{"id":"https://openalex.org/W2016861965","doi":"https://doi.org/10.1016/s0273-2300(03)00013-8","title":"Ninety-day oral toxicity study of lycopene from Blakeslea trispora in rats","display_name":"Ninety-day oral toxicity study of lycopene from Blakeslea trispora in rats","publication_year":2003,"publication_date":"2003-05-19","ids":{"openalex":"https://openalex.org/W2016861965","doi":"https://doi.org/10.1016/s0273-2300(03)00013-8","mag":"2016861965","pmid":"https://pubmed.ncbi.nlm.nih.gov/12758219"},"language":"en","primary_location":{"id":"doi:10.1016/s0273-2300(03)00013-8","doi":"https://doi.org/10.1016/s0273-2300(03)00013-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0273-2300(03)00013-8","pdf_url":null,"source":{"id":"https://openalex.org/S87719511","display_name":"Regulatory Toxicology and Pharmacology","issn_l":"0273-2300","issn":["0273-2300","1096-0295"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regulatory Toxicology and Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111713660","display_name":"D. Jonker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148297040","display_name":"Netherlands Organisation for Applied Scientific Research","ror":"https://ror.org/01bnjb948","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I148297040"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"D. Jonker","raw_affiliation_strings":["TNO Nutrition and Food Research, Utrechtseweg 48, P.O. Box 360, 3700 AJ, Zeist, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TNO Nutrition and Food Research, Utrechtseweg 48, P.O. Box 360, 3700 AJ, Zeist, The Netherlands","institution_ids":["https://openalex.org/I148297040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081174471","display_name":"C. Frieke Kuper","orcid":"https://orcid.org/0000-0001-8273-2915","observed_orcids":["https://orcid.org/0000-0001-8273-2915"]},"institutions":[{"id":"https://openalex.org/I148297040","display_name":"Netherlands Organisation for Applied Scientific Research","ror":"https://ror.org/01bnjb948","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I148297040"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"C.F. Kuper","raw_affiliation_strings":["TNO Nutrition and Food Research, Utrechtseweg 48, P.O. Box 360, 3700 AJ, Zeist, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TNO Nutrition and Food Research, Utrechtseweg 48, P.O. Box 360, 3700 AJ, Zeist, The Netherlands","institution_ids":["https://openalex.org/I148297040"]}]},{"author_position":"middle","author":{"id":null,"display_name":"N. Fraile","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. Fraile","raw_affiliation_strings":["Antibioticos S.A., R & D Center, Avda. de Antibioticos 59/61, 24080 L\u00e9on, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Antibioticos S.A., R & D Center, Avda. de Antibioticos 59/61, 24080 L\u00e9on, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073467890","display_name":"A. Estrella","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Estrella","raw_affiliation_strings":["Antibioticos S.A., R & D Center, Avda. de Antibioticos 59/61, 24080 L\u00e9on, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Antibioticos S.A., R & D Center, Avda. de Antibioticos 59/61, 24080 L\u00e9on, Spain","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108430673","display_name":"C. Rodr\u00edguez Otero","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"C. Rodr\u0131\u0301guez Otero","raw_affiliation_strings":["Vitatene S.A., Avda. de Antibi\u00f3ticos, 59/61, 24080 Le\u00f3n, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vitatene S.A., Avda. de Antibi\u00f3ticos, 59/61, 24080 Le\u00f3n, Spain","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108430673"],"corresponding_institution_ids":[],"apc_list":{"value":4210,"currency":"USD","value_usd":4210},"apc_paid":null,"fwci":3.9509,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.92189777,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"37","issue":"3","first_page":"396","last_page":"406"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13165","display_name":"Agricultural safety and regulations","score":0.5185999870300293,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13165","display_name":"Agricultural safety and regulations","score":0.5185999870300293,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.13040000200271606,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.10270000249147415,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lycopene","display_name":"lycopene","score":1.0},{"id":"https://openalex.org/keywords/blakeslea-trispora","display_name":"Blakeslea trispora","score":0.9950000047683716},{"id":"https://openalex.org/keywords/fungal-biomass","display_name":"fungal biomass","score":0.6489999890327454},{"id":"https://openalex.org/keywords/subchronic-toxicity","display_name":"subchronic toxicity","score":0.8019999861717224},{"id":"https://openalex.org/keywords/dietary-exposure","display_name":"dietary exposure","score":0.6439999938011169},{"id":"https://openalex.org/keywords/no-observed-effect-level","display_name":"no-observed-effect level","score":0.8809999823570251},{"id":"https://openalex.org/keywords/oral-toxicity","display_name":"oral