{"id":"https://openalex.org/W2016846515","doi":"https://doi.org/10.1097/00004872-199507000-00005","title":"Increased levels of bradykinin and its metabolites in tissues of young spontaneously hypertensive rats","display_name":"Increased levels of bradykinin and its metabolites in tissues of young spontaneously hypertensive rats","publication_year":1995,"publication_date":"1995-07-01","ids":{"openalex":"https://openalex.org/W2016846515","doi":"https://doi.org/10.1097/00004872-199507000-00005","mag":"2016846515","pmid":"https://pubmed.ncbi.nlm.nih.gov/7594437"},"language":"en","primary_location":{"id":"doi:10.1097/00004872-199507000-00005","doi":"https://doi.org/10.1097/00004872-199507000-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004872-199507000-00005","pdf_url":null,"source":{"id":"https://openalex.org/S115964404","display_name":"Journal of Hypertension","issn_l":"0263-6352","issn":["0263-6352","1473-5598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022682140","display_name":"Duncan John Campbell","orcid":"https://orcid.org/0000-0002-6896-7571","observed_orcids":["https://orcid.org/0000-0002-6896-7571"]},"institutions":[{"id":"https://openalex.org/I2800453128","display_name":"Austin Hospital","ror":"https://ror.org/010mv7n52","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800453128","https://openalex.org/I4210163497"]},{"id":"https://openalex.org/I77826658","display_name":"St Vincents Institute of Medical Research","ror":"https://ror.org/02k3cxs74","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I77826658"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Duncan J. Campbell","raw_affiliation_strings":["Date of receipt: 9 December 1994; revised: 28 March 1995; accepted: 20 April 1995","Dr D.J. Campbell, St Vincent's Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria, Australia 3065","the St Vincent's Institute of Medical Research, Fitzroy, and the *Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia","Date of receipt: 9 December 1994","accepted: 20 April 1995","revised: 28 March 1995"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Date of receipt: 9 December 1994; revised: 28 March 1995; accepted: 20 April 1995","institution_ids":[]},{"raw_affiliation_string":"Dr D.J. Campbell, St Vincent's Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria, Australia 3065","institution_ids":["https://openalex.org/I77826658"]},{"raw_affiliation_string":"the St Vincent's Institute of Medical Research, Fitzroy, and the *Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia","institution_ids":["https://openalex.org/I2800453128","https://openalex.org/I77826658"]},{"raw_affiliation_string":"Date of receipt: 9 December 1994","institution_ids":[]},{"raw_affiliation_string":"accepted: 20 April 1995","institution_ids":[]},{"raw_affiliation_string":"revised: 28 March 1995","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044592769","display_name":"Ann-Maree Duncan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800453128","display_name":"Austin Hospital","ror":"https://ror.org/010mv7n52","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800453128","https://openalex.org/I4210163497"]},{"id":"https://openalex.org/I77826658","display_name":"St Vincents Institute of Medical Research","ror":"https://ror.org/02k3cxs74","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I77826658"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ann-Maree Duncan","raw_affiliation_strings":["Date of receipt: 9 December 1994; revised: 28 March 1995; accepted: 20 April 1995","Dr D.J. Campbell, St Vincent's Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria, Australia 3065","the St Vincent's Institute of Medical Research, Fitzroy, and the *Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia","Date of receipt: 9 December 1994","accepted: 20 April 1995","revised: 28 March 1995"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Date of receipt: 9 December 1994; revised: 28 March 1995; accepted: 20 April 1995","institution_ids":[]},{"raw_affiliation_string":"Dr D.J. Campbell, St Vincent's Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria, Australia 3065","institution_ids":["https://openalex.org/I77826658"]},{"raw_affiliation_string":"the St Vincent's Institute of Medical Research, Fitzroy, and the *Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia","institution_ids":["https://openalex.org/I2800453128","https://openalex.org/I77826658"]},{"raw_affiliation_string":"Date of receipt: 9 December 1994","institution_ids":[]},{"raw_affiliation_string":"accepted: 20 April 1995","institution_ids":[]},{"raw_affiliation_string":"revised: 28 March 