{"id":"https://openalex.org/W2016776771","doi":"https://doi.org/10.1006/bbrc.1999.1442","title":"Pharmacological and Signaling Analysis of Human Chemokine Receptor CCR-7 Stably Expressed in HEK-293 Cells: High-Affinity Binding of Recombinant Ligands MIP-3\u03b2 and SLC Stimulates Multiple Signaling Cascades","display_name":"Pharmacological and Signaling Analysis of Human Chemokine Receptor CCR-7 Stably Expressed in HEK-293 Cells: High-Affinity Binding of Recombinant Ligands MIP-3\u03b2 and SLC Stimulates Multiple Signaling Cascades","publication_year":1999,"publication_date":"1999-10-01","ids":{"openalex":"https://openalex.org/W2016776771","doi":"https://doi.org/10.1006/bbrc.1999.1442","mag":"2016776771","pmid":"https://pubmed.ncbi.nlm.nih.gov/10512740"},"language":"en","primary_location":{"id":"doi:10.1006/bbrc.1999.1442","doi":"https://doi.org/10.1006/bbrc.1999.1442","is_oa":false,"landing_page_url":"https://doi.org/10.1006/bbrc.1999.1442","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111565564","display_name":"Susan K. Sullivan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67391869","display_name":"Neurocrine Biosciences (United States)","ror":"https://ror.org/05d84mm26","country_code":"US","type":"company","lineage":["https://openalex.org/I67391869"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan K. Sullivan","raw_affiliation_strings":["Neurocrine Biosciences Inc., 10555 Science Center Drive, San Diego 92121, USA","Neurocrine Biosciences Inc. 10555 Science Center Drive, San Diego, California, 92121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurocrine Biosciences Inc., 10555 Science Center Drive, San Diego 92121, USA","institution_ids":["https://openalex.org/I67391869"]},{"raw_affiliation_string":"Neurocrine Biosciences Inc. 10555 Science Center Drive, San Diego, California, 92121","institution_ids":["https://openalex.org/I67391869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035510553","display_name":"Douglas A. McGrath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67391869","display_name":"Neurocrine Biosciences (United States)","ror":"https://ror.org/05d84mm26","country_code":"US","type":"company","lineage":["https://openalex.org/I67391869"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas A. McGrath","raw_affiliation_strings":["Neurocrine Biosciences Inc. 10555 Science Center Drive, San Diego, California, 92121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurocrine Biosciences Inc. 10555 Science Center Drive, San Diego, California, 92121","institution_ids":["https://openalex.org/I67391869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113490804","display_name":"Dimitri E. Grigoriadis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67391869","display_name":"Neurocrine Biosciences (United States)","ror":"https://ror.org/05d84mm26","country_code":"US","type":"company","lineage":["https://openalex.org/I67391869"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dimitri Grigoriadis","raw_affiliation_strings":["Neurocrine Biosciences Inc. 10555 Science Center Drive, San Diego, California, 92121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurocrine Biosciences Inc. 10555 Science Center Drive, San Diego, California, 92121","institution_ids":["https://openalex.org/I67391869"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102957627","display_name":"Kevin B. Bacon","orcid":"https://orcid.org/0009-0001-8569-8625","observed_orcids":["https://orcid.org/0009-0001-8569-8625"]},"institutions":[{"id":"https://openalex.org/I67391869","display_name":"Neurocrine Biosciences (United States)","ror":"https://ror.org/05d84mm26","country_code":"US","type":"company","lineage":["https://openalex.org/I67391869"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kevin B. Bacon","raw_affiliation_strings":["Neurocrine Biosciences Inc. 10555 Science Center Drive, San Diego, California, 92121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurocrine Biosciences Inc. 10555 Science Center Drive, San Diego, California, 92121","institution_ids":["https://openalex.org/I67391869"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102957627"],"corresponding_institution_ids":["https://openalex.org/I67391869"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":0.4002,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.59697317,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"263","issue":"3","first_page":"685","last_page":"690"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemokine-receptors","display_name":"chemokine receptors","score":0.8920000195503235},{"id":"https://openalex.org/keywords/ccl19","display_name":"CCL19","score":0.8690000176429749},{"id":"https://openalex.org/keywords/ligand-binding-affinity","display_name":"ligand binding affinity","score":0.8040000200271606},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor-signaling","display_name":"G protein-coupled receptor signaling","score":0.8420000076293945},{"id":"https://openalex.org/keywords/calcium-mobilization","display_name":"calcium mobilization","score":0.9539999961853027},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9900000095367432},{"id":"https://openalex.org/keywords/mapk-activation","display_name":"MAPK activation","score":0.8709999918937683}],"concepts":[{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.7592663764953613},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.6378533244132996},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.623404860496521},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5942583084106445},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5563656687736511},{"id":"https://openalex.org/C48001867","wikidata":"https://www.wikidata.org/wiki/Q8041712","display_name":"XCL2","level":5,"score":0.533744215965271},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.5158090591430664},{"id":"https://openalex.org/C94205230","wikidata":"https://www.wikidata.org/wiki/Q5005868","display_name":"C-C chemokine receptor type 6","level":5,"score":0.5150332450866699},{"id":"https://openalex.org/C128879288","wikidata":"https://www.wikidata.org/wiki/Q5009764","display_name":"CC chemokine receptors","level":5,"score":0.5046638250350952},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.48578646779060364},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.47027498483657837},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.43735384941101074},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42142021656036377},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.407198041677475},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3551120162010193},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25612691044807434},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09874805808067322}],"mesh":[{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011869","descriptor_name":"Radioligand Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019707","descriptor_name":"Receptors, Chemokine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019707","descriptor_name":"Receptors, Chemokine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019707","descriptor_name":"Receptors, Chemokine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019742","descriptor_name":"Chemokines, CC","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019742","descriptor_name":"Chemokines, CC","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054400","descriptor_name":"Receptors, CCR7","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054415","descriptor_name":"Chemokine CCL19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054421","descriptor_name":"Chemokine CCL21","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/bbrc.1999.1442","doi":"https://doi.org/10.1006/bbrc.1999.1442","is_oa":false,"landing_page_url":"https://doi.org/10.1006/bbrc.1999.1442","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:10512740","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10512740","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W146783053","https://openalex.org/W1867960490","https://openalex.org/W1968098118","https://openalex.org/W1970866345","https://openalex.org/W1999023229","https://openalex.org/W2014392976","https://openalex.org/W2025159406","https://openalex.org/W2031488553","https://openalex.org/W2054736165","https://openalex.org/W2059207468","https://openalex.org/W2060245547","https://openalex.org/W2092280881","https://openalex.org/W2150295492","https://openalex.org/W2157069655","https://openalex.org/W2160272188","https://openalex.org/W2165401836","https://openalex.org/W2166295586","https://openalex.org/W2340807252","https://openalex.org/W4211128585","https://openalex.org/W4313333704","https://openalex.org/W4313333737"],"related_works":["https://openalex.org/W1993565072","https://openalex.org/W4385688089","https://openalex.org/W2031488553","https://openalex.org/W2075320283","https://openalex.org/W2105164677","https://openalex.org/W1971880112","https://openalex.org/W2151287578","https://openalex.org/W4237397121","https://openalex.org/W1971768767","https://openalex.org/W77149627"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
