{"id":"https://openalex.org/W2016758992","doi":"https://doi.org/10.1523/jneurosci.4637-04.2005","title":"Cell-Cycle Reentry and Cell Death in Transgenic Mice Expressing Nonmutant Human Tau Isoforms","display_name":"Cell-Cycle Reentry and Cell Death in Transgenic Mice Expressing Nonmutant Human Tau Isoforms","publication_year":2005,"publication_date":"2005-06-01","ids":{"openalex":"https://openalex.org/W2016758992","doi":"https://doi.org/10.1523/jneurosci.4637-04.2005","mag":"2016758992","pmid":"https://pubmed.ncbi.nlm.nih.gov/15930395","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6725006"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.4637-04.2005","doi":"https://doi.org/10.1523/jneurosci.4637-04.2005","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.4637-04.2005","pdf_url":"https://www.jneurosci.org/content/jneuro/25/22/5446.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/25/22/5446.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031405187","display_name":"Cathy A. Andorfer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cathy Andorfer","raw_affiliation_strings":["Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA. cathy.andorfer@sbri.org","Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, 10461, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA. cathy.andorfer@sbri.org","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, 10461, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108355145","display_name":"Christopher M. Acker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher M. Acker","raw_affiliation_strings":["Pathology, Albert Einstein College of Medicine, Bronx, New York 10461,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Albert Einstein College of Medicine, Bronx, New York 10461,","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040247985","display_name":"Yvonne Kress","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yvonne Kress","raw_affiliation_strings":["Albert Einstein College of Medicine , Bronx , NY 10461 ","Pathology, Albert Einstein College of Medicine, Bronx, New York 10461,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine , Bronx , NY 10461 ","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Pathology, Albert Einstein College of Medicine, Bronx, New York 10461,","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073037534","display_name":"Patrick R. Hof","orcid":"https://orcid.org/0000-0002-3208-1154","observed_orcids":["https://orcid.org/0000-0002-3208-1154"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick R. Hof","raw_affiliation_strings":["Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Department of Geriatrics and Adult Development, and Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York 10029, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Department of Geriatrics and Adult Development, and Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York 10029, and","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006563536","display_name":"Karen Duff","orcid":"https://orcid.org/0000-0002-6177-868X","observed_orcids":["https://orcid.org/0000-0002-6177-868X"]},"institutions":[{"id":"https://openalex.org/I125043107","display_name":"Nathan Kline Institute for Psychiatric Research","ror":"https://ror.org/01s434164","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I125043107"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Duff","raw_affiliation_strings":["Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962","institution_ids":["https://openalex.org/I125043107"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047196957","display_name":"Peter Davies","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Davies","raw_affiliation_strings":["Departments of Neuroscience and","Pathology, Albert Einstein College of Medicine, Bronx, New York 10461,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neuroscience and","institution_ids":[]},{"raw_affiliation_string":"Pathology, Albert Einstein College of Medicine, Bronx, New York 10461,","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.3695,"has_fulltext":true,"cited_by_count":508,"citation_normalized_percentile":{"value":0.99419208,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"25","issue":"22","first_page":"5446","last_page":"5454"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.8289999961853027},{"id":"https://openalex.org/keywords/cell-cycle-re-entry","display_name":"cell cycle re-entry","score":0.8399999737739563},{"id":"https://openalex.org/keywords/neuronal-death","display_name":"neuronal cell death","score":0.9539999961853027},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.9700000286102295},{"id":"https://openalex.org/keywords/tauopathy","display_name":"tauopathy","score":0.8930000066757202},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.972000002861023},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.7590000033378601},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.7260000109672546},{"id":"https://openalex.org/keywords/dna-synthesis","display_name":"DNA synthesis","score":0.8450000286102295},{"id":"https://openalex.org/keywords/tau-filaments","display_name":"tau filaments","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.856959342956543},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.6857268810272217},{"id":"https://openalex.org/C177738377","wikidata":"https://www.wikidata.org/wiki/Q7683003","display_name":"Tangle","level":2,"score":0.6819115281105042},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.578039288520813},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5683460831642151},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5377009510993958},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.5234353542327881},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5203030705451965},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4972722828388214},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.490416020154953},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4774942100048065},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3503996729850769},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.3087256848812103},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2770315408706665},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.23758786916732788},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.20131704211235046},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1906026005744934},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14916643500328064},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08378666639328003},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D001973","descriptor_name":"Bromodeoxyuridine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D016874","descriptor_name":"Neurofibrillary Tangles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053938","descriptor_name":"DNA Fragmentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1523/jneurosci.4637-04.2005","doi":"https://doi.org/10.1523/jneurosci.4637-04.2005","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.4637-04.2005","pdf_url":"https://www.jneurosci.org/content/jneuro/25/22/5446.