1995","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090819781","display_name":"Athena Kladis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800453128","display_name":"Austin Hospital","ror":"https://ror.org/010mv7n52","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800453128","https://openalex.org/I4210163497"]},{"id":"https://openalex.org/I77826658","display_name":"St Vincents Institute of Medical Research","ror":"https://ror.org/02k3cxs74","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I77826658"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Athena Kladis","raw_affiliation_strings":["Date of receipt: 9 December 1994; revised: 28 March 1995; accepted: 20 April 1995","Dr D.J. Campbell, St Vincent's Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria, Australia 3065","the St Vincent's Institute of Medical Research, Fitzroy, and the *Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia","Date of receipt: 9 December 1994","accepted: 20 April 1995","revised: 28 March 1995"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Date of receipt: 9 December 1994; revised: 28 March 1995; accepted: 20 April 1995","institution_ids":[]},{"raw_affiliation_string":"Dr D.J. Campbell, St Vincent's Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria, Australia 3065","institution_ids":["https://openalex.org/I77826658"]},{"raw_affiliation_string":"the St Vincent's Institute of Medical Research, Fitzroy, and the *Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia","institution_ids":["https://openalex.org/I2800453128","https://openalex.org/I77826658"]},{"raw_affiliation_string":"Date of receipt: 9 December 1994","institution_ids":[]},{"raw_affiliation_string":"accepted: 20 April 1995","institution_ids":[]},{"raw_affiliation_string":"revised: 28 March 1995","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038512239","display_name":"Stephen B. Harrap","orcid":"https://orcid.org/0000-0003-2907-6714","observed_orcids":["https://orcid.org/0000-0003-2907-6714"]},"institutions":[{"id":"https://openalex.org/I2800453128","display_name":"Austin Hospital","ror":"https://ror.org/010mv7n52","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800453128","https://openalex.org/I4210163497"]},{"id":"https://openalex.org/I77826658","display_name":"St Vincents Institute of Medical Research","ror":"https://ror.org/02k3cxs74","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I77826658"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Stephan B. Harrap","raw_affiliation_strings":["Date of receipt: 9 December 1994; revised: 28 March 1995; accepted: 20 April 1995","Dr D.J. Campbell, St Vincent's Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria, Australia 3065","the St Vincent's Institute of Medical Research, Fitzroy, and the *Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia","Date of receipt: 9 December 1994","accepted: 20 April 1995","revised: 28 March 1995"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Date of receipt: 9 December 1994; revised: 28 March 1995; accepted: 20 April 1995","institution_ids":[]},{"raw_affiliation_string":"Dr D.J. Campbell, St Vincent's Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria, Australia 3065","institution_ids":["https://openalex.org/I77826658"]},{"raw_affiliation_string":"the St Vincent's Institute of Medical Research, Fitzroy, and the *Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia","institution_ids":["https://openalex.org/I2800453128","https://openalex.org/I77826658"]},{"raw_affiliation_string":"Date of receipt: 9 December 1994","institution_ids":[]},{"raw_affiliation_string":"accepted: 20 April 1995","institution_ids":[]},{"raw_affiliation_string":"revised: 28 March 1995","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0948,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.8627135,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"13","issue":"7","first_page":"739???746","last_page":"739???746"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bradykinin","display_name":"bradykinin","score":0.8769999742507935},{"id":"https://openalex.org/keywords/spontaneously-hypertensive-rats","display_name":"spontaneously hypertensive rats","score":0.8700000047683716},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.671999990940094},{"id":"https://openalex.org/keywords/kallikrein-kinin-system","display_name":"kallikrein-kinin system","score":0.9409999847412109},{"id":"https://openalex.org/keywords/bradykinin-metabolism","display_name":"bradykinin metabolism","score":0.7329999804496765},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":0.6909999847412109},{"id":"https://openalex.org/keywords/adrenal-gland","display_name":"adrenal