://openalex.org/W2036565829","https://openalex.org/W2038269384","https://openalex.org/W2049675290","https://openalex.org/W2050431757","https://openalex.org/W2052332287","https://openalex.org/W2053121777","https://openalex.org/W2053640261","https://openalex.org/W2059309243","https://openalex.org/W2060367057","https://openalex.org/W2062870806","https://openalex.org/W2063907608","https://openalex.org/W2066557327","https://openalex.org/W2072576888","https://openalex.org/W2080599448","https://openalex.org/W2081445550","https://openalex.org/W2082855182","https://openalex.org/W2092990950","https://openalex.org/W2093008974","https://openalex.org/W2093381843","https://openalex.org/W2097935692","https://openalex.org/W2099956943","https://openalex.org/W2102515794","https://openalex.org/W2105224367","https://openalex.org/W2107260430","https://openalex.org/W2109215110","https://openalex.org/W2116447221","https://openalex.org/W2122718589","https://openalex.org/W2127338217","https://openalex.org/W2134966618","https://openalex.org/W2141655042","https://openalex.org/W2146588462","https://openalex.org/W2147999139","https://openalex.org/W2154981140","https://openalex.org/W2157970800","https://openalex.org/W2158364751","https://openalex.org/W2163166100","https://openalex.org/W2169180468","https://openalex.org/W2419053233","https://openalex.org/W4243954577"],"related_works":["https://openalex.org/W2072576888","https://openalex.org/W2344746490","https://openalex.org/W7096564124","https://openalex.org/W2015237292","https://openalex.org/W1996725138","https://openalex.org/W2524932670","https://openalex.org/W2053121777","https://openalex.org/W1970803505","https://openalex.org/W2614883925","https://openalex.org/W2063907608"],"abstract_inverted_index":{"Neuronal":[0],"cell":[1,118],"death":[2,38,216],"during":[3,112],"fatal":[4,32],"acute":[5],"viral":[6,222],"encephalomyelitis":[7,33],"can":[8,44],"result":[9],"from":[10,103,215],"damage":[11],"caused":[12,220],"by":[13,47,171,210,221],"virus":[14,29,175],"replication,":[15],"glutamate":[16,57,96],"excitotoxicity,":[17,206],"and":[18,106,120,152,174,194],"the":[19,26,50,72,89,110,191],"immune":[20,192],"response.":[21],"A":[22],"neurovirulent":[23],"strain":[24],"of":[25,74,88,93,109,126,139,146,154,186,198,205,217],"alphavirus":[27],"Sindbis":[28],"(NSV)":[30],"causes":[31],"associated":[34],"with":[35,49,80,135],"motor":[36,218],"neuron":[37],"in":[39,123,131,156,160,201],"adult":[40],"C57BL/6":[41],"mice":[42,77,100,133,148],"that":[43,196],"be":[45],"prevented":[46],"treatment":[48],"prototypic":[51],"noncompetitive":[52,94],"alpha-amino-3-hydroxy-5-methyl-4-isoxazole":[53],"propionic":[54],"acid":[55],"(AMPA)":[56],"receptor":[58,97,188],"antagonist":[59],"GYKI":[60],"52466":[61],"[Nargi-Aizenman":[62],"J,":[63],"et":[64],"al.":[65],"(2004)":[66],"Ann":[67],"Neurol":[68],"55:541-549].":[69],"To":[70],"determine":[71],"mechanism":[73,209],"protection,":[75],"NSV-infected":[76],"were":[78,101,168],"treated":[79,132,147],"7-acetyl-5-(4-aminophenyl)-8(R)-methyl-8,9-dihydro-7H-1,3-dioxolo-(4,5-h)-benzodiazepine":[81],"(talampanel),":[82],"a":[83,182,208],"potent,":[84],"orally":[85],"available":[86],"member":[87],"2,3":[90],"benzodiazepine":[91],"class":[92],"AMPA":[95,187],"antagonists.":[98],"Talampanel-treated":[99],"protected":[102],"NSV-induced":[104],"paralysis":[105],"death.":[107],"Examination":[108],"brain":[111],"infection":[113],"showed":[114],"significantly":[115],"less":[116],"mononuclear":[117],"infiltration":[119],"no":[121],"increase":[122],"astrocyte":[124],"expression":[125],"glial":[127],"fibrillary":[128],"acidic":[129],"protein":[130],"compared":[134],"untreated":[136],"mice.":[137],"Lack":[138],"CNS":[140],"inflammation":[141],"was":[142,177],"attributable":[143],"to":[144,149,162,166,203],"failure":[145],"induce":[150],"activation":[151],"proliferation":[153],"lymphocytes":[155],"secondary":[157],"lymphoid":[158],"tissue":[159],"response":[161,193],"infection.":[163,223],"Antibody":[164],"responses":[165],"NSV":[167],"also":[169],"suppressed":[170],"talampanel":[172],"treatment,":[173],"clearance":[176],"delayed.":[178],"These":[179],"studies":[180],"reveal":[181],"previously":[183],"unrecognized":[184],"effect":[185],"antagonists":[189],"on":[190],"suggest":[195],"prevention":[197],"immune-mediated":[199],"damage,":[200],"addition":[202],"inhibition":[204],"is":[207],"which":[211],"these":[212],"drugs":[213],"protect":[214],"neurons":[219]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}