{"id":"https://openalex.org/W2016855421","doi":"https://doi.org/10.1016/s0140-6736(00)02303-5","title":"Do escape mutants explain rapid increases in dengue casefatality rates within epidemics?","display_name":"Do escape mutants explain rapid increases in dengue casefatality rates within epidemics?","publication_year":2000,"publication_date":"2000-05-01","ids":{"openalex":"https://openalex.org/W2016855421","doi":"https://doi.org/10.1016/s0140-6736(00)02303-5","mag":"2016855421","pmid":"https://pubmed.ncbi.nlm.nih.gov/10866460"},"language":"en","primary_location":{"id":"doi:10.1016/s0140-6736(00)02303-5","doi":"https://doi.org/10.1016/s0140-6736(00)02303-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0140-6736(00)02303-5","pdf_url":null,"source":{"id":"https://openalex.org/S49861241","display_name":"The Lancet","issn_l":"0099-5355","issn":["0099-5355","0140-6736","1474-547X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103460973","display_name":"Mar\u00eda G. Guzm\u00e1n","orcid":"https://orcid.org/0000-0001-6161-9489","observed_orcids":["https://orcid.org/0000-0001-6161-9489"]},"institutions":[{"id":"https://openalex.org/I4210149705","display_name":"Instituto de Medicina Tropical \u201cPedro Kour\u00ed\u201d","ror":"https://ror.org/05a9hae73","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210122314","https://openalex.org/I4210149705"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Mar\u00eda G Guzm\u00e1n","raw_affiliation_strings":["Institute of Tropical Medicine Pedro Kouri, Havana, Cuba. lupe@ipk.sld.cu","Institute of Tropical Medicine \u201cPedro Kouri\u201d, Havana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Tropical Medicine Pedro Kouri, Havana, Cuba. lupe@ipk.sld.cu","institution_ids":["https://openalex.org/I4210149705"]},{"raw_affiliation_string":"Institute of Tropical Medicine \u201cPedro Kouri\u201d, Havana, Cuba","institution_ids":["https://openalex.org/I4210149705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113713565","display_name":"Gustavo Kour\u00ed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149705","display_name":"Instituto de Medicina Tropical \u201cPedro Kour\u00ed\u201d","ror":"https://ror.org/05a9hae73","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210122314","https://openalex.org/I4210149705"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Gustavo Kouri","raw_affiliation_strings":["Institute of Tropical Medicine \u201cPedro Kouri\u201d, Havana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Tropical Medicine \u201cPedro Kouri\u201d, Havana, Cuba","institution_ids":["https://openalex.org/I4210149705"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077156970","display_name":"Scott B. Halstead","orcid":"https://orcid.org/0000-0002-7818-348X","observed_orcids":["https://orcid.org/0000-0002-7818-348X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott B Halstead","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health and Hygiene, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health and Hygiene, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":7890,"currency":"USD","value_usd":7890},"apc_paid":null,"fwci":2.7313,"has_fulltext":false,"cited_by_count":92,"citation_normalized_percentile":{"value":0.90000474,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"355","issue":"9218","first_page":"1902","last_page":"1903"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dengue","display_name":"dengue","score":0.8389999866485596},{"id":"https://openalex.org/keywords/dengue-hemorrhagic-fever","display_name":"dengue hemorrhagic fever","score":0.902999997138977},{"id":"https://openalex.org/keywords/dengue-shock-syndrome","display_name":"dengue shock syndrome","score":1.0},{"id":"https://openalex.org/keywords/case-fatality-rate","display_name":"case fatality rate","score":0.8320000171661377},{"id":"https://openalex.org/keywords/escape-mutants","display_name":"escape mutants","score":0.7110000252723694},{"id":"https://openalex.org/keywords/heterotypic-antibodies","display_name":"heterotypic antibodies","score":0.8320000171661377},{"id":"https://openalex.org/keywords/antibody-dependent-enhancement","display_name":"antibody-dependent enhancement","score":0.6769999861717224},{"id":"https://openalex.org/keywords/dengue-virus-type-2","display_name":"dengue virus type 2","score":0.7649999856948853},{"id":"https://openalex.org/keywords/secondary-infection","display_name":"secondary infection","score":0.5199999809265137},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.41100001335144043}],"concepts":[{"id":"https://openalex.org/C533803919","wikidata":"https://www.wikidata.org/wiki/Q30953","display_name":"Dengue fever","level":2,"score":0.9823983907699585},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7146033644676208},{"id":"https://openalex.org/C2779635636","wikidata":"https://www.wikidata.org/wiki/Q476209","display_name":"Dengue virus","level":3,"score":0.6783337593078613},{"id":"https://openalex.org/C187316915","wikidata":"https://www.wikidata.org/wiki/Q92307203","display_name":"Case fatality rate","level":3,"score":0.592766523361206},{"id":"https://openalex.org/C14086860","wikidata":"https://www.wikidata.org/wiki/Q337120","display_name":"Neutralization","level":3,"score":0.5739225745201111},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5717691779136658},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.548541247844696},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4842088222503662},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42028194665908813},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4131372272968292},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3125552237033844},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30762165784835815},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.07362475991249084}],"mesh":[{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003462","descriptor_name":"Cuba","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003716","descriptor_name":"Dengue Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003716","descriptor_name":"Dengue Virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004196","descriptor_name":"Disease Outbreaks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019595","descriptor_name":"Severe Dengue","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D019595","descriptor_name":"Severe Dengue","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D019595","descriptor_name":"Severe Dengue","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D019595","descriptor_name":"Severe Dengue","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0140-6736(00)02303-5","doi":"https://doi.org/10.1016/s0140-6736(00)02303-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0140-6736(00)02303-5","pdf_url":null,"source":{"id":"https://openalex.org/S49861241","display_name":"The Lancet","issn_l":"0099-5355","issn":["0099-5355","0140-6736","1474-547X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet","raw_type":"journal-article"},{"id":"pmid:10866460","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10866460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lancet (London, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1483154637","https://openalex.org/W1777213512","https://openalex.org/W1785302422","https://openalex.org/W1879379129","https://openalex.org/W1991615440","https://openalex.org/W2021506055","https://openalex.org/W2023993266","https://openalex.org/W2028999441","https://openalex.org/W2030946826","https://openalex.org/W2035714742","https://openalex.org/W2038960384","https://openalex.org/W2109723200","https://openalex.org/W2141086218","https://openalex.org/W2143644459","https://openalex.org/W2274083554","https://openalex.org/W2412037270","https://openalex.org/W2460790455","https://openalex.org/W7073793896"],"related_works":["https://openalex.org/W7049054012","https://openalex.org/W7097921530","https://openalex.org/W2138507390","https://openalex.org/W2111222009","https://openalex.org/W7096467771","https://openalex.org/W2044817254","https://openalex.org/W1040320404","https://openalex.org/W2799790133","https://openalex.org/W2074092984","https://openalex.org/W2123227670"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}