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5689152","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6725006","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6725006","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6725006","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:15930395","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15930395","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.4637-04.2005","doi":"https://doi.org/10.1523/jneurosci.4637-04.2005","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.4637-04.2005","pdf_url":"https://www.jneurosci.org/content/jneuro/25/22/5446.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5059053383","display_name":"A Mouse Model of Tau Pathology in AD & Other Dementias","funder_award_id":"R37AG022102","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6271709587","display_name":null,"funder_award_id":"38623","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G6658907728","display_name":null,"funder_award_id":"AG022102","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G723260309","display_name":"A Mouse Model of Tau Pathology in AD and Other Dementias","funder_award_id":"R01AG022102","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7437547548","display_name":null,"funder_award_id":"38623","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016758992.pdf","grobid_xml":"https://content.openalex.org/works/W2016758992.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W14527431","https://openalex.org/W31255819","https://openalex.org/W150987474","https://openalex.org/W172529645","https://openalex.org/W1485747833","https://openalex.org/W1511517753","https://openalex.org/W1543637004","https://openalex.org/W1603257718","https://openalex.org/W1616592835","https://openalex.org/W1745634660","https://openalex.org/W1865619950","https://openalex.org/W1935951477","https://openalex.org/W1944699774","https://openalex.org/W1969209100","https://openalex.org/W1971775491","https://openalex.org/W1972553694","https://openalex.org/W1973541476","https://openalex.org/W1974208182","https://openalex.org/W1974760231","https://openalex.org/W1975596414","https://openalex.org/W1980768099","https://openalex.org/W1982487434","https://openalex.org/W1984482388","https://openalex.org/W1988147472","https://openalex.org/W1995167983","https://openalex.org/W2000280976","https://openalex.org/W2001775703","https://openalex.org/W2010934572","https://openalex.org/W2011338138","https://openalex.org/W2012666269","https://openalex.org/W2021590064","https://openalex.org/W2024041849","https://openalex.org/W2026771024","https://openalex.org/W2031139440","https://openalex.org/W2032576201","https://openalex.org/W2034915619","https://openalex.org/W2035282018","https://openalex.org/W2038120434","https://openalex.org/W2039005734","https://openalex.org/W2043661712","https://openalex.org/W2046780436","https://openalex.org/W2047151082","https://openalex.org/W2047649942","https://openalex.org/W2052139155","https://openalex.org/W2053063666","https://openalex.org/W2055022577","https://openalex.org/W2057768117","https://openalex.org/W2065028560","https://openalex.org/W2065384834","https://openalex.org/W2067856703","https://openalex.org/W2071147342","https://openalex.org/W2072538939","https://openalex.org/W2077699648","https://openalex.org/W2082429191","https://openalex.org/W2083219512","https://openalex.org/W2083347271","https://openalex.org/W2084453905","https://openalex.org/W2084700554","https://openalex.org/W2085417640","https://openalex.org/W2087781170","https://openalex.org/W2088519917","https://openalex.org/W2102701929","https://openalex.org/W2103440561","https://openalex.org/W2111405228","https://openalex.org/W2121506107","https://openalex.org/W2124633824","https://openalex.org/W2130118447","https://openalex.org/W2130723719","https://openalex.org/W2132661761","https://openalex.org/W2138302361","https://openalex.org/W2141839336","https://openalex.org/W2162643935","https://openalex.org/W2165300068","https://openalex.org/W2168092251","https://openalex.org/W2169557197","https://openalex.org/W2966127527"],"related_works":["https://openalex.org/W2055273929","https://openalex.org/W2016464067","https://openalex.org/W2016909990","https://openalex.org/W2074255165","https://openalex.org/W2582091597","https://openalex.org/W4412785278","https://openalex.org/W7096828094","https://openalex.org/W3022715577","https://openalex.org/W4407744712","https://openalex.org/W93810211"],"abstract_inverted_index":{"Mutations":[0],"in":[1,15,27,57,78],"the":[2,43,58,83,111],"microtubule-associated":[3],"protein":[4],"tau":[5,24,56,62,86,126],"gene":[6],"have":[7],"been":[8],"linked":[9,132],"to":[10],"neurofibrillary":[11],"tangle":[12],"(NFT)":[13],"formation":[14,38],"several":[16],"neurodegenerative":[17],"diseases":[18],"known":[19],"as":[20],"tauopathies;":[21],"however,":[22],"no":[23],"mutations":[25],"occur":[26,102],"Alzheimer's":[28],"disease,":[29],"although":[30],"this":[31],"disease":[32],"is":[33],"also":[34],"characterized":[35],"by":[36],"NFT":[37,105],"and":[39,67,81,120,128],"cell":[40,69,99],"death.":[41,70],"Importantly,":[42],"mechanism":[44,72,112],"of":[45,60,73,85,104,113,117],"tau-mediated":[46],"neuronal":[47],"death":[48,75,93,100],"remains":[49],"elusive.":[50],"Aged":[51],"mice":[52],"expressing":[53],"nonmutant":[54,125],"human":[55],"absence":[59],"mouse":[61],"(htau":[63],"mice)":[64],"developed":[65],"NFTs":[66],"extensive":[68],"The":[71],"neuron":[74],"was":[76],"investigated":[77],"htau":[79],"mice,":[80],"surprisingly,":[82],"presence":[84],"filaments":[87],"did":[88],"not":[89],"correlate":[90],"directly":[91],"with":[92],"within":[94],"individual":[95],"cells,":[96],"suggesting":[97],"that":[98,110,124],"can":[101],"independently":[103],"formation.":[106],"Our":[107],"observations":[108],"show":[109],"neurodegeneration":[114,129],"involved":[115],"reexpression":[116],"cell-cycle":[118,136],"proteins":[119],"DNA":[121],"synthesis,":[122],"indicating":[123],"pathology":[127],"may":[130],"be":[131],"via":[133],"abnormal,":[134],"incomplete":[135],"reentry.":[137]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":26},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":27},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":20},{"year":2017,"cited_by_count":20},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":22},{"year":2014,"cited_by_count":29},{"year":2013,"cited_by_count":25},{"year":2012,"cited_by_count":26}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}