{"id":"https://openalex.org/W2016864698","doi":"https://doi.org/10.1371/journal.pone.0018377","title":"Single Gene Deletions of Orexin, Leptin, Neuropeptide Y, and Ghrelin Do Not Appreciably Alter Food Anticipatory Activity in Mice","display_name":"Single Gene Deletions of Orexin, Leptin, Neuropeptide Y, and Ghrelin Do Not Appreciably Alter Food Anticipatory Activity in Mice","publication_year":2011,"publication_date":"2011-03-28","ids":{"openalex":"https://openalex.org/W2016864698","doi":"https://doi.org/10.1371/journal.pone.0018377","mag":"2016864698","pmid":"https://pubmed.ncbi.nlm.nih.gov/21464907","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3065493"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0018377","doi":"https://doi.org/10.1371/journal.pone.0018377","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0018377","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0018377&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0018377&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024855512","display_name":"Keith M. Gunapala","orcid":"https://orcid.org/0000-0002-6355-9499","observed_orcids":["https://orcid.org/0000-0002-6355-9499"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith M. Gunapala","raw_affiliation_strings":["Broad Fellows Program in Brain Circuitry, Division of Biology, California Institute of Technology, Pasadena, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Fellows Program in Brain Circuitry, Division of Biology, California Institute of Technology, Pasadena, California, United States of America","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031803892","display_name":"Christian M. Gallardo","orcid":"https://orcid.org/0000-0001-5702-0852","observed_orcids":["https://orcid.org/0000-0001-5702-0852"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian M. Gallardo","raw_affiliation_strings":["Broad Fellows Program in Brain Circuitry, Division of Biology, California Institute of Technology, Pasadena, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Fellows Program in Brain Circuitry, Division of Biology, California Institute of Technology, Pasadena, California, United States of America","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101456811","display_name":"Cynthia T. Hsu","orcid":"https://orcid.org/0000-0003-4122-2657","observed_orcids":["https://orcid.org/0000-0003-4122-2657"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia T. Hsu","raw_affiliation_strings":["Broad Fellows Program in Brain Circuitry, Division of Biology, California Institute of Technology, Pasadena, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Fellows Program in Brain Circuitry, Division of Biology, California Institute of Technology, Pasadena, California, United States of America","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101485668","display_name":"Andrew D. Steele","orcid":"https://orcid.org/0000-0001-8777-4970","observed_orcids":["https://orcid.org/0000-0001-8777-4970"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew D. Steele","raw_affiliation_strings":["Broad Fellows Program in Brain Circuitry, Division of Biology, California Institute of Technology, Pasadena, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Fellows Program in Brain Circuitry, Division of Biology, California Institute of Technology, Pasadena, California, United States of America","institution_ids":["https://openalex.org/I122411786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101485668"],"corresponding_institution_ids":["https://openalex.org/I122411786"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.6888,"has_fulltext":true,"cited_by_count":62,"citation_normalized_percentile":{"value":0.93163097,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"6","issue":"3","first_page":"e18377","last_page":"e18377"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.6685000061988831,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.6685000061988831,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.31349998712539673,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/food-anticipatory-activity","display_name":"food anticipatory activity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/orexin","display_name":"orexin","score":0.8709999918937683},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neuropeptide-y","display_name":"neuropeptide Y","score":1.0},{"id":"https://openalex.org/keywords/ghrelin","display_name":"ghrelin","score":1.0},{"id":"https://openalex.org/keywords/caloric-restriction","display_name":"caloric restriction","score":0.8600000143051147},{"id":"https://openalex.org/keywords/scheduled-feeding","display_name":"scheduled feeding","score":0.6309999823570251},{"id":"https://openalex.org/keywords/body-temperature","display_name":"body