{"id":"https://openalex.org/W2016913373","doi":"https://doi.org/10.1159/000182765","title":"Results of Long-Term Therapy with Growth Hormone in Two Dose Regimens in Turner Syndrome","display_name":"Results of Long-Term Therapy with Growth Hormone in Two Dose Regimens in Turner Syndrome","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W2016913373","doi":"https://doi.org/10.1159/000182765","mag":"2016913373","pmid":"https://pubmed.ncbi.nlm.nih.gov/8359786"},"language":"en","primary_location":{"id":"doi:10.1159/000182765","doi":"https://doi.org/10.1159/000182765","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000182765","pdf_url":null,"source":{"id":"https://openalex.org/S4210219815","display_name":"Hormone Research","issn_l":"0301-0163","issn":["0301-0163","1423-0046"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034845830","display_name":"H.E. Nienhuis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"H.E. Nienhuis","raw_affiliation_strings":["Department of Paediatrics, University of Utrecth, The Netherlands","Utrecht,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, University of Utrecth, The Netherlands","institution_ids":["https://openalex.org/I193662353"]},{"raw_affiliation_string":"Utrecht,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069278181","display_name":"Ciska Rongen\u2010Westerlaken","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Rongen-Westerlaken","raw_affiliation_strings":["Nijmegen,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nijmegen,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054571302","display_name":"Jan Maarten Wit","orcid":"https://orcid.org/0000-0002-1715-5020","observed_orcids":["https://orcid.org/0000-0002-1715-5020"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.M. Wit","raw_affiliation_strings":["Utrecht,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Utrecht,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036226074","display_name":"B. Otten","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B.J. Otten","raw_affiliation_strings":["Nijmegen,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nijmegen,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111662814","display_name":"de Muinck Keizer-Schrama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"de Muinck Keizer-Schrama","raw_affiliation_strings":["Rotterdam,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rotterdam,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111606112","display_name":"N.M. Drayer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N.M. Drayer","raw_affiliation_strings":["Groningen,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Groningen,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108477953","display_name":"Delemarre-van de Waal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Delemarre-van de Waal","raw_affiliation_strings":["Amsterdam Free University,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amsterdam Free University,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109239439","display_name":"Thomas Vulsma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Vulsma","raw_affiliation_strings":["Amsterdam, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amsterdam, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063096363","display_name":"Wilma Oostdijk","orcid":"https://orcid.org/0000-0003-0180-2470","observed_orcids":["https://orcid.org/0000-0003-0180-2470"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. Oostdijk","raw_affiliation_strings":["Leiden, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden, and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108424511","display_name":"Johan J. J. Waelkens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801238018","display_name":"Catharina Ziekenhuis","ror":"https://ror.org/01qavk531","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801238018"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J.J.J. Waelkens","raw_affiliation_strings":["Catherina Hospital, Eindhoven, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Catherina Hospital, Eindhoven, The Netherlands","institution_ids":["https://openalex.org/I2801238018"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8216,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.68840125,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"39","issue":"2","first_page":"31","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/turner-syndrome","display_name":"Turner syndrome","score":1.0},{"id":"https://openalex.org/keywords/growth-hormone-therapy","display_name":"growth hormone therapy","score":0.890999972820282},{"id":"https://openalex.org/keywords/dosing-regimen","display_name":"dosing regimen","score":0.7059999704360962},{"id":"https://openalex.org/keywords/injection-frequency","display_name":"injection frequency","score":0.7419999837875366},{"id":"https://openalex.org/keywords/height-velocity","display_name":"height velocity","score":0.9649999737739563},{"id":"https://openalex.org/keywords/adult-height-prediction","display_name":"adult