{"id":"https://openalex.org/W2016843393","doi":"https://doi.org/10.1021/tx00046a004","title":"Mechanisms of Chlorophyllin Anticarcinogenesis against Aflatoxin B1: Complex Formation with the Carcinogen","display_name":"Mechanisms of Chlorophyllin Anticarcinogenesis against Aflatoxin B1: Complex Formation with the Carcinogen","publication_year":1995,"publication_date":"1995-06-01","ids":{"openalex":"https://openalex.org/W2016843393","doi":"https://doi.org/10.1021/tx00046a004","mag":"2016843393","pmid":"https://pubmed.ncbi.nlm.nih.gov/7548730"},"language":"en","primary_location":{"id":"doi:10.1021/tx00046a004","doi":"https://doi.org/10.1021/tx00046a004","is_oa":false,"landing_page_url":"https://doi.org/10.1021/tx00046a004","pdf_url":null,"source":{"id":"https://openalex.org/S152840809","display_name":"Chemical Research in Toxicology","issn_l":"0893-228X","issn":["0893-228X","1520-5010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Research in Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057362309","display_name":"Vibeke Miller Breinholt","orcid":"https://orcid.org/0000-0003-2658-3315","observed_orcids":["https://orcid.org/0000-0003-2658-3315"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vibeke Breinholt","raw_affiliation_strings":["Department of Food Science and Technology, Oregon State University, Corvallis 97331, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Technology, Oregon State University, Corvallis 97331, USA","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047770704","display_name":"Michael I. Schimerlik","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Schimerlik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082820494","display_name":"Roderick H. Dashwood","orcid":"https://orcid.org/0000-0003-0351-4034","observed_orcids":["https://orcid.org/0000-0003-0351-4034"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roderick Dashwood","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112715943","display_name":"George Bailey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George Bailey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.6103,"has_fulltext":false,"cited_by_count":116,"citation_normalized_percentile":{"value":0.89298632,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"8","issue":"4","first_page":"506","last_page":"514"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10903","display_name":"Porphyrin and Phthalocyanine Chemistry","score":0.39399999380111694,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10903","display_name":"Porphyrin and Phthalocyanine Chemistry","score":0.39399999380111694,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.13699999451637268,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.13269999623298645,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chlorophyllin","display_name":"chlorophyllin","score":1.0},{"id":"https://openalex.org/keywords/aflatoxin-b1","display_name":"aflatoxin B1","score":1.0},{"id":"https://openalex.org/keywords/porphyrins","display_name":"porphyrins","score":0.7049999833106995},{"id":"https://openalex.org/keywords/chlorin-e6","display_name":"chlorin e6","score":0.6050000190734863},{"id":"https://openalex.org/keywords/protoporphyrin-ix","display_name":"protoporphyrin IX","score":0.9900000095367432},{"id":"https://openalex.org/keywords/zinc-protoporphyrin","display_name":"zinc protoporphyrin","score":0.9710000157356262},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.8920000195503235},{"id":"https://openalex.org/keywords/binding-dissociation-constant","display_name":"binding dissociation constant","score":0.5360000133514404},{"id":"https://openalex.org/keywords/molecular-modeling","display_name":"molecular modeling","score":0.3619999885559082},{"id":"https://openalex.org/keywords/dietary-aflatoxin-exposure","display_name":"dietary aflatoxin exposure","score":0.5320000052452087},{"id":"https://openalex.org/keywords/anticarcinogenesis","display_name":"anticarcinogenesis","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C2780679280","wikidata":"https://www.wikidata.org/wiki/Q379123","display_name":"Chlorophyllin","level":3,"score":0.8521714806556702},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.779068648815155},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.653687596321106},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.5858952403068542},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.5847427248954773},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.566152036190033},{"id":"https://openalex.org/C40758303","wikidata":"https://www.wikidata.org/wiki/Q212936","display_name":"Aflatoxin","level":2,"score":0.48645445704460144},{"id":"https://openalex.org/C2779671804","wikidata":"https://www.wikidata.org/wiki/Q619815","display_name":"Protoporphyrin IX","level":3,"score":0.47404834628105164},{"id":"https://openalex.org/C2781469039","wikidata":"https://www.wikidata.org/wiki/Q18388377","display_name":"Photosensitizer","level":2,"score":0.4733676612377167},{"id":"https://openalex.org/C2780441211","wikidata":"https://www.wikidata.org/wiki/Q422488","display_name":"Deoxyguanosine","level":3,"score":0.4731534421443939},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4251471757888794},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4171636700630188},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.39295658469200134},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.3134323060512543},{"id":"https://openalex.org/C2776373379","wikidata":"https://www.wikidata.org/wiki/Q43177","display_name":"Chlorophyll","level":2,"score":0.30163300037384033},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.26689547300338745},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.16323158144950867},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14176931977272034},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.13155972957611084},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.09429886937141418},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002627","descriptor_name":"Chemistry, Physical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002735","descriptor_name":"Chlorophyllides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002735","descriptor_name":"Chlorophyllides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014337","descriptor_name":"Trout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016587","descriptor_name":"Antimutagenic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016587","descriptor_name":"Antimutagenic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016604","descriptor_name":"Aflatoxin