temperature","score":0.4950000047683716},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.7379999756813049},{"id":"https://openalex.org/keywords/knockout-mice","display_name":"knockout mice","score":0.6759999990463257},{"id":"https://openalex.org/keywords/meal-timing","display_name":"meal timing","score":0.5139999985694885},{"id":"https://openalex.org/keywords/home-cage-behavior","display_name":"home cage behavior","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C2779357093","wikidata":"https://www.wikidata.org/wiki/Q422269","display_name":"Ghrelin","level":3,"score":0.9040111303329468},{"id":"https://openalex.org/C2777205416","wikidata":"https://www.wikidata.org/wiki/Q433807","display_name":"Orexigenic","level":5,"score":0.8844748735427856},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.8839520215988159},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7759675979614258},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7658513188362122},{"id":"https://openalex.org/C2779680196","wikidata":"https://www.wikidata.org/wiki/Q410857","display_name":"Orexin","level":4,"score":0.7627134323120117},{"id":"https://openalex.org/C93984277","wikidata":"https://www.wikidata.org/wiki/Q24782073","display_name":"Neuropeptide Y receptor","level":4,"score":0.7338033318519592},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5580814480781555},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.537379264831543},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.5207983255386353},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.35750138759613037},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2645789384841919},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.18185016512870789},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08831152319908142}],"mesh":[{"descriptor_ui":"D000068797","descriptor_name":"Orexins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001831","descriptor_name":"Body Temperature","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005247","descriptor_name":"Feeding Behavior","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009478","descriptor_name":"Neuropeptide Y","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D009478","descriptor_name":"Neuropeptide Y","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D031204","descriptor_name":"Caloric Restriction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054439","descriptor_name":"Ghrelin","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D054439","descriptor_name":"Ghrelin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0018377","doi":"https://doi.org/10.1371/journal.pone.0018377","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0018377","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0018377&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3065493","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3065493","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:21464907","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21464907","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.349.9099","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.349.9099","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/dc/a8/PLoS_One_2011_Mar_28_6(3)_e18377.tar.gz","raw_type":"text"},{"id":"pmh:oai:authors.library.caltech.edu:23504","doi":null,"is_oa":true,"landing_page_url":"https://resolver.caltech.edu/CaltechAUTHORS:20110429-105047118","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:db7d150a43a34459ace82021a25c0b3d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/db7d150a43a34459ace82021a25c0b3d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 6, Iss 3, p e18377 (2011)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0018377","doi":"https://doi.org/10.1371/journal.pone.0018377","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0018377","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0018377&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306135","display_name":"Ellison Medical Foundation","ror":"https://ror.org/01pqy3846"},{"id":"https://openalex.org/F4320308364","display_name":"Klarman Family Foundation","ror":"https://ror.org/004qcer42"},{"id":"https://openalex.org/F4320309398","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016864698.pdf","grobid_xml":"https://content.openalex.org/works/W2016864698.