{"id":"https://openalex.org/W2016880783","doi":"https://doi.org/10.1016/j.tetlet.2007.11.135","title":"Microwave-based synthesis of novel thienopyrimidine bioisosteres of gefitinib","display_name":"Microwave-based synthesis of novel thienopyrimidine bioisosteres of gefitinib","publication_year":2007,"publication_date":"2007-12-05","ids":{"openalex":"https://openalex.org/W2016880783","doi":"https://doi.org/10.1016/j.tetlet.2007.11.135","mag":"2016880783"},"language":"en","primary_location":{"id":"doi:10.1016/j.tetlet.2007.11.135","doi":"https://doi.org/10.1016/j.tetlet.2007.11.135","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tetlet.2007.11.135","pdf_url":null,"source":{"id":"https://openalex.org/S133942674","display_name":"Tetrahedron Letters","issn_l":"0040-4039","issn":["0040-4039","1873-3581"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tetrahedron Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052869077","display_name":"Manisha S. Phoujdar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manisha S. Phoujdar","raw_affiliation_strings":["Sinhgad College of Pharmacy, Pharmaceutical Chemistry, S. No. 44/1, Vadgaon (BK), Sinhgad Road, Pune 411 041, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sinhgad College of Pharmacy, Pharmaceutical Chemistry, S. No. 44/1, Vadgaon (BK), Sinhgad Road, Pune 411 041, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062476955","display_name":"M. K. Kathiravan","orcid":"https://orcid.org/0000-0001-8357-2730","observed_orcids":["https://orcid.org/0000-0001-8357-2730"]},"institutions":[{"id":"https://openalex.org/I878213199","display_name":"Savitribai Phule Pune University","ror":"https://ror.org/044g6d731","country_code":"IN","type":"education","lineage":["https://openalex.org/I878213199"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Muthu K. Kathiravan","raw_affiliation_strings":["Poona College of Pharmacy, Pune 411 038, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Poona College of Pharmacy, Pune 411 038, India","institution_ids":["https://openalex.org/I878213199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016240043","display_name":"Jitender B. Bariwal","orcid":"https://orcid.org/0000-0002-4521-5537","observed_orcids":["https://orcid.org/0000-0002-4521-5537"]},"institutions":[{"id":"https://openalex.org/I197181853","display_name":"Saurashtra University","ror":"https://ror.org/0250jpt55","country_code":"IN","type":"education","lineage":["https://openalex.org/I197181853"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jitender B. Bariwal","raw_affiliation_strings":["Department of Chemistry, Saurashtra University, Rajkot 360 005, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Saurashtra University, Rajkot 360 005, India","institution_ids":["https://openalex.org/I197181853"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004961522","display_name":"Anamik K. Shah","orcid":"https://orcid.org/0000-0001-9206-8368","observed_orcids":["https://orcid.org/0000-0001-9206-8368"]},"institutions":[{"id":"https://openalex.org/I197181853","display_name":"Saurashtra University","ror":"https://ror.org/0250jpt55","country_code":"IN","type":"education","lineage":["https://openalex.org/I197181853"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anamik K. Shah","raw_affiliation_strings":["Department of Chemistry, Saurashtra University, Rajkot 360 005, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Saurashtra University, Rajkot 360 005, India","institution_ids":["https://openalex.org/I197181853"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111850127","display_name":"Kishor S. Jain","orcid":"https://orcid.org/0000-0002-0784-7824","observed_orcids":["https://orcid.org/0000-0002-0784-7824"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kishor S. Jain","raw_affiliation_strings":["Sinhgad College of Pharmacy, Pharmaceutical Chemistry, S. No. 44/1, Vadgaon (BK), Sinhgad Road, Pune 411 041, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sinhgad College of Pharmacy, Pharmaceutical Chemistry, S. No. 44/1, Vadgaon (BK), Sinhgad Road, Pune 411 041, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111850127"],"corresponding_institution_ids":[],"apc_list":{"value":3610,"currency":"USD","value_usd":3610},"apc_paid":null,"fwci":2.0452,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.84892462,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"49","issue":"7","first_page":"1269","last_page":"1273"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13208","display_name":"Synthesis of heterocyclic compounds","score":0.49050000309944153,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13208","display_name":"Synthesis of heterocyclic compounds","score":0.49050000309944153,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.21789999306201935,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12270","display_name":"Microwave-Assisted Synthesis and Applications","score":0.13439999520778656,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thienopyrimidines","display_name":"thienopyrimidines","score":0.8629999756813049},{"id":"https://openalex.org/keywords/microwave-assisted-synthesis","display_name":"microwave-assisted synthesis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/chlorination","display_name":"chlorination","score":0.8519999980926514},{"id":"https://openalex.org/keywords/nucleophilic-substitution","display_name":"nucleophilic substitution","score":0.8730000257492065},{"id":"https://openalex.org/keywords/aniline","display_name":"aniline","score":0.9150000214576721},{"id":"https://openalex.org/keywords/antifolate-analogues","display_name":"antifolate analogues","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9659860134124756},{"id":"https://openalex.org/C2984548686","wikidata":"https://www.wikidata.org/wiki/Q905377","display_name":"Microwave irradiation","level":3,"score":0.6679798364639282},{"id":"https://openalex.org/C178907741","wikidata":"https://www.wikidata.org/wiki/Q745930","display_name":"Nucleophile","level":3,"score":0.6521933674812317},{"id":"https://openalex.org/C44838205","wikidata":"https://www.wikidata.org/wiki/Q127995","display_name":"Microwave","level":2,"score":0.48908692598342896},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4430682957172394},{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.43178728222846985},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4053894281387329},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2099331021308899},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.tetlet.2007.11.135","doi":"https://doi.org/10.1016/j.tetlet.2007.11.135","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tetlet.2007.11.135","pdf_url":null,"source":{"id":"https://openalex.org/S133942674","display_name":"Tetrahedron Letters","issn_l":"0040-4039","issn":["0040-4039","1873-3581"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tetrahedron Letters","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1511035091","https://openalex.org/W1709109739","https://openalex.org/W1966672421","https://openalex.org/W1999626047","https://openalex.org/W2049655823","https://openalex.org/W2055903396","https://openalex.org/W2065810173","https://openalex.org/W2115007832","https://openalex.org/W2173949843","https://openalex.org/W4230346864","https://openalex.org/W4235799017"],"related_works":["https://openalex.org/W2950199646","https://openalex.org/W2949405369","https://openalex.org/W1988919400","https://openalex.org/W2953015784","https://openalex.org/W2177278154","https://openalex.org/W3013208562","https://openalex.org/W2952389580","https://openalex.org/W2953139266","https://openalex.org/W2767939473","https://openalex.org/W2184992881"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}