height prediction","score":0.7870000004768372},{"id":"https://openalex.org/keywords/long-term-treatment","display_name":"long-term treatment","score":0.5839999914169312},{"id":"https://openalex.org/keywords/age-differences-in-treatment-response","display_name":"age differences in treatment response","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C2779683239","wikidata":"https://www.wikidata.org/wiki/Q202849","display_name":"Turner syndrome","level":2,"score":0.8875384330749512},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.7479510307312012},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7191371321678162},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.5684012770652771},{"id":"https://openalex.org/C2910742204","wikidata":"https://www.wikidata.org/wiki/Q202849","display_name":"Turner's syndrome","level":3,"score":0.5649469494819641},{"id":"https://openalex.org/C2991696056","wikidata":"https://www.wikidata.org/wiki/Q2299582","display_name":"Growth velocity","level":2,"score":0.543032705783844},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43849918246269226},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.32467836141586304},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32200610637664795}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001827","descriptor_name":"Body Height","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001846","descriptor_name":"Bone Development","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006128","descriptor_name":"Growth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014424","descriptor_name":"Turner Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1159/000182765","doi":"https://doi.org/10.1159/000182765","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000182765","pdf_url":null,"source":{"id":"https://openalex.org/S4210219815","display_name":"Hormone Research","issn_l":"0301-0163","issn":["0301-0163","1423-0046"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone Research","raw_type":"journal-article"},{"id":"pmid:8359786","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8359786","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone research","raw_type":"Clinical Trial"},{"id":"pmh:oai:pure.rug.nl:openaire_cris_publications/2535b0b0-7a83-4569-9506-8200609c666c","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11370/2535b0b0-7a83-4569-9506-8200609c666c","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NIENHUIS, HE, RONGENWESTERLAKEN, C, WIT, JM, OTTEN, BJ, KEIZERSCHRAMA, SMPFD, DRAYER, NM, DELEMARREVANDEWAAL, HA, VULSMA, T, OOSTDIJK, W & WAELKENS, JJJ 1993, 'RESULTS OF LONG-TERM THERAPY WITH GROWTH-HORMONE IN 2 DOSE REGIMENS IN TURNER SYNDROME', HORMONE RESEARCH, vol. 39, pp. 31-36.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/2535b0b0-7a83-4569-9506-8200609c666c","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/2535b0b0-7a83-4569-9506-8200609c666c","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"HORMONE RESEARCH, 39, 31 - 36","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7061862664","https://openalex.org/W2007013443","https://openalex.org/W2039258568","https://openalex.org/W1964380132","https://openalex.org/W2070906814","https://openalex.org/W2053243997","https://openalex.org/W2032314990","https://openalex.org/W2441358165","https://openalex.org/W2095383846","https://openalex.org/W2108585919"],"abstract_inverted_index":{"Girls":[0],"with":[1,42,140],"Turner":[2,141],"syndrome":[3,142],"were":[4,67],"divided":[5],"according":[6],"to":[7,38,69],"age":[8],"(group":[9],"A":[10],"6-12":[11],"years,":[12,146],"and":[13,18,26,31,65,132],"group":[14,90,104,107],"B":[15],"12-19":[16],"years)":[17],"human":[19],"growth":[20],"hormone":[21],"(GH)":[22],"dose":[23,60],"regimen":[24,114],"(A1":[25],"B1,":[27],"three":[28,124],"injections/week;":[29],"A2":[30,105],"B2,":[32],"six":[33,74,116],"injections/week).":[34],"All":[35],"groups":[36,63],"responded":[37],"GH,":[39],"24":[40],"IU/m2/week,":[41],"an":[43,83],"increase":[44,84],"in":[45,49,62,76,82,85,89,103,126,134],"height":[46,86,99,130],"velocity,":[47],"though":[48],"the":[50,53,59,93,98],"older":[51],"girls,":[52],"response":[54],"was":[55,101],"comparatively":[56],"poor.":[57],"Therefore,":[58],"regimens":[61],"B1":[64],"B2":[66],"increased":[68],"36":[70],"IU/m2/week":[71],"given":[72],"as":[73],"injections":[75],"both":[77],"groups.":[78],"This":[79],"change":[80,133],"resulted":[81],"velocity":[87,100],"only":[88],"B1.":[91],"During":[92],"first":[94],"2":[95],"years":[96],"only,":[97],"greater":[102],"than":[106,121],"A1.":[108],"The":[109],"conclusion":[110],"is":[111,118],"that":[112],"a":[113],"of":[115,123,128],"injections/week":[117,125],"more":[119],"effective":[120],"one":[122],"terms":[127],"initial":[129],"gain":[131],"predicted":[135],"adult":[136],"height.":[137],"In":[138],"girls":[139],"aged":[143],"over":[144],"16":[145],"GH":[147],"therapy":[148],"has":[149],"no":[150],"significant":[151],"effect.":[152]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}