toxicity","score":0.6539999842643738},{"id":"https://openalex.org/keywords/carotenoids","display_name":"carotenoids","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C2780022147","wikidata":"https://www.wikidata.org/wiki/Q208130","display_name":"Lycopene","level":3,"score":0.8374857902526855},{"id":"https://openalex.org/C2779225474","wikidata":"https://www.wikidata.org/wiki/Q842424","display_name":"Urinalysis","level":3,"score":0.7026510238647461},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6449893116950989},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.6047664284706116},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4783334732055664},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.45910289883613586},{"id":"https://openalex.org/C2987526018","wikidata":"https://www.wikidata.org/wiki/Q213449","display_name":"Food consumption","level":2,"score":0.4394971430301666},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.4244641661643982},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.4057255685329437},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39786118268966675},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.3896653652191162},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3844566345214844},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31343600153923035},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30598118901252747},{"id":"https://openalex.org/C28781525","wikidata":"https://www.wikidata.org/wiki/Q191907","display_name":"Carotenoid","level":2,"score":0.2309587299823761},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16209730505943298},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.08327406644821167},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C48824518","wikidata":"https://www.wikidata.org/wiki/Q396340","display_name":"Agricultural economics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077276","descriptor_name":"Lycopene","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002338","descriptor_name":"Carotenoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002338","descriptor_name":"Carotenoids","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D002624","descriptor_name":"Chemistry, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006403","descriptor_name":"Hematologic Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009090","descriptor_name":"Mucorales","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009090","descriptor_name":"Mucorales","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018533","descriptor_name":"Biomass","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019055","descriptor_name":"No-Observed-Adverse-Effect Level","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/s0273-2300(03)00013-8","doi":"https://doi.org/10.1016/s0273-2300(03)00013-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0273-2300(03)00013-8","pdf_url":null,"source":{"id":"https://openalex.org/S87719511","display_name":"Regulatory Toxicology and Pharmacology","issn_l":"0273-2300","issn":["0273-2300","1096-0295"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regulatory Toxicology and Pharmacology","raw_type":"journal-article"},{"id":"pmid:12758219","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12758219","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regulatory toxicology and pharmacology : RTP","raw_type":"Journal Article"},{"id":"pmh:oai:oai-pmh.tno.nl:14258","doi":null,"is_oa":false,"landing_page_url":"https://resolver.tno.nl/uuid:1116f80a-0530-46fd-9048-5e99ce0c68e5","pdf_url":null,"source":{"id":"https://openalex.org/S7407055233","display_name":"TNO Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Regulatory Toxicology and Pharmacology, 37(3), pp. 396-406.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:tudelft.nl:uuid:1116f80a-0530-46fd-9048-5e99ce0c68e5","doi":null,"is_oa":false,"landing_page_url":"http://resolver.tudelft.nl/uuid:1116f80a-0530-46fd-9048-5e99ce0c68e5","pdf_url":null,"source":{"id":"https://openalex.org/S4306402238","display_name":"Repository hosted by TU Delft Library (TU Delft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98358874","host_organization_name":"Delft University of Technology","host_organization_lineage":["https://openalex.org/I98358874"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Regulatory Toxicology and Pharmacology, 3, 37, 396-406","raw_type":"article"},{"id":"pmh:tno:oai:tudelft.nl:uuid:1116f80a-0530-46fd-9048-5e99ce0c68e5","doi":null,"is_oa":false,"landing_page_url":"http://resolver.tudelft.nl/uuid:1116f80a-0530-46fd-9048-5e99ce0c68e5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875},{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.6875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W121113269","https://openalex.org/W1444991424","https://openalex.org/W1500094131","https://openalex.org/W1859575465","https://openalex.org/W1865420805","https://openalex.org/W1923071885","https://openalex.org/W2016697139","https://openalex.org/W2060374949","https://openalex.org/W2070998132","https://openalex.org/W2097787934","https://openalex.org/W2120833432","https://openalex.org/W2125185188","https://openalex.org/W2125774648","https://openalex.org/W2128615035","https://openalex.org/W2145119829","https://openalex.org/W2150807618","https://openalex.org/W2168155283","https://openalex.org/W2168444374","https://openalex.org/W2255067610","https://openalex.org/W2415014809"],"related_works":["https://openalex.org/W2047611982","https://openalex.org/W2016531646","https://openalex.org/W2016697139","https://openalex.org/W2001521357","https://openalex.org/W2366976591","https://openalex.org/W2349586283","https://openalex.org/W7100848174","https://openalex.org/W1683533306","https://openalex.org/W2351135521","https://openalex.org/W2021769460"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