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1963755841","https://openalex.org/W1964357455","https://openalex.org/W1974219409","https://openalex.org/W1977208819","https://openalex.org/W1982148242","https://openalex.org/W1984548515","https://openalex.org/W1988890104","https://openalex.org/W1988975012","https://openalex.org/W1990388529","https://openalex.org/W1996172219","https://openalex.org/W2001618020","https://openalex.org/W2001660140","https://openalex.org/W2003166239","https://openalex.org/W2003967044","https://openalex.org/W2004779721","https://openalex.org/W2005520918","https://openalex.org/W2011692478","https://openalex.org/W2013002120","https://openalex.org/W2017709986","https://openalex.org/W2022726058","https://openalex.org/W2023615964","https://openalex.org/W2024362510","https://openalex.org/W2029818029","https://openalex.org/W2040079778","https://openalex.org/W2047031825","https://openalex.org/W2055196490","https://openalex.org/W2060140960","https://openalex.org/W2060682066","https://openalex.org/W2066283353","https://openalex.org/W2066511972","https://openalex.org/W2070822068","https://openalex.org/W2073036589","https://openalex.org/W2075019242","https://openalex.org/W2076357323","https://openalex.org/W2082622527","https://openalex.org/W2083126141","https://openalex.org/W2090912585","https://openalex.org/W2097596167","https://openalex.org/W2098059948","https://openalex.org/W2100996376","https://openalex.org/W2114765598","https://openalex.org/W2129528230","https://openalex.org/W2135340140","https://openalex.org/W2143609607","https://openalex.org/W2144690367","https://openalex.org/W2145701912","https://openalex.org/W2148181747","https://openalex.org/W2151069315","https://openalex.org/W2154555913","https://openalex.org/W2154935464","https://openalex.org/W2160557453","https://openalex.org/W2164528062","https://openalex.org/W2169014479","https://openalex.org/W2329130636"],"related_works":["https://openalex.org/W2169014479","https://openalex.org/W3022042051","https://openalex.org/W2098059948","https://openalex.org/W2011692478","https://openalex.org/W2460946029","https://openalex.org/W2022475811","https://openalex.org/W1982437733","https://openalex.org/W4379744455","https://openalex.org/W1984718611","https://openalex.org/W1498227379"],"abstract_inverted_index":{"Timing":[0],"activity":[1,23,39,147,214],"to":[2,25,48,74,136,152,158,168,204],"match":[3],"resource":[4],"availability":[5],"is":[6,59],"a":[7,16,60,118,173,262],"widely":[8],"conserved":[9],"ability":[10],"in":[11,28,51,155,210,295],"nature.":[12],"Scheduled":[13],"feeding":[14,26,229],"of":[15,19,54,62,82,95,117,212,248,291],"limited":[17],"amount":[18],"food":[20,37,45,121,145],"induces":[21],"increased":[22],"prior":[24],"time":[27,61,91,240],"animals":[29],"as":[30,32,217],"diverse":[31],"fish":[33],"and":[34,98,106,123,184,186,219,273],"rodents.":[35],"Typically,":[36],"anticipatory":[38,146],"(FAA)":[40,148],"involves":[41],"temporally":[42],"restricting":[43],"unlimited":[44],"access":[46],"(RF)":[47],"several":[49],"hours":[50],"the":[52,55,79,89,104,115,130,138,156,179,187,199,245,270,289],"middle":[53],"light":[56],"cycle,":[57],"which":[58],"day":[63],"when":[64],"rodents":[65],"are":[66,109,166],"not":[67,197,223,243,257,277,286],"normally":[68],"active.":[69],"We":[70],"compared":[71],"this":[72,284],"model":[73],"calorie":[75,86],"restriction":[76],"(CR),":[77],"giving":[78],"mice":[80,165,235,255],"60%":[81],"their":[83,292],"normal":[84],"daily":[85,238],"intake":[87,122],"at":[88],"same":[90],"each":[92],"day.":[93],"Measurement":[94],"body":[96,127,169],"temperature":[97],"home":[99],"cage":[100],"behaviors":[101],"suggests":[102],"that":[103,141,162,232,250,269],"RF":[105],"CR":[107,113,131,159,174,263],"models":[108],"very":[110],"similar":[111],"but":[112,149,221,241,283],"has":[114],"advantage":[116],"clearly":[119],"defined":[120],"more":[124],"stable":[125],"mean":[126],"temperature.":[128],"Using":[129],"model,":[132],"we":[133,177],"then":[134],"attempted":[135],"verify":[137],"published":[139],"result":[140],"orexin":[142,163],"deletion":[143,195,207],"diminishes":[144],"observed":[150],"little":[151],"no":[153],"diminution":[154],"response":[157,203],"and,":[160],"surprisingly,":[161],"KO":[164],"refractory":[167],"weight":[170],"loss":[171],"on":[172,261],"diet.":[175,264],"Next":[176],"tested":[178,275],"orexigenic":[180],"neuropeptide":[181],"Y":[182],"(NPY)":[183],"ghrelin":[185],"anorexigenic":[188],"hormone,":[189],"leptin,":[190],"using":[191],"mouse":[192],"mutants.":[193],"NPY":[194],"did":[196,222],"alter":[198],"behavior":[200,227],"or":[201],"physiological":[202],"CR.":[205],"Leptin":[206],"impaired":[208,259],"FAA":[209,260,279],"terms":[211],"some":[213],"measures,":[215],"such":[216],"walking":[218],"rearing,":[220],"substantially":[224],"diminish":[225],"hanging":[226],"preceding":[228],"time,":[230],"suggesting":[231],"leptin":[233],"knockout":[234,254],"do":[236,242,256,276],"anticipate":[237],"meal":[239],"manifest":[244],"full":[246],"spectrum":[247],"activities":[249],"typify":[251],"FAA.":[252,297],"Ghrelin":[253],"have":[258],"Collectively,":[265],"these":[266],"results":[267],"suggest":[268],"individual":[271],"hormones":[272],"neuropepetides":[274],"regulate":[278],"by":[280],"acting":[281],"individually":[282],"does":[285],"rule":[287],"out":[288],"possibility":[290],"concerted":[293],"action":[294],"mediating":[296]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}