B1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016604","descriptor_name":"Aflatoxin B1","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D016604","descriptor_name":"Aflatoxin B1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/tx00046a004","doi":"https://doi.org/10.1021/tx00046a004","is_oa":false,"landing_page_url":"https://doi.org/10.1021/tx00046a004","pdf_url":null,"source":{"id":"https://openalex.org/S152840809","display_name":"Chemical Research in Toxicology","issn_l":"0893-228X","issn":["0893-228X","1520-5010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Research in Toxicology","raw_type":"journal-article"},{"id":"pmid:7548730","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7548730","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical research in toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2642989272","display_name":null,"funder_award_id":"ES 03850","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G4288126918","display_name":"Reducing Susceptibility to Environmental Stress Throughout the Life Span","funder_award_id":"P30ES000210","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G5346176085","display_name":"MECHANISMS OF INHIBITION OF CHEMICAL CARCINOGENESIS","funder_award_id":"R01CA034732","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W256355212","https://openalex.org/W1906197854","https://openalex.org/W1964268979","https://openalex.org/W1968880139","https://openalex.org/W1982959605","https://openalex.org/W1990044454","https://openalex.org/W1992108302","https://openalex.org/W1997718808","https://openalex.org/W2000869533","https://openalex.org/W2007932757","https://openalex.org/W2037278432","https://openalex.org/W2041902242","https://openalex.org/W2045160008","https://openalex.org/W2057290105","https://openalex.org/W2069425097","https://openalex.org/W2071233897","https://openalex.org/W2074815894","https://openalex.org/W2085677566","https://openalex.org/W2089201387","https://openalex.org/W2098998130","https://openalex.org/W2120423700","https://openalex.org/W2133940665","https://openalex.org/W2271065304","https://openalex.org/W2323587270","https://openalex.org/W2327749329","https://openalex.org/W2332114341","https://openalex.org/W2333539293","https://openalex.org/W2409468669","https://openalex.org/W3006740266"],"related_works":["https://openalex.org/W1986121820","https://openalex.org/W2127308392","https://openalex.org/W2057290105","https://openalex.org/W2147264611","https://openalex.org/W2133940665","https://openalex.org/W2095526583","https://openalex.org/W2059656272","https://openalex.org/W7112941170","https://openalex.org/W4281758400","https://openalex.org/W2299815839"],"abstract_inverted_index":{"Chlorophyllin":[0],"(CHL),":[1],"a":[2,20,47,134,191,230],"food-grade":[3],"derivative":[4],"of":[5,25,94,98,102,130,138,142,145,149,161,167,172,186,202,216,224,233],"the":[6,81,95,103,131,146,159,170,178,221],"green":[7],"plant":[8],"pigment":[9],"chlorophyll,":[10],"has":[11],"recently":[12],"been":[13],"shown":[14],"in":[15,23,53,153,158,169,213],"this":[16],"laboratory":[17],"to":[18,74,122,204],"be":[19],"potent":[21],"inhibitor":[22],"vivo":[24],"hepatic":[26,217],"aflatoxin":[27],"B1":[28],"(AFB1)-DNA":[29],"adduction":[30,189],"and":[31,88,226],"hepatocarcinogenesis":[32],"(Breinholt":[33],"et":[34],"al.":[35],"(1995)":[36],"Cancer":[37],"Res.":[38],"55,":[39],"57-62).":[40],"We":[41],"report":[42],"here":[43],"that":[44,101,111],"CHL":[45,163,192,203,227,243],"forms":[46],"strong":[48],"noncovalent":[49],"complex":[50,132],"with":[51,116,155],"AFB1":[52,117,151,182,206,225],"vitro":[54,154],"(dissociation":[55],"constant":[56,194],"(Kd)":[57],"by":[58,209],"Scatchard":[59],"analysis":[60,108,185],"=":[61],"1.4":[62],"(+/-":[63],"0.4)":[64],"microM":[65,197],"based":[66],"on":[67],"copper":[68],"chlorin":[69],"content),":[70],"which":[71],"may":[72],"contribute":[73],"its":[75],"anticarcinogenic":[76],"activity.":[77],"Kd":[78],"values":[79],"for":[80,236],"related":[82],"porphyrins":[83,113],"chlorine":[84],"e6,":[85],"protoporphyrin":[86,90],"IX,":[87],"zinc":[89],"IX":[91],"were":[92],"also":[93],"same":[96,222],"order":[97],"magnitude":[99],"as":[100],"commercial":[104],"CHL.":[105],"Mole":[106],"ratio":[107],"provided":[109,238],"evidence":[110],"all":[112,242],"examined":[114],"associate":[115],"at":[118,241],"an":[119],"approximate":[120],"one":[121,123],"stoichiometric":[124],"ratio.":[125],"Energy":[126],"minimization":[127],"computer":[128],"modeling":[129],"indicates":[133],"favorable":[135],"association":[136],"energy":[137],"-20":[139],"kcal/mol,":[140],"independent":[141],"oxidation":[143],"state":[144],"8,9-double":[147],"bond":[148],"AFB1.":[150],"incubated":[152],"liver":[156],"microsomes":[157],"presence":[160],"added":[162],"showed":[164],"comparable":[165],"levels":[166],"inhibition":[168,193,215],"production":[171],"several":[173],"phase":[174],"1":[175],"metabolites,":[176],"including":[177],"postulated":[179],"procarcinogenic":[180],"metabolite":[181],"8,9-epoxide.":[183],"Kinetic":[184],"microsome-catalyzed":[187],"AFB1-DNA":[188,218],"suggested":[190],"near":[195],"10":[196],"chlorin.":[198],"In":[199],"vivo,":[200],"addition":[201],"concentrated":[205],"solutions":[207],"followed":[208],"gavage":[210,237],"administration":[211],"resulted":[212],"dose-dependent":[214],"adduction,":[219],"whereas":[220],"dosages":[223],"incorporated":[228],"into":[229],"single":[231],"bolus":[232],"trout":[234],"diet":[235],"less":[239],"protection":[240],"doses.(ABSTRACT":[244],"TRUNCATED":[245],"AT":[246],"250":[247],"WORDS)":[248]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}