gland","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C2779591629","wikidata":"https://www.wikidata.org/wiki/Q24745328","display_name":"Bradykinin","level":3,"score":0.9867618680000305},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7876646518707275},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7703946232795715},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5814634561538696},{"id":"https://openalex.org/C2776246183","wikidata":"https://www.wikidata.org/wiki/Q421924","display_name":"Kinin","level":4,"score":0.5116901397705078},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.488651305437088},{"id":"https://openalex.org/C153939273","wikidata":"https://www.wikidata.org/wiki/Q24721039","display_name":"Bradykinin receptor","level":4,"score":0.46830713748931885},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06631255149841309}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001920","descriptor_name":"Bradykinin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011918","descriptor_name":"Rats, Inbred SHR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00004872-199507000-00005","doi":"https://doi.org/10.1097/00004872-199507000-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004872-199507000-00005","pdf_url":null,"source":{"id":"https://openalex.org/S115964404","display_name":"Journal of Hypertension","issn_l":"0263-6352","issn":["0263-6352","1473-5598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hypertension","raw_type":"journal-article"},{"id":"pmid:7594437","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7594437","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of hypertension","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5799999833106995}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2427719326","https://openalex.org/W2027119717","https://openalex.org/W2437219247","https://openalex.org/W2094588632","https://openalex.org/W2023573230","https://openalex.org/W2048596747","https://openalex.org/W2321681050","https://openalex.org/W1983712550","https://openalex.org/W7095480548","https://openalex.org/W3015999681"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"determine":[2],"whether":[3],"tissue":[4,22,49,147],"kinin":[5],"levels":[6,23,80,89,103,142,160,210,241],"in":[7,15,34,42,83,92,106,143,166,180,190,211,224,242,255,260],"spontaneously":[8],"hypertensive":[9],"rats":[10],"(SHR)":[11],"differ":[12],"from":[13],"those":[14,261],"normotensive":[16,57],"rats.":[17,156,262],"DESIGN":[18],"AND":[19],"METHODS:":[20],"The":[21,115,158],"of":[24,52,97,110,121,161,173,192,200,221,230,244,258],"bradykinin-(1-9)":[25,37,79,88,117,162,209,222,240],"and":[26,30,36,38,50,55,67,78,85,87,95,108,128,137,148,154,163,170,187,197,227],"its":[27,164],"metabolites":[28,165],"bradykinin-(1-7)":[29,39,86],"bradykinin-(1-8)":[31,77],"were":[32,40,81,90,150],"measured":[33,41],"kidney,":[35,84,167],"adrenal,":[43,93,168],"lung,":[44],"heart,":[45],"aorta,":[46,144],"brown":[47,145],"adipose":[48,146],"brain":[51,149],"male":[53],"SHR":[54,98,111,122,153,175,193,232,246],"the":[56,129,184,207,216,228,231,238,256],"genetically":[58],"homogeneous":[59],"Donryu":[60,74,155],"rat":[61],"strain,":[62],"at":[63,125,134],"age":[64,135],"6,":[65],"10":[66,113,136],"20":[68,138],"weeks.":[69,101,114,139],"RESULTS:":[70],"In":[71],"comparison":[72],"with":[73,215,235,249],"rats,":[75],"bradykinin-(1-7),":[76],"increased":[82,91,159,177,208,239],"lung":[94,109,169],"heart":[96,171],"aged":[99,112],"6":[100],"Bradykinin-(1-7)":[102],"remained":[104],"elevated":[105],"adrenal":[107],"bradykinin-(1-7):":[116],"ratio":[118,131],"for":[119,152,252],"kidneys":[120,191],"was":[123,132],"reduced":[124,133,185,195],"all":[126],"ages":[127],"bradykinin-(1-8):bradykinin-(1-9)":[130,188],"Bradykinin":[140],"peptide":[141,254],"similar":[151],"CONCLUSION:":[157],"tissues":[172,243],"young":[174,225,245],"suggest":[176],"kallikrein":[178,233],"activity":[179],"these":[181],"tissues.":[182],"Moreover,":[183],"bradykinin-(1-7):bradykinin-(1-9)":[186],"ratios":[189],"indicate":[194],"endopeptidase-":[196],"carboxypeptidase-mediated":[198],"metabolism":[199],"bradykinin-(1-9),":[201],"which":[202],"may":[203],"have":[204],"contributed":[205],"to":[206],"this":[212,253],"tissue.":[213],"Together":[214],"previously":[217],"reported":[218],"hypotensive":[219],"effect":[220],"antagonism":[223],"SHR,":[226],"cosegregation":[229],"gene":[234],"blood":[236],"pressure,":[237],"are":[247],"consistent":[248],"a":[250],"role":[251],"pathogenesis":[257],"hypertension":[259]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
